AnatomyDiseasesChemicals and Drugs
DihydroergotamineErgotamineSumatriptanArteriovenous AnastomosisDihydroergocornineBenzamidesMigraine DisordersPiperazinesHydroxyzinePyrimidinesErgot AlkaloidsMethiothepinSerotonin Receptor Agonists
Nasal sprayMigranalErgotamineTrudhesaErgoloid mesylatesUpper Nasal SpaceInfusionMigraine headacheErgotIntravenousHeadacheInhibitorsAllergicINP104DoseTabletsSumatriptanMedicationSolutionLevelsAdministrationDrugsMigraineErgotamineFormulation of dihydroergotaminePharmacokineticsBioavailabilityIntramuscularMetabolismIntranasalDrugsEletriptanReceptorsOxytocicCYP3A4Adverse effectsDoctor's officeBoundDeviceRenalPlasmaRoute
Nasal spray9
  • It is administered as a nasal spray or injection and has an efficacy similar to that of sumatriptan. (wikipedia.org)
  • Subcutaneous and intramuscular injections are generally more effective than the nasal spray and can be self-administered by patients. (wikipedia.org)
  • DHE is available as a nasal spray and in ampules for subcutaneous, intramuscular and intravenous injection. (wikipedia.org)
  • Efficacy is variable in the nasal spray form with relative bioavailability of 32% compared to injection. (wikipedia.org)
  • Ergot alkaloids -- such as ergotamine tartrate ( Cafergot ) and dihydroergotamine mesylate (D.H.E. 45 Injection, Migranal Nasal Spray) -- are potent drugs that constrict blood vessels. (rxlist.com)
  • Abortive treatments come in various forms, including tablet (pill form), oral powders, nasal spray or powder, and self-administered injection or device use. (kaizenbraincenter.com)
  • Ketorolac: which comes in tablet form, nasal spray called SPRIX, or in the form of injection, which is called Toradol. (kaizenbraincenter.com)
  • Impel NeuroPharma, Inc., a commercial-stage biopharmaceutical company developing transformative therapies for people suffering from diseases with high unmet medical needs, with an initial focus on the central nervous system, announced that the U.S. Food and Drug Administration (FDA) approved TRUDHESA (dihydroergotamine mesylate) nasal spray (0.725 mg per spray) for the acute treatment of migraine with or without aura in adults. (mobilehealthtimes.com)
  • One bottle of dihydroergotamine nasal spray contains 4 sprays. (medbroadcast.com)
Migranal1
  • Dihydroergotamine (DHE), sold under the brand names D.H.E. 45 and Migranal among others, is an ergot alkaloid used to treat migraines. (wikipedia.org)
Ergotamine2
Trudhesa3
  • Serious or potentially life-threatening reductions in blood flow to the brain or extremities due to interactions between dihydroergotamine (the active ingredient in Trudhesa) and strong CYP3A4 inhibitors (such as protease inhibitors and macrolide antibiotics) have been reported rarely. (trudhesa.com)
  • Using Impel's proprietary Precision Olfactory Delivery (POD) technology, TRUDHESA gently delivers dihydroergotamine mesylate (DHE) quickly to the bloodstream through the vascular-rich upper nasal space. (mobilehealthtimes.com)
  • TRUDHESA bypasses the gut and potential absorption issues, offering rapid, sustained, and consistent symptom relief without injection or infusion, even when administered hours after the onset of a migraine attack. (mobilehealthtimes.com)
Ergoloid mesylates2
  • ergoloid mesylates decreases effects of nitroglycerin IV by pharmacodynamic antagonism. (medscape.com)
  • nitroglycerin IV increases effects of ergoloid mesylates by decreasing metabolism. (medscape.com)
Upper Nasal Space2
  • INP104 is an investigational drug device that delivers DHE mesylate to the upper nasal space using a Precision Olfactory Delivery technology and was developed to overcome the shortcomings of available DHE products. (bvsalud.org)
  • INP104 is a novel drug-device combination product that targets delivery of DHE mesylate to the upper nasal space, a previously unexplored route of administration, using a Precision Olfactory Delivery (I123 POD ® ) device. (impelpharma.com)
Infusion2
  • Dihydroergotamine mesylate injection (also known as DHE injection), which is mostly used as headache centers as an intravenous (IV) infusion. (kaizenbraincenter.com)
  • Because dihydroergotamine (DHE) is a costly infusion, encounters at which DHE was administered were analyzed separately. (bvsalud.org)
Migraine headache2
  • Dihydroergotamine is most effective if used at the first sign of a migraine headache with or without aura (warning signs that occur prior to the onset of a migraine headache). (medbroadcast.com)
  • The recommended dose of dihydroergotamine is one spray in each nostril (total of 2 sprays) at the first sign or symptom of a migraine headache, or as early as possible after the onset of migraine headache pain. (medbroadcast.com)
Ergot3
Intravenous2
  • Intravenous injection is considered very effective for severe migraine or status migrainosus. (wikipedia.org)
  • BACKGROUND: Dihydroergotamine (DHE) has long been used to treat migraine, but intravenous administration is invasive, frequently associated with adverse events (AEs), and not suitable for at-home administration. (bvsalud.org)
Headache2
  • D.H.E. 45® (dihydroergotamine mesylate) Injection, USP is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes. (rxlist.com)
