• Dihydroxyphenylalanine may refer to either of two chemical compounds: D-DOPA (R), 3,4-dihydroxyphenylalanine L-DOPA (S), 3,4-dihydroxyphenylalanine, a precursor of a neurotransmitter This set index article lists chemical compounds articles associated with the same name. (wikipedia.org)
  • Tyrosine is oxidized into dihydroxyphenylalanine (L-DOPA). (newworldencyclopedia.org)
  • The first drug that was discovered to successfully relieve symptoms of Parkinson disease was the amino acid l -3,4-dihydroxyphenylalanine (levodopa, or l -dopa). (britannica.com)
  • attenuates abnormally increased striatal phosphorylation of both Tyr15-Cdk5 and Thr75-DARPP-32, as does L-3,4-dihydroxyphenylalanine (L-dopa). (frontiersin.org)
  • L-DOPA affects anterior pituitary cell proliferation and apoptosis L-3,4-dihydroxyphenylalanine (L-DOPA) is released by hypothalamic neurons. (conicet.gov.ar)
  • L-DOPA, also known as Levodopa or L-3,4-dihydroxyphenylalanine, is synthesised in plants from the amino acid tyrosine, through oxidation. (jic.ac.uk)
  • The effect of L-3,4-dihydroxyphenylalanine (L-DOPA) on dopamine receptor gene expression in the brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys was investigated using in situ hybridization histochemistry with measures of changes in relative absorbance. (aspetjournals.org)
  • Ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] was shown to prolong the action of L-3,4-dihydroxyphenylalanine (L-DOPA) while suppressing dyskinesia in a single patient with Parkinson s disease (PD). (erowid.org)
  • The long-term decrease in 5-HT concentrations and tryptophan hydroxylase activity produced by MDMA was antagonized by depletion of vesicular monoamines with reserpine or interruption of monoamine synthesis with the decarboxylase inhibitor, monofluoro methyl DOPA (dihydroxyphenylalanine). (erowid.org)
  • This occurs by inhibiting the conversion of the tyrosine enzyme to DOPA (dihydroxyphenylalanine), reducing melanin, per the American Osteopathic College of Dermatology . (glam.com)
  • When dizocilpine was given to animals treated with NSD 1015, an inhibitor of 3,4-dihydroxyphenylalanine (DOPA) decarboxylase and monoamine oxidase, there was an increase in levels of DOPA and 3-methoxytyramine (3-MT). These findings suggest that dizocilpine stimulates DA synthesis and release in mouse brain. (eurekamag.com)
  • In their 1957 and 1958 papers [1.2], (Carlsson et al 1957) (Carlsson et al 1958) Carlsson and co-workers made the intriguing observation that the akinetic effects of reserpine could be reversed by an intravenous injection of the dopamine (and noradrenaline) precursor, 3,4- dihydroxyphenylalanine (DOPA). (lu.se)
  • Moreover, in the 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine (MPTP) mouse model, dopamine deficiency caused increased phosphorylation of both Tyr15-Cdk5 and Thr75-DARPP-32 in the striatum, which could be attenuated by administration of L-3,4-dihydroxyphenylalanine and imatinib (STI-571), a selective c-Abl inhibitor. (frontiersin.org)
  • Changes of D1 and D2 dopamine receptor mRNA in the brains of monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: correction with chronic administration of L-3,4-dihydroxyphenylalanine. (aspetjournals.org)
  • Effects of Naltrexone on the Accumulation of L-3,4-dihydroxyphenylalanine and 5-hydroxy-L-tryprtophan and on the Firing Rate Induced by Acute Ethanol Administration. (keio.ac.jp)
  • Look up dihydroxyphenylalanine in Wiktionary, the free dictionary. (wikipedia.org)
  • The recent application of positron emission tomography (PET)/computed tomography (CT) scanning with 18-fluoro-l-3,4 dihydroxyphenylalanine improved the ability to distinguish the two histopathologic forms of HI (focal and diffuse), whose differentiation heavily influences the therapeutic management of the patient. (nih.gov)
  • 12. Effects of handling or immobilization on plasma levels of 3,4-dihydroxyphenylalanine, catecholamines, and metabolites in rats. (nih.gov)
  • The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific. (nih.gov)
  • Interaction of several mono- and dihydroxybenzene derivatives of various depigmenting potencies with L-3,4-dihydroxyphenylalanine-melanin. (cdc.gov)
  • 7. Determination of urinary vanillactic acid and plasma dihydroxyphenylalanine as markers of non-secreting neuroblastoma by high-performance liquid chromatography with electrochemical detection. (nih.gov)