Differentiation identifies molecules. Medical search. Frequent questions

In the present study, a clinically proven case of IA in a patient who is a heterozygous mutation carrier of the activated leukocyte cell adhesion molecule ( ALCAM )/cluster of differentiation 166 (CD166) gene, is reported. (nih.gov)
The aim of the present study was to evaluate Tim‑3 and Gal‑9 expression and cluster of differentiation (CD)3+, CD8+ and forkhead box (FOX)p3+ T cell tumor‑infiltration in gastric cancer, as well as their impact on prognosis. (spandidos-publications.com)
Tim-3 was first identified as a molecule expressed in interferon (IFN)-γ-producing cluster of differentiation (CD)4 + T helper 1 (Th1) and CD8 + T cytotoxic 1 (Tc1) cells ( 4 ). (spandidos-publications.com)

4. Retinoic acid-induced CHD5 upregulation and neuronal differentiation of neuroblastoma. (nih.gov)
12. N-acetylaspartate (NAA) induces neuronal differentiation of SH-SY5Y neuroblastoma cell line and sensitizes it to chemotherapeutic agents. (nih.gov)
Ongoing projects in the section include studies on pigment epithelium-derived factor (PEDF), a multifunctional SERPIN protein that acts in neuronal differentiation and survival, and prevents angiogenesis, tumor growth and metastasis. (nih.gov)
Major areas of focus included research on unique germ cell molecules with important roles in fertilization and on the molecular properties of embryonic, neuronal, and spermatogonial stem cell maintenance and differentiation in both mammalian and nonmammalian model systems. (utsouthwestern.edu)

Recent work has suggested that targeting MYB by small-molecule inhibitors is feasible and that inhibition of MYB has potential as a therapeutic approach against acute myeloid leukemia. (nih.gov)
To facilitate the identification of small-molecule MYB inhibitors we have re-designed and improved a previously established cell-based screening assay and have employed it to screen a natural product library for potential inhibitors. (nih.gov)
These molecules hold promise in clinical retino-protection treatments, and elucidation of the mechanism of their actions is important for the development of therapies based on these natural factors and inhibitors. (nih.gov)
Thus, it is deacetylation-mediated repression of transcriptional inhibitors of OLG differentiation, such as Egr1 , Id2 , and Sox11 , that is thought to promote progression along the OLG lineage. (jneurosci.org)
Dr. Marc Engelhardt, Chief Medical Officer, said: "Our development strategy for derazantinib is focused on strengthening the clinical evidence on its differentiation versus other FGFR inhibitors based on its unique kinase inhibition spectrum and safety and tolerability profile. (basilea.com)
Along with our transformative deal with Lilly in December on small molecule Morphomer Tau TM inhibitors, this program further validates our Morphomer TM platform and illustrates AC Immune's leadership in precision medicine. (swissbiotech.org)
The company also is beginning preclinical development of oral small molecule Morphomer a-syn inhibitors and SupraAntigen TM a-syn antibodies as novel therapeutic candidates to treat PD and a-syn-related NeuroOrphan diseases. (swissbiotech.org)

1. Surface marker profiling of SH-SY5Y cells enables small molecule screens identifying BMP4 as a modulator of neuroblastoma differentiation. (nih.gov)

We have pioneered a hybrid molecule approach to maximize SGN stimulation in vivo , in which small molecule analogues of neurotrophins are linked to bisphosphonates, which in turn bind to cochlear bone. (frontiersin.org)
Environmental stimulation can differentially effect the proliferation, migration and differentiation of these cells in vivo. (labroots.com)
Using the zebrafish as an in vivo model system as well as rodent primary OLG cultures, this functional property of ATX was found to be mediated by its lysophospholipase D (lysoPLD) activity, which has been well characterized to generate the lipid signaling molecule lysophosphatidic acid (LPA). (jneurosci.org)
This study characterizes the autotaxin-lysophosphatidic acid signaling axis as a modulator of OLG differentiation in vivo in the developing zebrafish and in vitro in rodent OLGs in culture. (jneurosci.org)

