• Of high expression in the skin tissue, aryl hydrocarbon receptor (AhR) is a cytoplasmic protein responsible for maintaining skin homeostasis through proliferation, differentiation, cell arrest and apoptosis signals. (uaslp.mx)
  • Background Aquaporin 3 (AQP3) and Cellular-mesenchymal to epithelial transition factor (c-Met) are both overexpressed in human breast cancer and highly related to proliferation and migration. (scite.ai)
  • The cellular defects in ADPKD that have been known for a long time are increased cell proliferation and fluid secretion, decreased cell differentiation, and abnormal extracellular matrix. (basicmedicalkey.com)
  • Increased cAMP promotes protein kinase A activity, among other effectors, and, in turn, leads to cyst growth by promoting proliferation and fluid secretion of cyst-lining cells through chloride and aquaporin channels in ADPKD kidneys. (basicmedicalkey.com)
  • Additionally, the gene ERBB4 , which regulates diverse cellular processes in the inner ear such as cell proliferation and differentiation, was in the largest module. (biomedcentral.com)
  • These peptide-MHC-I complexes (pMHC-I) then traffic to the cell surface, where together with co-stimulatory molecules they trigger the proliferation and differentiation CD8 + T cells into cancer-specific cytotoxic T cells. (biomedcentral.com)
  • Background and Objectives: Cholesteatomatous chronic otitis media acquires epithelial proliferation and differentiation characteristics, which render it able to erode the underlying bone and cause complications. (koreamed.org)
  • Monocot leaves, where cell proliferation and differentiation are displayed along a linear developmental gradient, provide an ideally suited experimental system to study these processes. (biomedcentral.com)
  • It is not dissimilar to the gradient of proliferation and differentiation along developing roots [ 2 ] but, in contrast, it provides a unique opportunity to study chloroplast biogenesis and differentiation. (biomedcentral.com)
  • Aquaporin-5 (AQP5) is a water-specific channel located on the apical surface of airway epithelial cells. (plos.org)
  • Aquaporin-5 (AQP5) is a water-specific channel located on the apical membrane of epithelial cells in several sites in mammals, including corneal and pancreatic epithelium, secretory cells in salivary and lacrimal glands, and airway submucosal glands, bronchial epithelium and type I pneumocytes of the respiratory tract. (plos.org)
  • Pro-Inflammatory Responses in Human Bronchial Epithelial Cells Induced by Spores and Hyphal Fragments of Common Damp Indoor Molds. (cellsystems.eu)
  • The goal is to develop a cellular therapy for human diseases either (a) with adult stem/progenitor cells (MSCs), or (b) with therapeutic factors that MSCs produce in response to signals from injured tissues. (tamu.edu)
  • 4. Identification of miR-301a in Primary Human Atrial Fibroblasts and Bone Marrow-Derived Mesenchymal Progenitor Cells to Attenuate Endogenous Differentiation into Pro-Fibrotic Cells. (cellsystems.eu)
  • Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. (wikipedia.org)
  • Although NOD-like receptor protein 3 (NLRP3) inflammasome activation is known to. (koreamed.org)
  • BACKGROUND: Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. (koreamed.org)
  • Different from the APL cells, most non-APL AML cells express low levels of the ATO transporter Aquaporin-9 (AQP9) protein, making them less sensitive to ATO treatment. (biomedcentral.com)
  • Among characterized gene candidates, aquaporin 0 (AQP0) expressed as a surface protein in early- and late-stage erythropoiesis precursors and was not expressed on nonerythroid cells. (biomedcentral.com)
  • This protein complex has also been implicated in regulating a number of signaling pathways, including Wnt, mammalian target of rapamycin (mTOR), STAT3, cMET, phosphoinositide 3-kinase (PI3K)/AKT, G protein-coupled receptor (GPCR), and epidermal growth factor receptor (EGFR), as well as in the localization and activity of cystic fibrosis transmembrane conductance (CFTR). (basicmedicalkey.com)
  • Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
  • Aquaporin inhibition changes protein phosphorylation pattern following sperm motility activation in fish. (upv.es)
  • Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)
  • 수분통로단백질인 aquaporin 3 (AQP3)은 백반증, 건선 등 다양한 피부 관련 질병의 발현에 중요한 역할을 한다. (e-ajbc.org)
  • Aquaporin 3 (AQP3) plays an important role in the expression of various skin-related diseases such as vitiligo and psoriasis. (e-ajbc.org)
  • The study objective was to explore the relationship between c-Met and AQP3 in human breast cancer. (scite.ai)
