Differentiation basement membrane laminin. Medical search. Frequent questions

Diseases involving basement membranes at multiple locations include: Genetic defects in the collagen fibers of the basement membrane, including Alport syndrome and Knobloch syndrome Autoimmune diseases targeting basement membranes. (wikipedia.org)
Non-collagenous domain basement membrane collagen type IV is autoantigen (target antigen) of autoantibodies in the autoimmune disease Goodpasture's syndrome. (wikipedia.org)
Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts. (peptide.com)
BMs are specialized structures that underlie epithelia and surround organs and mainly comprise collagen IV, laminins, and heparan sulfate proteoglycans (HSPG). (nature.com)
The AM basement membrane contains laminin, fibronectin, and collagen type IV and VII, similar to the basement membrane of conjunctival tissue, but more than corneal epithelium. (touchophthalmology.com)
The Matrigel matrix consists of laminin, collagen IV, entactin and heparin sulphate proteoglycan. (szabo-scandic.com)
Accordingly, to clarify the molecular basis of tissue-specific differentiation and disease, a variety of 3D systems exploiting natural ECMs have been developed, such as reconstituted basement membrane (rBM) and purified collagen hydrogels. (ucsf.edu)
Its main components are laminin, type IV collagen, heparan sulfate proteoglycan (HSPG), and nestin as well as growth factors such as TGF-beta, EGF, IGF, FGF, tissue plasminogen activator, and other growth factors contained in EHS tumors. (yeasenbiotech.com)
The major structural protein of basement membrane, collagen type IV, in the lens capsule was substantially altered in the absence of SPARC. (silverchair.com)
It consists of approximately 60% laminin, 30% collagen IV and 8% entactin. (dicella.com)
In the temperature between 22-37°C matrigel forms matrix gel, because it is enough energy to form chains between collagen IV, laminin and heparin. (dicella.com)
During liver fibrosis, the composition of the ECM changes from one dominated by collagen IV and laminin [ 4 ], to one of fibrillar collagen, predominantly collagen I and III, as well as fibronectin [ 5 ]. (biomedcentral.com)
Although the mechanisms mediating the effects of the extracellular matrix (ECM) on breast carcinoma development in vivo are largely unknown, contributing factors may be adhesion mediated signaling and mechanical signals imparted on mammary epithelial cells from surrounding type-I collagen-rich stroma, either directly or across basement membrane proteins. (biomedcentral.com)
Type IV collagen is the main component of the basement membrane that gives strength to the blood-gas barrier (BGB). (biomedcentral.com)
Our study showed that type IV collagen and, therefore the basement membrane, play fundamental roles in coordinating alveolar morphogenesis. (biomedcentral.com)
In addition to its role in the formation of epithelium and vasculature, type IV collagen appears to be key for alveolar myofibroblast development by inducing their proliferation, differentiation and migration throughout the developing septum. (biomedcentral.com)
Corning Matrigel matrix is a solubilized basement membrane preparation extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma, a tumor rich in extracellular matrix proteins, including Laminin (a major component), Collagen IV, heparan sulfate proteoglycans, entactin/nidogen, and a number of growth factors. (cgenomix.com)
Collagen XV, a novel factor in zebrafish notochord differentiation and muscle development. (novotec-labs.com)
Immunohistochemical localization of Type IV collagen fibronectin and laminin in the juxtaglomerular apparatus of the rat kidney. (novotec-labs.com)
Collagen heterogeneity of thickened basement membranes of human diabetic dermis : tissular immunolabelling of collagen types I, III and IV by light and electron microscopy. (novotec-labs.com)
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (cusabio.com)
In type 1 bullous systemic lupus erythematosus (which accounts for most cases), antibodies against type VII collagen may weaken or block anchoring fibril-mediated connections between the lamina densa of the basement membrane and the papillary dermis. (medscape.com)