7 Among others, interleukin-3 (IL-3), formerly known as multi colony stimulating factor, has been implicated in survival, proliferation, and differentiation of HSC and hematopoietic progenitor populations. (haematologica.org)
CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells, e.g. in muscles CD81 promotes cell fusion and myotube maintenance. (exbio.cz)
Normal hematopoietic cell biology is strictly driven by complex interactions with microenvironment, involving signaling molecules that finely tune their activation, survival, proliferation and differentiation. (vimm.it)

Using an image-based, high-throughput screen, we identified the small molecule kartogenin, which promotes chondrocyte differentiation (EC50 = 100 nM), shows chondroprotective effects in vitro, and is efficacious in two OA animal models. (medicalxpress.com)

To identify and evaluate microRNAs in Ewing sarcoma involved in tumor progression and survival. (ior.it)
The interests of her section are in protein structure as it relates to function, with a focus on the interactions of components involved in cell differentiation, survival and maintenance. (nih.gov)
We have recently identified several molecules that work coordinately to regulate proliferation, survival and differentiation of these adult derived stem cells. (labroots.com)
2013). We previously demonstrated that the Src-kinase Lyn, the switch molecule that couples the BCR to downstream signaling, is crucially involved in the regulation of CLL cells survival (Contri A, J Clin Invest. (vimm.it)

NCI: Generation and study of zebrafish models to identify and place genes in functional pathways that effect growth and development, in particular, genes/pathways that, when altered, result in uncontrolled or cancerous growth. (nih.gov)
Master transcription factors establish enhancers to regulate cell identity genes by recruiting epigenetic machinery, and are sequentially exchanged during changes in cell identity (ie, differentiation). (nih.gov)
Based on 500 DEGs, 20 small-molecule drugs that potentially target genes with abnormal expression in cutaneous melanoma were obtained from the CMap database. (jcancer.org)
Lett) RNA-Sequencing identifies four commonly down-regulated ALS genes. (wisc.edu)
Matrix metalloproteinases were upregulated, apoptosis-related genes were differentially modulated, and immunoreceptor signaling molecules were upregulated. (biomedcentral.com)

MicroRNAs (miRNAs) finely regulate gene expression and play an important role in various cellular processes, including cell growth, differentiation, proliferation, and apoptosis. (genengnews.com)
The latter are of great interest as diverse cytokines have been shown to regulate the differentiation of mature blood cells from adult HSC. (haematologica.org)
Molecules that regulate T-cell development by modulating TCR signal strength have been described but components that specifically define the boundaries between positive and negative selection remain unknown. (nature.com)

Furthermore, related to the tissue homing sites of these two NK cell subsets a differing expression of chemokine receptors and adhesion molecules was identified. (sciencepop.org)
Although it has been argued that Angiopoietin-1 (Ang-1)/Tie2 has a nonessential role, enhanced signaling via Tie2 by Ang-1, and Mpl signaling by Thrombopoietin (Thpo), seem to induce HSC quiescence by activating cell adhesion molecules such as β1-integrin and N-cadherin 19 , 20 . (nature.com)
Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl-heidelberg.de)
Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. (cusabio.com)

Investigators are working on exploiting these molecules for experimental and potential therapeutic applications. (genengnews.com)
Therapeutic applications of small molecules with potent retinoprotective activities are highly sought. (nih.gov)
In leukaemia, the AKR1C3 isoform has been identified as a novel therapeutic target since its PGD2 reductase activity prevents cell differentiation. (bham.ac.uk)
Identifying this key protein further advances our knowledge of how the brain heals itself from the devastating effects of stroke, and may help to develop new therapeutic strategies to promote recovery. (nih.gov)
We believe that therapeutic developments coupled with the diagnostic tools needed to properly identify and select patients allow us to follow disease progression and confirm potential efficacy of therapeutic interventions. (swissbiotech.org)
Resulting antibodies have been applied to Pharma-derived high throughput screening in functional assays to identify lead candidates that fulfill a predefined list of biological activities and provide optimal potency essential for differential therapeutic application. (pharmiweb.com)

NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). (biomedcentral.com)
His will test the potential of a novel inhibitor of CDK4, which they've identified as being associated with about half of all FL cases, seeking to establish a new rational therapy to benefit a large proportion of FL patients. (cancer.org)
Derazantinib is an investigational orally administered small-molecule FGFR inhibitor with strong activity against FGFR1, 2, and 3.6 FGFR kinases are key drivers of cell proliferation, differentiation and migration. (basilea.com)