  • Real-time quantitative polymerase chain reaction and Western blotting were used to detect AQP3 expression in MCF-7 and MDA-MB-231 cells after human hepatocyte growth factor (hHGF) treatment and/or transfection with c-Met silencing small interfering (si)RNA. (scite.ai)
  • Conclusions Our study indicated that AQP3 expression was regulated by c-Met in human breast cancer. (scite.ai)
  • Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes). (wikipedia.org)
  • Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
  • Differentiation of Primary Human Pro-Fibrotic Mesenchymal Cells Influenced by Extracellular Matrix Environment Determined by Micro-RNA Expression (2018): 130. (cellsystems.eu)
  • Neutrophil gelatinase-associated lipocalin (NGAL in humans, siderocalin/24p3 in rodents) or lipocalin-2 (Lcn2) is secreted by cells [ 6 ] in an Fe 3+ -free apo form, which binds Fe 3+ through association with bacterial siderophores (forming holo-Lcn2). (biomedcentral.com)
  • [14] Studies in human models have demonstrated that Müller glia have the potential to serve as stem cells in the adult retina [15] and are efficient rod photoreceptor progenitors. (iiab.me)
  • Differentiation subsequently occurs in leaf primordia basipetally, resulting in a gradient of easily distinguishable cellular morphologies of distal differentiated cells towards the tip of the leaf, basal progenitor proliferating cells adjacent to the shoot apical meristem, and all possible intermediate stages in between. (biomedcentral.com)
  • Cells can communicate via physical interactions, in- cluding membrane bridge formation, such as tunneling nanotubes and cytonemes, and/or through the release of soluble factors [1-3]. (unicyte.ch)
  • In particular, stem cells are highly sensitive to extracellular signals that play a critical role in mainten- ance of stem cell characteristics, differentiation, and interplay with somatic cells. (unicyte.ch)
  • Gerontology (2017) 63 (3): 270-280. (karger.com)
  • Forensic sciences research 2017 2 (3): 152-157. (cdc.gov)
  • This mechanism is regulated by the expression of aquaporins in the contractile vacuole membrane. (hindawi.com)
  • V-ATPases move H + inside, lowering the vacuole's pH relative to the cytosol, promoting an osmosis gradient across the vacuole membrane, facilitating water entry through aquaporins in the vacuole membrane [ 5 , 6 ]. (hindawi.com)
  • Extracellular vesicle DNA from human melanoma tissues contains cancer-specific mutations. (gu.se)
  • Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming. (unicyte.ch)
  • Despite the importance of AQP4 in the pathophysiology of hydrocephalus, it's expression in human fetal life is not well-studied. (biomedcentral.com)
  • Human vision largely depends on cone photoreceptors. (nature.com)
  • Recently, we engineered an R91W;Nrl −/− mouse model 1 to analyze the impact of a human-blinding mutation found in RPE65 (the R91W) specifically on cone photoreceptors. (nature.com)
  • it inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha (all involved in early T-cell activation). (medscape.com)
  • Genes & Development 21 (3): 316-331. (mdc-berlin.de)
  • [3] They are to be critical to the development of the retina in mice, serving as promoters of retinal growth and histogenesis via a non-specific esterase mediated mechanism. (iiab.me)
  • High incidence of sudden cardiac death in one family with type-3 long QT syndrome: molecular genetics and electrophysiology mechanism analysis]. (cdc.gov)
  • Recent studies indicate that aquaporin 3 is overexpressed in many types of malignancies such as melanoma and primary effusion lymphomas as well as cancers of the lung, colon, stomach, esophagus, mouth, liver, and pancreatic duct. (wikipedia.org)
  • Recombinant analog of human stem cell growth factors. (drnadineaesthetics.com)
  • It leads to decreased expression of IL-3, IL-4, IL-5, and TNFα, and it inhibits mast cell and neutrophil activation. (medscape.com)
  • c-Met binds to HGF, resulting in the autophosphorylation and overexpression of c-Met, and this interaction participates in embryonic development, wound repair, tissue regeneration, cell differentiation, etc. (scite.ai)
  • Aquaporin-4 in Müller cell in rat, transfer water to vitreous body . (iiab.me)
  • These include hepatitis C virus, human immunodeficiency virus (HIV), and human T-cell lymphotrophic virus (HTLV). (medscape.com)
  • The human kidney contains approximately one million nephrons, each composed of at least 20 different cell types. (j-organoid.org)
  • Differentiation involves morphogenesis but also cell-appropriate organelle biogenesis programs. (biomedcentral.com)
  • Several other environmental factors including oxy- gen concentration and mechanical, metabolic, and bio- chemical conditions have been shown relevant in cell differentiation and have been reviewed extensively (Fig. 1) [3]. (unicyte.ch)
