Differentiation early embryo morphogenesis. Medical search. Frequent questions

During embryo development, naïve cell lineages undergo concurrent processes of fate specification and morphogenesis as critical steps towards the generation of differentiated tissues and organs. (elifesciences.org)
These early progenitor cells often travel long distances from their induction site to the site of terminal differentiation, making them vulnerable to environmental cues and movement of neighbouring tissues. (elifesciences.org)
Transcriptome profiling of the early stages in Atlantic cod revealed the presence of transcripts involved in patterning and development of tissues and organs long before activation of the zygotic genome. (biomedcentral.com)
Embryo-like models with spatially organized morphogenesis and structure of all defining embryonic and extra-embryonic tissues of the post-implantation human conceptus (that is, the embryonic disc, the bilaminar disc, the yolk sac, the chorionic sac and the surrounding trophoblast layer) remain lacking 1 , 2 . (nature.com)
Much of this process relies on the morphogenesis of the extra-embryonic tissues and the effect this has on the organization of embryonic cells. (nature.com)
As a consequence, cell fate acquisition and subsequent differentiation of endosperm tissues are affected to varying degrees of severity. (silverchair.com)
Morphogenesis: Morphogenesis refers to the processes by which cells and tissues arrange themselves spatially to give rise to the three-dimensional structure of an organism. (microbiologynote.com)
Her laboratory specializes in using engineered tissues and computational models to understand how mechanical forces direct developmental patterning events during tissue morphogenesis and during disease progression. (royalsociety.org)
Ref: Self-organization of the human embryo in the absence of maternal tissues. (futuristech.info)
Here, we establish an in vitro system to culture human embryos through implantation stages in the absence of maternal tissues and reveal the key events of early human morphogenesis. (futuristech.info)
At this time, a coordinated program of lineage diversification, cell-fate specification, and morphogenetic movements establishes the generation of extra-embryonic tissues and the embryo proper, and determines the conditions for successful pregnancy and gastrulation. (futuristech.info)
Our work with pollywog ( pwg ) maternal-effect mutants highlights the delicate control of the YSL during yolk morphogenesis, and provides novel insight into understanding which tissues of the embryo are affected by loss of a cohesive YSL. (rice.edu)
However, the mice were grossly normal when dab2 deletion was restricted to the embryo proper and the gene was retained in extraembryonic tissues using Meox2-Cre and Sox2-Cre. (biomedcentral.com)
Serotonergic neurotransmission modulates cell proliferation in several tissues, but is involved mainly in the morphogenesis of the craniofacial region 8 . (bvsalud.org)

Such human fully integrated and complete SEMs recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos, including the epiblast, the hypoblast, the extra-embryonic mesoderm and the trophoblast layer surrounding the latter compartments. (nature.com)
Expression analysis of several Hox genes in human embryos. (cnr.it)
Bioethicists from Case Western Reserve University School of Medicine and The Hastings Center, working with a research administrator at The Rockefeller University, are proposing a reexamination of an internationally recognized rule limiting in vitro research on human embryos to 14 days post-fertilization. (futuristech.info)
Using human embryos and human pluripotent stem cells, we show that the reorganization of the embryonic lineage is mediated by cellular polarization leading to cavity formation. (futuristech.info)
Together, our results indicate that the critical remodelling events at this stage of human development are embryo-autonomous, highlighting the remarkable and unanticipated self-organizing properties of human embryos. (futuristech.info)
We unveil the self-organizing abilities and autonomy of in vitro attached human embryos. (futuristech.info)

Within these papers he illustrated the importance of using certain techniques such as interposing Millipore filter paper between the epithelium and mesenchyme layers of developing mouse embryos to show that even in the absence of cell-to-cell contact, organogenesis could still occur via transduction of morphogenetic signaling molecules through the filter paper. (asu.edu)
In the cochlea of mouse embryos, it is highly expressed in prosensory cells and down-regulated at the onset of hair cell differentiation. (encyclopedia.pub)

