Differentiation and survival cell survival. Medical search. Frequent questions

Thus, we conclude that ADF/cofilin activity is not generally required for induction or progression of apoptosis in mammalian cells. (nature.com)
Interestingly, mitochondrial association of ADF and n-cofilin during apoptosis was preceded by, and dependent on, actin that translocated by a yet unknown mechanism to mitochondria during cell death. (nature.com)
These proteases are responsible for the dismantling of cells during apoptosis. (nature.com)
To test the relevance of ADF/cofilin activity for apoptotic processes, we here employed a genetically well-defined system of mouse embryonic fibroblasts (MEFs) devoid of any ADF/cofilin activity and challenged these cells with well-characterized apoptosis inducers. (nature.com)
Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
In summary, our work demonstrates that in mammalian cells ADF/cofilin activity is not generally required for efficient induction of apoptosis. (nature.com)
Pharmacological inhibition of ALDH1 activity in human fetal islet-epithelial cell clusters resulted in reduced endocrine cell differentiation and increased cell apoptosis, and was reversed with co-treatment of RAR/RXR agonists. (bepress.com)
Furthermore, siRNA knockdown of ALDH1A1 significantly decreased RAR expression and induced cell apoptosis via suppression of the phosphoinositide 3-kinase (PI3K) pathway and activation of caspase signals.Our findings indicate that ALDH1(+) cells represent a pool of endocrine precursors in the developing human pancreas and that ALDH1 activity is required during endocrine cell differentiation. (bepress.com)
AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. (biomedcentral.com)
Human pluripotent stem cells, including ESCs and iPSCs, are highly sensitive cells and undergo apoptosis during these routine procedures. (nih.gov)
Accumulation of genetic defects in hematopoietic precursors leads to impaired cellular differentiation, increased proliferative potential, unregulated proliferation, and defective apoptosis. (medscape.com)
Conclusion: For the protection of stem cells against apoptosis, different pathways, namely Phosphoinositide 3-Kinase (PI3K/AKT), Hypoxia-Inducible Factor (HIF1), Mitogen-Activated Protein Kinases (MAPK) and Hippo, are discussed. (benthamscience.com)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
Autophagy also regulates cell proliferation, differentiation, survival, and apoptosis, highlighting its role in maintaining cellular homeostasis [ 1 ]. (hindawi.com)
Another procent of cases is due to defects in in the gene that encodes the X-linked inhibitor-of-apoptosis XIAP (BIRC4) required for the survival and/or differentiation of NKT cells and also a potent regulator of lymphocyte homeostasis in vivo. (lu.se)

However, these cells have limitations, such as rapid maturation and a short lifespan in vivo . (newswise.com)
In previous studies, induced pluripotent stem cells (iPSCs) differentiated into imDCs, and sinomenine (SN) was used to inhibit the maturation of imDCs. (newswise.com)
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. (ca.gov)
Ultimately, these defects result in arrest of cell maturation and expansion of a clonal cell population. (medscape.com)
Specifically, the protein controls the activity of genes that regulate cell growth and division (proliferation), cell maturation and specialization (differentiation), cell movement (migration), and cell survival. (medlineplus.gov)
Alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OPN), and runt-related transcription factor 2 (Runx2) are commonly used to evaluate differentiation and maturation of osteoblasts. (frontiersin.org)
Scaffolds have been utilized in tissue regeneration to facilitate the formation and maturation of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. (hindawi.com)
During elongation and maturation, the phagophore encapsulates damaged proteins and cell organelles. (hindawi.com)

