• For example, unlike most benign tumors elsewhere in the body, benign brain tumors can be life-threatening. (wikipedia.org)
  • Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. (ajnr.org)
  • This article is an overview of the utility of PCT for assessment of brain tumors and describes the technique, its advantages, and limitations. (ajnr.org)
  • 1 , 2 Malignant brain tumors are characterized by neovascularity and increased angiogenic activity, with a higher proportion of immature and highly permeable vessels. (ajnr.org)
  • Traditionally, perfusion imaging of brain tumors has been performed with MR imaging, by using various perfusion imaging techniques and estimating tumor blood volume, blood flow, and permeability. (ajnr.org)
  • In view of the wider availability, faster scanning times, and low cost compared with MR perfusion, PCT is potentially well-suited to study brain tumors 6 , 7 and could potentially be useful as an easy tool for quantitative estimates of perfusion parameters and their use as imaging biomarkers. (ajnr.org)
  • While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
  • Other rare non-epithelial malignancies that may be encountered in effusion cytology include neuroblastoma, Wilms tumor, and metastatic brain tumors. (cytojournal.com)
  • 1 - 3 Intracranial brain tumors, most commonly medulloblastoma [ Figure 2 ], can metastasize to the peritoneal cavity via ventriculo-peritoneal shunts used to divert excess cerebrospinal fluid. (cytojournal.com)
  • This opens an exciting new chapter in the study of neurons and brain tumors. (science20.com)
  • This tumor represents about 4% of all primary brain tumors. (cancer.org)
  • Importantly, immune constituents of the tumor microenvironment (TME) can influence therapy response and cancer progression. (mdpi.com)
  • CSCs are enriched near macrophages, particularly near macrophage-containing intravasation sites called Tumor Microenvironment of Metastasis (TMEM) doorways. (nature.com)
  • Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
  • Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
  • ADI-270 is designed to home to solid tumors, with a highly specific targeting moiety for CD70 and an armoring technology of dominant negative TGF beta receptor to address immunosuppressive factors in the tumor microenvironment. (businesswire.com)
  • Multicellular tumor spheroid models give deeper insights into the tumor microenvironment, allowing researchers to visualize cell-to-cell interactions, how tumor cells absorb nutrients, and how they proliferate. (moleculardevices.com)
  • Here, we report that adipocytes from tumor-invasive mammary fat undergo de-differentiation to fibroblast-like precursor cells during tumor progression and integrate into the tumor microenvironment. (usda.gov)
  • Collectively, the metabolic interplay between tumor cells and adipocytes induces adipocyte mesenchymal transition and contributes to reconfigure the stroma into a more tumor-friendly microenvironment. (usda.gov)
  • This study aimed to clarify the role of mesenchymal stem cells (MSCs) as a component of the cancer microenvironment. (cancerindex.org)
  • Cancer-associated fibroblasts: The chief architect in the tumor microenvironment. (tamu.edu)
  • METHODS: Colonosphere cultures were established from human colorectal tumor specimens obtained from patients who underwent colon or liver resection for primary or metastatic adenocarcinoma. (knaw.nl)
  • CSCs have an enhanced ability to self-renew, which makes them uniquely capable of initiating and sustaining primary and metastatic tumor growth 3 . (nature.com)
  • AFP and β-hCG also may be useful in evaluating potential origins of poorly differentiated metastatic cancer. (aafp.org)
  • Combined with observations of neuroendocrine enrichment in cases of poor clinical response to androgen deprivation therapy, these findings support the notion that the clonal expansion of AR-negative neuroendocrine cells may play a critical role in the development of androgen-insensitive metastatic prostate cancer. (cancernetwork.com)
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
  • Most tumors metastatic to the serous membranes are of epithelial origin. (cytojournal.com)
  • Nevertheless, radioactive iodide treatment is used for most patients with Hürthle cell cancers after total and near-total thyroidectomy and in the treatment of patients with recurrent and metastatic Hürthle cell carcinoma. (medscape.com)
  • Argani, P. Intraductal spread by metastatic islet cell tumor (well-differentiated pancreatic endocrine neoplasm) involving the breast of a child, mimicking a primary mammary carcinoma. (hopkinsmedicine.org)
  • DGC-secreted FMOD promotes angiogenesis by activating integrin-dependent Notch signaling in endothelial cells. (tau.ac.il)
  • Collec-tively, these findings demonstrate that DGC-secreted FMOD promotes glioma tumor angiogenesis and growth through paracrine signaling in endothelial cells and identifies a DGC-produced protein as a potential therapeutic target in glioma. (tau.ac.il)
  • It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
  • Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
  • Vasculogenesis is the coalescence of new blood vessels from individual endothelial cells or progenitor cells. (hindawi.com)
  • This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
