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Goosecoid ProteinCell DifferentiationHomeodomain ProteinsActivinsGene Expression Regulation, DevelopmentalRepressor ProteinsTranscription FactorsOrganizers, EmbryonicGastrulaMesodermInhibinsEmbryonic InductionXenopus ProteinsGenes, HomeoboxT-Box Domain ProteinsEmbryo, NonmammalianIn Situ HybridizationZebrafish ProteinsDNA-Binding ProteinsXenopusSignal TransductionCells, CulturedMolecular Sequence DataMorphogenesisZebrafishBody PatterningStem CellsRNA, MessengerSkullCell LineTrans-ActivatorsBase SequenceNotochordSex DifferentiationFacial BonesTissue TransplantationEmbryonic Stem CellsPhenotypeGene ExpressionBone Morphogenetic ProteinsXenopus laevisEndodermHeadCell LineageEncyclopedias as TopicDevelopmental BiologySea UrchinsCytoplasmMedlinePlus
HomeoboxAmino acidsInhibitorMorphogenesisNeuralTranscriptionIntracellularRegulateAdenovirus proteinKinaseGenesMammalianEpithelial-mesenchymaPHOSPHATASERegulatory proteinTumorNucleusResiduesEvolutionarilyMeSHYeastBindMembraneEnhancerBoneNuclearReceptorHumansPlay a roleCellCellsFoundLevelsSpecificDomainDevelopment
Homeobox4
  • Vertebrate homeobox proteins lim-1, lim-2 (lim-5) and lim3. (embl.de)
  • C. elegans homeobox protein ceh-14. (embl.de)
  • C. elegans homeobox protein unc-97. (embl.de)
  • CTCDOs exhibited a hybrid epithelial-mesenchymal transition (EMT) state and an increased expression of stemness-associated markers including the two homeobox transcription factors Goosecoid and Pancreatic Duodenal Homeobox Gene-1 (PDX1), which were also detected in CTCs from CRC patients. (biomedcentral.com)
Amino acids2
  • Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
  • Finally, we identify the region of the Lrp6 protein with Wnt/PCP activity to a stretch of 36 amino acids, distinct from regions required for Wnt/β-catenin signaling. (silverchair.com)
Inhibitor3
  • Here we show that the Bone Morphogenetic Protein (BMP) and Wnt signaling pathways share Apcdd1 as a common inhibitor and that Apcdd1 is a taxon-restricted gene with novel domains and signaling functions. (xenbase.org)
  • Specifically, CTCDOs were more sensitive than XDOs to drugs affecting the Survivin pathway, which decreased the levels of Survivin and X-Linked Inhibitor of Apoptosis Protein (XIAP) inducing CTCDOs death. (biomedcentral.com)
  • Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. (bvsalud.org)
Morphogenesis3
  • The furry ( fry ) gene encodes an evolutionarily conserved protein with a wide variety of cellular functions, including cell polarization and morphogenesis in invertebrates. (nature.com)
  • The network model further provides the genomic regulatory code for subsequent steps of differentiation and morphogenesis. (biologists.com)
  • Both genes are expressed in the nascent mesoderm and neurectoderm , and morpholino knockdown of either causes defects in differentiation and morphogenesis of the mesoderm and neural plate . (xenbase.org)
Neural2
  • 2010), here we find that Apcdd1 potently inhibits BMP signaling in body axis formation and neural differentiation in chicken, frog, zebrafish. (xenbase.org)
  • Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)
Transcription4
  • Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (childrensmercy.org)
  • A family of double-stranded RNA-binding proteins that are related to NFATC TRANSCRIPTION FACTORS. (ouhsc.edu)
  • In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
  • They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (umassmed.edu)
Intracellular3
  • It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. (thermofisher.com)
  • Mammalian cysteine-rich intestinal protein (CRIP), a small protein which seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. (embl.de)
  • Protein-based carriers are promising vehicles for the intracellular delivery of therapeutics. (bvsalud.org)
Regulate1
  • Through physical interaction or modification of diverse protein clients, PML-NBs regulate a multitude of - often antithetical- biological processes such as antiviral and stress response, inhibition of cell proliferation and autophagy, and promotion of apoptosis or senescence. (bvsalud.org)
Adenovirus protein1
  • In this study, we designed and studied adenovirus protein fiber constructs with potential applications as carriers for the delivery of protein and nanoparticle cargoes. (bvsalud.org)
Kinase3
  • Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. (thermofisher.com)
  • S-phase kinase associated protein 2 [Source. (gsea-msigdb.org)
  • mitogen-activated protein kinase 11 [Source. (gsea-msigdb.org)
Genes1
Mammalian2
  • Localization patterns in the developing mice indicated that the Goosecoid protein encoded by GSC acts as an effector in a regulatory pathway that mediates bone and cartilage-related differentiation and growth during mammalian development. (genomeweb.com)
  • Mammalian and avian cysteine-rich protein (CRP), a 192 amino-acid protein of unknown function. (embl.de)
Epithelial-mesenchyma2
  • CTCDOs recapitulated several features of CRC CTCs including a hybrid epithelial-mesenchymal transition (EMT) state and elevated expression of stemness-associated proteins. (biomedcentral.com)