To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized, and clinical safety and efficacy also need to be proven. (nature.com)
We found that the expanded cells possessed significantly improved immune effector functions, including proliferation, differentiation, and cancer cell killing, both in vitro and in the humanized mouse model. (nature.com)
The current study was undertaken to evaluate the impact of onion juice intake on the bone mineral density (BMD) and bone loss in corroboration with antioxidant effects in human (in vivo) as well as inhibitory effects on the differentiation of osteoclasts in the cell line (in vitro). (nih.gov)
For in vitro studies, the RAW 264.7 (osteoclast progenitor) cells were used to examine the anti-osteoclastogenic effect of onion. (nih.gov)
The result of in vitro studies indicated that onion extract would effectively inhibit the osteoclastogenesis and its differentiation. (nih.gov)
The effects of iPSCs-imDCs and SN-iPSCs-imDCs on T-cell stimulatory function, and regulatory T (Treg) cell proliferative function in vitro were analyzed by mixed lymphocyte reaction. (newswise.com)
This study focused on exploring sinomenine (SN) to promote differentiation of induced pluripotent stem cells (iPSCs) into imDCs (SN-iPSCs-imDCs), and found SN-iPSCs-imDCs with worse donor-specific T-cell stimulatory function, and higher regulatory T-cell proliferative function in vitro and in vivo to induce high immune tolerance. (newswise.com)
We used VES and FBZ, at low concentrations, singly and in combination, to test their inhibitory effects on proliferation of human and mouse prostate cancer cells in vitro. (researchgate.net)
Neuregulin1α, which drives mucus cell differentiation in vitro, was expressed in normal airway submucosal glands and in lungs from patients with IPF. (bmj.com)
For instance, PLA could be combined with PGA to form poly(lactic- co -glycolic acid) (PLGA), which has degradation rate tailored with the tissue healing period and has been shown to support osteoblast cells attachment and growth in vitro and in vivo [ 22 - 24 ]. (hindawi.com)
This protocol describes a detailed procedure for resuspending and culturing human stem cell derived neurons that were previously differentiated from neural progenitors in vitro for multiple weeks. (jove.com)

Together with previous reports indicating that ASK1 functions as a pro-apoptotic signaling intermediate, these results suggest that ASK1 has a broad range of biological activities depending on cell types and/or cellular context. (nih.gov)
Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. (nature.com)
These results reveal that ciliary HH signaling mediates communication between the prechordal plate and the neurectoderm to provide cellular survival cues essential for development of the facial midline. (elifesciences.org)
Cellular signaling pathways are networks of genes, proteins, enzymes, cytokines, and other cellular species that "communicate" in order to govern the basic functions of cells. (american.edu)
Assistant Professor of Mathematics and Statistics Julia Chifman and her collaborators built a predictive mathematical model that connects four key cytosolic cellular signaling pathways in breast epithelial cells: the oncogenic pathway, the oxidative stress response pathway, the iron utilization pathway, and the iron homeostasis pathway. (american.edu)
The oncogenic signaling pathway includes cellular species that regulate the growth, differentiation, and survival of cells. (american.edu)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
Autophagy is a cellular catabolic process that eliminates damaged cell organelles, unfolded proteins, and various intracellular pathogens through lysosomal degradation. (hindawi.com)
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. (abcam.com)
Acetylation and deacetylation of histones, carried out by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively, affects cellular division, differentiation, death and survival. (lu.se)

While probing the basic biology of glial cells, Casaccia's lab also dissects the mechanisms of neurodegeneration in demyelinating disorders, such as MS. She looks at mitochondrial activity in neurons exposed to the cerebrospinal fluid (CSF) of patients with various neurodegenerative disorders, and she also analyses this CSF for insight into therapeutic targets and molecular pathways. (wikipedia.org)
In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
In this work, pathways governing mucus cell differentiation were investigated in lung tissues from patients with IPF and other chronic pulmonary disorders. (bmj.com)
Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. (researchgate.net)
It is usually considered that the differentiation process of MSCs depends on specialized external stimulating factors, including cell signaling pathways, cytokines, and other physical stimuli. (wjgnet.com)
NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)

All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. (mdpi.com)
These play critical roles in cell growth and survival, differentiation, embryonic development, and their related pathologies, including oncogenic transformation. (pewtrusts.org)

Here, we show that conditional knockout of Mef2c in nestin-expressing neural stem/progenitor cells (NSCs) impaired neuronal differentiation in vivo, resulting in aberrant compaction and smaller somal size. (ca.gov)
Our data support a crucial role for MEF2C in programming early neuronal differentiation and proper distribution within the layers of the neocortex. (ca.gov)

