• Modulation of Basic Helix-Loop-Helix Transcription Complex Formation by Id Proteins during Neuronal Differentiation. (lu.se)
  • The ability of Id proteins to affect HES-1 activity is of particular interest in neuronal cells, where regulation of HES-1 is essential for the timing of neuronal differentiation. (lu.se)
  • Real-time reverse transcription PCR is used to differentiate possible wild strains from vaccine-like strains ("intratypic differentiation"), using virus isolated in culture as the starting material. (cdc.gov)
  • The network laboratories are using real-time reverse transcription polymerase chain reaction (rRT-PCR) for intratypic differentiation laboratories and screening of vaccine derived polioviruses. (who.int)
  • Map 1: the map describes national viruses isolation, intratypic differentiation and nucleotide sequencing laboratories. (who.int)
  • Automatic differentiation (AD), also called algorithmic differentiation or simply â autodiffâ , is a family of techniques similar to but more general than backpropagation for efficiently and accurately evaluating derivatives of numeric functions expressed as computer programs. (jmlr.org)
  • This paper presents a minimization method for Lipschitz continuous, piecewise smooth objective functions based on algorithmic differentiation (AD). (optimization-online.org)
  • Our approach is to first understand how hESC interact with extracellular matrix materials by analyzing candidate adhesive substrate proteins and integrin receptors that mediate attachment, survival, proliferation and differentiation. (ca.gov)
  • Although the effects of high glucose on the proliferation and differentiation of rat and mouse BM-MSCs have been previously reported, the effects of high glucose on biological properties of human MSCs derived from gestational tissues which, due to their ease of isolation by noninvasive procedure, are considered more suitable sources of MSCs for clinical applications have yet to be determined. (hindawi.com)
  • Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). (nih.gov)
  • There is a critical need for new technologies to facilitate growth and differentiation of human embryonic stem cells (hESC) using clinically acceptable, animal-free reagents. (ca.gov)
  • T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ. (nature.com)
  • Beck's team further determined that the differentiation of PDC's may occur in the presence of monocytic or myeloid DC differentiation, or as a differentiation lineage possessing a predominant myoblast population. (news-medical.net)
  • Differentiation doesn't customize the learning experience for each student, but it does help ensure that groups of students, at different levels, receive lessons that are geared toward their particular abilities. (eschoolnews.com)
  • Here we examine the success rate of methods and data for differentiation by testing the ability of nine computational methods (CellNet, GarNet, EBseq, AME, DREME, HOMER, KMAC, diffTF and DeepAccess) to discover and rank candidate factors for eight target cell types with known reprogramming solutions. (nature.com)
  • At the Stem Cell Differentiation and Cytogenetics Group, we are interested in the effects of ionizing radiation on organs such as the brain, the heart, and the lung trying to elucidate the risks for patients treated with ionizing radiation as well as for astronauts, who are inevitably exposed to ionizing radiation on their missions into space. (gsi.de)
  • Here we present SR1001, a high-affinity synthetic ligand-the first in a new class of compound-that is specific to both RORα and RORγt and which inhibits T H 17 cell differentiation and function. (nature.com)
  • Our data demonstrate the feasibility of targeting the orphan receptors RORα and RORγt to inhibit specifically T H 17 cell differentiation and function, and indicate that this novel class of compound has potential utility in the treatment of autoimmune diseases. (nature.com)
  • McGeachy, M. J. & Cua, D. J. Th17 cell differentiation: The long and winding road. (nature.com)
  • RSK2, an ERK downstream kinase, is a novel mediator of skeletal muscle cell differentiation through its regulation of NFAT3 activity. (nih.gov)
  • Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4 + T effector cell subsets. (jci.org)
  • We explore differentiation under mixed input conditions by exposing cells to varied combinations of cytokines, experimentally mapping the "decision space" of the differentiation process at the single cell level. (weizmann.ac.il)
  • A research team from the University Hospitals of Cleveland Medical Center in western Pennsylvania has discovered the existence of myeloid neoplasms (MNs) that can undergo plasmacytoid dendritic cell (PDC) differentiation. (news-medical.net)
  • In addition, we examined whether these substrates will support differentiation of retinal pigmented epithelial cells, an important, clinically relevant cell type that is currently in clinical trials for eye disease. (ca.gov)
  • This surface proved to be efficient at supporting growth of undifferentiated hESC as well as differentiation of useful cell types. (ca.gov)
  • Dynamically and epigenetically coordinated gata/ets/sox transcription factor expression is indispensable for endothelial cell differentiation. (medicalxpress.com)
  • Using ES cells developed at the Center for iPS Cell Research and Application (CiRA) in Kyoto University, the research group collected RNA and histones of each cell immediately after VEGF stimulation (0 h), before differentiation (6 h), during differentiation (12 - 24 h), and after differentiation (48 h). (medicalxpress.com)
