Differentiation early follicle morphogenesis. Medical search. Frequent questions

In the ovarian follicle , activin increases FSH binding and FSH-induced aromatization . (wikidoc.org)
The vascular endothelium of the mature ovarian follicle maintains the capacity for rapid growth in response to angiogenic signals elaborated during the periovulatory process. (biomedcentral.com)
Interestingly, the elongation of the ovarian follicle, which progressively matures from a spherical to an elongated form, is generated by the follicular epithelium. (igred.fr)

At the same time, skin and hair follicles harbor a functional circadian clock that regulates gene expression with a periodicity of approximately twenty four hours. (aging-us.com)
The hair follicle regulates hair growth via a complex interaction between hormones , neuropeptides , and immune cells . (radonbiathlo673.cfd)
Activin also regulates the morphogenesis of branching organs such as the prostate , lung , and especially kidney . (wikidoc.org)

Promotes proliferation, survival, migration and differentiation of endothelial cells. (drugbank.com)
Other transplanted cells could be found among keratinocytes, hair follicle cells, endothelial cells and in derma. (genescells.ru)

BMP4 antagonizes organizer tissue and is expressed in early development in ectoderm and mesoderm tissue. (wikipedia.org)
9. Overexpression of R-spondin 3 in the murine ectoderm alters morphogenesis and development of hair follicles. (v4sdb2023.pl)
These proteins are involved in signal transduction from ectoderm to mesenchyme during development of the fetus and are indispensable for the differentiation of ectoderm-derived structures such as eccrine sweat glands, teeth, hair, skin, and/or nails. (springer.com)
The oral ectoderm and neural ectoderm that form the pituitary anlagen are in close contact during early embryogenesis, and this connection is critical for pituitary development. (medscape.com)
The neurohypophysis develops from the differentiation of neural ectoderm into the pars nervosa, the infundibular stem, and the median eminence. (medscape.com)

Premature ovarian failure is the extreme state of complete primordial follicle depletion. (medscape.com)

Beginning after completion of hair morphogenesis (postnatal day 14 in the mouse), hair growth cycles commence with catagen, an involution process of the hair follicle during which the majority of its epithelial compartments undergo apoptosis [ 1 ]. (aging-us.com)
In an anagen human hair follicle PPARγ expression is detected in the mesenchymal DP cells, epithelial cells of the outer root sheath (ORS), inner root sheath and matrix 16 . (nature.com)
How epithelial cells actively respond to mechanical constraints by adjusting how they generate force is important to understand tissue morphogenesis. (nature.com)
In addition to these basic aspects, our work is also medically relevant since 80% of cancers have an epithelial origin and deregulation of the mechanisms controlling their growth or their morphogenesis are involved in tumor development. (igred.fr)
We study on the one hand F-actin cytoskeleton function and dynamics at the apical domain and cell junctions of follicular epithelial cells, in contact with the germ cells during the early elongation of the follicles. (igred.fr)

Stimulates proliferation and differentiation of early progenitor cells within hair follicles. (plurisomes.com)
RAS protein plays a vital role in the modulation of cell survival, proliferation, and differentiation by molecular pathway signaling. (encyclopedia.pub)
RAS family proteins play a vital role in the modulation of cell survival, proliferation, and differentiation by signaling through a set of molecular pathways [ 10 ] . (encyclopedia.pub)

Induces anagen phase in resting hair follicles. (plurisomes.com)
[1] This complex interaction induces the hair follicle to produce different types of hair as seen on different parts of the body. (radonbiathlo673.cfd)

The hallmarks of development during pregnancy are the formation of tertiary branches, which terminate in alveolar buds, and the rapid proliferation of the luminal epithelium accompanied by differentiation and commitment to the secretory alveolar lineage. (biologists.com)
A conditional knockout in surface epithelium results in defects in hair follicle development and epidermal morphogenesis. (jax.org)
For example, purely physical mechanisms can account for branching morphogenesis of the embryonic mouse airway epithelium, when cultured ex vivo in the absence of biochemical patterning 14 . (nature.com)
Anatomically, this epithelium surrounds the germ cells within the reproductive organ, forming 'ovarian follicles' or 'egg chambers', precursors of the future egg. (igred.fr)
On the other hand, we analyze the involvement of the Dystrophin-Dystroglycan protein complex and the basal domain of the epithelium in the later follicle elongation phase and especially its implication in planar cell polarity and extracellular matrix organization. (igred.fr)
FGF-10 immunostaining could be related to cell proliferation in epithelium and cell differentiation in epithelium and ectomesenchyme. (bvsalud.org)

Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation , apoptosis , [3] metabolism , homeostasis , immune response , wound repair , [4] and endocrine function. (wikidoc.org)

BMP4 is found in early embryonic development in the ventral marginal zone and in the eye, heart blood and otic vesicle. (wikipedia.org)
An outstanding question in dermatology that researchers have studied for decades is: How do hair follicles emerge from a sea of seemingly uniform skin cells during embryonic development? (scitechdaily.com)
7. The effect of T-2 and zearalenone toxins on chicken embryonic development - Early results. (v4sdb2023.pl)

22 The underlying mechanism is believed to be a higher concentration of dihydrotestosterone (DHT) to androgen-sensitive hair follicles, causing thinning of the dermal papillae and shortening of the anagen phase. (jcadonline.com)
The histological morphology of hair follicles demonstrated an active anagen phase with the induction of stem cell factor. (biomedcentral.com)

Its action in wound repair and skin morphogenesis is through stimulation of keratinocytes and stromal cells in a dose-dependent manner. (wikidoc.org)

Using this combined approach, the research team was able to predict and validate key molecular changes that occur within a subpopulation of dermal progenitor cells as they differentiate and mature into cells uniquely capable of inducing hair follicles. (scitechdaily.com)
The scientists found that these dermal progenitor cells can be found spatially within a specific reservoir just peripheral to the forming hair follicle. (scitechdaily.com)

Arrows show dermal condensate (in red), a subpopulation of cells essential for embryonic hair follicle growth. (scitechdaily.com)
Current opinion views androgens as the pathogenic driver in the miniaturization of hair follicles of androgenetic alopecia by interfering with the dermal papilla. (nature.com)

citation needed] BMP4 also limits the extent to which neural differentiation in Xenopus embryos occurs by inducing epidermis formation rather than neural tissue. (wikipedia.org)
8. Investigating the role of YY1 Associated Factor 2 in mouse neural differentiation. (v4sdb2023.pl)

The influence of in vitro culture and sodium citrate supplementation on the development and differentiation of preimplantation rabbit embryos. (v4sdb2023.pl)
Ednra expression was shown for the first time in hair and vibrissal follicles of E15.5 Ednralacz/+ mouse embryos (Gordon et al. (progress-eng.co)

This is thought that inducing osteoblastic commitment and differentiation of stem cells such as mesenchymal stem cells. (wikipedia.org)
BMP4, in conjunction with FGF2, promote differentiation of stem cells to mesodermal lineages. (wikipedia.org)
After differentiation, BMP4 and FGF2 treated cells generally produces higher amounts of osteogenic and chondrogenic differentiation than untreated stem cells. (wikipedia.org)
In this research, we generate differentiated kidney cells (DKCs) from mouse pluripotent stem cells (mPSCs) analyzing their morphological, genetic, phenotypic, and spectroscopic characteristics along differentiation, highlighting that there are no reports of the use of Fourier transform infrared (FTIR) spectroscopy to characterize the directed differentiation of mPSCs to DKCs. (biomedcentral.com)
pointed out that Mage-D1 may participate in the proliferation of bone marrow mesenchymal stem cells (BMSCs) and the differentiation of odontoblasts through the NF-κB signalling pathway 21 . (researchsquare.com)
Total and conditional knock out of PPARγ in hair follicle bulge stem cells showed similar result where scarring alopecia was observed in mice with the loss of pilosebaceous units and inflammatory cells infiltration 18 , 19 . (nature.com)
Wu Y., Chen L., Scott P.G., Tredget E.E. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. (genescells.ru)
Morphogenesis and renewal of hair follicles from adult multipotent stem cells. (genescells.ru)
It houses several types of stem cells, which supply the entire hair follicle with new cells, and take part in healing the epidermis after a wound. (radonbiathlo673.cfd)
Constant using a earlier research, this lack of correlation can be the result of de novo methylation at already transcription ally silent CGI promoters in undifferentiated stem cells. (pkainhibitors.com)
Upregulation of Activin A drives pluripotent stem cells into a mesoendodermal fate, and thus provides a useful tool for stem cell differentiation and organoid formation. (wikidoc.org)

Increased IGFBP-4 and -5 protease along with lower amounts of IGFBP-4 binding activity and greater amounts of free IGF-I are some of the earliest developmental changes documented in bovine growing antral follicles. (bioone.org)
The granulosa cells and theca cells of the developing antral follicle and the steroidogenic cells of the corpus luteum produce and respond to angiogenic factors and vasoactive peptides. (biomedcentral.com)

