AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Transcription FactorsTranscription, GeneticCell DifferentiationDNA-Binding ProteinsPromoter Regions, GeneticGene Expression RegulationMolecular Sequence DataBase SequenceSp1 Transcription FactorRNA, MessengerCell LineTrans-ActivatorsGene Expression Regulation, DevelopmentalSignal TransductionBasic Helix-Loop-Helix Transcription FactorsBinding SitesTranscriptional ActivationNuclear ProteinsProtein BindingHomeodomain ProteinsCells, CulturedRepressor ProteinsAmino Acid SequenceTranscription Factor AP-1Forkhead Transcription FactorsMutationDNATransfectionCell NucleusReverse Transcriptase Polymerase Chain ReactionBasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2Kruppel-Like Transcription FactorsGenes, ReporterChromatin ImmunoprecipitationGene ExpressionGene Expression ProfilingSTAT3 Transcription FactorTranscription Factors, TFIIGATA4 Transcription FactorHeLa CellsCell LineageStem CellsNFATC Transcription FactorsYY1 Transcription FactorPaired Box Transcription FactorsMice, KnockoutZinc FingersTranscription Factor TFIIDNF-kappa BCell ProliferationCloning, MolecularRecombinant Fusion ProteinsPhenotypeMice, Inbred C57BLElectrophoretic Mobility Shift AssayMice, TransgenicActivating Transcription Factor 3Enhancer Elements, GeneticModels, BiologicalTranscription Initiation SiteSp3 Transcription FactorGATA3 Transcription FactorTumor Cells, CulturedPlasmidsBlotting, WesternPhosphorylationMEF2 Transcription FactorsGATA1 Transcription FactorRegulatory Sequences, Nucleic AcidOligonucleotide Array Sequence AnalysisCell Line, TumorDown-RegulationActivating Transcription Factor 2E2F1 Transcription FactorGATA2 Transcription FactorProto-Oncogene ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsUp-RegulationIn Situ HybridizationTranscription Factor TFIIBCell DivisionRNA Polymerase IIProtein Structure, TertiaryTCF Transcription FactorsLuciferasesEmbryonic Stem CellsHelix-Loop-Helix MotifsMicrophthalmia-Associated Transcription FactorGATA Transcription FactorsChromatinGene Expression Regulation, FungalSequence Homology, Amino AcidSTAT1 Transcription FactorDrosophila ProteinsGATA6 Transcription FactorE2F Transcription FactorsSOX9 Transcription FactorActivating Transcription FactorsImmunohistochemistry
ApoptosisELISA KitProteinMyogenicTumorPathwaysProgressionRegulateEnhancerCellHomogenatesLungCancerTyrosineRoleDevelopmentFamilyGrowthPhaseTerminal erythroid differentiationSignaling pathwayRegulatesBinds specificallyProteinsGenesE2F1ProliferationLung adenocarcinomaMurineDimerizationRepressionRegulatorySubunitErythroid cellsStem cellsPathogenesisRegulationActivatorRegulatorsHistoneTranscriptionalTransformationCell cycleStateAffectPotentialFactHuman
Apoptosis5
ELISA Kit1
  • Description: A sandwich ELISA kit for detection of Cluster Of Differentiation from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lotuskringpoeldijk.nl)
Protein6
  • Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the E2F family of transcription factors. (wikipedia.org)
  • These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. (wikipedia.org)
  • This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. (wikipedia.org)
  • E2F transcription factor 2 (E2F2) protein is the transcription factor that plays an important role in tumorigenesis. (journalsmededu.pl)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Myogenic4
  • myogenic differentiation 1 [Source:HGNC Sym. (gsea-msigdb.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Myogenic Factor 5 (MYF5) in Tissue homogenates and other biological fluids. (1elisakits.com)
  • Description: Quantitative sandwich ELISA for measuring Human Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
  • Description: Quantitative sandwich ELISA for measuring Mouse Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
Tumor5
  • E2F2 effects the cell cycle, tumor suppressor proteins, and can also be transformed by proteins of small DNA tumor viruses. (journalsmededu.pl)
  • Jin L, Sturgis EM , Zhang Y, Huang Z, Song X, Li C, Wei Q, Li G . Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma. (viictr.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates or other biological fluids. (1elisakits.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in serum, plasma, tissue homogenates and other biological fluids. (1elisakits.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
Pathways4
  • The objective of the study is to provide a summary of the current knowledge on the neoplastic pathways that involve E2F2. (journalsmededu.pl)
  • Numerous studies have demonstrated a role for E2F2 in various signaling pathways. (journalsmededu.pl)
  • Further investigations of E2F2 pathways are warranted for a clearer understanding of neoplastic processes and to identify novel pharmacological treatments. (journalsmededu.pl)
