• Dihydromorphine is a moderately strong analgesic and is used clinically in the treatment of pain and also is an active metabolite of the analgesic opioid drug dihydrocodeine. (wikipedia.org)
  • Dihydromorphine can be made by several processes, including hydrogenating morphine or opium or by demethylating either dihydrocodeine or tetrahydrothebaine. (chemeurope.com)
  • These individuals convert dihydrocodeine into its active metabolite, dihydromorphine, more rapidly and completely than other people. (drugs.com)
  • When prescribing dihydrocodeine-containing drugs, healthcare providers should choose the lowest effective dose for the shortest period of time and inform patients and caregivers about these risks and the signs of dihydromorphine overdose. (drugs.com)
  • The brand name Numorphan is derived by analogy to the Nucodan name for an oxycodone product (or vice versa) as well as Paramorphan/Paramorfan for dihydromorphine and Paracodin (dihydrocodeine). (wikipedia.org)
  • Acetyldihydrocodeine can be described as the 6-acetyl derivative of dihydrocodeine and is metabolised in the liver by demethylation and deacetylation to produce dihydromorphine . (wikidoc.org)
  • Dihydromorphine (Paramorfan, Paramorphan) is a semi-synthetic opioid structurally related to and derived from morphine. (wikipedia.org)
  • The 7,8-double bond in morphine is reduced to a single bond to get dihydromorphine. (wikipedia.org)
  • The process for manufacturing dihydromorphine from morphine for pharmaceutical use was developed in Germany in the late 19th century, with the synthesis being published in 1900 and the drug introduced clinically as Paramorfan shortly thereafter. (wikipedia.org)
  • Dihydromorphine is slightly stronger than morphine as an analgesic with a similar side effect profile. (wikipedia.org)
  • The relative potency of dihydromorphine is about 1.2 times that of morphine. (wikipedia.org)
  • Dihydromorphine is regulated in the same fashion as morphine in Germany under the BtMG, Austrian SMG, and Swiss BtMG, where it is still used as an analgesic. (wikipedia.org)
  • Dihydromorphine and morphine are also used alongside each other in clinical use in Japan and is regulated as such Dihydroheroin Acetyldihydrocodeine Morphine Nicodicodeine Nicocodeine Thebacon Rama Rao Nadendla. (wikipedia.org)
  • Like metopon , dihydromorphine may be less addictive overall and have better bioavailability after oral administration than morphine. (chemeurope.com)
  • Dihydromorphine has a longer duration of action (6 hours vs 4 hours for morphine). (chemeurope.com)
  • Hydromorphone's side effect profile, explored in greater detail in the section on side effects, is closer to that of dihydromorphine than that of morphine and importantly produces less nausea and vomiting and fewer histamine-related side effects than morphine as a result. (bionity.com)
  • DHC is far superior to codeine, as it is converted to dihydromorphine (itself far superior to the morphine that codeine is converted to) and doesn't have the metabolic conversion limit of about 400mg/day that your body is able to make use of codeine before the enzymes run out and it can't make any more morphine for a while. (healingwell.com)
  • Not to be confused with dihydromorphine , which is a different derivative of the morphine family. (worldlibrary.net)
  • Since acetyldihydrocodeine has higher lipophilicity than codeine and is converted into dihydromorphine rather than morphine , it can be expected to be more potent and longer lasting, and also have higher bioavailability than codeine. (wikidoc.org)
  • hydromorphone, morphine, and dihydromorphine. (medhelp.org)
  • Morphine , the archetypal opioid , and other opioids (e.g., codeine , oxycodone , hydrocodone , dihydromorphine, pethidine ) all exert a similar influence on the cerebral opioid receptor system. (kiwix.org)
  • Dihydromorphine (Paramorfan, DHM, Paramorphan) is a semi-synthetic opioid invented in Germany in the first years of the twentieth century. (chemeurope.com)
  • This rapid conversion results in higher than expected serum dihydromorphine levels. (drugs.com)
  • However, in women who are ultra-rapid metabolizers (those with multiple copies of the gene for CYP450 2D6), higher-than-expected levels of dihydromorphine may be excreted in breast milk and result in dangerously high serum dihydromorphine levels in breastfed infants. (drugs.com)
