These other metabolites are not known to have any pharmacologic effects, and are further converted in part by conjugation (phase II metabolism) into polar metabolites, mainly sulfates and glucuronides. (druglib.com)
Sulfate and glucuronide conjugates of both ethinyl estradiol and phase I metabolites, which are excreted in bile, can undergo enterohepatic circulation. (druglib.com)
To address this, concentrations of testosterone, sex hormone binding globulin, androstanediol glucuronide (a metabolite of dihydrotestosterone) and estradiol were measured in stored serum specimens from men examined in the morning sample of the first phase of NHANES III (1988-1991). (cdc.gov)
A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. (reference.md)
RECLIPSEN Tablets provide an oral contraceptive regimen of 21 white round tablets each containing 0.15 mg desogestrel (13-ethyl-11-methylene-18, 19-dinor-17 alpha-pregn-4-en-20-yn-17-ol) and 0.03 mg ethinyl estradiol (19-nor-17 alpha-pregna-1,3,5 (10)-trien-20-yne-3, 17, diol). (druglib.com)
Benzene-1,2-diol1
These are compounds containing 4-(2-aminoethyl) pyrocatechol [4-(2-aminoethyl) benzene-1,2-diol] or a derivative thereof. (hmdb.ca)
Androstanediol glucuronide2
Erkeklik hormonları (androgens) testosteron ve DHT (dihidrotestosteron) (dihydrotestosterone), erkeklik hormonlarının hammaddesi DHEA (dehidroepiandrosteron)(dehydrotestosterone) ve erkeklik hormonlarının yıkım ürünlerinin ADT-G (androsterone glucuronide) ve 3 α-diol-G ( 3 α-androstanediol glucuronide) kan dolaşımında ve hücre içinde (deri kıl kökleri ve yağ bezleri) bulunan miktarlarının dağılımı. (polikistikover.net)
Kıl köklerinin bulunduğu deri hücresinde üretilen kan dolaşımına girmeyen buz dağının görünmeyen büyük kısmı ise 3 α- androstanediol glucuronide (3α diol G) ve androsterone Glucuronide (ADT-G) dönüşerek deri hücresinden kan dolaşımına girmektedir. (polikistikover.net)
Metabolite1
Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice. (hirosaki-u.ac.jp)
The androgen testosterone (17 -hydroxyandrostenone) has a molecular weight of 288 daltons. (cdc.gov)
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Hormone2
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Acid1
In particular, tamoxifen-N-glucuronide and uridine 5'-diphosphate can be biosynthesized from tamoxifen and uridine diphosphate glucuronic acid through the action of the enzyme UDP-glucuronosyltransferase 1-4. (foodcomex.org)
Human1
Accumulating evidence demonstrates that many of the 17 human UGTs characterized to date exhibit tissue-specific patterns of expression. (aspetjournals.org)
Free1
16179545 ). NADA exists in both free and conjugated (glucuronide) forms. (hmdb.ca)
Patients1
For this pilot study, portal venous blood and pancreatic juice samples were collected from 17 patients who underwent pancreaticoduodenectomy for peri-ampullary tumors. (bvsalud.org)
Found1
[ 17 ] Genetic polymorphisms of the UGT1A1 promoter, specifically the T-3279G and the thymidine-adenine (TA)7 dinucleotide repeat TATAA box variants, were found to be commonly inherited in white individuals with high allele frequency. (medscape.com)
Metabolites6
BACKGROUND: Results of recent studies have demonstrated that genetic variants of the enzyme steroid 5α reductase type II (SRD5A2) are associated with serum concentrations of major androgen metabolites such as conjugates of androstane-3α,17β-diol-glucuronide (3α-diol-G). However, this association was not consistently found among different ethnic groups. (elsevierpure.com)
Serum levels of sex steroids and the three major glucuronidated androgen metabolites, androstane-3alpha,17beta-diol-17glucuronide, androstane-3alpha,17beta-diol-3glucuronide, and androsterone-glucuronide, were analyzed. (nih.gov)
THF-diols, LTX-diols, and/or their metabolites likely act additively to disrupt endocrine function in male and female rats at concentrations (0.5-1 ppm) that are 200-fold lower than those of classical phytoestrogen endocrine disruptors. (nih.gov)
The majority of metabolites in the circulation are sulfates, with glucuronides accounting for most of the urinary metabolites (5). (nih.gov)
Significantly lower levels of two precursor hormones, dehydroepiandrosterone sulfate and androstene-3β,17β-diol, were found in women with sexual dysfunction ( P = 0.006 and P = 0.020, respectively). (medscape.com)
Significantly lower levels of the two precursor steroids dehydroepiandrosterone sulfate and androstene-3β,17β-diol but not the major androgen metabolite ADT-G were found in women with HSDD. (medscape.com)
Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES). (lookformedical.com)
Androgen3
The androgen testosterone (17 -hydroxyandrostenone) has a molecular weight of 288 daltons. (cdc.gov)
