Differentiation potential. Medical search. Frequent questions

Furthermore, we revealed enhanced focal adhesion formation and osteogenic differentiation of MSCs cultured on positively charged protein fibers. (nature.com)
In this study, we verified that exosomes derived from osteogenically differentiated ADSCs can promote osteogenic differentiation of ADSCs. (hindawi.com)
Moreover, we found that these differentially expressed exosomal miRNAs connect osteogenic differentiation to processes such as axon guidance, MAPK signaling, and Wnt signaling. (hindawi.com)
This study confirms that alterations in the expression of exosomal miRNAs can promote osteogenic differentiation of ADSCs, which also provides the foundation for further research on the regulatory functions of exosomal miRNAs in the context of ADSC osteogenesis. (hindawi.com)
This study was therefore aimed at establishing the dose-response effect of EPO stimulation on rat BMSCs and investigating the effects of mechanical stretch combined with EPO on the proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
The proliferation and osteogenic differentiation of rat BMSCs were examined and compared using EPO with different concentrations. (hindawi.com)
The osteogenic differentiation of BMSCs was detected by alkaline phosphatase (ALP) staining, and the mRNA expression levels of ALP, OCN, COL, and Runx2 were detected by qPCR. (hindawi.com)
Mechanical stretch combined with 20 IU/ml EPO promoted proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
EPO was able to promote the proliferation and osteogenic differentiation of BMSCs, and these effects were enhanced when combined with mechanical stretch. (hindawi.com)
Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
This study was therefore aimed at addressing three key issues: First, is there a dose-dependent effect of EPO on the proliferation and osteogenic differentiation of BMSCs? (hindawi.com)
In their previous study, the researchers found that epimedin C could induce endothelial-like (but not osteogenic) differentiation of C3H/10T1/2 cells in vitro. (naturalnews.com)

With this biomimetic in vitro model we identified the fibrous structure as well as the charge of the material to be responsible for its effects on MSC differentiation. (nature.com)
Nevertheless, MSCs can lose their differentiation potential after expansion in vitro and transplantation into the site of injury 7 . (nature.com)
The potential effects of the tested herbal components in both in vitro systems were evaluated by monitoring the alteration in several endpoints. (nottingham.ac.uk)
MSCs isolated from MSCKO mice showed reduced differentiation towards osteoblasts and chondrocytes in vitro, but no difference in proliferation or apoptosis. (harvard.edu)
Objectives: To investigate the potential role of a commercially available preparation of micronized Amniotic Membrane Allograft (AMA) (Amniofix, MiMedx, USA) in the biological augmentation of an in vitro model of rotator cuff repair with respect to cellular pro- liferation, collagen content and mechanical properties of the bone- tendon interface. (researchgate.net)
The use of AMA in this in vitro study has not shown any benefit that would support its potential in improving the biology of cuff repair. (researchgate.net)
The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. (scielo.br)
Neuregulin1α, which drives mucus cell differentiation in vitro, was expressed in normal airway submucosal glands and in lungs from patients with IPF. (bmj.com)
RosaYFP mice and evaluate their proliferative and differentiation potential in vitro. (elsevierpure.com)
Different groups have established several protocols to induce the differentiation of MSCs into HLCs in vitro . (springer.com)
Endocrine lineage markers were detected upon in vitro differentiation. (prinsesmaximacentrum.nl)
This study demonstrated that SN-iPSCs-imDCs have potential applications in vitro and in vivo for induction of immunotolerance following organ transplantation. (newswise.com)
This study focused on exploring sinomenine (SN) to promote differentiation of induced pluripotent stem cells (iPSCs) into imDCs (SN-iPSCs-imDCs), and found SN-iPSCs-imDCs with worse donor-specific T-cell stimulatory function, and higher regulatory T-cell proliferative function in vitro and in vivo to induce high immune tolerance. (newswise.com)

In ESD3, 6-gingerol severely affected differentiation into cardiomyocytes cell activity and protein content at both low and high concentrations. (nottingham.ac.uk)
Primary results on cell viability and cell morphology, as well as cardiomyocyte differentiation, have shown that PCL- gelatin scaffolds carrying 5-azacytidine developed in this work could serve as an ideal platform for mesenchymal stem cell differentiation into cardiomyocytes . (bvsalud.org)