  • Domańska J, Poboży K, Domański P, Fudalej M, Deptała A, Badowska-Kozakiewicz A. The role of E2F2 in signaling pathways associated with cancer pathogenesis and potential treatment: A review of current studies. (journalsmededu.pl)
Progression3
  • E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry. (journalsmededu.pl)
  • Pocket proteins Rb, p107 and p130 play central roles in cell cycle progression and differentiation. (eu.org)
  • Pocket proteins play essential roles in cell cycle progression, quiescence and differentiation, and their functional disruption is associated with human cancer. (eu.org)
Regulate1
  • MicroRNAs are small evolutionarily conserved nucleotide sequences that regulate gene expression after transcription, by mRNA degradation or inhibition of translation. (ccij-online.org)
Enhancer1
Cell8
  • E2F Transcription Factors in Cancer, More than the Cell Cycle. (journalsmededu.pl)
  • The gene, which is called MYBL2 , encodes a transcription factor that helps to control the cell division cycle. (elifesciences.org)
  • The transcriptomes of 1846 single cells were profiled by SmartSeq2 at different timepoints throughout a 54-day differentiation protocol that converted H1 human embryonic stem cells to a variety of brain cell types. (uth.edu)
  • We engineered SOX2Cit/+ and DCXCit/Y hESC lines to target progenitors and neurons throughout neural differentiation for single-cell transcriptomic profiling, then identified discrete cell types consisting of both rostral (cortical) and caudal (mid/hindbrain) identities. (uth.edu)
  • From the single-cell transcriptomic data a Bayesian algorithm generated a unified lineage tree, and predicted novel regulatory transcription factors. (uth.edu)
  • We found that JOA at lower concentration significantly inhibited the proliferation of CML cells expressing mutant BCR-ABL (T315I mutation included) and wild-type BCR-ABL, which was due to that JOA induced the cell differentiation and the cell cycle arrest at G0/G1 phase. (jcancer.org)
  • Mechanistically, the cell differentiation mediated by JOA may be originated from the inhibition of BCR-ABL/c-MYC signaling in CML cells expressing wild-type BCR-ABL and BCR-ABL-T315I. (jcancer.org)
  • BCR-ABL oncogene encodes a BCR-ABL tyrosine kinase (TK), which triggers different downstream targets including c-Myc, STAT5 and CrkL, which participated in the control of cell differentiation, proliferation, migration and other cellular behaviors [ 3 - 5 ]. (jcancer.org)
Homogenates3
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Cluster Of Differentiation (CD163) in samples from serum, plasma, tissue homogenates or other biological fluids. (lotuskringpoeldijk.nl)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Cluster Of Differentiation (CD163) in serum, plasma, tissue homogenates and other biological fluids. (lotuskringpoeldijk.nl)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Cluster Of Differentiation (CD163) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (lotuskringpoeldijk.nl)
Lung1
  • Most importantly, the natural NNMT inhibitor yuanhuadine can reverse epidermal growth factor receptor tyrosine kinase inhibitor resistance in lung cancer cells. (bvsalud.org)
Cancer1
  • E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer. (journalsmededu.pl)
Tyrosine1
  • JOA displayed the activity of inhibiting the BCR-ABL and promoted differentiation of not only imatinib -sensitive but also imatinib -resistant cells with BCR-ABL mutation, which could become a potent lead compound to overcome the imatinib -resistant induced by inhibitors of BCR-ABL tyrosine kinase in CML therapy. (jcancer.org)
Role1
  • Given the predominant role of transcription, we sought to investigate whether transcription timing is rate limiting for de novo methylation and determines the asynchrony of methylation events. (biomedcentral.com)
Development1
  • Cardiac hypertrophy is an important and independent risk factor for the development of cardiac myopathy that may lead to heart failure. (mdpi.com)
Family2
  • NF-κB, a family of transcription factors, mediates immune and inflammatory signaling [ 8 ]. (oncotarget.com)
  • LIG_RB_pABgroove_1 (LxDLFD), LIG_RB_LxCxE_1 (LxCxE) and LIG_RBL1_LxSxE_2 (LxSxE).The LxDLFD motif binds to a deep groove formed between the A and B subdomains and is present in E2F family transcription factors (E2F1-5). (eu.org)
Growth2
  • We also identified differential enrichment of transcription factor binding motifs in CGIs acquiring methylation early or late in oocyte growth. (biomedcentral.com)
  • transforming growth factor beta 2 [Source:H. (gsea-msigdb.org)
Phase1