We found that knockdown of Bonus in early oogenesis results in severe defects in ovarian development and in ectopic expression of genes that are normally repressed in the germline, demonstrating its essential function in the ovary. (elifesciences.org)
At present no proven method can determine that a woman has no primordial follicles remaining in the ovary, so, in effect, this term is merely a construct (ie, a concept that cannot be proven). (medscape.com)

Subsequent studies further confirmed that Mage-D1 inhibits the NF-κB signalling pathway by combining with IκB kinase β (IKKβ) 22 , which is a vital regulator of odontoblast differentiation. (researchsquare.com)

These protease-induced decreases in IGFBP-4 and -5 likely cause increased levels of bioavailable (or free) IGFs that stimulate steroidogenesis and mitogenesis in developing dominant follicles, which ultimately prepare the follicle(s) and oocyte(s) for successful ovulation and fertilization. (bioone.org)
Following ovulation the neovascularization during the early stages of corpus luteum development has been compared to the rapid angiogenesis observed during tumor formation. (biomedcentral.com)
Additionally, reproductive hormones regulate RAS activity in the cellular physiological function of ovarian follicles during pre-ovulatory maturation and ovulation. (encyclopedia.pub)

BMP4 stimulates differentiation of overlying ectodermal tissue. (wikipedia.org)

By modulating this signal in mice, they were able to regulate hair follicle size during the early skin development. (scitechdaily.com)
The presence of estradiol in developing ovarian follicles usually inhibits spermatogonia development in adjacent or contralateral seminiferous tubules. (medscape.com)
The development of new tools and culture techniques has also enabled the factors that influence branching morphogenesis in the embryonic and pubertal gland to be identified. (biologists.com)
After birth, mammary development is arrested until puberty, when extensive elongation of the ducts, accompanied by secondary branching, takes place, thus providing a readily accessible system in which to study branching morphogenesis. (biologists.com)
Further studies confirmed that p75NTR participates in the regulation of tooth development maybe by changing the activity of the key factor distal-less homeobox/msh homeobox (Dlx/Msx), and melanoma-associated antigen D1 (Mage-D1) seems to be play a role in the differentiation and mineralization of EMSCs 5 , 6 . (researchsquare.com)
In this system, hormones are responsible for transmitting information between the organs, in addition to being essential in functions such as reproduction, being involved in the normal development of organisms, and in brain function and differentiation. (ivis.org)
Sensory circuits are typically established during early development, yet how circuit specificity and function are maintained during organismal growth has not been elucidated. (sdbonline.org)
Epigenetic regulation of gene expression is an essential mechanism that guides cell differentiation during development. (elifesciences.org)
For this, we analyze the modes of communication between the germ cells and the follicular cells, allowing the synchronization of their growth during the development of the ovarian follicles and thus ensuring the homeostasis of the reproductive organ. (igred.fr)
In the ovarian cycle, repeated patterns of specific cellular proliferation, differentiation, and transformation occur that accompany the process of follicular development and the formation and function of the corpus luteum [ 2 ] . (encyclopedia.pub)
However, the principles and terms inherent to the concept of 4D bioprinting are still in early development. (cellculturedish.com)

BMP4 also plays important roles in adipose tissue: it is essential for white adipogenesis, and promotes adipocyte differentiation. (wikipedia.org)
It was shown to inhibit keratinocyte proliferation and promotes terminal differentiation 17 . (nature.com)

Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)

Moreover, it has been shown that in the SVZ BMP4 has a prodifferentiative effect, since it rescues a defect of terminal differentiation in SVZ neurospheres where the gene Tis21/BTG2 - required for terminal differentiation - has been deleted. (wikipedia.org)
Since our mRNA expression studies were performed using whole skin, we asked which compartments of the skin and hair follicles contribute to the robust rhythmic circadian gene expression in telogen. (aging-us.com)
Inherited alopecia is correlated with a number of abnormalities including hormonal factors, alterations of gene transcription factors, impaired morphogenesis of hair follicles, and other cell signaling pathways (Tomann et al. (progress-eng.co)

In some species (e.g., bovine), evidence indicates that decreases in IGFBP-4 and -5 levels in estrogen-dominant preovulatory follicles are likely due, in part, to increased protease activity, whereas lower levels of IGFBP-2 are not due to increased proteolysis. (bioone.org)

We illustrate where such mechanisms of pattern formation arise in biological systems from cellular to tissue scales, with an emphasis on morphogenesis. (mpi-cbg.de)

The papilla is a large structure at the base of the hair follicle. (radonbiathlo673.cfd)

Recent studies showed that treatment of hair follicles by agonistic modulators induced entry into catagen with an anti-inflammatory mechanism 20 . (nature.com)
anagen is the active growth phase, catagen is the regression of the hair follicle phase, telogen is the resting stage, exogen is the active shedding of hair phase and kenogen is the phase between the empty hair follicle and the growth of new hair. (radonbiathlo673.cfd)