ECM components (i.e., fibronectin or collagens) directly interact with membrane receptors (i.e., integrins), particularly, by influencing cell behavior. (springer.com)
MECs synthesize key extracellular matrix (ECM) proteins of the meninges such as various collagens, as well as fibronectin, laminin and tenascin, important for pia basal lamina integrity and thus for neuronal support and function [ 7 ]. (biomedcentral.com)

As seen with the electron microscope, the basement membrane is composed of two layers, the basal lamina and the reticular lamina. (wikipedia.org)
The most notable examples of basement membranes is the glomerular basement membrane of the kidney, by the fusion of the basal lamina from the endothelium of glomerular capillaries and the podocyte basal lamina, and between lung alveoli and pulmonary capillaries, by the fusion of the basal lamina of the lung alveoli and of the basal lamina of the lung capillaries, which is where oxygen and CO2 diffusion occurs (gas exchange). (wikipedia.org)
They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. (pearltrees.com)
The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. (pearltrees.com)
In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)
It also forms a few specialized structures such as cartilage, tendons, and the basement membrane (also called the basal lamina). (biologywise.com)
Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. (lookformedical.com)

Laminins [ ( PUBMED:2404817 ) ] are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation. (embl.de)
2-5 The basement membrane provides a substrate that promotes epithelial cell adhesion, migration, and differentiation 5-7 and prevents epithelial cell apoptosis. (touchophthalmology.com)
The extracellular matrix (ECM), the noncellular component of the microenvironment, influences cell growth, survival, migration and tissue-specific differentiation through a repertoire of receptors including integrins, syndecans and discoidin receptors. (ucsf.edu)
Most importantly, our study revealed that excessive reactive oxygen species(ROS)generated by high salt disturbed the expression of cardiac‐related genes, detrimentally affecting the above process including EMT, cell migration, differentiation, cell proliferation and apoptosis, which is the major cause of malformation of heart tubes. (uea.ac.uk)
We also show that Col4a1 and Col4a2 mutants displayed disrupted myofibroblast proliferation, differentiation and migration. (biomedcentral.com)

Basement membrane proteins have been found to accelerate differentiation of endothelial cells. (wikipedia.org)
An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)
Using antibodies to podocyte proteins important for podocyte function, we found that Lmx1b(-/-) podocytes express near-normal levels of nephrin, synaptopodin, ZO-1, alpha3 integrin, and GBM laminins. (nih.gov)
Corning ® BioCoat ™ Matrigel ® Matrix Cellware is a solubilized basement membrane preparation extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma, a tumor rich in ECM proteins. (daigger.com)
To confirm the immunohistochemical results, three proteins, fascin, CK14 and laminin-5γ2, which were overexpressed in ESCC on tissue microarray, were detected in 12 ESCC cell lines by Western blot assay. (biomedcentral.com)
8,9 The underlying stromal matrix contains proteins that suppress transforming growth factor (TGF)-β signaling in fibroblasts, and consequently inhibit the proliferation and differentiation into myofibroblasts, extracellular matrix production, and scar formation. (touchophthalmology.com)
Inhibition of proteoglycan biosynthesis was accompanied by an inhibition of laminin deposition into extracellular matrix as determined by immunostaining of cultures and by immunoblotting of cell-associated proteins. (rupress.org)
Ceturegel™ Matrix LDEV-Free Matrix is a soluble basement membrane preparation extracted from EHS mouse tumors rich in extracellular matrix proteins. (yeasenbiotech.com)
Matrigel matrix is reconstituted basement membrane specimen, which is extracted from tumors enriched in extracellular matrix proteins (e.g. (dicella.com)
Laminin is key proteins in the basement membranes of the airway and alveolar epithelium, endothelium, bronchial and vascular smooth muscle cells, nerve cells, and visceral pleura. (biolamina.com)

Schwann cells synthesize two heparan sulfate proteoglycans, one that is a component of the Schwann cell basement membrane and a smaller one that is an integral component of the Schwann cell plasma membrane. (rupress.org)

Effects of inhibition of proteoglycan synthesis on the differentiation of cultured rat Schwann cells. (rupress.org)
These results indicate that Schwann cell proteoglycans play an essential role in basement membrane assembly, and that the integral plasma membrane proteoglycan is not required for the basement membrane to exert its effects on Schwann cell differentiation. (rupress.org)