Her main work with bicaudal allowed her to publish a paper in 1977, "Genetic analysis of pattern-formation in the embryo of Drosophila melanogaster. (wepapers.com)
The dissertation topic focused on genetic patterns in Drosophila embryos and the various mutations that can occur throughout development (Resnik 2012). (wepapers.com)
The remainder of the article explains the morphogenesis of the species Drosophila melanogaster (the fruit fly ). (infomutt.com)
Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene. (cnr.it)
Thus, we examined epithelial polarity establishment during early Drosophila development. (rupress.org)
In the Drosophila embryo, apical constriction in a strip of epithelial cells along the ventral midline results in the folding of the tissue and the internalization of ventral cells, forming a ventral furrow (VF). (nature.com)

microRNAs (miRNAs) have emerged as regulators of a broad spectrum of neurodevelopmental processes, including brain morphogenesis, neuronal differentiation, and survival. (oregonstate.edu)
We have previously utilised an NT2.D1 neurosphere based model of neuronal differentiation to study the effects of a variety of compounds on neural development [7] . (plos.org)
The chapter points out the difference between human brains and those of other primates, in terms of elements such as the retention of the fetal neuronal growth rate during early childhood, the altered transcriptional activity of certain genes, and the presence of human-specific alleles of developmental regulatory genes. (oxfordsciencetrove.com)
Different processes, from proliferation and neuronal versus glial fate determination to differentiation and myelination all are modulated by thyroid hormone. (sciencesconf.org)

At the early stages of embryonic development, the vertebrate face has a common plan. (medscape.com)
In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)
Here, we examine this question during the early stages of morphogenesis of the embryonic laterality organ, the first organ to form during vertebrate development, using the zebrafish as a model organism. (elifesciences.org)
Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp). (cnr.it)
The chapter analyzes the Danio rerio, the zebrafish, which has a vertebrate model system that develops externally as a transparent embryo and completes embryogenesis in one day. (oxfordsciencetrove.com)
Puelles andIntroduction Rubenstein, 1993), and neither the identity nor the source of inductive signals that trigger the differentiation of ventralIn vertebrate embryos, the patterning of the nervous sys- forebrain neurons has been established. (fliphtml5.com)
This experiment has been the foundation of today's advanced molecular and cellular level understanding of how patterning and organization of the vertebrate embryo is accomplished. (elsevier.com)

Induction of pancreatic endocrine cells from pluripotent stem cells including iPSCs in vitro offers promise as a solution, but continues to face problems including high reagent costs and cumbersome differentiation procedures. (bvsalud.org)
The developing embryo, from which pluripotent stem cells originate, undergoes a series of dynamic metabolic transitions synchronized to its molecular development. (conditionmed.org)

This chapter focuses on reptiles and birds which undergo discoidal meroblastic cleavage, wherein the early cell divisions do not cut through the yolk of the egg but form a blastoderm. (oxfordsciencetrove.com)
These include segregation of the pluripotent embryonic and extra-embryonic lineages, and morphogenetic rearrangements leading to generation of a bilaminar disc, formation of a pro-amniotic cavity within the embryonic lineage, appearance of the prospective yolk sac, and trophoblast differentiation. (futuristech.info)
Embryos display key landmarks of normal development, including epiblast expansion, lineage segregation, bi-laminar disc formation, amniotic and yolk sac cavitation, and trophoblast diversification. (futuristech.info)
In teleosts, the Yolk Syncytial Layer (YSL) is functionally similar to the anterior visceral endoderm found in mice and is required for morphogenesis of the overlying blastoderm. (rice.edu)
In embryos lacking maternal Map3k4, the YSL undergoes a rapid and catastrophic retraction and the YSN lose their normal distribution around the yolk. (rice.edu)
The prechordal plate of pwg mutant embryos deflect laterally or plunge into the yolk, and the overall animalward extension of the prechordal plate is diminished. (rice.edu)
These data show that the p38 MAPK pathway is essential for maintaining normal yolk cell equilibrium during early development and that without proper cues from the YSL, the blastoderm cannot complete its morphogenetic movements. (rice.edu)
The inert yolk or vitellin furnishes nourishment for the developing embryo. (biologydiscussion.com)
In some lower animals the amount of yolk is less in egg, so that the embryo hatches in earlier stages of development, called a larva. (biologydiscussion.com)