[7] [8] Activin, inhibin and a number of other structurally related proteins such as anti-Müllerian hormone , bone morphogenetic protein , and growth differentiation factor belong to the TGF-β protein superfamily . (wikidoc.org)

Aging is associated with a decline in the number of ovarian follicles, menstrual irregularities, ovarian hormonal deficiency, anovulation, decreased fertility, and, finally, a complete and irreversible cessation of menses known as menopause, usually occurring at a mean age of 51 years. (medscape.com)

This stage is followed by telogen during which the hair follicle remains in relative quiescence. (aging-us.com)
The clock genes that we identified as upregulated in telogen/early anagen were all CLOCK/BMAL1 target genes, including Pers, Dbp and Rev-Erbα. (aging-us.com)
While these genes show a clear circadian pattern of expression in skin, as was previously demonstrated [ 9 - 11 ], their amplitude was higher during telogen and early anagen (Figure 1 ), indicating that in skin, the expression of clock controlled genes is dependent both on circadian mechanism and the hair growth cycle. (aging-us.com)

In their study, they identified a cell signaling pathway that controls this differentiation process and the induction of hair follicles. (scitechdaily.com)
With the exception of EDA1 and NEMO , both localized on the X chromosome, all other genes encoding components of the TNFα-related signaling pathway involved in differentiation of skin appendages, are localized on the autosomes (Table 1 ). (springer.com)
The purpose of this report is to review current literature on the structure and function of components of the TNFα-related signaling pathway, to present a novel approach to their contribution in the differentiation of skin appendages and to discuss the role of mutations of genes encoding components of this pathway in the origin of HED. (springer.com)
The signaling via the TNFα-related pathway, which is critical for differentiation of skin appendages, has been elucidated mainly due to the investigations performed in mice (Mikkola 2009 ). (springer.com)
Comparative full transcriptome profile analysis of the hair bulb region of normal and miniaturized hair follicles from vertex and occipital region in males with and without androgenetic alopecia revealed that next to the androgen receptor as well the retinoid receptor and particularly the PPAR pathway is involved in progressive hair miniaturization. (nature.com)

ESP is the earliest known protein to be recognized as a marker for the specification of the equatorial segment, and it allows this region to be traced through all phases of acrosomal biogenesis. (bioone.org)

The hair follicles you have as an adult are the ones you were born with, and hair follicles that are lost by injury or inflammation generally cannot be recovered," she said. (scitechdaily.com)

Occult primary ovarian insufficiency presents as unexplained infertility in a patient with a normal basal serum follicle-stimulating hormone (FSH) level. (medscape.com)

24,25 Current well-established treatment modalities focus on reducing the androgenic effects on hair follicles (5a-reductase inhibitors), stimulating hair growth (minoxidil), or transferring androgen-independent hair to the affected scalp (hair transplantation). (jcadonline.com)
In our recent study we found that circadian clock genes play a role in regulation of the hair growth cycle during synchronized hair follicle cycling, uncovering an unexpected connection between these two timing systems within skin. (aging-us.com)
In mice, the two initial hair growth cycles are synchronized such that the majority of hair follicles are in a similar stage of the hair growth cycle at a given time. (aging-us.com)
In order to systematically discover transcriptional activity associated with the hair growth cycle, we profiled mRNA expression at a genome-wide level over multiple time points corresponding to morphogenesis and two synchronized hair growth cycles. (aging-us.com)
The growing body of evidence now supports that a wide range of neuropeptides, neurotransmitters, and neurohormones modulating systemic stress responses can indeed alter hair growth, indicating that hair follicles represent an important target for stressors [ 8 ]. (biomedcentral.com)
Dynamic Ppargc1a expression in the mouse hair cycle suggests a possible role in regulating hair growth and differentiation. (nature.com)
Well known diseases of the hair follicle include alopecia [2] or hair loss, hirsutism or excess hair growth and lupus erythematosus . (radonbiathlo673.cfd)

BMP4 secretion helps cause differentiation of the ureteric bud into the ureter. (wikipedia.org)

It is therefore important to understand how our genes sculpt these organs into a specific form (morphogenesis) and with an appropriate size (growth). (igred.fr)

Light microscopic immunofluorescent observations revealed that during acrosome biogenesis ESP first appears in the nascent acrosomal vesicle in early round spermatids and subsequently segregates to the periphery of the expanding acrosomal vesicle, thereby defining a peripheral equatorial segment compartment within flattened acrosomal vesicles and in the acrosomes of early and late cap phase, elongating, and mature spermatids. (bioone.org)