  • Although more highly transcribed genes acquire methylation earlier, the major transitions in the oocyte transcriptome occur well before the de novo methylation phase, indicating that transcription is generally not rate limiting in conferring permissiveness to DNA methylation. (biomedcentral.com)
Terminal erythroid differentiation8
  • Objective To predict potential regulators of terminal erythroid differentiation by single-cell transcriptome data mining, and then focus on exploring the expression pattern and function of nuclear transcription factors NFYB and NFYC in terminal erythroid differentiation. (magtechjournal.com)
  • cells among different stages of terminal erythroid differentiation in mouse fetal liver were sorted by flow cytometry, NFYB and NFYC expression levels were then detected by RT-qPCR. (magtechjournal.com)
  • In addition, the expression of NFYB and NFYC was inhibited by lentivirus-mediated shRNA interference and the efficiency of terminal erythroid differentiation and enucleation was examined. (magtechjournal.com)
  • Knockdown of Nfyb and Nfyc in mouse fetal liver derived erythroid cells significantly inhibited terminal erythroid differentiation and enucleation ( P ＜0.05). (magtechjournal.com)
  • Conclusions NFYB and NFYC promote the terminal erythroid differentiation. (magtechjournal.com)
  • Nuclear transcription factors NFYB and NFYC promote terminal erythroid differentiation[J]. Basic & Clinical Medicine, 2022, 42(6): 920-926. (magtechjournal.com)
  • 9] An X, Schulz VP, Li J, et al .Global transcriptome analyses of human and murine terminal erythroid differentiation[J].Blood,2014, 123: 3466-3477. (magtechjournal.com)
  • 13. Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. (nih.gov)
Signaling pathway1
  • The WNT signaling pathway is an evolutionarily conserved pathway that regulates many biological processes such as embry- onic development, cell polarity, cell migration, cell fate determi- nation, and cell differentiation [23,24]. (omipalisibinhibitor.com)
Regulates7
  • The Wilms' tumor suppressor gene WT1 encodes a nuclear transcription factor [11,12], which regulates the development of organs, tissues and activates or represses numerous target genes resulting in different biological effects such as growth, differenti- ation, and apoptosis [13,14]. (omipalisibinhibitor.com)
  • During mice fetal testis development, WT1 regulates early sex determi- nation, embryonic testicular cord assembly and maintenance [17,18], peritubular myoid cells, and fetal Leydig cells differentiation [19]. (omipalisibinhibitor.com)
  • Studies have shown that WT1 regulates the polarity and cytoskeleton of mouse podocytes and plays a vital role in podocyte differentiation and survival [20,21]. (omipalisibinhibitor.com)
  • In mice SCs, WT1 indirectly regulates the polarity of SCs through WNT4 [22] while the regulative mechanism of WT1 on the differentiation of bovine SCs is rarely reported. (omipalisibinhibitor.com)
  • 3. Erythroid Kruppel-like factor regulates the G1 cyclin dependent kinase inhibitor p18INK4c. (nih.gov)
  • Here, we show that the zinc finger transcription factor CASZ1 up-regulates MYOD signature genes and induces skeletal muscle differentiation in normal myoblasts and ERMS. (nih.gov)
  • HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
Binds specifically1
  • E2F2 binds specifically to RB1 in a cell-cycle dependent manner. (nih.gov)
Proteins7
  • Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. (nih.gov)
  • The SCs secrete a variety of growth factors and proteins that regulate their maturation and the development of GCs during the differentiation process [3e7]. (omipalisibinhibitor.com)
  • These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. (cancerindex.org)
  • As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (cancerindex.org)
  • E2F2 effects the cell cycle, tumor suppressor proteins, and can also be transformed by proteins of small DNA tumor viruses. (journalsmededu.pl)
  • The vertebrate Myb transcription factors comprise a small family of important regulatory proteins. (123dok.net)
  • HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
Genes4
  • The mixture altered genes associated with pathways such as "genotoxicity" and "nuclear factor erythroid 2-related factor 2 (Nrf2). (nih.gov)
  • One of the genes regulated through this mechanism en-codes the B-Myb transcription factor, which has been shown to be critically required for early embryonal de-velopment in the mouse. (123dok.net)
  • A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. (nih.gov)
  • We've previously shown which has a focus on site in the 3′UTR of DHFR mRNA and a leads to lack of suppressed the manifestation of cell routine control genes E2F2 and Myc via binding to 3′-UTR miRNA reputation elements [23]. (bioinf.org)