When nonhuman mammalian development is compared with human development, the study subjects must be compared at the same developmental stage (fetal, perinatal, postnatal) When collected appropriately, data from experimental studies of nonhuman mammalian embryos elucidate important aspects of human facial development. (medscape.com)
Here, we reveal essential roles for PQBP1 and a binding partner, WBP11 , in early development of Xenopus embryos. (xenbase.org)
Tissue development is a key process for life starting from the earliest embryonic stages during which cells differentiate into later organs composing an entire body. (exeter.ac.uk)
Throughout this paper I will detail the early career of Dr. Nusslein-Volhard and the ways in which her research helped to revolutionize the field of developmental biology as it pertains to embryonic development and gene analysis/function. (wepapers.com)
The endomesoderm gene regulatory network (GRN) models the transcriptional control system defining vegetal specification of the sea urchin( Strongylocentrotus purpuratus ) embryo during the first 30 hours of development. (biologists.com)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
We report a study of early Atlantic cod development that used a genome-wide oligonucleotide microarray to examine the composition and putative roles of polyadenylated transcripts. (biomedcentral.com)
Today, it is generally thought that the combination of determinants deposited by the mother during oogenesis and the inductive signals between different cells trigger the specification of different cell lineages during development of the embryo [ 7 , 8 ]. (biomedcentral.com)
Morphogenesis (from the Greek morph shape and genesis creation) describes the process of cellular differentiation , distribution and growth that takes place during the embryonic development of an organism , which gives rise to tissuess , organss and anatomy . (infomutt.com)
In 1995 , the Nobel Prize for Physiology and Medicine was awarded for studies concerning the genetic control of early embryonic development to Christiane N sslein-Volhard , Edward B. Lewis and Eric Wieschaus. (infomutt.com)
Their researches identified genetic screens and exemplified the role played in early embryological development by Hox genes . (infomutt.com)
The term morphogenesis can also be used to describe the development of unicellular life forms that do not have an embryonic stage in their life cycle, or to refer to the evolution of a body structure within a taxonomic group . (infomutt.com)
Consistent with a role for miRNAs in neurobehavioral development, target prediction analyses identified multiple miRNAs misexpressed in the ethanol-exposed cohorts that were also predicted to target inversely expressed transcripts known to influence brain morphogenesis. (oregonstate.edu)
This SEM platform will probably enable the experimental investigation of previously inaccessible windows of human early post implantation up to peri-gastrulation development. (nature.com)
Implantation of the human embryo leads to a number of changes in organization that are essential for gastrulation and future development 1 . (nature.com)
Recording and contextualizing the science of embryos, development, and reproduction. (asu.edu)
Human embryonic stem cells (hESc) can also be used to analyze the in vitro development from undifferentiated pluripotent cells leading to terminally differentiated cell types, recapitulating the process of early embryonic development [5] . (plos.org)