The BMP4 signaling has been found in formation of early mesoderm and germ cells. (wikipedia.org)
To demonstrate the use of the MPS for future studies on the (patho-)biology of bone, we built a simplified 3D model for early de novo bone formation. (bvsalud.org)
In consequence, the process of initiation, formation, and differentiation of skin appendages is disturbed. (springer.com)
In the ovarian cycle, repeated patterns of specific cellular proliferation, differentiation, and transformation occur that accompany the formation and regression of the corpus luteum. (encyclopedia.pub)

The study of mechanisms controlling growth and morphogenesis is based on dynamic multi-scale biological processes (molecular, cellular and tissular) and requires approaches involving developmental biology, genetics, cell biology and biophysics. (igred.fr)

Pluripotent neurotrophic factor that plays a role in neuronal differentiation and survival. (plurisomes.com)

showed that knocking out Mage-D1 can induce the expression of autophagy-related genes by enhancing the activity and differentiation of osteoclasts, thereby accelerating the process of periodontitis 23 . (researchsquare.com)
We conrmed this association at 3 3 CGI linked genes, in the course of random differentiation, methylation and expression the two increased in any respect 3 CGIs. (pkainhibitors.com)
With the three genes with greater pro moter CGI methylation following differentiation, only RBM38 also has a three CGI. (pkainhibitors.com)
Just about every of the three chosen genes with 3 CGI methylation right after differentiation also includes a promoter CGI. (pkainhibitors.com)

Jacques Loeb broadened and corrected his earlier claims concerning artificial parthenogenesis in sea urchins in a series of experiments in 1900. (asu.edu)

To test the hypothesis that differentiation related methylation alterations at these areas affect CTCF binding, we exploited published genome scale DNA methylation and CTCF ChIP information sets. (pkainhibitors.com)

Moreover, FTIR spectroscopy resulted in a non-invasive, rapid and precise technic that together with principal component analysis allows to characterize chemical and structurally both kind of cells and also discriminate and determine different stages along the cell differentiation process. (biomedcentral.com)
These cells, surrounding the hair follicles, secrete signaling molecules that control the progression of the hair cycle. (jcadonline.com)
DHH/PTC1 signaling triggers differentiation of Leydig cells by up-regulating Steroidogenic Factor 1 and expression of cytochrome P450 Side-Chain Cleavage enzyme located outside testicular cord [ 145 ]. (regenmedres-journal.org)
Study of PCNA expression revealed that application of transfected cells terminate proliferative processes in regenerating wound earlier then application of untransfected cells. (genescells.ru)

The superfamily includes large families of growth and differentiation factors. (wikipedia.org)
Hair follicles undergo continuous cycles of growth, involution and rest. (aging-us.com)
There are many human diseases in which abnormalities in hair appearance, texture or growth are early signs of local disease of the hair follicle or systemic illness. (radonbiathlo673.cfd)

Male patterned hair loss, or androgenetic alopecia (AGA) is the most common form of hair loss, prominent in males and characterized by progressive miniaturization of hair follicles 1 . (nature.com)

Pregnancy: Based on animal data, spironolactone tablets may affect sex differentiation of the male during embryogenesis ( 8.1 ). (nih.gov)

Based on epidemiological studies and laboratory animals, ED hypothetically affect reproduction, thyroid function and brain differentiation. (ivis.org)

We show the up-regulation of PGC1a in the inner and outer root sheath (IRS/ORS) of hair follicles from AGA patients and the dynamic expression in the mouse hair cycle. (nature.com)

Anatomy63

Organisms18

Diseases2

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes58

Disciplines and Occupations2

Information Science3

Ovarian follicle3

Regulates3

Endothelial cells2

Ectoderm5

Primordial follicle1

Epithelial5

Proliferation and differentiation3

Induces2

Epithelium6

Apoptosis1

Embryonic development3

Anagen phase2

Keratinocytes1

Progenitor2

Dermal2

Neural differentiation2

Embryos2

Stem cells11

Antral2

Ovary2

Regulator1

Ovulation3

Stimulates1

Development11

Promotes2

Hematopoietic1

Gene3

Bovine1

Tissue1

Papilla1

Catagen2

Proteins1

Menstrual1

Telogen3

Pathway5

Protein1

Adult1

Basal1

Hair Growth7

Secretion1

Organs1

Peripheral1

Formation4

Molecular1

Pluripotent1

Genes4

Experiments1

Alterations1

Cells4

Growth3

Alopecia1

Embryogenesis1

Thyroid1

Regulation1