  • Previously, in the region that controls the function of the transcription factor that promotes differentiation from ES cells to a specific cell type, bivalent modifications of histones such as the accelerator and brake histone marks for transcription were thought to have coexisted. (medicalxpress.com)
  • To use this knowledge to improve beta cell differentiation protocols. (lu.se)
  • Zhang, F. P., Meng, G. X. & Strober, W. Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17-producing T cells. (nature.com)
  • For several decades now, differentiation has been on many school districts' lists of prioritized initiatives. (edutopia.org)
  • Differentiation has been a common fixture in classrooms for decades and is designed to address the needs of all students, who may be at varying levels, within a single classroom. (eschoolnews.com)
  • The result is the derivative of the expression, with respect to the variable of differentiation, with a unit, the input expression unit divided by the variable of differentiation unit if any. (maplesoft.com)
  • The protein GATA2, which binds to ETV2 and supports vascular endothelial differentiation, was induced immediately thereafter. (medicalxpress.com)
  • Among the chromatin accessibility methods, complex methods DeepAccess and diffTF have higher correlation with the ranked significance of transcription factor candidates within reprogramming protocols for differentiation. (nature.com)
  • In contrast to adipogenic differentiation, high glucose suppressed osteogenic differentiation and downregulated the expression levels of osteogenic gene runt-related transcription factor 2 ( RUNX2 ), collagen type I ( COL1A1 ), osteonectin ( ON ), and osteocalcin ( OCN ) of mouse BM-MSCs and MG63 cells [ 7 , 9 ]. (hindawi.com)
  • Furthermore, they found that a transcription factor group essential for blood vessel differentiation (ETS/GATA/SOX) has a previously unknown role. (medicalxpress.com)
  • According to the document, MTCU views differentiation as "a primary policy driver for the system. (ocufa.on.ca)
  • An increase in adipogenic differentiation levels was accompanied by an upregulation of the expression levels of several adipogenic genes including peroxisome proliferator-activated receptor gamma ( PPAR γ ), adipocyte protein 2 ( AP2 ), adipose tissue-specific secretory factor ( ADSF ), sterol regulatory element-binding protein 1C ( SREBP1C ), lipoprotein lipase ( LPL ), adiponectin ( ADIPOQ ), and glucose transporter type 4 ( GLUT4 ) [ 8 , 9 , 11 ]. (hindawi.com)
  • In the process of blood vessel differentiation, the function of the protein ETS variant 2 (ETV2), which determines the differentiation into vascular endothelium, was first induced within 6 hours of differentiation stimulation. (medicalxpress.com)
  • Although high glucose transiently downregulated the expression levels of some osteogenic genes examined, its effect on the osteogenic differentiation levels of the MSCs is not clearly demonstrated. (hindawi.com)
  • At 48 hours, after differentiation into vascular endothelium was determined, a system of transcription was established in which genes unique to vascular endothelial differentiation were induced. (medicalxpress.com)
  • Manel, N., Unutmaz, D. & Littman, D. R. The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. (nature.com)
  • Robustly generate three-dimensional, patterned brain organoid cultures from human pluripotent stem cells without matrix embedding by using STEMdiff™ Midbrain Organoid Differentiation Kit. (stemcell.com)
  • However, the effect of high glucose on adipogenic differentiation of human bone marrow and gestational tissue-derived MSCs is still poorly characterized. (hindawi.com)
  • This study aims to investigate the effects of high glucose on proliferation as well as adipogenic and osteogenic differentiation of human MSCs derived from bone marrow and several gestational tissues including chorion, placenta, and umbilical cord. (hindawi.com)
  • A note on the Lebesgue differentiation theorem in spaces of homogeneous type. (projecteuclid.org)
  • We prove that the Lebesgue differentiation theorem holds in the general setting of spaces of homogeneous type if the balls are subspaces of homogeneous type. (projecteuclid.org)
  • OCUFA is pleased to release its Policy Statement of University Differentiation in Ontario and its Strategic Mandate Agreements 2014-17: Summary of Observations document. (ocufa.on.ca)
  • These reports were designed to assist our members in understanding and responding to the Government of Ontario's "Differentiation Framework" and Strategic Mandate Agreements (SMAs) with university administrations. (ocufa.on.ca)
  • Generally, WTO agreements permit differentiation on public health grounds, either by defining 'discrimination' so as not to include legitimate regulatory distinctions, or through explicit public health exceptions. (who.int)
  • Differentiation therapy is a method to treating advanced cancers in which malignant cells are encouraged to differentiate into more mature forms using pharmacological agents. (wikipedia.org)
  • Forward-, reverse- and mixed- mode automatic differentiation combinators with a common API. (haskell.org)
  • By precisely defining the main differentiation techniques and their interrelationships, we aim to bring clarity to the usage of the terms â autodiffâ , â automatic differentiationâ , and â symbolic differentiationâ as these are encountered more and more in machine learning settings. (jmlr.org)