Pattern formation in the embryo is severely impaired with development arresting at premature stages, while in the endosperm, the effects of the glo1-1 mutation are manifest at the free-nuclear or syncytial stage. (silverchair.com)
Embryogenesis: Embryogenesis is the early stage of development that occurs after fertilization. (microbiologynote.com)
By investigating factors that influence placental development and function, FNPS aims to improve our understanding of these conditions and develop strategies for early detection and intervention. (fnps-society.org)
Understanding these early stages of development is crucial not only for unraveling the mysteries of life's origins but also for providing insights into potential causes of developmental disorders. (fnps-society.org)
Here, we consider the metabolism of the early embryo through development, and look at the nutrient milieu within the developing stem cell niche. (conditionmed.org)
The development of new tools and culture techniques has also enabled the factors that influence branching morphogenesis in the embryonic and pubertal gland to be identified. (biologists.com)
After birth, mammary development is arrested until puberty, when extensive elongation of the ducts, accompanied by secondary branching, takes place, thus providing a readily accessible system in which to study branching morphogenesis. (biologists.com)
The hallmarks of development during pregnancy are the formation of tertiary branches, which terminate in alveolar buds, and the rapid proliferation of the luminal epithelium accompanied by differentiation and commitment to the secretory alveolar lineage. (biologists.com)
Our own data show that EDCs mixtures present in human amniotic fluid interfere with thyroid hormone signalling and brain development in Xenopus embryos [3]. (sciencesconf.org)
A new technique that allows embryos to develop in vitro beyond the implantation stage (when the embryo would normally implant into the womb) has been developed by scientists at the University of Cambridge allowing them to analyse for the first time key stages of human embryo development up to 13 days after fertilisation. (futuristech.info)
Here we report the use of a novel in vitro system to study the post-implantation development of the human embryo. (futuristech.info)
Our findings highlight the species-specificity of these developmental events and provide a new understanding of early human embryonic development beyond the blastocyst stage. (futuristech.info)
The YSL undergoes dramatic reorganization during early development through processes that mirror the morphogenetic movements of the blastoderm. (rice.edu)
In addition to its role in the formation of epithelium and vasculature, type IV collagen appears to be key for alveolar myofibroblast development by inducing their proliferation, differentiation and migration throughout the developing septum. (biomedcentral.com)
Embryogenesis or embryogeny may be defined as the formation and development of embryos. (biologydiscussion.com)
Their embryos continue development until they attain a form resembling the adult. (biologydiscussion.com)
Recently, we have focused on the role of Shh/Gli3 and 5'Hoxd genes in regulating several aspects of limb development, including early digit patterning, as well as condensation and differentiation of cartilage precursors during final morphogenesis of the limb skeleton. (nih.gov)
Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)
We identified a mouse mutant that causes embryonic gonadal sex reversal: the development of ovaries in an XY embryo. (plos.org)
The study of the new dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. (biomedcentral.com)

