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Dental EnamelCell DifferentiationDental Enamel ProteinsEnamel OrganDental Enamel HypoplasiaAmelogenesisDental Enamel SolubilityAmelogeninAmeloblastsTooth CalcificationEnamel MicroabrasionMatrix Metalloproteinase 20Cells, CulturedTooth RemineralizationTooth ErosionToothMolarGene Expression Regulation, DevelopmentalStem CellsDental Enamel PermeabilityIncisorDentinTranscription FactorsSignal TransductionCariostatic AgentsSex DifferentiationCell LineHardnessEmbryonic Stem CellsCell LineageAmelogenesis ImperfectaRNA, MessengerMicroscopy, Electron, ScanningCell DivisionGene Expression RegulationCell ProliferationDental BondingOdontogenesisTretinoinAcid Etching, DentalFluoridesPhosphoric AcidsMolecular Sequence DataTooth, DeciduousOrthodontic BracketsDNA-Binding ProteinsFluorosis, DentalOsteogenesisOsteoblastsPhenotypeHomeodomain ProteinsReverse Transcriptase Polymerase Chain ReactionDental CariesMice, Inbred C57BLMice, KnockoutImmunohistochemistryBase SequenceHardness TestsMicroradiographyTooth DiscolorationAntigens, DifferentiationMaterials TestingMice, TransgenicShear StrengthGene ExpressionTime FactorsTooth AbrasionMesenchymal Stromal CellsComposite ResinsAdipogenesisDentifricesTooth Bleaching AgentsDental Stress AnalysisBicuspidTooth CrownIn Situ HybridizationSurface PropertiesMyoblastsTranscription, GeneticNeuronsDental EtchingDental CementsCell Culture TechniquesBisphenol A-Glycidyl MethacrylateMuscle DevelopmentHematopoietic Stem CellsTrans-ActivatorsAdipocytesBone Marrow CellsKeratinocytesBone Morphogenetic ProteinsTumor Cells, CulturedAdhesivesEmbryo, MammalianPromoter Regions, GeneticBasic Helix-Loop-Helix Transcription FactorsMesodermDimethyl SulfoxideDental PellicleGene Expression Profiling
Amelogenesis imperfectaMineralizationDentinMesenchymalOdontoblastsProteinsMorpho-differentiationMorphogenesisPeriodontalTissueExtracellularOdontoblast differentiationOdontogenic differentiationProliferation and differentiationEpithelialThicknessMaturationHypoplasiaBoneStem cellsOrganDentine and enamelCellApoptosisInduceDevelopmentalPhenotypesAbnormalitiesOccursStagesGrowthTeethMechanicalSurfaceJunctionFormationOrganicTooth budMandibularCuspCells
Amelogenesis imperfecta6
  • 230) cause junctional epidermolysis bullosa (JEB), a rare, genetically heterogeneous, mucocutaneous blistering disease with amelogenesis imperfecta (AI), a developmental enamel defect. (bmj.com)
  • According to PSYKNOWHOW.COM , the main cause of the development of amelogenesis imperfecta is the disruption of enamel formation. (medicinelearners.com)
  • The congenital disruption of tooth enamel formation that occurs in the course of amelogenesis imperfecta is caused by proteins that are malfunctioning. (medicinelearners.com)
  • The main cause of the development of amelogenesis imperfecta is the disruption of enamel formation. (medicinelearners.com)
  • Amelogenesis imperfecta is a congenital defect that destroys tooth enamel. (medicinelearners.com)
  • Amelogenesis imperfecta refers to a group of development anomalies of the teeth (also referred as hereditary dysplasia) that affects the genome of the individual and is related to at least one of the stages of enamel formation, being a hereditary characteristic that affects both the deciduous as the permanent dentition. (bvsalud.org)
Mineralization5
  • Teeth, composed of three mineralized tissues (dentine, cementum, and enamel), constitute important models for gaining insight into the general processes of biological mineralization. (researchsquare.com)
  • Further studies confirmed that p75NTR participates in the regulation of tooth development maybe by changing the activity of the key factor distal-less homeobox/msh homeobox (Dlx/Msx), and melanoma-associated antigen D1 (Mage-D1) seems to be play a role in the differentiation and mineralization of EMSCs 5 , 6 . (researchsquare.com)
  • Calcium has important roles in cell differentiation, protein secretion and cell death besides its central role in enamel mineralization. (edu.au)
  • In contrast, EMD did not induce osteoblastic differentiation of GF (evidenced by lack of mineralization or ALP activity) but increased up to two-fold both their number and the amount of matrix produced. (tau.ac.il)
  • Degradation of matrix extracellular phosphoglycoprotein (MEPE) and DMP-1 and release of acidic serine-rich and aspartate-rich MEPE-associated motif (ASARM) peptides are chiefly responsible for the hypophosphatemic rickets mineralization defect and changes in osteoblast-osteoclast differentiation. (medscape.com)
Dentin9
  • The research on odontogenesis deals with tooth germ formation, cell differentiation and extracellular matrix production (ameloblasts/enamel, odontoblasts/dentin), innervation and vascularization of dental pulp, periodontal apparatus, particularly ligaments and also with the alveolar bone. (cas.cz)