Casaccia published a first-author Nature paper in 1996 showing that nerve growth factor highly specifically promotes the death of oligodendrocytes but not neurons, oligodendrocyte precursor cells, or astrocytes. (wikipedia.org)
Here we turn to the issue of how progenitor cells within these regions differentiate into neurons and glial cells, the two major cell types that populate the nervous system. (mhmedical.com)
Remarkably, approximately half of the neurons generated in the mammalian nervous system are lost through programmed cell death. (mhmedical.com)
We examine the factors that regulate the survival of neurons and the possible benefits of widespread neuronal loss. (mhmedical.com)
Neurotrophins are secreted molecules that promote growth, differentiation, and survival of neurons. (nyu.edu)
This protocol facilitates the use of human pluripotent stem cell-derived neurons for high content screening applications. (jove.com)
Human pluripotent stem cell-derived neurons are increasingly relevant in the areas of basic research, drug development, and degenerative medicine. (jove.com)
In addition to human iPSCs, it can be used to replate culture of primary neurons or to resuspend them for fact sorting or single cell sequencing. (jove.com)

Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes, including osteogenic differentiation. (frontiersin.org)
This study aimed to find out more candidate miRNA-mRNA pairs involved in the osteogenic differentiation of MC3T3-E1 cells. (frontiersin.org)
The MC3T3-E1 cells were cultured and incubated in the osteogenic differentiation medium for 14 days. (frontiersin.org)
There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, mmu-miR-3470b-Chek2, mmu-miR-3470b-Dlgap5, mmu-miR-466b-3p-Chek1, and mmu-miR-466c-3p-Chek1. (frontiersin.org)
The Arhgap11a, H2afx, Chek2, Dlgap5, and Chek1 were hub genes downregulated in MC3T3-E1 cells after osteogenic differentiation, verified by RT-qPCR results. (frontiersin.org)
Our study characterizes miR-211-5p targeting Arhgap11a promotes the osteogenic differentiation of MC3T3-E1 cells, which provides novel targets to promote the osteogenesis process during bone repair. (frontiersin.org)
Denosumab treatment induces osteogenic differentiation of GCTB cells. (bvsalud.org)

Human induced pluripotent stem (iPS) cells can differentiate into somatic cells ( 1 ). (spandidos-publications.com)

We report here that expression of constitutively active ASK1 (ASK1DeltaN) induces neurite outgrowth in the rat pheochromocytoma cell line PC12. (nih.gov)
Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)
Stimulation of hedgehog signaling induces carcinogenesis or promotes cell survival in cancers of multiple organs. (rti.org)

This invention will significantly improve quality assurance, characterization, and application of pluripotent stem cells in both pre-clinical and clinical settings. (nih.gov)

Isolated human fetal islet-epithelial cell clusters were treated with ALDH1 inhibitors, retinoic acid receptor (RAR) agonists and ALDH1A1 small interfering (si)RNA.In the developing human pancreatic cells, high ALDH1 activity frequently co-localised with key stem-cell markers as well as endocrine transcription factors. (bepress.com)
Hedgehog ligands were expressed at higher levels in some cancer epithelial cell lines compared to noncancerous epithelial cells. (rti.org)
However, cyclopamine reduced viability of cancer epithelial cell lines, including MDA-MB-435, but did not specifically affect fibroblasts or epithelial cells from benign breast, including MCF10AT. (rti.org)