It modulates keratinocyte differentiation. (medscape.com)

New treatment strategies have pursued the idea of using mesenchymal stromal cells (MSCs) in combination with osteoinductive materials to guide differentiation of MSCs into bone cells ensuring complete bone regeneration. (nature.com)
Interaction of MSCs with bone morphogenic proteins (BMPs) in an alginate scaffold mimicking the extracellular matrix (ECM) in vivo enhances their differentiation into bone cells 9 . (nature.com)
With the in-depth researches of MSCs, an increasing number of studies have indicated that the therapeutic effects of MSCs can be attributed not only to their differentiation capacity but also to their paracrine action [ 21 ]. (hindawi.com)
MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)

Furthermore, mechanical stretch may induce the differentiation of BMSCs into mature osteoblasts and enhance the deposition of the bone matrix [ 18 - 20 ]. (hindawi.com)
BMP2 is a cytokine and growth factor that stimulates the differentiation of myoblasts to osteoblasts. (naturalnews.com)

5-Azacytidine incorporated polycaprolactone-gelatin nanoscaffold as a potential material for cardiomyocyte differentiation. (bvsalud.org)

Cellular differentiation is the process in which a stem cell changes from one type to a differentiated one. (wikipedia.org)
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. (tocris.com)
This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. (tocris.com)
Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. (tocris.com)
Microarray analyses indicated that Foxl1 + cells express stem cell markers such as Prom1 as well as differentiation markers such as Ck19 and Hnf4a. (elsevierpure.com)
The concept of the cancer stem cell is based on the fact that a subpopulation of glioma cells share common features with NSCs, including self-renewal and the differentiation potential to glial and neuronal cells [ 4 ]. (biomedcentral.com)
C3H/10T1/2 is a clonal mouse embryo line used in the developmental determination of vertebrate stem cell lineages and their subsequent differentiation. (naturalnews.com)
M, Peterson C. 2018 Haematopoietic stem suggests that during differentiation a stem cell approaches a stable equili- cells: entropic landscapes of differentiation. (lu.se)
Single cells in these populations exhibit different com- stem cell differentiation, Shannon information binations of regulator activity that suggest the presence of multiple theory, entropy configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)

At the Disorders of Sexual Differentiation Program, our team of specialists in pediatric endocrinology , genetics , social work , urology and psychology work with families to create the most ideal outcomes for their children. (choc.org)
Our Disorders of Sexual Differentiation Program team has been on the forefront of research in this area. (choc.org)
When a child's genitalia appears atypical at birth, the CHOC Center Urology Center Disorders of Sexual Differentiation Program team immediately becomes part of the child's care. (choc.org)
What are disorders of sexual differentiation? (choc.org)
Chronic toxicity: There are data for 3 trophic levels, most sensitive fish '(Pimephales promelas) NOEC 301d (increased vitellogenin and lack of sexual differentiation F1 males) = 1 ng/L. (janusinfo.se)

To induce differentiation and maturation of the immortalized cell lines, terminating the HPV-E6/E7 expression through a gene induction system has been believed to be essential. (lu.se)
An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. (scielo.br)

Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
The lack of complete and high-quality epigenetic and transcriptome maps in GSCs hinders our understanding of the underlying critical differences at the transcriptional level between malignant GSCs and normal NSCs, as well as the epigenetic machinery involved in regulating their proliferation and differentiation. (biomedcentral.com)

Results In IPF, the bronchiolised and enlarged distal airspaces stained for SOX2 are consistent with epithelial differentiation characteristic of conducting airway epithelium. (bmj.com)
Activation of abnormal respiratory epithelial differentiation programs may contribute to the expression of MUC5B and bronchiolisation of the distal lung, a salient feature of IPF. (bmj.com)
Vascularization or vasculogenesis is defined as the differentiation of epithelial progenitor cells (EPCs) into mature epithelial cells to enable the formation of new blood vessels. (naturalnews.com)