SPARC (secreted protein,acidic and rich in cysteine) is a matricellular glycoprotein that regulates cell-cell and cell-matrix interactions, cellular proliferation and differentiation, and the expression of genes encoding extracellular matrix components. (silverchair.com)
Specific laminin isoforms are present in different tissue microenvironments and are essential for cell survival, proliferation, and differentiation. (biolamina.com)
The formation of the mammalian respiratory unit is initiated during the transition between the pseudoglandular and canalicular/saccular stages and is characterized by coordinated proliferation and differentiation of epithelial and mesenchymal cells. (biomedcentral.com)

This suggests that other α chains, and hence other isoforms, act redundantly to laminin 1 in posterior notochord and ISV development. (johnshopkins.edu)
We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
Laminins are crucial for lung development where different laminin isoforms exhibit specific, non-overlapping functions. (biolamina.com)
1997) whereas laminin isoforms 211 and 221 have a role in smooth muscle cell differentiation. (biolamina.com)

Laminin is a large molecular weight glycoprotein present only in basement membranes in almost every animal tissue. (embl.de)

When expression of laminin α4 and laminin α1 are simultaneously disrupted, notochord differentiation and ISVs are as severely affected as sly or gup mutants. (johnshopkins.edu)
Laminin α1 expression is restricted to early human lung morphogenesis, whereas the expression of laminin α5 in the human lung is continuous from early lung development through adult life (Pierce et al. (biolamina.com)
1996). Expression of laminin α5 begins in early lung development and persists into adulthood with a widespread expression. (biolamina.com)

Expression of glomerular basement membrane (GBM) collagens is reduced in Lmx1b(-/-) mice, suggesting one basis for NPS nephropathy. (nih.gov)

The different laminin chains share a 600-residue domain I/II which oligomerises into a rod-like coiled-coil structure forming the long arm of laminins. (embl.de)

We previously reported that two zebrafish loci, grumpy (gup) and sleepy (sly), encode laminin β1 and γ1, which are important both for notochord differentiation and for proper intersegmental blood vessel (ISV) formation. (johnshopkins.edu)

All five laminin α chains are present during early embryonic lung development but normal adult lung tissue contains primarily laminin α3, α4, and α5 chains (Miner et al,1997). (biolamina.com)

Moreover, live imaging of transgenic embryos expressing enhanced green fluorescent protein in forming ISVs reveals that the vascular defects in these embryos are due to an inability of ISV sprouts to migrate correctly along the intersegmental, normally laminin-rich regions. (johnshopkins.edu)
Laminin IV domain is also found in the perlecan protein, an integral component of basement membranes, which serves also as an attachment substrate for cells, but it is not found in short laminin chains (alpha4 or beta3). (embl.de)
Laminin 411 markedly induced the expression of the genes Foxa2 and Sox17 , markers for pancreatic precursor cells, efficiently induced IPC differentiation from MSCs, and up-regulated insulin expression at both mRNA and protein levels. (biomedcentral.com)
Analyzing the protein expression patterns of Fas, FADD, caspase 8, CDC25B, fascin, CK14, CK4, annexin I, laminin-5γ2 and SPARC would be valuable to develop rational strategies for early detection of lesions at risk in advance as well as for prevention and treatment of ESCC. (biomedcentral.com)
As a basement membrane protein, COL4A1 is commonly expressed in many tissues and cell types. (cusabio.com)