  • You should not use sumatriptan injection or take any other headache medication for more than 10 days per month. (medlineplus.gov)
Inhibitors1
  • Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of DIHYDROERGOTAMINE with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. (rxlist.com)
Allergic1
INP1042
  • Systemic dihydroergotamine (DHE) mesylate has a rapid onset and sustained effect, and we have previously reported similar plasma levels of DHE mesylate from 20 minutes achieved with INP104 in our Phase 1, STOP 101 trial. (impelpharma.com)
  • INP104 has the potential to deliver well tolerated, rapid and effective symptom relief, predictably and consistently, without injection. (impelpharma.com)
Dose2
  • D.H.E. 45 Injection is administered in a dose of 1 mL intravenously, intramuscularly or subcutaneously. (rxlist.com)
  • You may use your first dose of sumatriptan injection in a doctor's office or other medical facility where you can be monitored for serious reactions. (medlineplus.gov)
Tablets1
  • RESCRIPTOR tablets contain delavirdine mesylate, a synthetic non-nucleoside reverse transcriptase inhibitor (NNRTI) of the human immunodeficiency virus type 1 (HIV-1). (drugs.com)
Sumatriptan10
  • Sumatriptan injection is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). (medlineplus.gov)
  • Sumatriptan injection is also used to treat the symptoms of cluster headaches (severe headaches usually on one side of the head or around one eye). (medlineplus.gov)
  • Sumatriptan injection comes as a solution (liquid) to inject subcutaneously (just under your skin). (medlineplus.gov)
  • However, if your symptoms do not improve after you use sumatriptan, do not use a second injection without talking to your doctor. (medlineplus.gov)
  • Sumatriptan injection comes in a pre-filled auto-injection device and in vials to be used with disposable syringes. (medlineplus.gov)
  • If you are using vials of sumatriptan injection, your doctor or pharmacist will tell you what type of syringe you should use. (medlineplus.gov)
  • Call your doctor if your headaches do not get better or occur more frequently after using sumatriptan injection. (medlineplus.gov)
  • Call your doctor if you need to use sumatriptan injection to treat more than four headaches in 1-month period. (medlineplus.gov)
  • Do not use prefilled injection devices or vials of sumatriptan injection more than once. (medlineplus.gov)
  • do not use sumatriptan injection if you are taking a monoamine oxidase A (MAO-A) inhibitor such as isocarboxazid (Marplan), phenelzine (Parnate), or tranylcypromine (Nardil) or if you have taken one of these medications in the past 2 weeks. (medlineplus.gov)
Medication1
  • Our D.H.E. 45 (dihydroergotamine mesylate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
Solution2
Levels1
  • Because CYP 3A4 inhibition elevates the serum levels of DIHYDROERGOTAMINE, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. (rxlist.com)
Administration1
  • Compatibility of doxorubicin hydrochloride liposome injection with selected other drugs during simulated Y-site administration. (stabilis.org)
Drugs3
  • Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection. (stabilis.org)
  • Visual, turbidimetric, and particle-content assessment of compatibility of vinorelbine tartrate with selected drugs during simulated Y-site injection. (stabilis.org)
  • Visual compatibility of amsacrine with selected drugs during simulated Y-site injection. (stabilis.org)
Migraine13
  • The therapeutic activity of dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT 1D receptors. (nih.gov)
  • Intravenous injection is considered very effective for severe migraine or status migrainosus. (wikipedia.org)
  • Migraine Injection Pens: Do They Work? (healthmatch.io)
  • An alternative to a medical visit is an at-home solution - a migraine injection pen. (healthmatch.io)
  • What are migraine self-injection pens? (healthmatch.io)
  • Migraine injection pens are easy to use. (healthmatch.io)
  • Self-injection pens provide migraine patients with a unique opportunity to prevent or alleviate their symptoms without leaving the house. (healthmatch.io)
  • Those who choose migraine self-injection pens can carry them around easily, use them anytime and anywhere (as needed), and don't need medical supervision. (healthmatch.io)
  • For the treatment of migraine and to terminate an acute attack of cluster headache, dihydroergotamine mesylate is usually given by subcutaneous or intramuscular injection in doses of 1 mg repeated, if necessary, after 30 to 60 minutes up to a maximum daily dose of 3 mg. (pocketdrugguide.com)
  • The usual nasal dose of dihydroergotamine mesylate for an acute migraine attack is 500 micrograms sprayed into each nostril as a 0.4% solution, followed after 15 minutes by an additional 500 micrograms in each nostril. (pocketdrugguide.com)
  • Sumatriptan injection is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). (medlineplus.gov)
  • For instance, in January 2021 , the FDA accepted Impel's 5O5 (b)(2) New Drug Application (NDA) for INP104, a dihydroergotamine mesylate (DHE) delivered directly into the vascular-rich upper nasal space using Impel's proprietary Precision Olfactory Delivery (POD) technology, which is used for the acute treatment of migraine headaches with or without aura in adults. (countyenews.com)