  • In past research, this team identified plant-derived proanthocyanidins (PACs) as promising treatments for dental issues because these compounds can strengthen dentin, the layer of the tooth under the enamel. (acs.org)
  • To enhance enamel and dentin matrix production, we have created functionalized bioengineered GelMA tooth buds with decellularized tooth bud extracellular matrix (dtB ECM)," said Blagajcevic. (dentistrytoday.com)
  • Radiographically talon cusps are radiopaque structures, in which the enamel, dentin and occasionally the pulp can be seen. (bvsalud.org)
  • A talon cusp consists of enamel and dentin, containing various amounts of pulpal tissue 6 . (bvsalud.org)
  • The development of teeth is initiated by epithelial-mesenchymal interactions, which form dental papilla cells and dental sac cells, subsequently forming pulp, dentin, cementum, periodontal ligament and proper alveolar bone, except enamel 1 - 4 . (researchsquare.com)
  • specifically, enamel is deposited by ameloblasts derived from the epithelium, while dentin is deposited by odontoblasts derived from mesenchymal cells. (ispub.com)
  • Relationships regarding boron released through surface area pre-reacted wine glass ionomer using enamel/dentin as well as effect on ph. (bms-387032inhibitor.com)
  • In addition to the high prevalence of dental enamel anomalies, in many enamel alterations, its presence is absent or in small amount, and therefore there is a greater possibility of dental caries, since the dentin is unprotected 3 , which hinders or overlaps diagnosis of the initial lesion. (bvsalud.org)
Mesenchymal5
  • Simvastatin coating of TiO₂ scaffold induces osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells. (nih.gov)
  • they are capable of stimulating the differentiation of pluripotent mesenchymal cells to osteoprogenitor cells. (allenpress.com)
  • Other theories include aberrant hyperactivity of dental lamina, outward folding of the inner enamel epithelium, altered endocrine functions and a transient focal hyperplasia of the mesenchymal dental papilla as possible developers of the anomaly 1,7 . (bvsalud.org)
  • pointed out that Mage-D1 may participate in the proliferation of bone marrow mesenchymal stem cells (BMSCs) and the differentiation of odontoblasts through the NF-κB signalling pathway 21 . (researchsquare.com)
  • 13 Proliferation of bone marrow-derived human mesenchymal stem cells: role of enamel matrix proteins. (vinastemcelllab.com)
Odontoblasts2
  • Here, we investigated the effect of GDF-5 on the proliferation of dental pulp cells and their differentiation into odontoblasts by assaying the expression levels of odontoblast marker genes. (ispub.com)
  • Localization of OFD1 to the main cilium of tooth ectomesenchymal odontoblasts and renal epithelial cells is usually therefore speculated to be crucial for proper cellular differentiation of both cell types [3], [4]. (liveconscience.com)
Proteins6
  • Bone morphogenetic proteins (BMP), known as active components of odontogenic differentiation and tooth development, have been used as a growth factor in an appropriate medium. (scielo.br)
  • We have found that enamel cells contain an unusually high abundance of intracellular calcium homeostasis proteins, consistent with their calcium-oriented biology. (edu.au)
  • All calcium-handling proteins characterised in enamel cells are structurally identical to those expressed in other cell types (see ToothPrint 2-D gel database). (edu.au)
  • and the maturation stage, in which the newly mineralized enamel undergoes final calcification process, and the remaining proteins are removed. (bvsalud.org)
  • Emdogain® (EMD), a formulation of Enamel Matrix Proteins (EMP), is used clinically for periodontal regeneration, where it stimulates cementum formation and promotes gingival healing. (tau.ac.il)
  • 1 Neural stem/progenitor cell proliferation and differentiation: role of sonic hedgehog and wingless/int-1 proteins. (vinastemcelllab.com)
Morpho-differentiation2
  • Hyperactivity of the enamel organ during morpho-differentiation has been attributed to its formation. (jnsbm.org)
  • As with other dental abnormalities, talon cusp development occurs during the morpho-differentiation stage of odontogenesis 7 . (bvsalud.org)
Morphogenesis2
Periodontal2
  • Reconstructive periodontal surgery using an enamel matrix protein derivative (EMD) has been shown to enhance periodontal wound healing and regeneration. (editionscdp.fr)
  • 5 Differentiation of periodontal stem/progenitor cells: roles of tgf-β1. (vinastemcelllab.com)
Tissue8
  • Gelatin methacrylate (GelMA) hydrogel can be used to encapsulate postnatal dental stem cells (DSCs) and support odontogenic differentiation and mineralized tissue formation. (dentistrytoday.com)
  • It consists of enamel, dentine and a variable amount of pulp tissue. (jnsbm.org)