  • The workshops I facilitate are typically not teachers' first professional learning on differentiation. (edutopia.org)
  • We propose to develop novel, well-defined, synthetic extracellular matrices for growth and differentiation of hESC. (ca.gov)
  • While I was doing this, a background process in my mind linked me back to the post I wrote on VC Fund Differentiation (or lack thereof) . (feld.com)
  • The conversation also explores the idea of defining the summation for non-integer values and how it affects the differentiation process. (physicsforums.com)
  • The differentiating cells also actively alter these signals by producing relevant cytokines, thus influencing the differentiation process through extracellular feedbacks. (weizmann.ac.il)
  • Differentiation indeed is important. (themaninblue.com)
  • These results demonstrate that RSK2 is an important kinase for NFAT3 in mediating myotube differentiation. (nih.gov)
  • While this is a good sign in general, it is becoming increasingly important for RPO suppliers to create differentiation within the growing and probably overcrowded marketplace. (hrotoday.com)
  • Transcription factors SOX and FLI1, both important for endothelial differentiation, were induced between 12 and 24 hours. (medicalxpress.com)
  • In an individualized learning scenario, the teacher still drives instruction - but, unlike differentiation, an individualized lesson is designed to accommodate the particular needs for an individual learner, rather than a group. (eschoolnews.com)
  • The group concluded by stating that acute leukemia with PDC differentiation and typical cases of acute myeloid leukemia, NOS, or acute myelomonocytic leukemia are indistinguishable. (news-medical.net)
  • A prestigious group of educators are convening at the Intercontinental Hotel in Sydney's CBD on the 16th and 17th of this month to share strategies for improving learning achievement through differentiation. (tommarch.com)
  • According to this analysis, diversification - or differentiation, as it is called in a still bubbling national debate in South Africa - is simply no longer optional. (universityworldnews.com)
  • Six of the seven cases exhibited intermediate subpopulations, which evidence differentiation from a population of leukemic myeloblasts. (news-medical.net)
  • It is known that significant percentages of visceral adipocytes are derived from mesenchymal stem cells and high glucose enhances adipogenic differentiation of mouse bone marrow-derived MSCs (BM-MSCs). (hindawi.com)
  • In an effort to help break the cycle of endless differentiation PD and find solutions for common differentiation obstacles, I've worked with many teachers to create work-arounds that accomplish the intended goal of the problematic practice and also respect teachers' professionalism, as illustrated here with two examples. (edutopia.org)
  • The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17 + T helper cells. (nature.com)
  • RPO suppliers should consider creating an optimal mix of onshore-nearshore-offshore delivery mechanisms to leverage the benefits of global sourcing and create differentiation in a market filled with onshore-centric models. (hrotoday.com)
  • Suppliers need to use technology to create standardized models across back-office, non-distinctive processes to leverage and provide economies of scale benefits to their clients, while creating differentiation through high value-added elements around analytics. (hrotoday.com)
  • I don't even know what differentiation means anymore as it all blurs together. (feld.com)
  • Differentiation means that you have a choice and the people who are making the phones, they're going to compete on their view of innovation," Schmidt argued. (slashgear.com)
  • Endogenous product differentiation in credit markets: what do borrowers pay for? (norges-bank.no)
  • The first differentiation agent found to be successful was all-trans-retinoic acid (ATRA) in the treatment of acute promyelocytic leukemia (APL). (wikipedia.org)
  • We found that high glucose reduced proliferation but enhanced adipogenic differentiation of all MSCs examined. (hindawi.com)
  • The groups study present evidence of myeloid neoplasms derived from patients with acute leukemias which encompass a spectrum of PDC differentiation which result in outcomes that do not fit into the categories of MPD MN or BPDCN. (news-medical.net)
  • Speaking at CES this week, where many manufacturers revealed devices running older versions of Android but promised Ice Cream Sandwich upgrades at some point later this year, Schmidt argued that "differentiation is positive, fragmentation is negative," PCMag reports. (slashgear.com)
  • India and other emerging countries have rejected the concept of differentiation and have called for respecting the existing mandate. (domain-b.com)
  • C) A new concept proposal for the EC differentiation switch. (medicalxpress.com)
  • Differentiation between initializing static and dynamic values in Houdini VEX. (github.com)
  • While differentiation is usually studied under polarizing conditions, applying only one signal at a time, cells in vivo are expected to sense a more complex environment, in which they may be simultaneously exposed to combinations of cytokines. (weizmann.ac.il)
  • However, there's another significant roadblock to enacting successful, sustainable differentiation initiatives: the pervasive tendency of professional learning facilitators to dismiss teacher voice. (edutopia.org)