For this, we identified transcription factors effective in inducing hepatocyte differentiation of these cells. (ca.gov)
To clarify the role of the CD99 molecule in promoting osteoblastic differentiation of osteosarcoma cells. (ior.it)
7. Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells. (nih.gov)
11. TrkA neurogenic receptor regulates differentiation of neuroblastoma cells. (nih.gov)
1Aa is a small molecule analogue of NT-3 that has been shown to activate cells through TrkC, the NT-3 receptor, although its activity on SGNs has not previously been described. (frontiersin.org)
Our results provide the first evidence that a small molecule analogue of NT-3 can stimulate SGNs and promote regeneration of synapses between SGNs and inner hair cells. (frontiersin.org)
Through this type of research, scientists have been able to identify stem cells within the adult intestine that are capable of forming the cell types needed to continually renew this organ throughout life. (nih.gov)
The investigators also distinguished among miRNAs present in latently virus- infected nontumorogenic endothelial cells and Kaposi's sarcoma cells, identifying 15 virally regulated miRNAs in the endothelial cells. (genengnews.com)
For example, when the researchers deleted the transcription factor ETS proto-oncogene 1 (ETS1), the amount of cancer-killing T cells was increased by enhancing differentiation to the intermediate state (increasing flow into the lake). (stjude.org)
On the other hand, knocking out the transcription factor recombination signal binding protein for immunoglobulin kappa J region (RBPJ) increased the accumulation of intermediate state T cells by blocking terminal differentiation (damming the river at the lake). (stjude.org)
We increased the amount of cancer-killing T cells by differentiating them from upstream precursors, and we could also block terminal differentiation to increase accumulation of the functional cells. (stjude.org)
Development of red blood cells occurs through differentiation of hematopoietic stem cells (HSCs) into more committed progenitors and finally into erythrocytes. (nih.gov)
We identified KDR+/CD34high/CD144+/CD43-/CD45- hemato-endothelial progenitor cells (HEPs) forming organized, vasculature-like structures and giving rise to CD34low/CD144-/CD43+/CD45+ hematopoietic progenitor cells. (haematologica.org)
Inhibition of IL-3 signalling blocked hematopoietic differentiation and arrested the cells in the HEP stage. (haematologica.org)
2 In several studies, the hemogenic endothelium (HE), which is predominantly present in the AGM, has been identified as the primary cell source responsible for the emergence of definitive hematopoietic cells. (haematologica.org)
3-5 The emergence of hematopoietic cells from the HE (also referred to as endothelial to hematopoietic transition [EHT]), is controlled by distinct cell-intrinsic signals mediated by transcription factor (TF) activation, as well as important cell-extrinsic factors such as cell-cell interactions, extracellular matrix molecules, and cytokines. (haematologica.org)
DLBCL often involves CD-20, which is a membrane-embedded surface molecule that plays a role in the development and differentiation of B cells into plasma cells for the production of antibodies. (medscape.com)
As they describe in their paper published in the journal Science , the team has found that when a compound with molecules of kartogenin in it comes in contact with certain kinds of stem cells, chondrocytes develop, resulting in new cartilage growth, possibly paving the way perhaps, to a long sought treatment for osteoarthritis. (medicalxpress.com)
To find a substance that might spur mesenchymal stem cells (which occur naturally in cartilage) into action, the researchers tried over 22,000 different molecule compounds before hitting on kartogenin. (medicalxpress.com)
Molecules that promote the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes may stimulate the repair of damaged cartilage. (medicalxpress.com)
ALS patient induced-pluripotent stem cells (iPSCs) were collected for RNA sequencing after 14 days of terminal differentiation. (wisc.edu)
In the recent study using adult peripheral blood mononuclear cells (PBMCs), we identified two profound changes in T cells induced by calcitriol. (nih.gov)
In this supplement, we will determine if calcitriol has the same effect on T cells and if supplementation of calcitriol in the culture changes differentiation of Foxp3+ Tregs from human umbilical cord blood or infant PBMCs. (nih.gov)
Salivary molecules may also inhibit upregulation of mitogenic, WNT, Hedgehog, and stress pathways and enhance the activity of T regulatory cells, production of IL-10, and suppressors of cytokine signaling molecules (SOCS). (biomedcentral.com)
Tick salivary molecules also inhibit the function of immune cells present at the bite site. (biomedcentral.com)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)
Extracellular antigens (eg, from many bacteria) must be processed into peptides and complexed with surface class II MHC molecules on professional APCs (which specialize in presenting antigens to T cells) to be recognized by CD4 helper T (Th) cells. (msdmanuals.com)
Follicular dendritic cells are a distinct lineage, do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)
The data presented here identify the extracellular factor autotaxin (ATX) as a novel upstream signal modulating HDAC1/2 activity and gene expression in cells of the OLG lineage. (jneurosci.org)
EPS) pone.0087131.s002.eps (393K) GUID:?F6D22D46-3DC0-44B7-ADE3-865ACE77EA18 Figure S3: Expression of IL-12 receptor and perforin mRNAs by human NK cell differentiation towards specific phenotypes will contribute to a better understanding of NK cell differentiation and facilitate tailored production of NK cells for immunotherapy. (sciencepop.org)
In this study, we show that addition of a specific low dosage of IL-12 for an NK cell differentiation program from cord bloodstream Compact disc34+ stem cells can lead to significantly elevated proportions of cells with appearance of Compact disc62L aswell as KIRs and Compact disc16 that are preferentially portrayed on mature Compact disc56dim peripheral bloodstream NK cells. (sciencepop.org)
Entirely, these data offer proof that IL-12 directs individual NK cell differentiation towards older NK cells with improved properties for potential cancers therapies. (sciencepop.org)
To better understand the role of BTB-Kelch proteins for the differentiation of myoblasts cells, we designed short hairpin RNA (shRNA) molecules to inhibit mRNA expression of five BTB-Kelch proteins found in Mus musculus (mouse). (umsystem.edu)
Most studies have shown that extrinsic signals from niche cells affect HSCs by influencing cell cycle-related molecules in HSCs. (nature.com)
May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. (cusabio.com)
An adhesion molecule on leukocytes that binds to endothelial cells in blood vessels. (unboundmedicine.com)