  • These results indicate that, although GDF-5 may have no effect on cell proliferation in isolated dental pulp tissue, it could promote odontoblast differentiation. (ispub.com)
  • However murine enamel epithelium is a very small tissue. (edu.au)
  • 2008). Human adipose-derived stem cells as future tools in tissue regeneration: Osteogenic differentiation and cell-scaffold interaction. (neidos.it)
  • Tooth enamel is the hardest tissue in vertebrates. (northwestern.edu)
  • The tissue that covers the teeth's crown, called dental enamel, promotes protection and coating to the dental element. (bvsalud.org)
  • Dental enamel is an unusual tissue that, once formed, does not go through remodeling like other hard tissues. (bvsalud.org)
Extracellular2
  • Both cell-derived microstructures and extracellular matrix components play critical roles in the preorganization and oriented deposition of calcium phosphate and serve as passive supports in dentine and enamel. (researchsquare.com)
  • First a protein-rich extracellular matrix is secreted on top of dentine to form a template layer of immature enamel. (edu.au)
Odontoblast differentiation3
  • Subsequent studies further confirmed that Mage-D1 inhibits the NF-κB signalling pathway by combining with IκB kinase β (IKKβ) 22 , which is a vital regulator of odontoblast differentiation. (researchsquare.com)
  • Nevertheless, the effect of GDF-5 on odontoblast differentiation from dental pulp tissues remains unknown. (ispub.com)
  • In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)
Odontogenic differentiation4
  • This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. (scielo.br)
  • Consequently, PLDL and PDL seemed to be promising scaffold candidates for odontogenic regeneration at least as HA-TCP, when they were applied with the DPSC induced for odontogenic differentiation. (scielo.br)
  • They have a higher odontogenic differentiation capacity compared to other cell groups due to their content of specific progenitor cells. (scielo.br)
  • The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. (scielo.br)
Proliferation and differentiation1
  • These promising but preliminary results suggest that dTB ECM can be used to enhance dental stem cells DSC proliferation and differentiation, advancing the GelMA tooth bud model towards future clinical applications," Blagajcevic said. (dentistrytoday.com)
Epithelial1
  • The close histopathologic and immunohistochemical resemblance among adamantinomatous craniopharyngioma, adamantinoma of the jaw, and calcifying odontogenic cyst suggests an odontogenic epithelial differentiation for these tumors. (medscape.com)
Thickness3
  • The AI phenotype was consistent with enamel of near normal thickness and variable focal hypoplasia with surface irregularities including pitting. (bmj.com)
  • The enamel powder had been smelted in the fire several times in deepenings, until the wanted thickness of enamels had been reached. (bilder-aus-dem-ofen.de)
  • The thickness of the enamel is often reduced at certain points or over an area. (medicinelearners.com)
Maturation2
  • Enamel is produced in two major stages termed secretion and maturation. (edu.au)
  • This matrix is degraded during enamel maturation, but a small amount of organics remains in the final biocomposite, where its presence and that of water affect the mechanical properties. (northwestern.edu)
Hypoplasia2
  • Congenital enamel hypoplasia leads to the fact that the enamel formation is impaired. (medicinelearners.com)
  • Deletion of the Ofd1 gene (Ofd14-5/+-) in mice causes missing/supernumerary teeth, enamel hypoplasia, and polycystic kidney disease analogous to human oral-facial-digital syndrome type 1 [4]. (liveconscience.com)
Bone4
  • An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. (scielo.br)
  • PSCs are considered to exert their effects exclusively in intramembranous bone formation, since Ctsk -Cre-mediated deletion of Sp7 , an essential transcriptional factor for osteoblast differentiation, impacted intramembranous but not endochondral bone formation 3 . (nature.com)
  • Growth/differentiation factor-5 (GDF-5) belongs to the bone morphogenetic protein (BMP) family, which is expressed in dental pulp tissues. (ispub.com)
  • Growth/differentiation factor-5 (GDF-5) is a member of the bone morphogenetic protein (BMP) family, which is a subgroup of the transforming growth factor- (TGF-) superfamily. (ispub.com)
Stem cells2
Organ1
  • Within the tooth bud created by this process, a differentiation of various cell types occurs: the enamel organ, the dental papilla, and the dental lamina. (bionity.com)
Dentine and enamel1
  • Further research on tooth dentine and enamel will explore the age at which the isotopic differences first appeared and investigate different patterns of mobility and landscape-use in the study area. (eurekalert.org)
Cell2
Apoptosis1
  • Epidermis erradication of both Infrared or IGF-1R or in the these animals gradually decreased epidermal breadth without affecting differentiation as well as apoptosis. (bms-387032inhibitor.com)