  • Vascular tumors are benign neoplasms, which result from proliferating endothelial cells. (nih.gov)
  • Carcinoma cells that have undergone an epithelial-mesenchymal transition differentiate into endothelial cells and contribute to tumor growth. (tamu.edu)
  • Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
  • The availability of an anti-androgen receptor (AR) monoclonal antibody has allowed the identification of both AR-positive and AR-negative neuroendocrine subpopulations in both benign and malignant tumors [5]. (cancernetwork.com)
  • Sarcoma is a rare type of cancer and typically produces malignant tumors derived from the connective tissue. (curesarcoma.org)
  • Liposarcomas are malignant tumors of the lipocytes ( fat cells ) and are not commonly found in pet birds. (ivis.org)
  • Cancer stem cells (CSCs) alone can initiate and maintain tumors, but the function of non-cancer stem cells (non-CSCs) that form the tumor bulk remains poorly understood. (tau.ac.il)
  • Furthermore, conditional silencing of FMOD in newly generated DGCs in vivo inhibits the growth of GSC-initiated tumors due to poorly developed vasculature and increases mouse survival. (tau.ac.il)
  • High grade or grade III tumor cells are poorly differentiated. (barnesjewish.org)
  • Cancer cells that don't look well-differentiated or poorly differentiated are called moderately differentiated, or grade II. (barnesjewish.org)
  • Waterfowl may develop tumors in areas that are poorly feathered, suggesting an association with exposure to sunlight. (ivis.org)
  • Most solid tumors including lung cancer cells are believed to contain poorly differentiated cancer stem-like cells (CSCs) that initiate tumorigenesis and confer resistance to chemotherapy. (cdc.gov)
  • Stem cell and differentiation markers were analyzed by immunoblotting and fluorescence-activated cell sorting. (knaw.nl)
  • a) Neural induction: neuroectoderm (neural dish) differentiation occurs consuming the AVE. The mesodermal cells begin. (biopaqc.com)
  • These factors cause the upregulation of many genes involved in cell proliferation, differentiation, migration and apoptosis (programmed cell death), causing the growth of benign tumors. (wikipedia.org)
  • Three human colon carcinoma cell lines with variable degrees of differentiation and a normal colon fibroblast cell line were used to generate a suitable in vitro model for investigation of photosensitizer concentration as well as the applied light dose. (bioone.org)
  • Recent studies have focused on neuroendocrine differentiation as a mechanism by which these tumors escape hormonal control [2-4]. (cancernetwork.com)
  • However, the proportion of neuroendocrine differentiation was found to be much higher in follow-up studies and it is now thought that 50% to 100% of all prostate neoplasms (including benign prostatic tissue) contain at least some neuroendocrine cells [3,5]. (cancernetwork.com)
  • Differentiation is the process by which cells lose their primitive, stem-cell-like properties that include the ability to grow and multiply, and instead develop specialized shapes and functions. (science20.com)
  • and it is generally not aggressive until the tumor cells sustain mutations that block differentiation. (science20.com)
  • Beyond the standard approach of using drugs that kill tumor cells, another promising strategy is to identify compounds that promote differentiation, which causes tumor cells to stop dividing and growing. (sciencedaily.com)
  • To address this need, Stegmaier and her team developed a method to screen small molecules for their ability to trigger differentiation in neuroblastoma cells. (sciencedaily.com)
  • First, they treated these cells with drugs known to induce differentiation and looked for accompanying changes in the activity levels of genes. (sciencedaily.com)
  • Using this genetic signature for differentiation, they then screened nearly 2,000 small molecules and identified one compound that strongly promoted differentiation in neuroblastoma cells, especially when combined with a drug already approved to treat this type of cancer. (sciencedaily.com)
  • Rhabdomyoblastic differentiation in a malignant peripheral nerve sheath tumor (MPNST) is termed malignant triton tumor (MTT), a rare neoplasm that poses a diagnostic dilemma in the differential diagnosis of neck masses and portends poor prognosis. (hindawi.com)
  • Tumors with skeletal muscle differentiation and malignant Schwann cells are classified as a subtype or a histologic variant of MPNST [ 9 , 10 ] and are referred to as malignant triton tumor (MTT) [ 11 ]. (hindawi.com)
  • Inducing de-differentiation by Xbp1s overexpression promotes tumor progression despite lower adiposity. (usda.gov)
  • Synovial sarcoma (SS) is a rare malignant soft tissue sarcoma that originates from primitive mesenchymal cells with epithelial differentiation potential. (bvsalud.org)
  • Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)
  • We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
  • Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
  • Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
  • Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
  • Specifically, they can reveal the tumor infiltration capacity (or incapacity) of drugs, as well as their inhibitory effects on metastasis. (moleculardevices.com)