  • At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. (karger.com)
  • Intracellular amastigote protocols need further refinement, but we describe a first generation tool for high-throughput comparative molecular characterization of patients' isolates, based on the changing expression profiles of promastigotes during in vitro differentiation. (cambridge.org)
  • This manuscript systematically defines the brain expression of AQP4 in human brain development under control (n = 13) and hydrocephalic conditions (n = 3). (biomedcentral.com)
  • Background: Aquaporin (AQP) expression has been investigated in various malignant neoplasms, and the overexpression of AQP is related to poor prognosis in some malignancies. (koreamed.org)
  • Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease. (cellsystems.eu)
  • The cap mesenchyme secretes Wingless family member 11 (Wnt-11), which promotes ureteric bud differentiation. (j-organoid.org)
  • Human colon function ex vivo: Dependence on oxygen and sensitivity to antibiotic. (cellsystems.eu)
  • Combining these data with information about avian migratory patterns, landscape characteristics, and weather conditions, over space and time, will provide the foundation for developing spatial analytical and forecasting models to assess the risk for human illness. (cdc.gov)
  • Secondary Sjögren syndrome is diagnosed when, in the presence of a connective-tissue disease, symptoms of oral or ocular dryness exist in addition to criterion 3, 4, or 5, above. (medscape.com)
  • to understand how it moves between birds, mosquitoes, and humans and to better predict future outbreaks. (cdc.gov)
  • The parenchymal fluid contributes to the glymphatic system, and plays a fundamental role in pediatric hydrocephalus, with aquaporin 4 (AQP4) as the primary facilitator of these fluid movements. (biomedcentral.com)
  • Müller glia are currently being studied for their role in neural regeneration, a phenomenon which is not known to occur in humans. (iiab.me)
  • FLA are those that live free in the environment that do not strictly need a host, and parasitic that needs a host and are mostly pathogenic to humans with the ability to generate serious diseases [ 8 ]. (hindawi.com)
  • Defects in the primary cilia are linked to a wide spectrum of human diseases, collectively termed ciliopathies. (basicmedicalkey.com)
  • however, few differences and morphological structures led to the lack of classification and differentiation between the diverse species of amoebas [ 9 ]. (hindawi.com)
  • A collaborative 3-year research project is being conducted on lands administered by the U.S. Fish and Wildlife Service, the National Park Service, and other federal lands, and on state, local, and private lands along the Atlantic and Mississippi flyways. (cdc.gov)
  • In the kidney, aquaproin-3 is unresponsive to the antidiuretic hormone vasopressin, unlike aquaporin-2. (wikipedia.org)
  • In contrast to earlier models that featured nephron-like structures, these advances have improved the differentiation efficiency and similarity to the human kidney. (j-organoid.org)
  • Aquaporin 3 levels are often lower in psoriasis than in healthy skin. (wikipedia.org)
  • Evidence for the involvement of aquaporins in sperm motility activation of the teleost gilthead sea bream (Sparus aurata). (upv.es)
  • Under hydrocephalic conditions, GSC adjacent to characteristic ventricular zone disruption showed signs of early differentiation into astrocytes which may affect normal gliogenesis and contribute to the white matter dysgenesis. (biomedcentral.com)
  • Pacing and clinical electrophysiology : PACE 2018 3 41 (6): 620-626. (cdc.gov)
  • The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3. (gu.se)
  • The volume of amniotic fluid varies at different stages of pregnancy [ 2 , 3 ], and the average amniotic fluid volume is 400 mL at term [ 4 ]. (researchsquare.com)
  • Finally, WNV surveillance data from CDC is being studied to determine the spatial and temporal relationships between disease outbreaks in birds and animals and human illness. (cdc.gov)
  • An altered response in macrophage phenotype following damage in aged human skeletal muscle: implications for skeletal muscle repair. (cellsystems.eu)
  • In particular circumstances, some can reach humans or animals, promoting several health complications. (hindawi.com)
  • When reconstituted with 5 ml of sterile 0.01 N HCl, a concentration of approximately 3 mg/ml is achieved. (cellsystems.eu)
  • With the help of AQP0 staining, we could define up to five stages of erythropoiesis in both mouse and human bone marrow using flow cytometry. (biomedcentral.com)