An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)
We identified 715 upregulated DEGs and 603 downregulated DEGs between MC3T3-E1 cells with and without osteoblast induction by analyzing the raw data of the GSE46400 dataset. (frontiersin.org)
The RT-qPCR also determined declined expressions of miR-204-5p and miR-24-3p concomitant with elevated expressions of miR-211-5p, miR-3470b, miR-466b-3p, and miR-466c-3p in the MC3T3-E1 cells, with osteoblast induction compared with undifferentiated MC3T3-E1 cells. (frontiersin.org)
The impairment of proliferation, differentiation, and mineralization in osteoblast is the main pathophysiological mechanism of osteoporosis, which has been proven by previous studies ( 4 , 5 ). (frontiersin.org)
Osteoblast mainly originates from mesenchymal stem cells (MSCs), and it is involved in bone formation, remodeling, and reconstruction via the formation of a bone matrix and regulation of bone resorption ( 6 ). (frontiersin.org)
Runx2 belongs to the Run family and is an essential upstream transcription factor during osteoblast differentiation. (frontiersin.org)
Osterix (OSX) is a transcription factor in the SP family, which is essential for osteoblast differentiation, and its expression is closely related to Runx2 ( 9 ). (frontiersin.org)
26 ] has shown that osteoblast survival and growth were significantly enhanced in the PLLA/HA composite scaffolds compared to the plain PLLA scaffolds. (hindawi.com)
In this study, the expression of RANKL, special AT-rich sequence-binding protein 2 (SATB2, a marker of osteoblast differentiation), and sclerostin/SOST (a marker of mature osteocytes) was analyzed before and after treatment with denosumab in six cases of GCTB. (bvsalud.org)

The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
Why Differentiate Dendritic Cells ex vivo ? (rndsystems.com)

NSC proliferation and survival were not affected. (ca.gov)
The hedgehog pathway regulates epithelial-mesenchymal interactions, differentiation, proliferation and survival during development. (rti.org)

As a result, the protein cannot bind to DNA and regulate gene function, which leads to poorly controlled cell proliferation and migration during development. (medlineplus.gov)

TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. (fishersci.com)

Through analysis of epigenetic changes and transcriptional changes in glial cells, mostly oligodendrocytes, they are able to understand how certain stimuli or environmental influences may lead to disease phenotypes. (wikipedia.org)
Mainly we try to understand how dynamic and coordinated changes of chromatin modifications including histone modification and DNA methylation (epigenetic codes) regulate gene expression in eukaryotic cells. (pewtrusts.org)
We seek to identify novel epigenetic regulators and characterize their roles in controlling the patterns of epigenetic codes during normal cell differentiation and tissue development. (pewtrusts.org)

ASK1DeltaN-induced neurite outgrowth was strongly inhibited by treatment with the p38 inhibitor SB203580 but not with the MEK inhibitors, suggesting that activation of p38, rather than of ERK, is required for the neurite-inducing activity of ASK1 in PC12 cells. (nih.gov)
In addition to promoting cell adhesion, poly-lysine surface treatments support neurite outgrowth and improve the survival of many central nervous system (CNS) primary cells in culture. (thomassci.com)

She went on to explore oligodendrocyte progenitor cell (OPC) development, discovering that the cyclin-dependent kinase inhibitor p27 is critical to OPC development, such that differentiation in impaired and proliferation continues. (wikipedia.org)

We also observed that ASK1DeltaN induced expression of several neuron-specific proteins and phosphorylation of neurofilament proteins, confirming that PC12 cells differentiated into mature neuronal cells by ASK1. (nih.gov)
Artemin is one of four members of the glial cell line-derived-neurotrophic factor (GDNF) family of proteins. (nyu.edu)
This kit contains the following optimized proteins and reagents to drive the efficient differentiation of mouse monocytes into dendritic cells. (rndsystems.com)

Leukemia cutis is defined by migration of leukemic cells to the skin. (medscape.com)
The pathophysiology underlying the specific migration of leukemic cells to the skin is not clear. (medscape.com)
Signaling through CysLT1R results in increased proliferation, survival and migration of intestinal epithelial cells, whereas signaling through CysLT2R leads to differentiation of colorectal cancer cells. (lu.se)

Class II mutations cause defects in myeloid cell differentiation. (medscape.com)
Class I mutations promote cell survival and proliferation. (medscape.com)
Mutations in the NF1 gene may result in dysregulation in RAS/RAF/MEK/ERK signaling, which can cause cells to grow, divide and copy themselves in an uncontrolled manner, and may result in tumor growth. (merck.com)
Osteocyte-like cells were confirmed to have mutations, as identified using mutation-specific antibodies. (bvsalud.org)
Mutations in p53, found in most cancers, lead to uncontrollable cell division. (medscape.com)