Immunohistochemistry helps to identify the proteins specific to each subtype. (medscape.com)
This will limit their ability to adapt their proper shape or select communication partners because of a shortage of proteins required as cellular building blocks or signalling molecules. (neurosciencenews.com)
BTB-Kelch substrate adaptor proteins may influence the differentiation of C2C12 myoblasts into myotubules. (umsystem.edu)
Further analysis will identify any differences in the differentiation of C2C12 myoblasts into myotubules following shRNA-mediated knockdown of these BTB-Kelch proteins. (umsystem.edu)
AC Immune's Morphomer platform enables identification of a new class of low molecular weight compounds via rational chemical design that enables generation of small molecules, called Morphomers, which bind with high specificity to misfolded proteins, working to break up neurotoxic aggregates and inhibit aggregation and seeding. (swissbiotech.org)

Single nucleotide polymorphism (SNP) analysis was performed to identify potential mechanisms of in vitro resistance. (cdc.gov)
SNPs corresponding to other known mechanisms of azole resistance were not identified in the remaining 26 in vitro resistant isolates. (cdc.gov)
We have previously shown that a small molecule BDNF analogue coupled to risedronate binds to bone matrix and promotes SGN neurite outgrowth and synaptogenesis in vitro . (frontiersin.org)
Addressing validated targets generated proprietary molecules with novel modes of intervention and the knowledge of first-generation molecules enabled a well guided in vitro differentiation. (pharmiweb.com)

Here, we used induced pluripotent stem cell (iPSC) technology and established a 3-dimensional, organoid-like differentiation system (hemanoid) maintaining the structural cellular integrity to evaluate the effect of cytokines on embryonic hematopoietic development. (haematologica.org)
The knowledge on anomalous expression or activity of signaling molecules in the leukemic counterparts still requires transformation, in order to better comprehend malignant hematopoietic cell conversion, invasiveness, migration, trafficking and homing, and to identify new targets for innovative therapies. (vimm.it)
Although many studies are currently available on normal hematopoietic cell physiology, the knowledge on anomalous expression or activity of signaling molecules in the malignant counterparts still requires further investigation. (vimm.it)

