Differentiation gata. Medical search. Frequent questions

This study aimed to explore adipogenic transcriptional dynamics before (proliferation) and after (differentiation) initial preadipocyte differentiation in ducks. (biomedcentral.com)
We explored 36 mRNA-seq libraries in order to study transcriptome dynamics during proliferation and differentiation processes at 6 time points. (biomedcentral.com)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Finally, we manually assembled a proposed regulation network model of subcutaneous preadipocyte differentiation base on the expression data, and suggested that E2F1 may serve as an important link between the processes of duck subcutaneous preadipocyte proliferation and differentiation. (biomedcentral.com)
For the first time we comprehensively analyzed the transcriptome dynamics of duck subcutaneous preadipocyte proliferation and differentiation. (biomedcentral.com)
Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
The hallmarks of development during pregnancy are the formation of tertiary branches, which terminate in alveolar buds, and the rapid proliferation of the luminal epithelium accompanied by differentiation and commitment to the secretory alveolar lineage. (biologists.com)
3) that were divided into two major clusters corresponding to the main phases observed during the preadipocyte culture: proliferation and differentiation. (biomedcentral.com)
Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
Therefore, growth of adipose tissue includes the hypertrophy of already existing adipocytes and the proliferation and differentiation of new ones from MSCs. (biomedcentral.com)
In vitro differentiation of murine erythroleuekemia cells recapitulates many aspects of the erythroid terminal differentiation program, including hemoglobin synthesis and proliferation arrest. (imrpress.com)
MAPK can cause the activation of transcription factors in the nucleus, participate in the process of signal transmission from the cell surface to the nucleus, and regulate cell proliferation and differentiation. (cusabio.com)
This pathway can also affect the proliferation and differentiation of red blood cells. (cusabio.com)
Studies have shown that ERK signaling pathway is also involved in signal transduction of osteoblast differentiation and proliferation. (cusabio.com)
Through its activity as a transcription factor and its interactions with other proteins, the GATA1 protein regulates the growth and division (proliferation) of immature red blood cells and platelet-precursor cells (megakaryocytes) and helps with their differentiation. (medlineplus.gov)
Signals from these growth factors are integrated with environmental influences, such as lung fluid volume and hyperoxia, to cause cellular proliferation and differentiation. (medscape.com)
They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators. (bvsalud.org)

Thus, GATA-2 and GATA-3 regulate adipocyte differentiation through molecular control of the preadipocyte-adipocyte transition. (nih.gov)
Although studies have identified several miRNAs that regulate erythroid commitment and differentiation, we do not understand the mechanism by which the crucial erythroid transcription factors, GATA-1and NF-E2 directly regulate and control differentiation via miRNA pathways. (molcells.org)
Zhang, F. P., Meng, G. X. & Strober, W. Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17-producing T cells. (nature.com)
TBX21 (Th1) , GATA3 (Th2) , RORγt (Th17) and FOXP3 (Treg) are the primary subset-specific transcription factors of these CD4 + T cell subsets and can regulate T cell differentiation. (oncotarget.com)
However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown. (bmj.com)

Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. (nih.gov)
Constitutive GATA-2 and GATA-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. (nih.gov)
In the early stage of adipocyte differentiation, ERK1/2 promotes adipocyte differentiation by promoting the expression of C/EBPα and PPARγ. (cusabio.com)
In the late stage of adipocyte differentiation, activated ERK1/2 phosphorylates PPARγ to inactivate it and inhibit adipocyte differentiation. (cusabio.com)
JNK signaling pathway also plays an important role in regulating adipocyte differentiation. (cusabio.com)
In addition, the ERK5/BMK1 pathway, an atypical MAPK pathway, is involved in the regulation of adipocyte differentiation and fat metabolism. (cusabio.com)

On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)
We discuss the contributions of PU.1 to the block to terminal differentiation exhibited by the erythroleukemia cells as well as the role of GATA-1 in restoring normal differentiation. (imrpress.com)

The transcription factor GATA-2 has specific but unclarified roles in early hematopoiesis. (elsevierpure.com)
The transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer. (semanticscholar.org)
Id3 was required for relief of inhibition by the transcription factor GATA-3 at the Foxp3 promoter. (diagenode.com)