Finally, we describe the existence of a core biochemical pathway that programs the death of nerve cells. (mhmedical.com)
Concomitant with the reduction of HH pathway activity, Tctn2 mutants exhibited increased cell death in the neurectoderm and facial ectoderm, culminating in a collapse of the facial midline. (elifesciences.org)
Enhancing HH signaling by decreasing the gene dosage of a negative regulator of the pathway, Ptch1 , decreased cell death and rescued the midface defect in both Tctn2 and Cc2d2a mutants. (elifesciences.org)
This protein negatively regulates the RAS/MAPK pathway, which helps to control cell growth, differentiation and survival. (merck.com)
Discussion: Activation of the PI3K/AKT pathway decreases the concentration of apoptotic factors, while the HIF pathway protects stem cells against the micro-environment of tissue (hypoxia). (benthamscience.com)
Using real-time, quantitative PCR, laser capture microdissection, and immunohistochemistry, distinctive patterns of expression of the hedgehog pathway members patched 1 (PTCH1), smoothened, GLI1, GLI2 and the 3 hedgehog ligands were identified for epithelial cells and stromal fibroblasts in benign breast and breast cancer. (rti.org)
Hedgehog-mediated transcription, as indicated by a reporter of GLI-dependent promoter activity and by expression of GLI1 transcripts, was reduced by the hedgehog pathway inhibitor cyclopamine in both MDA-MB-435 cancer epithelial cells and MCF10AT epithelial cells, a cell line derived from benign breast. (rti.org)

Hepatocytes derived from iPS cells are suitable for transplantation into patients with liver insufficiency and for use in toxicity tests ( 2 ). (spandidos-publications.com)
Moshayedi P, Nih LR, Llorente IL, Berg AR, Cinkornpumin J, Lowry WE, Segura T, Carmichael ST. Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain. (duke.edu)
Timing of intra-arterial neural stem cell transplantation after hypoxia-ischemia influences cell engraftment, survival, and differentiation. (anaspec.com)

Melton, D.A. "Stemness": Transcriptional profiling of embryonic and adult stem cells. (benthamscience.com)
however, PTCH1, also a transcriptional target of hedgehog signaling in many cell types, was not increased. (rti.org)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repression and transcriptional activation. (lu.se)

In this respect, the introduction of checkpoint inhibitors to unleash the activity of tumor-reactive T cells has been a milestone in cancer immunotherapy. (nature.com)
RANKL inhibition blocks tumor-induced osteoclastogenesis, and survival, and is used to treat unresectable GCTBs. (bvsalud.org)
Bone tumors include osteosarcoma and small-cell malignant tumors (such as Ewing sarcoma or Askin tumor). (msdmanuals.com)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
In this study, global GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
The treatment choice - surgery, chemotherapy and/or radiotherapy - depends on the clinical staging and the degree of histopathological differentiation of the tumor 6 . (bvsalud.org)
Brain Tumor Registry of the United States analytic data set and primary malignant ependymal tumours from the SEER 13 registries research data file were used to evaluate incidence and survival, respectively. (cdc.gov)

It also promotes extracellular matrix (ECM) deposition and permits transportation for nutrient and gases and waste removal for cell survival [ 2 ]. (hindawi.com)

Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating in specific directions. (wjgnet.com)

After 7 days of culture, the cells were subjected to reverse transcription‑quantitative PCR analysis. (spandidos-publications.com)
She found that p27 regulates the differentiation of oligodendrocytes by modulating transcription of the gene for myelin basic protein. (wikipedia.org)
Singularly, SPDEF, a transcription factor associated with mucus metaplasia, was rarely detected in mucus cells in IPF. (bmj.com)
Mucus cells lining abnormal airways from patients with IPF expressed MUC5B and SOX2 but lacked SAM pointed domain containing ETS transcription factor (SPDEF) and forkhead box A3(FOXA3). (bmj.com)
These results demonstrate modulation of GLI-mediated transcription in both cancer and benign-derived epithelial cells by cyclopamine and sonic hedgehog, and further suggest that hedgehog signaling contributes to the survival of only the cancer epithelial cells. (rti.org)
[ 8 ] Other classification systems categorize the ectodermal dysplasias based on defects in cell-cell communication and signaling, adhesion, transcription regulation, or development. (medscape.com)

