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  • progenitor
  • So-called canonical β-catenin-dependent Wnt signalling has apparently opposing effects at different developmental stages on subsequent cardiomyocyte differentiation (reviewed by Tzahor, 2007 ), which may be linked to a positive effect on progenitor expansion and a brake on differentiation (reviewed by Bergmann, 2010 ). (biologists.org)
  • The protein levels of brachyury (mesoderm protein), Nkx2.5 (cardiac progenitor cell protein) and α-Actinin (cardiomyocyte biomarker) decreased in Rictor knockdown group during cardiogenesis. (ijbs.com)
  • ESCs
  • Combination of T3SS-mediated GMT delivery and Activin A treatment showed an additive effect, resulting in on average 60% of the ESCs differentiated into cardiomyocytes. (sigmaaldrich.com)
  • development
  • In order to optimize cell delivery for therapeutic efficacy, a greater understanding of parameters that impact stem cell differentiation, survival, growth, and development are needed. (rsc.org)
  • DNA microarray data suggests that enhanced CM differentiation in the low crosslink density hydrogels was not tissue specific but rather a result of favoured EB development and cell proliferation. (rsc.org)
  • The Wnt signalling pathway is a key regulator of heart development and particularly of cardiomyocyte differentiation (reviewed by Gessert and Kühl, 2010 ). (biologists.org)
  • This has fueled the development of stem cell-based strategies to provide the damaged heart with new cardiomyocytes. (springer.com)
  • Growth differentiation factor 15 (GDF15) is induced during heart failure development, and may influence different processes in cardiac remodeling. (ahajournals.org)
  • phenotype
  • Similarly, in the study by Watanabe et al, 7 the grafted fetal cardiomyocytes seemed to maintain their fetal phenotype in the normal host heart for the 5 weeks of the study. (ahajournals.org)
  • Additionally
  • Additionally, enhanced EB growth and differentiation in low crosslink density hydrogels was independent of RGD ligand density and not a consequence of enhanced diffusion. (rsc.org)