The basement membrane, also known as base membrane is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling. (wikipedia.org)
Thus any modification of ECM components can be transmitted via integrins and impact on cell movement during development and proliferation, differentiation, apoptosis. (springer.com)
Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
The peri-islet membrane, which encapsulates the islets, separates the endocrine cells from the exocrine pancreas and serves as a barrier from immune cell infiltration to the islets. (nature.com)
Each laminin is a heterotrimer assembled from alpha, beta and gamma chain subunits, secreted and incorporated into cell-associated extracellular matrices. (embl.de)
The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and other receptors. (embl.de)
Corning BioCoat Matrigel Matrix Cellware is effective for the attachment and differentiation of both normal and transformed anchorage dependent epithelial and other cell types including neurons and oligodendrocytes. (daigger.com)
In vitro studies indicate that Dab2 establishes epithelial cell polarity and organization by directing endocytic trafficking of membrane glycoproteins. (biomedcentral.com)
BioCoat products support cell attachment, proliferation and growth, as well as differentiation of primary cells and cell lines in serum-containing and serum-free cultures. (szabo-scandic.com)
The interaction of cells with the basement membrane is an important factor in the regulation of cell behaviour. (szabo-scandic.com)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
These newly available materials led to compelling evidence that the physical cellular environment is far from inert, but acts as a biological and mechanical signal to regulate cell-type specific function, differentiation, and morphology 1 . (mimetas.com)
Clonogenicity is maintained which promotes both goblet and non-goblet cell differentiation while excluding inflammatory cells and their protease activities. (eyewiki.org)
Amniotic membrane can be used in cases of partial and total limbal stem cell deficiency. (eyewiki.org)
[20] For cases of partial limbal stem cell loss, and also in the case of persistent epithelial defects, amniotic membrane has shown to enhance epithelialization and improve vision with and without allogeneic limbal cell transplantation. (eyewiki.org)
At room temperature, it aggregates to form a biologically active three-dimensional matrix, which simulates the structure, composition, physical properties, and functions of the cell basement membrane in vivo, which is beneficial to the culture and differentiation of cells in vitro. (yeasenbiotech.com)
By contrast, the absence of SPARC had no apparent morphological effect on the early stages of lens formation, cell proliferation or fiber cell differentiation. (silverchair.com)
The matrigel might cause differentiation of a variety of cell types like endothelial cells (e.g. (dicella.com)
Cell damage was assessed using MTT assays, and the lactate dehydrogenase (LDH) release rate and flow cytometry were used to detect the accumulation of reactive oxygen species (ROS) and mitochondrial membrane potential respectively. (sdbonline.org)
2000). Laminin 111, expressed by epithelial and mesenchymal cells in the mouse developing lung, plays a role in branching morphogenesis and in epithelial cell polarity (Schuger et al. (biolamina.com)
Studies of laminin α5-deficient mice indicate that laminins 511 and 521 are essential for normal lobar septation in early lung development and normal alveolarization and distal epithelial cell differentiation and maturation in late lung development (Nguyet et al, 2005). (biolamina.com)
Laminin 332 is well associated with cutaneous epithelial cell functions, however, laminin γ2 null mice have only minimal changes in lung development, and it's suggested that laminin 332 in the lung have a role in response to injury or disease processes. (biolamina.com)
Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)
Another type of MMPs are called as the MT-MMPs (Membrane Type Matrix Metalloproteinases) that are localized to the cell surface. (periobasics.com)

Biohit provides monoclonal antibodies to Fibronectins, Tenascin, Laminins and Vitronectin. (biohithealthcare.com)

Integrins are a key component of hemidesmosomes which serve to anchor the epithelium to the underlying basement membrane. (wikipedia.org)
1999). However, branching morphogenesis is not affected in laminin α5, γ2, or α3 knockouts even though integrins α3 and α6 are the primary adhesive receptors for α3 and α5 laminins. (biolamina.com)

Amniotic membrane transplantation has been used as a graft or as a dressing in different surgical subspecialties. (eyewiki.org)
With intraoperative steroid injection into the surrounding tissue defect, amniotic membrane transplantation has a comparable recurrence rate to conjunctival autograft. (eyewiki.org)
In addition to pterygium surgery, amniotic membrane transplantation (AMT) has been used for other conjunctival reconstructive purposes. (eyewiki.org)

Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)

The composition of extracellular matrix (ECM) is tissue specific, however, its functions with respect to cellular adhesion, communication, and differentiation remain uniform irrespective of the change in composition. (biologywise.com)

Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells. (acrobiosystems.com.cn)

They are classified into 5 groups according to substrate specificity and internal homology: collagenases, gelatinases, stromelysins, membrane-type MMPs, and others, including matrilysins 8 . (bvsalud.org)

Unique properties of human amniotic membrane (AM) confer several advantages in the management and treatment of various OSDs. (touchophthalmology.com)
[2] During the same year, Brown used rabbit peritoneum as a temporary patch for ocular surface burns which Sorsby later modified with human amniotic membrane in 1946 and 1947. (eyewiki.org)

Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)

The three-dimensional culture matrix formed by Matrix can promote the adherence and differentiation of epithelial cells, hepatocytes, sertoli cells, melanoma cells, vascular endothelial cells, thyroid cells, and hair follicle cells. (yeasenbiotech.com)

The basement membrane sits between epithelial tissues including mesothelium and endothelium, and the underlying connective tissue. (wikipedia.org)
Fas, FADD, caspase 8, CDC25B, fascin, CK14, CK4, annexin I, laminin-5γ2 and SPARC were analyzed using immunohistochemistry on tissue microarray containing 205 ESCC and 173 adjacent precursor lesions as well as corresponding normal mucosa. (biomedcentral.com)
For ulcers with significant tissue loss, amniotic membrane may be applied in layers to build thickness to the defect. (eyewiki.org)
The extracellular matrix (ECM) consists of interstitial connective tissue and basement membrane (BM). (biohithealthcare.com)
GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)

AM is the innermost layer of the placenta and is composed of an epithelial monolayer, an underlying thick basement membrane, and an avascular stroma. (touchophthalmology.com)
Amniotic membrane, or amnion, is the innermost layer of the placenta and consists of a thick basement membrane and an avascular stromal matrix. (eyewiki.org)

abstract = "Laminins are major constituents of basement membranes and have wide ranging functions during development and in the adult. (johnshopkins.edu)

Here we report high‐salt exposure inhibited basement membrane breakdown by affecting RhoA, thus disturbing the expression of Slug/E‐cadherin/N‐cadherin/Laminin and interfering with mesoderm formation during the epithelial‐mesenchymal transition(EMT). (uea.ac.uk)

Laminin α4 and α5 are also expressed in vascular endothelial basement membrane in late embryonic lungs. (biolamina.com)
We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)

Ceturegel™ Matrix also supports the regeneration of peripheral nerves and the differentiation of bovine fallopian tube epithelial cells. (yeasenbiotech.com)
The lens capsule, which is also called the lens basement membrane, is a specialized extracellular matrix produced anteriorly by the lens epithelium and posteriorly by newly differentiated fiber cells. (silverchair.com)
These results underscore the importance of the capsular extracellular matrix in the maintenance of lens transparency and indicate that SPARC participates in the synthesis, assembly and/or stabilization of the lens basement membrane. (silverchair.com)
HSCs undergo phenotypic changes from quiescent vitamin A storing cells, involved in maintenance of the normal basement matrix, into proliferative myofibroblast-like cells, expressing myogenic markers such as alpha smooth muscle actin (αSMA). (biomedcentral.com)
Extracellular Matrix Deposition, lysyl oxidase expression, and myofibroblastic differentiation during the initial stages of cholestatic fibrosis in the rat. (novotec-labs.com)

Lung branching morphogenesis likely involves integrin interactions with laminins. (biolamina.com)

Since laminin 111 has been shown to play a role in branching morphogenesis, it has been suggested that laminin 111 could be central for this integrin interaction (Nguyet and Senior, 2006). (biolamina.com)

Removal of ocular surface tumors results in a defect which is often revised with amniotic membrane. (eyewiki.org)

[7] [8] Furthermore, the stromal face of amniotic membrane suppresses myofibroblast differentiation of normal fibroblasts to reduce scar and vascular formation. (eyewiki.org)

The dynamics of RACK1 levels in isolated adult SC of mice, i.e., progressively high during differentiation and low compared to proliferating conditions, and RACK1 silencing indicated that RACK1 promotes both the formation of myotubes and the accretion of nascent myotubes. (sdbonline.org)