If the diagnosis of pancreatic ductal adenocarcinoma is considered, ductal differentiation can be demonstrated by using additional immunohistochemical markers such as mucin-related glycoproteins (MUC1, MUC5AC) and/or oncoproteins (CEA, B72.3, CA125). (nih.gov)
Exploiting large preexisting gene-expression databases, we developed a biologically supervised computational model to predict markers that correspond with BC differentiation. (nih.gov)
Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. (biomedcentral.com)
Objective: To establish cultures of cells from the pulp of permanent teeth by the explant method assessing parameters usually presented by stem cells, such as the expression of certain markers and the differentiation ability into osteogenic, adipogenic, and chondrogenic lineages. (bvsalud.org)
The isolated cells may be considered stem cells, based on the current criteria for their characterization, such as plastic adherence, expression of certain markers, and the absence of others, as well as multi-differentiation potential, which showed to be promising for the application in tissue regeneration. (bvsalud.org)

Based on these results, the researchers concluded that epimedin C effectively promotes vascularization both in the BMP2-dependent bone formation model and in the 4T1 mammary tumor-bearing model by inducing the endothelial-like differentiation of C3H/10T1/2 in vivo. (naturalnews.com)

This pure protein-based and chemically modifiable, fibrous ECM model allows the investigation of MSC behavior on biomimetic materials to unfold new vistas how to direct cells' differentiation for the development of new bone regenerating strategies. (nature.com)
Therefore, it is important to understand how MSC differentiation into bone cells is controlled and how this process can be guided or improved by externally added factors. (nature.com)
Upon differentiation, other ELLU clones shift from fetal to adult hemoglobin expression, giving rise to more mature cells. (lu.se)
Differentiation continues in adulthood as adult stem cells divide and create fully differentiated daughter cells during tissue repair and during normal cell turnover. (wikipedia.org)
However, metabolic composition does get altered quite dramatically where stem cells are characterized by abundant metabolites with highly unsaturated structures whose levels decrease upon differentiation. (wikipedia.org)
Expression of β-catenin targets important for differentiation was reduced in MSCKO cells. (harvard.edu)
However, mutating K49R or K345R in β-catenin to mimic deacetylation restored nuclear localization and differentiation potential in MSCKO cells. (harvard.edu)
Herein, we report a potential leukocyte differentiation antigen gene VSTM1 ( V-set and transmembrane domain-containing 1 ) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation. (biomedcentral.com)
VSTM1 ( V-set and transmembrane domain-containing 1 ) encodes a potential leukocyte differentiation antigen that is highly expressed in myeloid cells, but silenced in multiple leukemia cell lines [ 1 ]. (biomedcentral.com)
From the download therapeutic potential of differentiation in cancer and normal stem cells 2009 examples of the BPH to the Dots neurons of available many eGift, from modem Radcliffe to JavaScript Rowling, the surgery computed esophageal with years. (rachelhornaday.com)
Stem cells have potential as a source of cells and tissues for research and treatment of disease. (tocris.com)
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids. (tocris.com)
This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. (scielo.br)
They have a higher odontogenic differentiation capacity compared to other cell groups due to their content of specific progenitor cells. (scielo.br)
The authors sought to identify mechanisms driving the differentiation of mucus cells during the bronchiolisation process. (bmj.com)
Clonogenic assays demonstrated that up to 3.6% of Foxl1 + cells had proliferative potential. (elsevierpure.com)
We conclude that adult human pancreatic tissue has potential for expansion into 3D structures harboring progenitor cells with endocrine differentiation potential. (prinsesmaximacentrum.nl)
A new study reveals comprehensive and unique epigenetic properties of glioma stem cells, leading to novel molecular insights and therapeutic potentials toward glioblastoma multiforme treatment. (biomedcentral.com)
The hypothesis that the TRP classic or canonical (TRPC) deters adipocyte differentiation was investigated in 3T3-L1 cells employing the channel-specific activator and antagonist, silencing, and overexpression techniques. (edu.hk)
Among the 6 C isoforms tested, only TRPC-6 inhibited the differentiation of fat cells. (edu.hk)
Continuous ligation of LILRB1 modulated cellular differentiation, conferred a unique phenotype upon the resultant cells, induced a profound resistance to CD95-mediated cell death, and inhibited secretion of cytokines IL-10, IL-12p70, and TGF-β. (ashpublications.org)
When mutated, oncogenes have the potential to cause normal cells to become cancerous. (medlineplus.gov)
These proteins play important roles in cell division, cell differentiation, and the self-destruction of cells (apoptosis). (medlineplus.gov)
For example, certain cells called stem cells have the potential to produce a wide variety of tissue types or even possibly an entire organism. (msdmanuals.com)
In addition, cells were assessed for multi-differentiation potential. (bvsalud.org)
Similarly, the cells showed differentiation ability into all three lineages of cells tested. (bvsalud.org)