Do miRNAs contribute to specify the germ-band type and the body structure in the insect embryo? (biomedcentral.com)

Role of Orthopedia (Otp) in proliferation, migration and differentiation of the murine neuroendocrine hypothalamus. (cnr.it)
In neonatal murine cochlear organoids and explants, Lin28B antagonizes the activity of let7 miRNA and increases Akt-mTORC1 signaling to promote hair cell regeneration from immature supporting cells by inducing their de-differentiation and proliferation as well as by directly converting them into hair cells [ 3 ] . (encyclopedia.pub)
We also show that Col4a1 and Col4a2 mutants displayed disrupted myofibroblast proliferation, differentiation and migration. (biomedcentral.com)
The formation of the mammalian respiratory unit is initiated during the transition between the pseudoglandular and canalicular/saccular stages and is characterized by coordinated proliferation and differentiation of epithelial and mesenchymal cells. (biomedcentral.com)
Extensive renovation of the epithelium, cell proliferation, apoptosis and changes in the shape and positioning of cell groups are determined by morphogenetic gradients that play critical roles during the morphogenesis of teeth 13 . (bvsalud.org)

During preimplantation stages, differentiation occurs between precursors of embryonic and extraembryonic structures. (medscape.com)

There he continued his research on tissue morphogenesis and appendage differentiation in fish. (asu.edu)
Dr Nelson's contributions to the fields of tissue mechanics and morphogenesis have been recognized by a number of awards, including a Burroughs Wellcome Fund Career Award at the Scientific Interface (2007), a Packard Fellowship (2008), a Sloan Fellowship (2010), the MIT TR35 (2010), the Allan P. Colburn Award (2011), a Dreyfus Teacher-Scholar Award (2012), and a Faculty Scholars Award from the Howard Hughes Medical Institute (2016). (royalsociety.org)
How epithelial cells actively respond to mechanical constraints by adjusting how they generate force is important to understand tissue morphogenesis. (nature.com)

At the molecular level, knockdown of PQBP1 in Xenopus animal cap explants inhibits target gene induction by FGF but not by BMP, Nodal or Wnt ligands, and knockdown of either PQBP1 or WBP11 in embryos inhibits expression of fgf4 and FGF4 -responsive cdx4 genes. (xenbase.org)
We characterized Xenopus laevis C-C motif chemokine ligand 19.L (ccl19.L) and C-C motif chemokine ligand 21.L (ccl21.L) during early Xenopus embryogenesis. (bvsalud.org)
The collective findings indicate that ccl19.L and ccl21.L might play important roles in morphogenesis and dorsal-ventral patterning during early embryogenesis in Xenopus. (bvsalud.org)

Both genes are expressed in the nascent mesoderm and neurectoderm , and morpholino knockdown of either causes defects in differentiation and morphogenesis of the mesoderm and neural plate . (xenbase.org)
Differentiation is controlled by specific regulatory genes and signaling pathways. (microbiologynote.com)
To directly test this model of Shh function, we have restored cell survival in Shh mutant embryos after transient Shh expression by concomitant removal of the pro-apoptotic genes Bak/Bax to intercept cell death, in order to rescue the proposed late Shh role. (nih.gov)

The open-access paper in eLife details the activities of two signaling pathways, Nodal and BMP4, in experimental models of early mammalian embryos. (medicallyprime.com)

Here we show that transient disruption of brain morphogenesis by ethanol exposure results in behavioral hyperactivity in larval zebrafish challenged with changes in lighting conditions. (oregonstate.edu)
We characterize the activation kinetics of these reagents in vitro and demonstrate their efficacy in zebrafish embryos that express NfsB either ubiquitously or in defined cell populations. (cdc.gov)

Despite the importance of the developmental pathways followed by these small groups of progenitor cells and their impact on the physiology of the organism, we still know little about the set of developmental strategies that progenitor cells deploy in vivo to overcome the challenges imposed by the environment as they travel to the site of terminal differentiation. (elifesciences.org)
It notes the link between gene expression and cell differentiation by addressing how referencing extracellular signals having have a key role in differentiation, as they by triggering intracellular signalling pathways that impact gene expression. (oxfordsciencetrove.com)
These factors operate in signaling pathways that are used extensively in a number of processes in both the embryo and adult. (nih.gov)
Both pathways are integral to the process known as gastrulation, when the body plan of the embryo is created. (medicallyprime.com)

Our research focuses on characterising the stem and progenitor cells that build the hypothalamus and characterising the molecular networks that direct hypothalamic morphogenesis, growth and differentiation. (sheffield.ac.uk)
Fu T, Towers M & Placzek M (2017) Fgf10(+) progenitors give rise to the chick hypothalamus by rostral and caudal growth and differentiation. . (sheffield.ac.uk)
It involves a series of cell divisions, growth, and differentiation, leading to the formation of a multicellular embryo. (microbiologynote.com)
UBM is useful to investigate the growth and differentiation of tumors as well as to detect early molecular expression of cancer-related biomarkers in vivo and to monitor the effects of cancer therapies. (hindawi.com)

Early ontogeny is associated with dramatic gene expression changes that underlie and determine the developmental processes. (biomedcentral.com)
Identifying the direct target promoters of developmental gene-regulators will be critical to understand how these regulators function and to link regulatory cascades in developmental genetic programs to the basic cellular processes that drive morphogenesis of anatomic structures. (nih.gov)

Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)