The two most common and studied downstream molecular adaptors are the myeloid differentiation factor 88 (MyD88) and Toll-interleukin-1 receptor domain-containing adapter-inducing interferon-β (TRIF). (diabetesjournals.org)
CD81 has been also identified as a receptor for the hepatitis C virus. (exbio.cz)
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. (thermofisher.com)
More than 100 receptor molecules have been identified. (unboundmedicine.com)
A molecule whose structure mimics a cellular receptor, and binds those agents (e.g., cytokines, drugs or hormones) that normally bind to the receptor. (unboundmedicine.com)

To identify Plcγ1 effector molecules involved in regulation of erythroid differentiation, we assessed changes occurring at the global transcriptional and DNA methylation level after inactivation of Plcγ1. (nih.gov)

The NHLBI is building on this legacy by identifying the molecular pathways that drive lung disease progression or promote resilience and repair. (nih.gov)
Although the study is based on animal models, Harkany stresses that other studies already indicate harmful effects in humans, while this report identifies the very molecular mechanisms that can also apply to humans. (neurosciencenews.com)
Thus, together, our data suggest that an ATX-LPA-HDAC1/2 axis regulates OLG differentiation specifically during the transition from OLG progenitor to early differentiating OLG and via a molecular mechanism that is evolutionarily conserved from at least zebrafish to rodent. (jneurosci.org)

We also identified small molecules and culture conditions (extracellular matrix composition and stiffness) that promote proliferation and hepatocyte-specific differentiation. (ca.gov)
The PAMPS are comprised of bacterial, parasitic, or viral components, and the binding of these PAMPS to the extracellular domain of TLRs results in the activation of intracellular adaptor molecules. (diabetesjournals.org)

Based on different gene expression profiles, subtypes of macrophages (eg, M1, M2), which have different roles in amplifying or limiting the inflammatory response, have been identified. (msdmanuals.com)

Their work showed which individual transcription factors and their networks are responsible for each T cell differentiation state, providing targets for improving immunotherapy. (stjude.org)

In conclusion, we identified the 8 candidate biomarkers and potential key signaling pathways in cutaneous melanoma through comprehensive microarray analyses. (jcancer.org)
In CLL, little is known about the alterations affecting the mechanisms involved in the preservation of Signal Transduction Pathways (STPs) homeostasis that is maintained by different molecules. (vimm.it)

The research group mapped biologically active regions on the PEDF polypeptide, and identified binding partners and cell signaling receptors for this serpin that trigger different activities. (nih.gov)
They can be distinguished by antigen-specific surface receptors and other cell surface molecules called clusters of differentiation (CDs), whose presence or absence define some subsets. (msdmanuals.com)

Therefore, it is important to investigate the regulation of histone acetylation and identify key regulatory molecules. (biomedcentral.com)

The following is a list of human clusters of differentiation (or CD) molecules. (wikipedia.org)

Active enhancer marks (H3K27ac, H3K4me1/2) found at PAX3-FOXO1 bound enhancers decrease over myogenic differentiation, including the super enhancer regulating MYOD1. (nih.gov)
Exposure to PGD2 disrupted the expression of myogenic regulators (MyoD and myogenin) during differentiation and suppressed cell fusion, \(\alpha\)-actin expression and creatine kinase activity. (bham.ac.uk)

Additionally, the role of PGD2 in adult muscle differentiation was investigated using the mouse myoblast cell line C2C12. (bham.ac.uk)

They then used this information to enhance anticancer activity in preclinical models by promoting or blocking T-cell differentiation. (stjude.org)

I will talk about how to harness single cell proteomic methods, bulk transcriptomic profiling, and mathematical modeling, to investigate the kinetics of the phenotypic adaptation of a panel of BRAFV600 mutated patient-derived melanoma cell lines and patient biopsies upon BRAF inhibition, with an eye towards identifying strategies for halting the adaptive response so as to lead to prolonged tumor growth inhibition. (selectbiosciences.com)