For the first time, three androgen diols including 5-androstene-3β,17β-diol (5-adiol), 5α-androstane-3α,17β-diol (3α-adiol), 5α-androstane-3β,17β-diol (3β-adiol), the glucuronide or sulfate conjugate of 5-adiol and 3α-adiol were measured and observed to be dramatically reduced after NADT. (nih.gov)
Our earlier report suggested that androst-5-ene-3beta,7beta-diol (Delta(5)-androstenediol or Adiol) is a natural hormone with androgenic activity and that two potent antiandrogens, hydroxyflutamide (Eulexin) and bicalutamide (Casodex), fail to block completely the Adiol-induced androgen receptor (AR) transactivation in prostate cancer cells. (lookformedical.com)
Ethinyl estradiol3
Ethinyl estradiol is also extensively metabolized, both by oxidation and by conjugation with sulfate and glucuronide. (nih.gov)
Sulfates are the major circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. (nih.gov)
Twenty-eight (28) yellow tablets each containing 90 mcg of levonorgestrel (17α)-(-)13-ethyl-17-hydroxy-18, 19-dinorpregn-4-en-20-yn-3-one, a totally synthetic progestogen, and 20 mcg of ethinyl estradiol, (17α)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol. (rxlist.com)
3beta1
and no. 10, 3beta-methylcarbonate-androst-5-ene-7,17-dione] that have no androgenic activity and could also block the Adiol-induced AR transactivation in prostate cancer PC-3 cells. (lookformedical.com)
Sulfate1
Norethindrone undergoes extensive biotransformation, primarily via reduction, followed by sulfate and glucuronide conjugation. (nih.gov)
Acid2
1,3-Dichloro-2-propanol (1,3-DCP) cannot be analysed by phenylboronic acid derivatization, which is the most commonly applied procedure for the analysis of 3-MCPD, because phenylbo- ronic acid only reacts with diols. (optik-temmel.at)
12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin. (glpbio.com)
DHEA1
Similarly, the 88% mortality rate seen in LPS challenge was reduced to 17% and 8.5%, by treatment with DHEA and AED, respectively. (lookformedical.com)
METHODS1
METHODS: Using a retrospective cohort of children aged 6 months to 17 years in 8 managed care organizations that comprise the Vaccine Safety Datalink and who had a diagnosis of sickle cell anemia from 1999 to 2006, we conducted matched case-control and self-controlled case series studies to examine the association of trivalent inactivated influenza vaccination with hospitalization for sickle cell crisis in the 2 weeks after vaccination. (cdc.gov)
Tissues4
To define the lowest observed adverse effect level (LOAEL) for the THF-diols and LTX-diols in rats, we examined the nature of their interaction (additive or synergistic) and quantified the concentration of THF-diols in rat tissues. (nih.gov)
We were unable to detect THF-diols in tissues from rats treated with 10 ppm of the compounds, suggesting that metabolism may be involved. (nih.gov)
However, no exhaustive investigations on the expression of these 17 catalytically active isoforms in various human tissues have been reported until now, probably due to difficulties with carrying out differential determination because of the sequence similarities. (aspetjournals.org)
Concentrations2
CONCLUSIONS: The genetic variation of SRD5A2 is associated with circulating 3α-diol-3G and 3α-diol-17G concentrations in Chinese elderly men. (elsevierpure.com)
Higher concentrations (1-2 ppm) of THF-diols were required to block male sexual behavior. (nih.gov)
Hormones1
[ 17 ] Intracrinology is the production of hormones within a cell to exert their activity in that same cell with minimal release of active hormones into the circulation. (medscape.com)
Steroids4
Free steroids and sulphate ester fractions could then be separated using mixed mode anion exchange chromatography, which can also be used to separate steroid glucuronides. (bl.uk)
Unsaturated steroids with most of the skeleton of cholestane containing a 3 b -hydroxyl group and an aliphatic side chain of 8 or more carbon atoms attached to position 17 form the group of sterols. (gerli.com)
They are typically polyhydroxy C24 steroids with a pentadienolide ring at C-17. (gerli.com)
Their structure is closely related to bufadienolides but these C23 steroids possess a butenolide ring located at C-17. (gerli.com)
Production1
indications are that high fat levels lead to production of bile acids (17), which may have a cocarcinogenic effect. (nih.gov)
Results2
RESULTS: The well-described SRD5A2 missense variant rs523349 (V89L) was modestly associated with the 3α-diol-17G concentration (P = 0.040). (elsevierpure.com)
Results of haplotype analysis suggested that the presence of an A-C-G haplotype leads to an increased 3α-diol-3G concentration, a finding consistent with results of single SNP analysis. (elsevierpure.com)