The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. (elifesciences.org)
The foxa gene is an integral component of the endoderm specification subcircuit of the endomesoderm gene regulatory network in the Strongylocentrotus purpuratus embryo. (biologists.com)
Dissection of Otx2 roles during gastrulation: requirement of Otx2 in the visceral endoderm for specification of anterior identity, and in the early neuroectoderm for maintenance of the anterior identity (forebrain and midbrain). (cnr.it)
The constitutive dab2 deleted embryos showed a spectrum in the degree of endoderm disorganization in E5.5 and no mutant embryos persisted at E9.5. (biomedcentral.com)

His early adulthood passion of linking classical embryology with developmental anatomy and medicine was joined by his later pursuit of combining research ethics and science education with public policy. (asu.edu)

Members of this family have numerous roles, including regulation of cell adhesion, cell differentiation, directed cell motility, intracellular signaling and stabilization of f-actin at the sarcomeric Z-line in muscle. (rice.edu)
Our study showed that type IV collagen and, therefore the basement membrane, play fundamental roles in coordinating alveolar morphogenesis. (biomedcentral.com)
Sonic hedgehog (Shh) signaling plays key roles in stem cell maintenance, developmental morphogenesis, and cancer pathogenesis. (nih.gov)
These results suggested dual Shh roles that can be uncoupled: a transient role in directing cell fate and morphogenesis, and a sustained role in promoting growth. (nih.gov)

In contrast, short germ-band species start gastrulation with just a few segments, and then progressively add new ones from an undifferentiated growth zone situated at the posterior end of the embryo [ 1 ]. (biomedcentral.com)
It is therefore likely that miRNAs influence the mechanisms that specify the germ-band type and body structure, which is related to the metamorphosis mode, in insect embryos. (biomedcentral.com)
Only gradually did these "globules" organise into rudiments (germ layers) which, in turn, took on the characteristics of the various organs of the embryo. (biologydiscussion.com)

I also show that the anterior neural plate of pwg mutant embryos fail to converge dorsally to the same extent as in wild embryos. (rice.edu)
This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)

2019). Akin to the dynamic nutrient requirements of the developing embryo, discrete in vitro cell states have distinct metabolic profiles (Zhou et al. (conditionmed.org)
Ref: Self-organization of the in vitro attached human embryo. (futuristech.info)

The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. (elifesciences.org)

The morphogenes (proteins that control morphogenesis) that determine the fate of cells are proteins that interact with DNA . (infomutt.com)

E) Expression of pqbp1 and ncam mRNA in the neural plate of early neurula embryos. (xenbase.org)
Furthermore, exposure of neural plate explants tomatch those of the ventral neurons generated in these SHH leads to the differentiation of motor neurons in addi-two subdivisions of the forebrain in vivo. (fliphtml5.com)

Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)
Bonner's studies of cellular slime molds have shed light on some of the big questions of biology including the origins of multicellularity and the nature of morphogenesis. (asu.edu)

Mouse naive embryonic stem cells have recently been shown to give rise to embryonic and extra-embryonic stem cells capable of self-assembling into post-gastrulation structured stem-cell-based embryo models with spatially organized morphogenesis (called SEMs) 3 . (nature.com)

The consistent ultrasound image obtained with the UBM can be used to visualize and guide injection into target organs [ 9 , 10 ], including mouse embryo, to aid in targeted delivery of drugs and viral particles [ 7 , 11 ]. (hindawi.com)

In the mouse, a transporting epithelium is established around the 8-16-cell stage through a process known as compaction where cell definition is lost and the outer cells of the embryo form tight junctions, giving rise to the blastocyst. (conditionmed.org)
For example, purely physical mechanisms can account for branching morphogenesis of the embryonic mouse airway epithelium, when cultured ex vivo in the absence of biochemical patterning 14 . (nature.com)