The cellular mechanism coordinating the balance between HSC quiescence and differentiation is not fully understood. (nature.com)

2) Information theoretical and computational approaches for dissecting the high-dimensional single cell data with a particular focus on resolving tumor heterogeneity and dynamics of the signal transduction network for anticipating therapy resistance and identifying effective combination therapies. (selectbiosciences.com)

In short, we identified 500 DEGs between cutaneous melanoma samples and normal samples. (jcancer.org)
The identified candidate drugs have provided several directive significances for the synthesis medicine for melanoma. (jcancer.org)

So far, 15 mammalian Galectins (Gal-1-15) have been identified, all containing a conserved CRD consisting of approximately 130 amino acids. (nature.com)

Utilizing small molecule screening, we identified certain epigenetic modulators as unique protein dependencies, especially in PAX-fusion RMS. (nih.gov)
Previous studies suggested that a protein called growth and differentiation factor 10 (GDF10) was involved in the early stages of axonal sprouting. (nih.gov)

His group has developed a new technique to efficiently survey large numbers of candidate sequences that could identify the microRNAs (miRNAs) in which these sequences are found. (cancer.org)

Taken together, our findings identify Plcγ1 and its downstream target mH2A2, as a 'non-canonical' Epo signaling pathway essential for erythroid differentiation. (nih.gov)

The scientists showed they could precisely interrupt the flow of the differentiation process, thereby enhancing antitumor efficacy. (stjude.org)

Thymocyte cell fate is dictated by the nature of TCR-major-histocompatibility-complex (MHC)-peptide interactions, with signals of higher strength leading to death (negative selection) and signals of intermediate strength leading to differentiation (positive selection) 1 . (nature.com)

10. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (nih.gov)
Scientists found that a molecule known as growth and differentiation factor 10 (GDF10) plays a key role in repair mechanisms following stroke. (nih.gov)
2003). Abnormalities of molecules involved in STPs are connected to CLL pathogenesis and a critical role has already been ascribed, as previously highlighted, to BCR-Lyn axis (Contri A, J Clin Invest. (vimm.it)
This is consistent with current evidence that the beta subunit is the principal site for binding of cytoskeletal and signalling molecules, whereas the alpha subunit has a regulatory role. (embl-heidelberg.de)
Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. (cusabio.com)

Uncovering the mechanisms that control development and differentiation of the digestive tract before birth and in neonatal life could generate new insights for regenerative therapies to treat digestive cancers and other diseases, as well as provide new insights into disease pathogenesis. (nih.gov)
Our findings uncover a critical regulator of T-cell development that controls the balance between death and differentiation. (nature.com)

Scientists from St. Jude Children's Research Hospital comprehensively examined the transcription factors involved in T-cell differentiation states in cancer. (stjude.org)

Integrators of epidermal growth and differentiation: distinct functions for beta 1 and beta 4 integrins. (embl-heidelberg.de)

Nicotinic acid similarly affects both processes, inhibiting lipolysis and promoting adipocyte differentiation through PPARγ activation. (biomedcentral.com)

The Fertility and Infertility Branch (FIB) supports research aimed at alleviating human infertility and reproductive disorders, identifying new contraceptive leads, and expanding fundamental knowledge about the processes that underlie the success or failure of human reproduction. (nih.gov)

Anatomy61

Organisms11

Diseases7

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes60

Disciplines and Occupations1

Information Science4

Cluster of differentiat3

Neuronal4

Inhibitors7

Small molecule screens1

Vivo4

Proliferation and differentiation3

High-throughput screen1

Survival4

Genes5

Regulate3

Adhesion molecules4

Therapeutic6

Inhibitor3

Cells38

Proteins5

Vitro4

Hematopoietic3

Receptor5

Transcriptional1

Molecular3

Extracellular2

Gene1

Targets1

Pathways2

Receptors2

Histone acetylation1

Clusters1

Myogenic2

Adult1

Preclinical1

Inhibition1

Cellular1

Signal transduction1

Melanoma2

Mammalian1

Protein2

MicroRNAs1

Downstream1

Efficacy1

Interactions1

Role5

Development2

Transcription1

Integrins1

Activation1

Processes1