Therefore, VSTM1-v1 might represent an important myeloid leukocyte differentiation antigen and provide a potential target for the diagnosis and treatment of leukemia. (biomedcentral.com)

Our findings propose that it is not necessary to employ gene induction systems to establish immortalized erythroid cell lines sustaining differentiation potential and describe novel cellular characteristics for desired functionally competent clones. (lu.se)
With a few exceptions, cellular differentiation almost never involves a change in the DNA sequence itself. (wikipedia.org)
In cytopathology, the level of cellular differentiation is used as a measure of cancer progression. (wikipedia.org)
1 Activation of DCs through toll-like receptors (TLRs) for "infectious nonself" or other "danger" signals normally initiates a process of cellular differentiation resulting in "mature" DCs capable of stimulating T-cell and natural killer (NK)-cell responses. (ashpublications.org)
Downloaded from plays a mechanistic role in cellular decision-making processes ( a ) 2 during differentiation is currently the object of intense study. (lu.se)

During terminal differentiation, a precursor cell formerly capable of cell division permanently leaves the cell cycle, dismantles the cell cycle machinery and often expresses a range of genes characteristic of the cell's final function (e.g. myosin and actin for a muscle cell). (wikipedia.org)
We conclude that SIRT1 deacetylates β-catenin to promote its accumulation in the nucleus leading to transcription of genes for MSC differentiation. (harvard.edu)

Previously, the V1-3 isoforms of the transient receptor potential channel (TRP) have been shown to promote or prevent adipocyte differentiation. (edu.hk)
We demonstrate that the inhibitory receptor LILRB1 (ILT2, LIR1, CD85j) is selectively up-regulated during DC differentiation from monocyte precursors in culture. (ashpublications.org)

Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
In this work, pathways governing mucus cell differentiation were investigated in lung tissues from patients with IPF and other chronic pulmonary disorders. (bmj.com)

We investigated whether a molecular classification of tumor cell differentiation, based on a developmental biology approach, can provide additional prognostic information. (nih.gov)

Pancreatic ductal adenocarcinomas, especially when poorly differentiated/undifferentiated, may be diffusely and strongly positive for calretinin creating a potential diagnostic challenge with malignant mesothelioma. (nih.gov)
These agents decrease cohesiveness of abnormal hyperproliferative keratinocytes and may reduce potential for malignant degeneration. (medscape.com)

Here, we report that erythroid cell lines established from human bone marrow using simple expression of HPV-E6/E7 are capable of normal erythroid differentiation, without turning gene expression off. (lu.se)
The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
Differentiation happens multiple times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types. (wikipedia.org)
Differentiation may continue to occur after terminal differentiation if the capacity and functions of the cell undergo further changes. (wikipedia.org)
citation needed] Development begins when a sperm fertilizes an egg and creates a single cell that has the potential to form an entire organism. (wikipedia.org)
Our data indicate that BC can be subclassified into three subtypes, on the basis of their differentiation states: basal, intermediate, and differentiated, where only the most primitive tumor cell subpopulation within each subtype is capable of generating xenograft tumors and recapitulating downstream populations. (nih.gov)
Demcollari, TI , Cujba, A-M & Sancho, R 2017, ' Phenotypic plasticity in the pancreas: new triggers, new players: Cell Differentiation and DevelopmentCell Differentiation and Development ', Current Opinion in Cell Biology , vol. 49, pp. 38-46. (kcl.ac.uk)
Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)
Whether a cell used for a clone produces a specific type of tissue, a specific organ, or an entire organism depends on the potential of the cell-that is, how highly the cell has developed into a particular type of tissue. (msdmanuals.com)

We found that keratin 14 (KRT14) marks the most primitive differentiation state that precedes KRT5 and KRT20 expression. (nih.gov)
These findings provide a potential reason why VSTM1 expression levels were reduced so markedly in AML and CML-AP/BC patients. (biomedcentral.com)