  • Of note, increased migration was accompanied by higher levels of the epithelial-mesenchymal transition (EMT) regulator Twist-related protein 2 (TWIST2). (bvsalud.org)
PHOSPHATASE3
  • It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. (jefferson.edu)
  • protein phosphatase 2 catalytic subunit alp. (gsea-msigdb.org)
  • Furthermore, two streptavidin-conjugated model proteins, alkaline phosphatase and horseradish peroxidase can be delivered into the cell cytoplasm in their enzymatically active form. (bvsalud.org)
Regulatory protein3
  • Leucine-Responsive Regulatory Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • This graph shows the total number of publications written about "Leucine-Responsive Regulatory Protein" by people in this website by year, and whether "Leucine-Responsive Regulatory Protein" was a major or minor topic of these publications. (rush.edu)
  • Below are the most recent publications written about "Leucine-Responsive Regulatory Protein" by people in Profiles. (rush.edu)
Tumor2
  • CTCs analysis through liquid biopsies provides not only a full repertoire of tumor biological material (including proteins, lipids, sugars and nucleic acids) but also a sample of living tumor cells endowed with metastatic ability [ 3 ]. (biomedcentral.com)
  • Promyelocytic leukemia protein (PML) modulates diverse cell functions that contribute to both tumor suppressor and pro-oncogenic effects, depending on the cellular context. (bvsalud.org)
Nucleus2
  • In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (jefferson.edu)
  • A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS . (nih.gov)
Residues1
  • We used as a basic structural framework the fibrous shaft segment of the adenovirus fiber protein comprising of residues 61-392, connected to the fibritin foldon trimerization motif at the C-terminal end. (bvsalud.org)
Evolutionarily1
  • The Furry (Fry) gene encodes a large protein (~ 330 kDa) that is evolutionarily conserved from yeast to humans. (nature.com)
MeSH2
  • Proto-Oncogene Proteins c-rel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
Yeast1
  • Saccharomyces cerevisiae (Baker's yeast) rho-type GTPase activating protein RGA1/DBM1. (embl.de)
Bind2
  • Some LIM domains bind protein partners via tyrosine-containing motifs. (embl.de)
  • They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
Membrane1
  • Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). (thermofisher.com)
Enhancer4
Bone1
Nuclear4
  • The high nuclear levels of b-catenin results from the high accumulation of the disheveled protein at the vegetal pole of the egg. (wikipedia.org)
  • Below are the most recent publications written about "Nuclear Factor 90 Proteins" by people in Profiles. (ouhsc.edu)
  • Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified. (nih.gov)
  • The promyelocytic leukemia protein (PML) is the core organizer of cognate nuclear bodies (PML-NBs). (bvsalud.org)
Receptor1
  • a protein required for the differentiation of the set of six touch receptor neurons in this nematode. (embl.de)
Humans2
  • Based on results of their analyses, the study's authors argued that Goosecoid likely has a key role in development in humans and other mammals, contributing to everything from face and skull features to joint development. (genomeweb.com)
  • Polyglutamine-binding protein 1 ( PQBP1 ) is an RNA-splicing factor that, when mutated, in humans causes Renpenning syndrome, an X-linked intellectual disability disease characterized by severe cognitive impairment, but also by physical defects that suggest PQBP1 has broader functions in embryonic development. (xenbase.org)
Play a role1
  • They are expressed predominately in hematopoietic cells and may play a role in lymphocyte differentiation. (childrensmercy.org)
Cell3
  • Whole cell extracts (30 µg lysate) of HeLa (Lane 1), SH-SY5Y (Lane 2), A549 (Lane 3), A-431 (Lane 4) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). (thermofisher.com)
  • In addition, PML ablation in MDA-MB-231 cells led to higher protein levels of hypoxia-inducible factor 1-alpha (HIF1a), resulting in a higher cell hypoxic response. (bvsalud.org)
  • They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators. (bvsalud.org)
Cells2
  • Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
  • a protein required for the asymmetric division of vulval blast cells. (embl.de)
Found2
  • LIM domains coordinate one or more zinc atoms, and are named after the three proteins (LIN-11, Isl1 and MEC-3) in which they were first found. (embl.de)
  • A LEUCINE and DNA-binding protein that is found primarily in BACTERIA and ARCHAEA. (rush.edu)
Levels1
  • Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression. (nih.gov)
Specific1
  • Helianthus annuus (Common sunflower) pollen specific protein SF3. (embl.de)
Domain1
  • Fry protein is composed of an N-terminal Furry domain (FD) with HEAT/Armadillo repeats followed by five regions without any recognizable functional domains. (nature.com)
Development2
  • Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. (thermofisher.com)
  • Drosophila melanogaster (Fruit fly) protein apterous, required for the normal development of the wing and halter imaginal discs. (embl.de)