Chemical compounds that modulate atrial and ventricular cell fate could be used to improve subtype-specific differentiation of endogenous or exogenously delivered progenitor cells in order to promote cardiac regeneration. (biomedcentral.com)
Thus, small molecules capable of influencing the fate decisions and differentiation programs of multipotent progenitor cells could facilitate therapeutic regeneration of lost myocardium. (biomedcentral.com)
GATA-3-deficient embryonic stem cells exhibit an enhanced capacity to differentiate into adipocytes, and defective GATA-2 and GATA-3 expression is associated with obesity. (nih.gov)
In this study, we identified miR-199b-5p as a key regulator of human erythropoiesis, and its expression was up-regulated during the erythroid differentiation of K562 cells. (molcells.org)
Furthermore, the increase of miR-199b-5p in erythroid cells occurred in a GATA-1- and NF-E2-dependent manner during erythrocyte maturation. (molcells.org)
The up-regulation of miR-199b-5p during erythroid differentiation was dependent on the binding of GATA-1 and NF-E2 to its gene locus, which activated its transcription and maintained its high expression level in mature erythroid cells. (molcells.org)
Exogenous expression of GATA-2 in TG-GFP + /CD45 - cells from the AGM region inhibited their differentiation into CD45 + cells. (elsevierpure.com)
Loss of GATA-2 function through the disruption of the GATA-2 locus enhanced the earlier emergence of CD45 + cells in the yolk sac of the 9.5-day conceptus. (elsevierpure.com)
These results demonstrated that GATA-2 is expressed in the precursor of hematopoietic cells and works as a gatekeeper to preserve their immaturity. (elsevierpure.com)
A reduction of GATA-2 expression or activity is required for the differentiation of precursors to hematopoietic cells. (elsevierpure.com)
These defects reflect the essential role of Gata-1 in stimulating the development, self-renewal, and/or maturation of red blood cell and platelet precursor cells. (wikipedia.org)
The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17 + T helper cells. (nature.com)
Manel, N., Unutmaz, D. & Littman, D. R. The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. (nature.com)
Although differentiation of naïve CD4 + T cells has been considered to be an irreversible process, accumulating evidence suggests that T cells are much more flexible than initially believed with the ability to interchange between helper phenotypes 15 . (nature.com)
To determine the scope of the GATA-1/Foxo3 cooperativity, and to develop functional insights, we analyzed the GATA-1/Foxo3-dependent transcriptome in erythroid cells. (nih.gov)
Using ES cells developed at the Center for iPS Cell Research and Application (CiRA) in Kyoto University, the research group collected RNA and histones of each cell immediately after VEGF stimulation (0 h), before differentiation (6 h), during differentiation (12 - 24 h), and after differentiation (48 h). (medicalxpress.com)
Previously, in the region that controls the function of the transcription factor that promotes differentiation from ES cells to a specific cell type, bivalent modifications of histones such as the accelerator and brake histone marks for transcription were thought to have coexisted. (medicalxpress.com)
In vitro differentiation of Th9 cells from the larger CD4 + T cell population provides increased numbers of Th9 cells to facilitate research into their functions. (rndsystems.com)
The culture medium from CD4 + T cell differentiation procedures should be analyzed to confirm that the cells are secreting cytokines relevant to the desired cell subset. (rndsystems.com)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. (diagenode.com)
Furthermore, Id3(-/-) T cells showed greater differentiation into the T(H)17 subset of helper T cells in vitro and in a mouse asthma model. (diagenode.com)
It also provides an opportunity to study the changes occurring during reprogramming of tumor cells into their normal differentiation program. (imrpress.com)
It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. (qedbio.com)
Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). (qedbio.com)
The focus of this review is to highlight the role of statins in modulating the function and differentiation of various blood cells. (archivesofmedicalscience.com)
For example, humans are derived from fertilized eggs, and this process involves the differentiation of embryonic stem cells. (cusabio.com)
Abnormal differentiation of cells can lead to cancerous cells. (cusabio.com)
The ERK-MAPK signaling pathway plays a role in the differentiation of mesenchymal stem cells (MSCs) into adipocytes [1] [2] . (cusabio.com)
p38 pathway plays a very important role in the osteogenic differentiation of mesenchymal stem cells (MSCs). (cusabio.com)
Inhibition of the p38 MARK pathway down-regulates the activity of protein kinase C ( PKC ), which plays an important role in osteogenic differentiation of cells. (cusabio.com)
The p38 signaling pathway regulates the differentiation direction of stem cells, which may be related to the regulation of the stability of p53 protein [3] [4] . (cusabio.com)
In this preprint, the authors found that ELT-3, a GATA factor that is mostly expressed in the hypodermal cells in C. elegans , is present in early endodermal progenitors and drives gut specification in C. angaria . (biologists.com)
Results: Light microscopy analysis revealed a decreased expression of GATA-3-positive cells when bone loss progressed. (bvsalud.org)
Differentiation into Th1 depends on the presence of IFN-γ and IL-12, which bind to receptors on the surface of CD4 T cells 5 . (bvsalud.org)
This binding initiates a cascade of events that culminates in differentiation into Th1 cells, by increasing the transcription factor T-bet 12 . (bvsalud.org)
Th2 cells have a differentiation process which is dependent on IL-4, which causes the activation of the transcription factor STAT 6 . (bvsalud.org)
The GATA1 protein is involved in the specialization (differentiation) of immature blood cells. (medlineplus.gov)