Transcriptomic analyses provide an efficient approach to explore the temporal gene expression profiles in embryos and to search for the developmental regulators. (biomedcentral.com)
During early neurogenesis, multiple gene expression profiling studies revealed widespread changes in mRNA and miRNA abundance in ethanol-exposed embryos. (oregonstate.edu)
We are analyzing the normal developmental function of early transcription factors that regulate digit patterning (Gli3, 5'Hoxd), with the long-term aim of linking regulatory cascades and patterned gene expression to the morphogenesis of specific structures. (nih.gov)

Although it is possible to culture structures derived from human blastocysts ex vivo, these cultures do not recapitulate the events and structural organization of the in vivo embryos 6 ( Supplementary Information ). (nature.com)

H) Phenotypes of tailbud stage embryos dorsally targeted with control (CT) or the indicated amount of pqbp1 MO1. (xenbase.org)
right panel, embryos injected dorsally with pqbp1 mRNA (2 ng) at the four-cell stage. (xenbase.org)

Knockdown of PQBP1 causes defective embryo morphogenesis. (xenbase.org)
Dorsal overexpression of ccl19.L and ccl21.L and knockdown of Ccl19.L and Ccl21.L inhibited gastrulation, but their functions were different in cell behaviors during morphogenesis. (bvsalud.org)

We describe the isolation and characterisation of a mutation that induces aberrant globular embryo and endosperm morphology, globby1-1 ( glo1-1 ). (silverchair.com)

In the embryo, the signals that induce the formation of mammary placodes from the skin are beginning to be elucidated. (biologists.com)

Recent data show that maternal levels of thyroid hormone during early pregnancy is associated with offspring's IQ and brain structure [1]. (sciencesconf.org)

Early stages are controlled by gametic transcripts, which are subsequently substituted with transcripts from the genome of the zygote. (biomedcentral.com)
5%) at each stage showing transcripts that are downregulated or upregulated early (NF9-10) or late (NF10.5-12). (xenbase.org)

These data concur that provides both early and past due features in the developing pancreas and is vital for maintenance of appearance and correct GSK1838705A pancreatic duct morphology32. (immune-source.com)
During pancreatic endocrine advancement serves early to determine endocrine cell destiny while directs endocrine cell differentiation34. (immune-source.com)
are laminin-like diffusible chemotactic protein involved with pancreatic morphogenesis and are likely involved in the legislation of duct-cell and foetal GSK1838705A islet cell migration. (immune-source.com)
These observations claim that is important in pancreatic morphogenesis both prenatally and in the regenerating adult rat pancreas. (immune-source.com)
In a previous study, we developed a low-cost, simplified differentiation method, but its efficiency for inducing pancreatic endocrine cells was not sufficient: induction of endocrine cells is non-uniform, resulting in colonies containing relatively high ratio of non-pancreatic-related cells. (bvsalud.org)

The scope of the conference ranges from embryonic induction and the gastrula organizer itself to its signaling systems, cell behavior during gastrulation, morphogenesis and pattern formation. (elsevier.com)

and (3) evidence of developmental dynamism relating to ability to progress, in a structurally organized manner, through morphologically characterized developmental milestones of the early post-implantation human embryo following initial aggregate formation 3 . (nature.com)

b) The bicoid mRNA is expressed as bicoid protein , resulting in a protein gradient with the highest concentration of protein on the left side of the embryo. (infomutt.com)
With COVID-19 infections rising, people have eagerly scheduled appointments for the updated mRNA COVID-19 vaccines approved earlier this month, but many have faced issues getting. (medicallyprime.com)

The is normally portrayed in early pancreatogenesis in every endodermally produced cells but isn't discovered in differentiated endocrine cells at late-gestation29. (immune-source.com)
null mice embryos demonstrated impaired endocrine differentiation and perturbed duct morphogenesis during embryogenesis30. (immune-source.com)
Furthermore to GSK1838705A flaws in endocrine advancement null embryos demonstrated flaws in duct advancement31. (immune-source.com)
cell function or blood sugar homeostasis suggesting that's dispensable for afterwards occasions of endocrine differentiation. (immune-source.com)