Vγ9Vδ2 T cells recognize pyrophosphates secreted by many microbes or overproduced by malignant cells in the context of butyrophilin 3A1 molecules. (nature.com)
Casaccia found in 2002 that the delicate balance of proapoptotic and antiapoptotic molecules determine the propensity for cell death. (wikipedia.org)
We discuss some of the molecules that specify neuronal and glial cell fates and how they are regulated. (mhmedical.com)
Upon activation, immature dendritic cells mature and increase the expression of class II MHC and co-stimulatory molecules important for effective antigen presentation to naïve T cells. (rndsystems.com)
As PDL and PLL are synthetic molecules, they do not stimulate biological activity in the cells cultured on them, and they do not introduce impurities carried by natural polymers. (thomassci.com)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)

Aldehyde dehydrogenase 1 (ALDH1), a human stem-cell marker, is an enzyme responsible for converting retinaldehydes to retinoic acids (RAs) to modulate cell differentiation. (bepress.com)
This technology includes the use of the combination of the compounds Chroman-1 and Emricasan to achieve virtually 100% cell survival during human pluripotent stem cell passaging, cryopreservation/thawing, and differentiation in 2D and 3D cultures. (nih.gov)
This includes the analysis of genes in germline stem cell proliferation and differentiation. (ncl.ac.uk)
Stem Cell Rev. Rep. , 2019 , 16 (1), 103-117. (benthamscience.com)
Ramalingam, M. Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine. (benthamscience.com)
Zhang, Y. Integrin β1 increases stem cell survival and cardiac function after myocardial infarction. (benthamscience.com)
Aifantis, I. Regulation of stem cell function by protein ubiquitylation. (benthamscience.com)
Mora MV, Ibán MAR, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. (wjgnet.com)

Peroxisome proliferator-activated receptor gamma ligands inhibit transforming growth factor-beta-induced, hyaluronan-dependent, T cell adhesion to orbital fibroblasts. (anaspec.com)
Poly-D-Lysine (PDL) and Poly-L-Lysine (PLL) are synthetic compounds that enhance cell adhesion and protein absorption by altering surface charges on the culture substrate. (thomassci.com)
In 2003, Lamartine reclassified the ectodermal dysplasias into the following 4 functional groups based on the underlying pathophysiologic defect: (1) cell-to-cell communication and signaling, (2) adhesion, (3) development, and (4) other. (medscape.com)
Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)

studies on cell cycle regulation and genome instability. (ncl.ac.uk)
The regulation of these functions ensures that cells start and stop growing at specific times and that they are positioned correctly during development. (medlineplus.gov)
Zhou JQ, Wan HY, Wang ZX, Jiang N. Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells. (wjgnet.com)
[ 7 ] Similarly, in 2001, Priolo and Laganà reclassified the ectodermal dysplasias into 2 main functional groups: (1) defects in developmental regulation/epithelial-mesenchymal interaction and (2) defects in cytoskeleton maintenance and cell stability. (medscape.com)

In addition to her research on oligodendrocytes, Casaccia studied neurotrophins and their role in cell survival and differentiation in the central nervous system. (wikipedia.org)
Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. (novusbio.com)

Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines. (anaspec.com)
Sufficient porosity is needed to accommodate cell proliferation and differentiation, which will eventually enhance tissue formation [ 2 , 3 ]. (hindawi.com)
Background: Stem cells are of two types: embryonic and adult stem cells and they act as a repair system by replenishing body tissue. (benthamscience.com)
Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)

We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. (ncl.ac.uk)

In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), providing a new powerful means for the classification, prediction of survival, and response to treatment of lymphomas. (lu.se)

Human liver organoids are formed from the assembly of hepatocyte-like cells differentiated from iPS cells, human umbilical vascular endothelial cells and mesenchymal stem cells ( 9 ). (spandidos-publications.com)

Inhibition of ALDH1-mediated retinoid signalling impairs human fetal islet cell differentiation and survival. (bepress.com)
Moreover, pharmacological inhibition of HDACs I/II activity in rd1 organotypic retinal explants decreased activity of poly-ADP-ribose-polymerase and strongly reduced photoreceptor cell death. (lu.se)