  • Dihydromorphine, often labelled with the isotope tritium in the form of [3H]-dihydromorphine, is used in scientific research to study binding of the opioid receptors in the nervous system. (wikipedia.org)
  • Dihydromorphine acts as an agonist at the μ-opioid (mu), δ-opioid (delta) and κ-opioid (kappa) receptors. (wikipedia.org)
  • Agonist of the μ-opioid and δ-opioid receptors is largely responsible for the clinical effects of opioids like dihydromorphine with the μ agonism providing more analgesia than the δ. (wikipedia.org)
  • Dihydromorphine, often labelled with the isotopes iodine-129 and tritium , was amongst tools utilised in the 20th century research which eventually led to the theory and discovery of opioid receptors in the human nervous system. (chemeurope.com)
  • Dihydromorphine is an opioid that is used for the management of moderate to severe pain such as cancer, although its less effective in treating things such as neuropathic pain and is generally considered inappropriate and ineffective for psychological pain. (worldheritage.org)
  • Receptor binding analysis with [ 3 H]dihydromorphine further supports the opiate alkaloid selectivity and opioid peptide insensitivity of this receptor. (jimmunol.org)
  • Meptazinol is a unique centrally active opioid analgesic , which inhibits [ 3 H]dihydromorphine binding with IC50 of 58 nM. (selleckchem.com)
  • The DEA has assigned dihydromorphine and all of its salts, esters, &c the ACSCN of 9145. (wikipedia.org)
  • Description Dihydromorphine-6-β-D-glucuronide Product reference number M-276-HY Formula C23H29NO9.CF3CO2H Molecular weight 577.50 DEA No. 9145 CI Supplied as trifluoroacetate salt Appearance white lyophilized powder. (lipomed-usa.com)
  • Under the Controlled Substances Act, dihydromorphine is listed as a Schedule I substance along with heroin. (wikipedia.org)
  • With embranes from normal ICR mice, glucose (100-400 mg/dl) caused small but significant concentrationdependent decreases in receptor affinities for [ 3 H]naloxone and [ 3 H]dihydromorphine, both in the absence and presence of 20 mM NaCI, without changing the maximum number of binding sites. (diabetesjournals.org)
  • Manganese ions enhance binding of the tritiated opiate agonists dihydromorphine and levorphanol 78% and 64%, respectively, while binding of the tritiated antagonists naloxone, levallorphan, and diprenorphine is unaffected. (elsevier.com)
  • Magnesium and nickel ions also selectively enhance [ 3 H]dihydromorphine binding with no effect on [ 3 H]naloxone binding. (elsevier.com)
  • By contrast, cupric and ferrous ions lower the binding of [ 3 H]dihydromorphine far more than that of [ 3 H]naloxone. (elsevier.com)
  • Magnesium and nickel ions also selectively enhance [3H]dihydromorphine binding with no effect on [3H]naloxone binding. (elsevier.com)
  • By contrast, cupric and ferrous ions lower the binding of [3H]dihydromorphine far more than that of [3H]naloxone. (elsevier.com)
  • For this reason, in the United States, dihydromorphine shares a Schedule I designation with these other opioids, under the Controlled Substances Act of 1970. (chemeurope.com)
  • Tritium-labeled dihydromorphine (DHM-3H) was accumulated by the synaptosomal fraction (nerve endings) of rat cerebral cortex. (umich.edu)
  • The potency of sodium in inhibiting [ 3 H]dihydromorphine binding is reduced 5 fold by the addition of manganese ions. (elsevier.com)
  • The potency of sodium in inhibiting [3H]dihydromorphine binding is reduced 5 fold by the addition of manganese ions. (elsevier.com)
  • Individuals and organisations are lobbying for the United States to legalise and approve dihydromorphine for use alongside other analgesics. (chemeurope.com)
  • citation needed] Under the 1961 international Single Convention on Narcotic Drugs treaty dihydromorphine is a Schedule I narcotic subject to control, and other countries' laws may vary. (wikipedia.org)
  • At the present time, dihydromorphine is most commonly used in Japan, and is used, though still perhaps relatively rarely, in Europe but has in fact been used more and in greater overall quantities in recent decades in some countries such as the Czech Republic, Slovakia and others in the region. (chemeurope.com)
  • Tous les résultats de la recherche seront tirés du « National Drug Schedules » du site Web en anglais. (napra.ca)
  • It is primarily metabolised by CYP2D6 and CYP3A4 to dihydromorphine and nordihydrocodeine, however it is unclear whether the parent drug, metabolites or a combination of both result in dihydrocodeine's analgesic activity. (bpac.org.nz)