Induce1
  • showed that knocking out Mage-D1 can induce the expression of autophagy-related genes by enhancing the activity and differentiation of osteoclasts, thereby accelerating the process of periodontitis 23 . (researchsquare.com)
Developmental3
  • A talon cusp is a rare dental developmental anomaly in which an additional cusp-like structure projects from the cement-enamel junction of the maxillary or mandibular anterior teeth, in either the primary or permanent dentition 1 . (bvsalud.org)
  • Our findings show that distinct 'calcium-binding protein fingerprints' exist for the major developmental stages of enamel formation. (edu.au)
  • According to Ribas and Czlusniak 5 , developmental disorders in the enamel are presented as structural abnormalities, which may affect both dentitions, having a systemic, local or hereditary character. (bvsalud.org)
Phenotypes1
  • Environmental cues found throughout neural crest migratory routes play a fundamental role not only in instructing the precursor's differentiation into particular phenotypes, but also in controlling their proliferation and survival [ 7 ]. (biomedcentral.com)
Abnormalities1
  • Abnormalities included hypodontia and microdontia, root development and enamel structure damage, over-retention of primary teeth, impaction, premature eruption, decreased temporomandibular joint mobility, inability to open the mouth, and jaw and facial deformities. (dental-tribune.com)
Occurs1
  • Innovations in this space include treatments like whitening and enamel strengthening, but Sensodyne works by treating the exposed dentine that occurs naturally and removes pain. (world-media-group.com)
Stages1
  • These processes occur through genetic influence and environmental change, thus, the development of enamel defects can result from any damage occurring at these stages 2 . (bvsalud.org)
Growth2
  • In this system however, osteoblast differentiation of PSCs is selectively inhibited by Sp7 deficiency but PSCs are still present and may still play a role in skeletal growth. (nature.com)
  • During tooth development, a preformed organic matrix is thought to be integral to the biological control over the precipitation of an amorphous precursor phase, its transformation into hydroxylapatite, and the growth of individual OHAp nanowires in enamel. (northwestern.edu)
Teeth3
  • Missing contact points with neighboring teeth and very soft tooth enamel can appear. (medicinelearners.com)
  • On the other hand, the differentiation from other diseases of the teeth with similar symptoms is particularly relevant in order to be able to initiate adequate treatment. (medicinelearners.com)
  • These include acquired enamel disorders or dentinogenesis imperfecta , which is an autosomal dominant inherited structural disorder of tooth dentition (teeth eruption from the jaw). (medicinelearners.com)
Mechanical1
  • 3-5] We report here on our recent discovery, by APT and correlative techniques, of a Mg-rich amorphous intergranular phase in regular enamel, and of iron-rich intergranular phases in pigmented rodent enamel (Figure 1), and the dramatic influence that these intergranular phases have on enamel mechanical properties and its resistance to acid corrosion. (northwestern.edu)
Surface2
  • Surface enamel remineralization: Biomimetic apatite nanocrystals and fluoride ions different effects. (neidos.it)
  • The enamel surface can shine and tend to split quickly. (medicinelearners.com)
Junction1
  • A talon cusp is a supernumerary structure projecting from the dento-enamel junction to a variable distance towards the incisal edge of an anterior tooth. (jnsbm.org)
Formation2
  • Rat and mouse enamel formation has been most comprehensively characterised and appears to be a good model for human. (edu.au)
  • The tendency to impaired tooth enamel formation is innate. (medicinelearners.com)
Organic2
  • Enamel is an organic combination between silicates and different oxides of metals. (bilder-aus-dem-ofen.de)
  • 6] We further discuss the localization of residual organic macromolecules, carbonate, and water in the intergranular phases and discuss the differentiation between organic and inorganic carbon (Figure 2). (northwestern.edu)
Tooth bud1
  • We found that dTB ECM powder can be used to enhance DSC differentiation in GelMA tooth bud constructs," he said. (dentistrytoday.com)
Mandibular1
  • Introducción: La realización de implantes cortos y extracortos en situaciones de extrema reabsorción maxilar y mandibular supone que la colocación del implante se realiza en condiciones de escaso volumen óseo residual y, por lo tanto. (bvsalud.org)
Cusp1
  • A wide synonymy has been used in the literature to describe talon cusps, including central odontoma, evaginatus odontoma, tuberculous premolar, Leong's premolar, occlusal enamel pearl, and Eagle's cusp. (bvsalud.org)
Cells1