  • We also initiated and completed a Phase 1 study of PUR3100, our orally inhaled formulation of dihydroergotamine (DHE) for acute migraine, allowing us to begin 2023 by announcing data that we believe illustrates a potentially positive pharmacokinetic and pharmacodynamic profile for PUR3100 - including a rapid systemic exposure within the targeted therapeutic range, and fewer side effects compared to intravenous (IV) dosing. (pulmatrix.com)
Ergotamine3
  • Dihydroergotamine Mesylate Injection, USP is ergotamine hydrogenated in the 9, 10 position as the mesylate salt. (nih.gov)
  • Dihydroergotamine (DHE) is a semi-synthetic form of ergotamine approved in the US in 1946. (wikipedia.org)
  • Dihydroergotamine is a semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor effects than ergotamine. (pocketdrugguide.com)
Formulation of dihydroergotamine1
Pharmacokinetics2
  • Previous studies do not provide insight into the pharmacokinetics of intranasal cobalamin administration in comparison with cobalamin injection. (nih.gov)
  • The Phase 1 study was designed as a double-dummy, double-blinded trial to assess the safety, tolerability, and pharmacokinetics of three dose levels of single doses of inhaled PUR3100 with IV placebo, as compared to IV DHE (DHE mesylate injection) with inhaled placebo. (pulmatrix.com)
Bioavailability2
  • Absolute bioavailability for the subcutaneous and intramuscular route have not been determined, however, no difference was observed in dihydroergotamine bioavailability from intramuscular and subcutaneous doses. (nih.gov)
  • Although dihydroergotamine is incompletely absorbed from the gastrointestinal tract, the low bioavailability is determined primarily by extensive first-pass hepatic metabolism. (pocketdrugguide.com)
Intramuscular5
  • Dihydroergotamine Mesylate Injection, USP is a clear, colorless solution supplied in sterile ampules for intravenous, intramuscular, or subcutaneous administration. (nih.gov)
  • Only 6% to 7% of unchanged dihydroergotamine is excreted in the urine after intramuscular injection. (nih.gov)
  • Peak plasma-dihydroergotamine concentrations have been attained within 1 to 2 hours after oral doses, 30 minutes after intramuscular injection, 15 to 45 minutes after subcutaneous injection, and 45 to 55 minutes after intranasal doses. (pocketdrugguide.com)
  • The gold standard for cobalamin deficiency treatment is administration of cobalamin by intramuscular injection. (nih.gov)
  • Ten inpatients and outpatients of a geriatrics unit were recruited and randomly assigned to receive a single dose of 1000 μg cobalamin administered either by intranasal spray or intramuscular injection (5 per group). (nih.gov)
Metabolism9
Intranasal1
  • dihydroergotamine intranasal, norepinephrine. (medscape.com)
Drugs8
  • A doctor will explain how often you should give yourself injections and how to store the drugs to ensure their effectiveness. (healthmatch.io)
  • Injection pens deliver drugs subcutaneously (under your skin). (healthmatch.io)
  • Self-injection pens³ are widely used to deliver drugs that help with various conditions, including diabetes , rheumatoid arthritis, multiple sclerosis, and psoriasis. (healthmatch.io)
  • Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection. (stabilis.org)
  • Visual, turbidimetric, and particle-content assessment of compatibility of vinorelbine tartrate with selected drugs during simulated Y-site injection. (stabilis.org)
  • Compatibility of doxorubicin hydrochloride liposome injection with selected other drugs during simulated Y-site administration. (stabilis.org)
  • Visual compatibility of amsacrine with selected drugs during simulated Y-site injection. (stabilis.org)
  • Visual compatibility of sargramostim with selected antineoplasic agents, anti-infectives, or other drugs during simulated Y-site injection. (stabilis.org)
Eletriptan1
Receptors1
  • Dihydroergotamine binds with high affinity to 5-HT 1D α and 5-HT 1D β receptors. (nih.gov)
Oxytocic1
CYP3A42
  • Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of DIHYDROERGOTAMINE with potent CYP3A4 inhibitors including protease inhibitors and macrolide antibiotics. (nih.gov)
  • Because CYP3A4 inhibition elevates the serum levels of DIHYDROERGOTAMINE, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. (nih.gov)
Adverse effects1
  • Side effects possible adverse effects include diarrheavomitingblood in stoolspain at injection site. (gumaho.com)
Doctor's office1
  • While it's possible to get an injection in the emergency department or the doctor's office, it requires time. (healthmatch.io)
Bound2
  • Dihydroergotamine mesylate is 93% plasma protein bound. (nih.gov)
  • Dihydroergotamine is 90 to 95% bound to plasma proteins. (pocketdrugguide.com)
Device1
  • This allows a single-device system to manage a variety of delivery options, including different viscosities (up to 300 cP and much higher with a new variation on the technology), injection volumes, and primary containers. (countyenews.com)
Renal1
Plasma1
Route1