Moreover, γδ T cells can directly kill target cells without the involvement of dendritic cells (DCs) and perform dual functional roles in antitumor and anti-infective immunity. (nature.com)
Immature dendritic cells (imDCs) play an important role in the induction of donor-specific transplant immunotolerance. (newswise.com)
Immature dendritic cells (imDCs) play an important role in the induction of donor-specific transplant immune tolerance. (newswise.com)
For the differentiation of dendritic cells from mouse bone marrow. (rndsystems.com)
Dendritic cells (DCs) are key mediators of both innate and adaptive immune responses. (rndsystems.com)
The CellXVivo ™ Mouse Dendritic Cell Differentiation Kit contains the media and cytokine components to generate immature and mature dendritic cells from mouse bone marrow. (rndsystems.com)
Morphology of Mouse Dendritic Cells Derived from PBMCs. (rndsystems.com)
Mouse PBMCs were differentiated into immature mouse dendritic cells by culturing for 5 days in reagents included in the CellXVivo ™ Mouse Monocyte-derived Dendritic Cells Differentiation Kit. (rndsystems.com)
Immature dendritic cells exhibit characteristic dendritic cell morphology. (rndsystems.com)
Phenotypic Analysis of Cultured Immature and Mature Mouse Dendritic Cells. (rndsystems.com)
Immature dendritic cells (left, blue) and TNF-α-treated mature dendritic cells (right, red), derived from bone marrow cells cultured with the CellXVivo ™ Mouse Dendritic Cell Differentiation Kit, were stained for flow cytometry with antibodies for CD11c, B7-2/CD86, MHC class II (I-A/I-E), or CD40 (open histograms). (rndsystems.com)
Immature dendritic cells have the phenotype of CD11c + , with intermediate expression of B7-2/CD86, MHC class II, and little to no CD40. (rndsystems.com)
Mature dendritic cells have the phenotype of CD11c + , with increased expression of B7-2/CD86, MHC class II, and CD40. (rndsystems.com)
Kit-derived Mature Mouse Dendritic Cells Induce Proliferation of Allogeneic T Cells. (rndsystems.com)
Serial dilutions of TNF-α-treated mature dendritic cells were incubated with allogeneic mouse T cells for 3 days. (rndsystems.com)

Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Further experiments revealed that bone marrow stromal cells produced TGF-β in response to dihydrotestosterone (DHT), and neutralization of TGF-β in the DHT-treated stromal cells reversed the suppressive effects. (jci.org)
Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)
The stromal cell products responsible for these effects of estrogens have not been identified. (jci.org)
Giant cell tumors of bone (GCTBs) are locally aggressive tumors with the histological features of giant cells and stromal cells. (bvsalud.org)

Cytokines produced by DCs can also promote the differentiation of CD4 + T helper cells as part of immune activation. (rndsystems.com)

These findings highlight the importance of protein acetylation for photoreceptor cell death and survival and propose certain HDAC classes as novel targets for the pharmacological intervention in RP. (lu.se)

Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)

Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)

Recent findings have revealed other underrated roles in the differentiation process of MSCs, such as material morphology and exosomes. (wjgnet.com)

[ 1 , 2 , 3 ] Owing to the variety of hematologic malignancies or proliferative disorders that may be associated with leukemia cutis, terms such as myeloid or lymphoid leukemia cutis have been used to further classify the leukemic cells. (medscape.com)

Several lines of evidence support the hypothesis that gonadal steroids exert effects on the development of B cells in bone marrow. (jci.org)
Androgens also exert effects on B cell development in bone marrow. (jci.org)

This abnormal cell growth and movement leads to malformations in the middle of the face, particularly affecting the nose, which leads to openings (clefts) in the nose. (medlineplus.gov)
Pancreatic cancer with cachexia and elevated human growth differentiation factor 15 (GDF15). (medscape.com)