Grobstein's graduate studies at UCLA helped to broaden the scope of biology as it probed the relatively new field of morphogenesis and inductive cell interactions. (asu.edu)

Role of Otx2 in Embryonic Stem Cells (ESCs): Otx2 is an intrinsic determinant required to maintain the ESC metastable state by antagonizing ground state pluripotency and promoting commitment to differentiation. (cnr.it)
To establish protocols for the safe and efficient differentiation of healthy cells for therapies, we must develop a better understanding of the dynamic continuum of metabolic states that span pluripotency and differentiation, and how to influence them. (conditionmed.org)

Our data describes an early and novel role for Map3k4, p38a and Mxtxl activity that is required for proper morphogenesis of the YSL and the blastoderm. (rice.edu)

Such theories of preformation persisted well in the eighteenth century by which time (in 1759) the German investigator Caspar Friedrich Wolff (1733-1794) offered experimental evidence that no preformed embryo existed in the egg of the chicken. (biologydiscussion.com)
The Rice lab employs a unique experimental system mimicking growth in confined spaces that allows human embryonic stem cells to divide and differentiate, but in a controlled shape similar to that of the embryo. (medicallyprime.com)

The last two decades have witnessed major insights into the molecular controls determining thyroid hormone availability and action in the brain, notably the requirement for thyroid hormone from the earliest stages of neurogenesis, the first trimester of pregnancy in humans. (sciencesconf.org)
We find human-specific molecular signatures of early cell lineage, timing, and architecture. (futuristech.info)

Thus, Lin28B functions in hair cell regeneration through mitotic and non-mitotic mechanisms, which are dependent on mitotic division or trans-differentiation of supporting cells into hair cells, respectively. (encyclopedia.pub)
The group aims to understand the mechanisms of morphogenesis and cell differentiation within an embryo. (royalsociety.org)
Neuroendocrine mechanisms, particularly those related to 5-HT, are associated with the differentiation and activation of osteoblasts and osteoclasts. (bvsalud.org)

This chapter looks into cell differentiation and stem cells. (oxfordsciencetrove.com)
Finally, our work will also assist in the rational design of differentiation protocols of human embryonic stem cells to specific cell types for disease modelling and cell replacement therapy. (futuristech.info)

Our goal is therefore to understand how the hypothalamus develops in the embryo and how the proper embryonic assembly of the hypothalamus holds the key to robust adult function. (sheffield.ac.uk)

Therefore, the antagonistic actions of Lin28B and let7 miRNA coordinate the timing of prosensory cell cycle withdrawal for hair cell differentiation. (encyclopedia.pub)

Muriel Wheldale Onslow studied flowers in England with genetic and biochemical techniques in the early twentieth century. (asu.edu)

In the developing embryos, the hypothalamus is built with precision. (sheffield.ac.uk)

Anatomy65

Organisms21

Diseases1

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes67

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science5

Tissues14

Human embryos6

Mouse embryos2

Drosophila6

Neuronal4

Vertebrate7

Pluripotent stem2

Yolk9

Development37

Insect embryo1

Proliferation5

Precursors1

Tissue3

Xenopus3

Genes3

Mammalian1

Zebrafish2

Pathways4

Growth and differentiation4

Processes2

Lineages1

Endoderm4

Embryology1

Roles4

Germ3

Mutant2

Vitro2

Progenitor cells1

Fate1

Neural plate2

Cellular2

Embryonic and extra-embryonic1

Organs1

Epithelium2

Gene expression3

Vivo1

Dorsally2

Knockdown2

Induces1

Signals1

Maternal1

Transcripts2

Pancreatic5

Gastrulation1

Post-implantation1

MRNA2

Endocrine4

Inductive1

Pluripotency2

Map3k41

Experimental2

Molecular2

Mechanisms3

Stem Cells2

Adult1

MiRNA1

Genetic1

Hypothalamus1