• 6 November 2023, London - Stanley Capital Partners ("Stanley Capital" / "SCP"), the specialist healthcare and resource efficiency private equity investor is pleased to announce that its portfolio company, Laboratoire X.O ("LXO"), has completed the acquisition of the prescription drug Nimodipine under the brand name Nimotop® from Bayer for several markets globally excluding mainland China. (stanley-capital.com)
  • This increase in [Zn 2+ ] i was attenuated by concurrent addition of Gd 3+ , verapamil, ω-conotoxin GVIA, or nimodipine, consistent with Zn 2+ entry through voltage-gated Ca 2+ channels. (jneurosci.org)
  • More importantly for PD, blocking these channels with isradipine, the most potent of the dihydropyridine (DHP) channel antagonists at L-type Ca 2 + channels with the Cav1.3 subunit, protects these neurons in in vitro and in vivo models of parkinsonism. (touchneurology.com)
  • The analytes were then detected by monitoring the transitions m/z 372.1 m/z 312.0 for isradipine and 419.0 343.0 for nimodipine using API 3000 LCMS/MS system (Applied Biosystems) with Turbo Ion Spray interface. (ajrconline.org)
  • Additionally, the beneficial effects of nimodipine + MeHg exposure support the hypothesis that MeHg-induced changes in calcium homeostasis mediate the behavioral toxicity seen with MeHg exposure. (auburn.edu)
  • A little-appreciated option for enhancing lithium's mood stabilizing effects is nimodipine, a dihydropyridine calcium blocker. (bipolarnews.org)
  • Nimodipine is a dihydropyridine calcium channel blocker. (guidetoimmunopharmacology.org)
  • Rational alternatives exist, including an ACE inhibitor/calcium channel blocker (CCB) or a dihydropyridine CCB/ b blocker combination. (medscape.com)
  • Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells. (targetmol.com)
  • Nimodipine is the only approved 2nd generation dihydropyridine calcium channel blocker that is available in three different formulations (oral tablets, oral solutions and intravenous infusion solutions) in several markets globally. (stanley-capital.com)
  • Nisoldipine (INN) is a calcium channel blocker of the dihydropyridine class. (mosinterchem.com.cn)
  • Following that, one dihydropyridine CCB (nimodipine) was administered chronically to mice with and without chronic co-exposure to 15 ppm Methylmercury (MeHg), a toxicant known to elevate intracellular calcium concentration and cause cognitive and motor impairments. (auburn.edu)
  • Based on previous reports about the antileishmanial activity of dihydropyridine-CCBs, this work aimed to investigate whether the in vitro anti- Leishmania infantum and anti- Trypanosoma cruzi activities of this therapeutic class would be shared by other non-dihydropyridine-CCBs. (hindawi.com)
  • Nimodipine specifically blocks the calcium influx gene CACNA1C that has been repeatedly been associated with the vulnerability to bipolar disorder and depression. (bipolarnews.org)
  • If a patient taking lithium experiences a tremor at a dose that is not fully effective, nimodipine can be added in order to lower the lithium dose enough to eliminate the tremor. (bipolarnews.org)
  • Research showed that a year on the combination of lithium and nimodipine was more effective than a year of either drug alone. (bipolarnews.org)
  • The disparities between the in vitro and in vivo effects may relate, in part, to the sympathetic activation triggered by dihydropyridine-induced vasodilation, which blunts any direct negative chronotropic and inotropic effects. (medscape.com)
  • These data demonstrated that non-dihydropyridine-CCBs present antiprotozoal activity and could be useful candidates for future in vivo efficacy studies against Leishmaniasis and Chagas' disease. (hindawi.com)
  • These studies further support the main indication of nimodipine, by clarifying some mechanisms of the anti-ischemic activity of the compound. (nih.gov)
  • In this study, we performed a large-scale screen of 640,000 compounds to identify the dihydropyridine (DHP) class of anti-hypertensives as a priority compound hit. (bvsalud.org)
  • Manidipine is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. (adooq.com)
  • Early treatment with nimodipine reduces the severity of neurological deficits resulting from vasospasm in subarachnoid haemorrhage (SAH) patients. (nih.gov)
  • While we conclude that nimodipine treatment is not likely to improve amyloid pathology or decrease neuritic dystrophy in AD, it is worth noting that nimodipine did not worsen the phenotype suggesting its use is safe in AD patients. (nih.gov)
  • The objective of this study was to test the effects of FDA-approved L-type calcium channel antagonist nimodipine on amyloid accumulation and dystrophic neurite formation in 5XFAD mice, a mouse model of amyloid pathology. (nih.gov)
  • A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. (bvsalud.org)
  • Nimodipine was well tolerated and crossed the blood brain barrier, as expected, but there was no effect on Aβ accumulation or on the relative amount of neuritic dystrophy, as assessed by either immunoblot, dot blot or immunofluorescence imaging of Aβ42 and dystrophic neurite marker LAMP1. (nih.gov)