Thus, human endocrine cells are not in direct contact with the vascular BM components but with the invaginated peri-islet membrane. (nature.com)

As of 2017, other roles for basement membrane include blood filtration and muscle homeostasis. (wikipedia.org)
It has become evident that laminin α1 and laminin α5 have central roles in the development of the human lung. (biolamina.com)

Gel filtration analysis revealed that both the basement membrane and plasma membrane proteoglycans were affected. (rupress.org)
Other MMPs, known as membrane-type MMPs (MT-MMP), are linked to the plasma membrane either by a transmembrane domain or by a glycosyl-phosphatidyl inositol linkage, attached to the hemopexin domain. (periobasics.com)
Two other members of the MT-MMP subfamily, MMP-17 (MT4-MMP) and MMP-25 (MT6-MMP) are anchored to the plasma membrane via a glycosyl-phosphatidyl inositol (GPI) anchor. (periobasics.com)

The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)

They were "early" corresponding to mild and moderate DYS with overexpression of fascin, FADD and CDC25B and underexpression of Fas, caspase 8, CK4 and annexin I, "intermediate" to severe DYS and CIS with overexpression of FADD and CK14, and "late" to invasive lesions (ESCC) and to advanced pTNM stage ESCC lesions with overexpression of CK14, laminin-5γ2 and SPARC. (biomedcentral.com)

The basement membrane is also essential for angiogenesis (development of new blood vessels). (wikipedia.org)
The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of the Î²1 chain, is known to be a functional motif with effects on the inhibition of tumor metastasis, the regulation of sensory axonal response and the inhibition of angiogenesis through high affinity to the 67 kDa laminin receptor. (peptide.com)

Laminin α4 is seen in the pericellular basement membrane of smooth muscle cells lining the airway epithelium (Nguyet and Senior, 2006). (biolamina.com)
Laminin α5 also co-localizes with laminins α1-α3 in the BM of airway epithelium and it is the only laminin α chain found in the visceral pleural basement membrane (Nguyet and Senior, 2006). (biolamina.com)

The lens cells immediately beneath the capsule showed aberrant morphology, with numerous protrusions into the lens basement membrane. (silverchair.com)

found that the most significant changes in laminin and integrin expression pattern were found during the development from the pseudo glandular stage to the canalicular stage (Virtanen et al. (biolamina.com)
The integrin α6 null mouse does not have a reported lung phenotype, however integrin α3/integrin α6 double knockout mice have several features reminiscent of the laminin α5 knockout (De Arcangelis et al. (biolamina.com)

Furthermore, the expression of the genes known to govern insulin expression including Pdx1 and Ngn3 was markedly induced by laminin 411, which suggests that Pdx 1 and Ngn 3 signaling pathways are involved in laminin 411 induced-insulin expression machinery. (biomedcentral.com)

However, when beta-xyloside-treated cultures were supplied with exogenous basement membrane, Schwann cells produced numerous myelin segments. (rupress.org)

Anatomy23

Organisms5

Diseases4

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes25

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Collagen22

Fibronectin2

Basal lamina7

Migration5

Proteins10

Heparan sulfate proteoglycans1

Proteoglycan2

Proliferation and differentiation3

Isoforms4

Glycoprotein1

Expression of laminin3

Collagens1

Different laminin1

Notochord differentiation1

Five laminin1

Protein5

Cell25

Tenascin1

Integrins2

Amniotic Membrane Transplantation3

Receptors1

Adhesion1

Culture and differentiation1

Substrate1

Human amniotic2

Chains1

Endothelial cells1

Tissue5

Thick basement membrane2

Abstract1

Mesenchymal1

Embryonic2

Matrix5

Interactions1

Morphogenesis1

Tumors1

Myofibroblast1

Promotes1

Vascular1

Roles2

Plasma membrane3

Fibrosis1

Overexpression1

Angiogenesis2

Epithelium2

Morphology1

Integrin2

Induced-insulin1

Myelin1