A specialized type of differentiation, known as terminal differentiation, is of importance in some tissues, including vertebrate nervous system, striated muscle, epidermis and gut. (wikipedia.org)

The haemorrhagic potential was assessed by Saurin's classification. (bmj.com)
The model had an overall accuracy of 99%, a sensitivity of 88%, a specificity of 99%, a PPV of 87%, and an NPV of 99% for detection of multiple small bowel abnormalities and respective classification of bleeding potential. (bmj.com)
Conclusion We developed and tested a CNN-based model for automatic detection of multiple types of small bowel lesions and classification of the respective bleeding potential. (bmj.com)

The theoretical model that we recently proposed based on the redox potential of CNTs was used to analyze the experimental results. (cdc.gov)
Additionally, surface morphology of CNTs substantially influenced the reaction kinetics, while the doped particles in the center hollow parts of CNTs (AuCl3@DWCNT) shifted the redox potential in a different direction. (cdc.gov)
These findings make it possible to predict the chemical and biological reactivity of CNTs based on the structural and chemical nature and their influence on the redox potential. (cdc.gov)

They found that this bioactive plant component is a good promoter of vascularization and may have potential applications in bone regeneration. (naturalnews.com)

Scigala DK, Fabris MA, Badenes-Ribera L, Zdankiewicz-Scigala E, Longobardi C. Alexithymia and Self Differentiation: The Role of Fear of Intimacy and Insecure Adult Attachment. (behavsci.ir)

Consequently, PLDL and PDL seemed to be promising scaffold candidates for odontogenic regeneration at least as HA-TCP, when they were applied with the DPSC induced for odontogenic differentiation. (scielo.br)
Nakashima M. Bone morphogenetic proteins in dentin regeneration for potential use in endodontic therapy. (scielo.br)

Abnormal differentiation of the respiratory epithelium is a feature of idiopathic pulmonary fibrosis (IPF). (bmj.com)

abstract = "The pancreas has a very limited regenerative potential during homeostasis. (kcl.ac.uk)

Some differentiation occurs in response to antigen exposure. (wikipedia.org)
Disorders of sex differentiation, also known as disorders of sexual development or DSD, are conditions in which the sexual development that occurs during fetal growth does not happen as it should. (choc.org)

American Bladder( OAB) commercials of potential DOWNLOAD LO QUE SOCRATES DIRIA A WOODY ALLEN: CINE Y FILOSOFIA (ESPASA HOY) . (rachelhornaday.com)

However, it's far too early to see the approach as a way to avoid the use of human embryos for research or potential treatments. (sciencedaily.com)

download therapeutic potential of differentiation in cancer and normal stem to absolute children. (rachelhornaday.com)
Twelve-year-old Winnie Willis tells a download therapeutic potential of differentiation in cancer and with blockers. (rachelhornaday.com)
the DNA methylation processes, histone modifications , and RNA based arrangements is today considered as a potential therapeutic approach to CVD management. (bvsalud.org)

What are some potential strategies for cloud migration and customer experience in the near future? (nojitter.com)

Traditionally, CMT pathophysiology has been categorized into 2 processes: a predominant demyelinating process resulting in low conduction velocities (CMT1) and a predominant axonal process resulting in low potential amplitudes (CMT2). (medscape.com)

Bone morphogenetic proteins (BMP), known as active components of odontogenic differentiation and tooth development, have been used as a growth factor in an appropriate medium. (scielo.br)

Anatomy80

Organisms11

Diseases6

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes53

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science3

Osteogenic differentiation12

Vitro13

Cardiomyocytes2

Modulates1

MSCs4

Osteoblasts2

Cardiomyocyte1

Stem cell9

Sexual differentiation5

Induce differentiation2

Proliferation2

Epithelial3

Markers5

Promotes1

Cells26

Diagnosis1

Cellular5

Genes2

Receptor2

Pathways2

Molecular1

Malignant2

Cell9

Expression2

Tissues1

Classification3

Redox potential3

Bone regeneration1

Adult1

Regeneration2

Abnormal1

Abstract1

Occurs2

Bladder1

Human1

Therapeutic3

Migration1

Process1

Proteins1