E2F11
  • In addition to a constitutively occupied E2F1-Sp1 site immediately upstream of the cyclin E transcription start region, there is downstream a cell cycle-regulated site (termed CERM) that may function as a cyclin E-repressor module. (nih.gov)
Proliferation2
  • E2F Transcription Factor 2 (E2F2) could contribute to cancer development, because it plays a critical role in many cellular processes, including the cell cycle, proliferation, differentiation, DNA damage response, and cell death. (nih.gov)
  • BTG anti-proliferation factor 2 [Sour. (gsea-msigdb.org)
Lung adenocarcinoma1
  • E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry. (journalsmededu.pl)
Murine2
  • 7. Subcellular transport of EKLF and switch-on of murine adult beta maj globin gene transcription. (nih.gov)
  • 14. Chromatin-binding in vivo of the erythroid kruppel-like factor, EKLF, in the murine globin loci. (nih.gov)
Dimerization1
Repression1
Regulatory3
  • 11. EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation. (nih.gov)
  • Embryonal rhabdomyosarcoma (ERMS) is a childhood cancer that expresses myogenic master regulatory factor MYOD but fails to differentiate. (nih.gov)
  • The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+ CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg transcriptional signature. (gsea-msigdb.org)
Subunit1
  • Barrier to autointegration factor 1, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3, and splicing factor 3b subunit 4 as early-stage cancer decision markers and drivers of hepatocellular carcinoma. (namswlab.com)
Erythroid cells2
  • 4] Chaturvedi CP, Hosey AM, Palii C, et al .Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells[J].Proc Natl Acad Sci U S A,2009, 106: 18303-18308. (magtechjournal.com)
  • 4. Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells. (nih.gov)
Stem cells2
  • However, upon removal of the stemness factors, pluripotent stem cells, such as embryonic stem cells (ESCs), exhibit EMT-like cell behavior and lose stemness signatures. (bvsalud.org)
  • The fact that a single differentiation cue can elicit multiple differentiation responses may reflect the challenges associated with achieving sensitive and directed differentiation in cultured stem cells. (bvsalud.org)
Pathogenesis1
  • [ 4 ] Previous studies have indicated that miRNAs, as a novel class of immune regulators, play an essential role in multiple physiopathological processes such as immune cell differentiation, establishment of immunological tolerance and involvement in the pathogenesis of multiple autoimmune diseases. (medscape.com)
Regulation2
  • 12. EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2. (nih.gov)
  • Its expression regulation is critically modulated by multiple physiopathological factors such as inflammation, stress, Epstein-Barr virus infection and sex hormones. (medscape.com)
Activator1
  • 13] Zhu X, Wang Y, Pi W, et al .NF-Y recruits both transcription activator and repressor to modulate tissue- and developmental stage-specific expression of human γ-globin gene[J].PLoS One,2012, 7: e47175. (magtechjournal.com)
Regulators2
  • Methods Using published single-cell transcriptome data of human terminal erythropoiesis, SCENIC analysis was performed to predict stage-specific transcription regulators. (magtechjournal.com)
  • 8] Huang P, Zhao Y, Zhong J, et al .Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells[J].Proc Natl Acad Sci U S A,2020, 117: 12868-12876. (magtechjournal.com)
Histone2
  • 10] Nardini M, Gnesutta N, Donati G, et al .Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination[J].Cell,2013, 152: 132-143. (magtechjournal.com)
  • 8. Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for β-globin gene expression. (nih.gov)
Transcriptional1
  • 17. Chromatin structure and transcriptional control elements of the erythroid Krüppel-like factor (EKLF) gene. (nih.gov)
Transformation1
  • clusters with two additional miRNAs miR-23 and miR-27 on chromosome 9 (cluster-1: and it is connected with differentiation we explored the part of in mobile transformation. (bioinf.org)
Cell cycle1
State1
  • These observations suggest that extracellular Stx4 contributes to early mesoderm induction while simultaneously activating an element that alters the differentiation state. (bvsalud.org)
Affect1
  • The differentiation of SCs mainly involves the formation of polarity and blood-testis barrier (BTB), while the degree of this differentiation can directly affect the sperm quality [2]. (omipalisibinhibitor.com)
Potential1
  • E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer. (journalsmededu.pl)
Fact1
Human1
  • 20. Isolation, genomic structure, and expression of human erythroid Krüppel-like factor (EKLF). (nih.gov)