  • Carcinoid tumors have high potential for metastasis. (medscape.com)
  • The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. (medscape.com)
  • The CSC theory is attractive because it offers an explanation for tumor heterogeneity, for the inefficiency of metastasis formation and for tumor regrowth after an apparently complete remission. (medscape.com)
  • LSCs have stem cell characteristics such as self-renewal capacity, quiescence and drug resistance, causing metastasis and relapse. (lu.se)
  • The term 'microinvasive carcinoma' is no longer recommended, and the term 'superficially invasive squamous cell carcinoma' (SISCCA) should be used instead. (cancer.org.au)
  • On the preclinical front, we are prioritizing the development of ADI-270 as our lead preclinical candidate in renal cell carcinoma and other solid tumor indications. (businesswire.com)
  • Adicet has reprioritized its preclinical pipeline to focus on the development of ADI-270 as its lead preclinical candidate for renal cell carcinoma, with potential in other solid tumor indications. (businesswire.com)
  • Although hormonal treatment is an important palliative measure in the management of patients with advanced prostate carcinoma, the vast majority of cases end in relapse due to overgrowth of androgen-independent tumor cell populations [1]. (cancernetwork.com)
  • O carcinoma de células escamosas foi o segundo tumor mais frequente (15% de todos os tumores). (scielo.br)
  • Surgical excision is the main treatment for patients with Hürthle cell carcinoma. (medscape.com)
  • thus, radioactive iodide treatment, which is the most useful nonsurgical therapy for recurrent well-differentiated thyroid carcinoma, is not always useful in patients with Hürthle cell carcinoma. (medscape.com)
  • Jillard et al reported that post-thyroidectomy 131 I therapy improves survival in patients with Hürthle cell carcinoma. (medscape.com)
  • [ 35 , 36 ] Retinoic acid therapy also may be considered in patients with Hürthle cell carcinoma that does not take up radioactive iodide, although this is not yet a standard form of therapy. (medscape.com)
  • Hürthle cell carcinoma is considered a radiosensitive tumor. (medscape.com)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
  • Nevoid basal cell carcinoma syndrome (Gorlin syndrome). (curesarcoma.org)
  • Squamous cell carcinoma. (cancer.net)
  • Black people are more likely to be diagnosed with squamous cell carcinoma. (cancer.net)
  • Angiosarcoma is rare, accounting for less than 2% of all soft-tissue sarcomas, and may vary from highly differentiated tumors to those with significant anaplasia, often making these tumors difficult to differentiate from melanoma or carcinoma. (medscape.com)
  • Homogeneity on sonography is associated with the pure type of mucinous carcinoma of the breast, in which margins are usually well defined, and the tumor is isoechoic relative to the fat surrounding the breast tissue on ultrasound. (radiopaedia.org)
  • PET-CT may help to differentiate pure from mixed mucinous carcinoma and to evaluate the aggressiveness of the tumor. (radiopaedia.org)
  • To explain the origin of occult carcinoma in situ cells, 2 models have been proposed. (medscape.com)
  • Lip squamous cell carcinoma is a malignant lesion of aggressive behavior, which must be recognized by health professionals to prevent damage to patient's health. (bvsalud.org)
  • To present incisional biopsy importance as an effective clinical approach for the diagnosis of lip squamous cell carcinoma and actinic cheilitis malignancy as well as the professional's lack of knowledge on these two diseases. (bvsalud.org)
  • This procedure confirmed the diagnosis of lip squamous cell carcinoma. (bvsalud.org)
  • The physician and dentist must be aware of the main clinical features of lip squamous cell carcinoma so that they can establish its correct diagnosis and early treatment. (bvsalud.org)
  • This malign neoplasia's synonyms are squamous cells carcinoma, squamous-cellular carcinoma and spinous cellular carcinoma. (bvsalud.org)
  • A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
  • We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
  • Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)
  • Histologic evaluation of tumor angiogenesis by using various markers such as MVD, MVCP, and TVA is also limited by this regional heterogeneity, and its confounding effect is worsened by its small size and a limited number of samples obtained with surgical biopsy. (ajnr.org)
  • In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
  • Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
  • These observations stimulated an intensive search for the mechanisms regulating tumor angiogenesis. (hindawi.com)
  • Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
  • In cancer, the development of blood vessels can feed tumors and allow them to grow, and drugs that block angiogenesis are being tested as cancer treatment. (ucsfhealth.org)
  • If the horizontal interneuron cell division was allowed to proceed unchecked, highly differentiated tumors formed that resembled normal horizontal neurons. (science20.com)
  • After irradiation, cell lines with cytosolic or mitochondrial PPIX localization indicate a loss of mitochondrial transmembrane potential resulting in growth arrest, whereas membrane-bound PPIX induces a loss of membrane integrity and consequent necrosis. (bioone.org)