In this context, the Forkhead transcription factor, Foxo3, amplified GATA-1-mediated transcriptional activation. (nih.gov)
However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)
Finally, we established 3 groups of transcriptional models to describe Ly6C high to Ly6C low MC subset differentiation, immune checkpoint regulation, Ly6C high MC to MΦ subset differentiation and Ly6C low MC to lymphocyte functional adaptation. (frontiersin.org)
Among them, Runx2 is a key target gene affecting osteogenic activity, and Cbfa1 regulates the differentiation of MSCs into osteoblasts at the transcriptional level. (cusabio.com)

To elucidate the expression profile of GATA-2, we prepared transgenic mouse lines containing the green fluorescent protein (GFP) gene driven by GATA-2 gene regulatory elements. (elsevierpure.com)
In the process of blood vessel differentiation, the function of the protein ETS variant 2 (ETV2), which determines the differentiation into vascular endothelium, was first induced within 6 hours of differentiation stimulation. (medicalxpress.com)
The protein GATA2, which binds to ETV2 and supports vascular endothelial differentiation, was induced immediately thereafter. (medicalxpress.com)
GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. (bmj.com)
Aberrant DNA methylation of GATA binding protein 3 (GATA3), interleukin-4 (IL-4), and transforming growth factor-β (TGF-β) promoters in. (oncotarget.com)
Background GATA1 encodes a protein, GATA1, which belongs to the GATA family of transcription factors. (qedbio.com)

Reporter gene assays were conducted to examine combinatorial effects of GATA-targeted compounds and bromodomain and extraterminal domain (BET) inhibition on chamber-specific gene expression. (biomedcentral.com)
Overexpression of FLI1 in erythroblasts causes inhibition of differentiation and ultimately the development of pre-T cell lymphoblastic leukemia/lymphoma [ 11 ]. (biomedcentral.com)

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. (edu.au)

We show that NAD + regulates CD4 + T-cell differentiation through tryptophan hydroxylase-1 ( Tph1 ), independently of well-established transcription factors. (nature.com)
It is speculated that hypermethylation of the RUNX3 gene promoter and overexpression of GATA-4, a transcription factor that regulates differentiation and function of yolk sac endoderm, may play important roles in the pathogenesis of yolk sac tumors (YSTs). (medscape.com)

According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
To understand the development of adiposity, it is crucial to identify the genes which expression is associated with adipogenic differentiation. (biomedcentral.com)

In the present study, we identified miR-199b-5p as a positive erythroid regulator, that was regulated by the key erythroid transcription factors GATA-1 and NF-E2. (molcells.org)
Previously, we described a role for the master regulator of erythropoiesis, GATA-1, in inducing genes encoding components of the autophagy machinery. (nih.gov)
GATA-3 acts as a master regulator of Th2 differentiation 12-13 . (bvsalud.org)

This indicated the involvement of epigenetic modulators in the regulation of GATA-dependent transcription. (biomedcentral.com)
Taken together, our results establish a functional link among the erythroid transcription factors GATA-1/NF-E2, miR-199b-5p and c-Kit, and provide new insights into the coupling of transcription and post-transcription regulation in erythroid differentiation. (molcells.org)
GATA-1/Foxo3 repressed expression of Exosc8, a pivotal component of the exosome complex, which mediates RNA surveillance and epigenetic regulation. (nih.gov)

GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. (wikipedia.org)

During development, GATA3 plays a key role in cell differentiation. (bmj.com)

Our data demonstrate the feasibility of targeting the orphan receptors RORα and RORγt to inhibit specifically T H 17 cell differentiation and function, and indicate that this novel class of compound has potential utility in the treatment of autoimmune diseases. (nature.com)

