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  • diagnostic
  • The study proposes to validate the diagnostic value of diffusion kurtosis in major basal ganglia regions using a cross-sectional study and to assess the prognostic value through 3-year longitudinal follow-up. (clinicaltrials.gov)
  • acute
  • Diffusion-weighted brain magnetic resonance imaging showing multifocal small acute infarctions in the internal border zone of both the cerebral hemisphere (A) and left cerebellar hemisphere (B). (nih.gov)
  • Diffusion-weighted brain MRI revealed multifocal small embolic acute infarctions in the internal border zone of both cerebral hemispheres, temporooccipital lobes of both PCA territory, and left cerebellar hemisphere (Fig. 1). (nih.gov)
  • No statistic significance was found comparing CBV and T0 in relation with NIHSS or MRS. Conclusion: The hemodynamic parameters derived from perfusion MR imaging may be helpful adjunct to predict the outcome and severity in acute stroke patients. (uni-muenchen.de)
  • clinically
  • To provide clinically prognostic and useful information, changes in imaging biomarker readouts must provide consistent changes reflective of specific underlying alterations in tissue properties including cellular viability, biochemical, and molecular responses to therapeutic intervention. (aacrjournals.org)
  • tissue
  • 01). A precise topical coincidence was demonstrated between changes in nuclear magnetic resonance diffusion images, pattern of histological damage, ATP-depleted areas, and local tissue acidosis, the lesion area amounting to between 24.1% and 27.6% of the hemisphere at the level of the caudate-putamen. (ahajournals.org)
  • The concept of diffusion/perfusion mismatch attracted great attention since it may represent the tissue at risk or at least an index of penumbra. (uni-muenchen.de)
  • analyze
  • Computer-based image averaging was used to analyze DWI data obtained 24 hours after MCAo and light-microscopic histopathology obtained at 3 days. (pptaglobal.org)
  • efficacy
  • Promising approaches for the individualization of oncology patient care include the development of imaging-based biomarkers as early readouts of therapeutic efficacy ( 1 , 2 ). (aacrjournals.org)
  • What is the comparative efficacy of filter embolic protection and proximal balloon occlusion systems in preventing embolization during carotid artery stenting (CAS), as detected by diffusion-weighted magnetic resonance imaging (DW-MRI)? (acc.org)
  • prediction
  • Besides, the prediction outcome of CAD had a strong correlation with the DWI scores that were graded by experienced radiologists according to the Prostate Imaging-Reporting and Data System Version 2 (PI-RADS v2). (urotoday.com)
  • To investigate the clinical potential of pretreatment apparent diffusion coefficient (ADC) on diffusion-weighted magnetic resonance imaging (DWI) for therapy response and outcome prediction in patients with liver-predominant metastatic colorectal cancer (CRC) undergoing radioembolization with 90 Yttrium-microspheres (90Y-RE). (springermedizin.de)
  • Therefore 18 F-FDG PET/CT imaging performed prior to radiotherapy and chemotherapy has been considered to be a new biomarker in the prediction of treatment response in nasopharyngeal cancers and it is a functional method of imaging that has been used in the staging of tumor in oncology [ 5 , 6 ]. (alliedacademies.org)
  • inflammatory
  • This study evaluated the temporal effect of treatment-associated inflammatory activity on diffusion magnetic resonance imaging and 2-[ 18 F]-fluoro-2-deoxy- d -glucose-positron emission tomography imaging (FDG-PET) biomarkers to delineate the effects of the inflammatory response on imaging readouts. (aacrjournals.org)
  • Results revealed that treatment-associated inflammatory response following tumor therapy resulted in the accentuation of tumor diffusion response along with a corresponding increase in tumor FDG uptake due to the presence of glucose-consuming activated macrophages. (aacrjournals.org)
  • The dynamics and magnitude of potential inflammatory response should be considered when interpreting imaging biomarker results. (aacrjournals.org)
  • reflects
  • Histological examination supports the model that the observed increase in diffusion reflects an increase of extracellular space following treatment. (aacrjournals.org)
  • changes
  • Interpretation of imaging biomarker readouts of tumor treatment response should take into consideration the potential for changes in cell type subpopulations within the tumor mass over time. (aacrjournals.org)
  • More specifically, as the tumor cells are killed during treatment, diffusion values have been shown to increase in those regions of positive response, thus providing an opportunity for the use of DW-MRI-determined changes in ADC as a surrogate for cellular death. (aacrjournals.org)
  • Limbic and callosal white matter changes in euthymic bipolar I disorder: an advanced diffusion magnetic resonance imaging tractography study. (semanticscholar.org)