Cancer cells continue to produce lactate via glycolysis when oxygen is abundant (the Warburg effect) ( 14 ). (spandidos-publications.com)
Consequently, several human diseases, including cancer and neurodegenerative disorders, are caused by defects in this highly regulated form of cell death. (nature.com)
furthermore, the expanded γδ T cells were adoptively transferred into late-stage liver and lung cancer patients. (nature.com)
Furthermore, a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells. (nature.com)
Among these 132 patients, 8 liver cancer patients and 10 lung cancer patients who received ≥5 cell infusions showed greatly prolonged survival, which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy. (nature.com)
Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy, which will inspire further clinical investigations and eventually benefit cancer patients. (nature.com)
Administered alone, FBZ inhibited proliferation faster than VES in both mouse and human prostate cancer cell lines and a synergistic effect between both was also observed. (researchgate.net)
prostate cancer cell lines and a synergistic effect between both was also o bserved. (researchgate.net)
Shende, P. Role of liposome-based stem cells for multimodal cancer therapy. (benthamscience.com)
Prognosis varies by cancer type, cell differentiation, and stage. (msdmanuals.com)
Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
With an average survival rate of three years, IBC accounts for about 2.5% of all breast cancer types in the US. (bvsalud.org)
In the USA, obesity has recent- obesity is associated with progres- aberrations of cancer cells, summa- ly surpassed tobacco use as the sion but not incidence [9]. (who.int)
HER2 classification in breast cancer cells: A new explainable machine learning application for immunohistochemistry. (cdc.gov)
Evaluation of race/ethnicity-specific survival machine learning models for Hispanic and Black patients with breast cancer. (cdc.gov)
We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)

Squamous cell carcinoma (SCC) is a malignant neoplasia, originating from the oral lining epithelium, responsible for approximately 90-95% of malignancies in this location. (bvsalud.org)
squamous cell carcinoma. (bvsalud.org)
Squamous cell carcinoma (SCC), sometimes referred to "spinocellular carcinoma" or "epidermoid carcinoma", accounts for 90% of the malign neoplasias occurring in the oral mucosa 2,6,7,9,15 . (bvsalud.org)
A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)

Results In IPF, the bronchiolised and enlarged distal airspaces stained for SOX2 are consistent with epithelial differentiation characteristic of conducting airway epithelium. (bmj.com)

Early into her professorship at Robert Wood Johnson Medical School, Casaccia returned to her postdoctoral findings, exploring the role of p27 in oligodendrocyte differentiation, to understand how myelin development occurs. (wikipedia.org)

Although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. (researchgate.net)
Ependymal tumours are neuroectodermal tumours that although ependymoma, clear cell ependymoma, tanycytic ependymoma and rare have a significant impact on the quality of life and mortality papillary ependymoma. (cdc.gov)

for example, there are inconsistent views 24 on the intratumoral γδ T-cell signature as the most favorable prognostic biomarker 25 of cancers and discussions on the pro- and antitumor activities of γδ T cells. (nature.com)

Necessary for the survival of CD4+ and CD8+ immature thymocytes. (fishersci.com)

Anatomy35

Organisms10

Diseases29

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes53

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science5

Health Care16

Apoptosis15

Maturation8

Vitro11

Cellular10

Pathways7

Embryonic development2

Neuronal differentiation2

Neurons8

Osteogenic differentiation7

Induced plur1

Induces3

Pluripotent Stem1

Epithelial cell3

Osteoblast9

Vivo2

Proliferation and survival2

Controlled cell proliferation1

Lymphocyte1

Epigenetic3

Neurite outgrowth2

Progenitor1

Proteins3

Migration3

Mutations5

Pathway7

Transplantation3

Transcriptional3

Tumor8

Promotes1

Tissues1

Transcription6

Molecules6

Stem-cell8

Adhesion4

Regulation4

Neurotrophins2

Tissue4

Somatic1

Gene expression1

Endothelial1

Inhibition2

Dendritic cells15

Stromal6

Cytokines1

Protein1

Metabolism1

Precursors1

MSCs1

Proliferative1

Bone marrow2

Growth2

Cancer17

Squamous cell carc4

Characteristic1

Findings1

Significant2

Cancers1

Immature1