Epithelial differentiation is delayed, and surfactant deficiency is associated. (medscape.com)

Exogenous oleic acid alone successfully induced duck subcutaneous preadipocyte differentiation. (biomedcentral.com)

Complex genetic networks control hematopoietic stem cell differentiation into progenitors that give rise to billions of erythrocytes daily. (nih.gov)

Here we present SR1001, a high-affinity synthetic ligand-the first in a new class of compound-that is specific to both RORα and RORγt and which inhibits T H 17 cell differentiation and function. (nature.com)
McGeachy, M. J. & Cua, D. J. Th17 cell differentiation: The long and winding road. (nature.com)
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. (mcw.edu)
Our findings unravel a new pathway orchestrating CD4 + T-cell differentiation and demonstrate that NAD + may serve as a powerful therapeutic agent for the treatment of autoimmune and other diseases. (nature.com)
Dynamically and epigenetically coordinated gata/ets/sox transcription factor expression is indispensable for endothelial cell differentiation. (medicalxpress.com)
Following cell differentiation, flow cytometry can be used to verify the expression of established cell surface or intracellular markers of CD4 + T cell subsets. (rndsystems.com)
Intracellular markers include transcription factors that control CD4 + T cell differentiation as well as signature cytokines as they traffic through secretory organelles. (rndsystems.com)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
T-bet and STAT-4, two Th1 promoting transcription factors, and STAT-6 and GATA-3, transcription factors which govern T helper cell type 2 (Th2) cell polarisation, were examined in duodenal biopsies by western blotting. (bmj.com)
We also discuss the role of certain cell cycle regulators in the decision to resume normal differentiation and in the resulting terminal cell divisions and arrest. (imrpress.com)
To use this knowledge to improve beta cell differentiation protocols. (lu.se)
Cell differentiation is the process where a cell changes from one type to many different types. (cusabio.com)
In the process of cell differentiation, there are differences in morphological structure and physiological function. (cusabio.com)
Cell differentiation occurs throughout life. (cusabio.com)
The JNK signaling pathway can affect a variety of life processes such as cell growth, cell differentiation, and cell death. (cusabio.com)
This signal together with the T Cell Receptor (TCR) induces the expression of GATA-3. (bvsalud.org)

JNK can change the mRNA level of osteocalcin , so the activation of JNK can induce osteoblast differentiation. (cusabio.com)

T/A(GATA)A/G), on the expression-regulating sites of its target genes and in doing so either stimulates or suppresses the expression of these target genes. (wikipedia.org)
In patients with breast cancer, expression of FLI1 is strongly correlated with advanced stage, poor differentiation, and lymph node metastasis. (biomedcentral.com)

We also prepared a mouse line in which GFP reporter sequences were inserted into the endogenous GATA-2 gene. (elsevierpure.com)

In the early embryo, the endoderm GRN is initiated by SKN-1, which activates a gene cascade driven by six GATA transcription factors - two MEDs, two ENDs, and two ELTs. (biologists.com)

T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ. (nature.com)

Strikingly, the authors were able to move C. angaria network into C. elegans by knocking out the entire GATA cascade in C. elegans and replacing it with Can-ELT-3 and Can-ELT-2, which strongly supports the conclusion that Can-ELT-3 and Can-ELT-2 drive endoderm specification and differentiation, respectively. (biologists.com)

This study aims to explore molecule signaling mediating MC subset differentiation in HHcy and control mice. (frontiersin.org)

Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. (bvsalud.org)

Transcription factors SOX and FLI1, both important for endothelial differentiation, were induced between 12 and 24 hours. (medicalxpress.com)

Both GATA-1 and NF-E2 bound upstream of the miR-199b gene locus and activated its transcription. (molcells.org)

Anatomy66

Organisms8

Diseases8

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes63

Disciplines and Occupations1

Information Science4

Proliferation18

Regulate5

Adipocyte6

Terminal differentiation2

Transcription Factor GATA3

Cells40

Transcriptional4

Protein6

Inhibition2

Mammary-gland1

Regulates2

Adipogenic differentiation2

Regulator3

Regulation3

Erythroid transcription1

GATA31

Inhibit1

Epithelial1

Preadipocyte1

Hematopoietic1

Cell16

Induce1

Expression2

Endogenous1

Driven1

Lineage1

Endoderm1

Subset1

Proteins1

FLI11

Upstream1