  • 3 Most gliomas, especially high-grade ones, show a high degree of regional heterogeneity within the tumor based on tumor cellularity, edema, and necrosis. (ajnr.org)
  • The determination is used in the assessment of the activity of acute and recurring inflammations as well as of tumors with cell necrosis (Schmid, 1975). (cdc.gov)
  • In vitro, ivacaftor does not alter LPS-induced CD80 and tumor necrosis factor alpha mRNA increases in BV2 microglial cells, while augmenting mRNA levels of these markers in mouse macrophages and differentiated human THP-1-derived macrophages. (lu.se)
  • Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer , with subsequent spontaneous necrosis of the primary tumour. (medscape.com)
  • Prognosis --Several studies have demonstrated that a large proportion of neuroendocrine differentiated prostatic neoplasms are positive for neuron-specific enolase and chromogranin A [4,6]. (cancernetwork.com)
  • Similarly, serum bombesin levels appear to be a useful prognostic tool in cases of neuroendocrine differentiated disease. (cancernetwork.com)
  • These include small cell neuroendocrine cancers , lymphomas , and sarcoma and make up less than 1% of esophageal cancers. (cancer.net)
  • These tumors are generally considered benign and have to be differentiated from other neuroendocrine tumors. (nepjol.info)
  • Although interspecies distinctions in cell-type particular factors exist, eventually and pursuing implantation and gastrulation, 3 specific germ levels emerge: endoderm (which forms the liner of organs), mesoderm (gives rise to bone tissue, muscle tissue, and vasculature), and ectoderm (that results the anxious system and epidermis). (biopaqc.com)
  • Combined AFP and β-hCG testing is an essential adjunct in the evaluation and treatment of nonseminomatous germ cell tumors, and in monitoring the response to therapy. (aafp.org)
  • Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
  • Literature suggests that the only known risk factor for extragonadal germ cell tumors (EGCTs) is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors. (medscape.com)
  • In extragonadal germ cell tumors, no evidence of a primary malignancy is present in either the testes or ovaries by radiologic imaging or physical examination. (medscape.com)
  • Extragonadal germ cell tumors produce a rich symptomatology and may reach large volumes if they arise in silent areas. (medscape.com)
  • Controversy remains regarding the origin of extragonadal germ cell tumors (EGGCTs). (medscape.com)
  • The classic theory suggests that germ cell tumors (GCTs) in these areas are derived from local transformation of primordial germ cells misplaced during embryogenesis. (medscape.com)
  • According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal germ cell tumors may be explained by differences in the cellular environment between the gonad and the anterior mediastinum. (medscape.com)
  • During this stage of germ cell development, aberrant chromatid exchange events associated with crossing over can occur. (medscape.com)
  • Malignant transformation of germ cells is the result of a multistep process of genetic changes. (medscape.com)
  • Hematologic malignancies are frequently associated with mediastinal germ cell tumors. (medscape.com)
  • Highly differentiated yolk-sac tumors make up 30% of mediastinal germ cell tumors, providing a possible basis for this association. (medscape.com)
  • The balance of the p53-mdm2 interaction has been shown to be disrupted in intracranial germ cell tumors (ICGCTs). (medscape.com)
  • Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in France. (who.int)
  • Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden. (who.int)
  • Melanoma tumour cells exhibit pronounced heterogeneity within a single tumour, amongst concurrent tumours within the same patient and amongst tumours from different patients. (nature.com)
  • Circulating tumour cells (CTCs), which are responsible for haematogenous spread of tumours, also reflect this heterogeneity. (nature.com)
  • They express markers of less differentiated cone together with neuronal/ganglion cell markers with marked inter- and intra-tumor heterogeneity. (nih.gov)
  • The CSC is defined as a cancer cell with self-renewing capacity that can regenerate the original tumor in all its differentiated heterogeneity. (medscape.com)
  • Delineate the heterogeneity of human hematopietic stem cell (HSC) populations at different ontogenetic stages and identify novel markers for improved HSC isolation. (lu.se)
  • BACKGROUND & AIMS: Stem cells of normal tissues have resistance mechanisms that allow them to survive genotoxic insults. (knaw.nl)
  • Benign tumor growth causes a mass effect that can compress neighboring tissues. (wikipedia.org)
  • We investigated the expression of immune checkpoints (ICs) on lymphoid populations within the CRC TME and compared with cells from normal colon tissues using samples from 50 patients with varying disease stages. (mdpi.com)
  • Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
  • The cells release those granules into the tissues to destroy the "invader. (dogsnaturallymagazine.com)
  • The cells do not invade the deeper tissues. (barnesjewish.org)
  • Spheroids are three-dimensional (3D) cell aggregates that can mimic tissues and microtumors. (moleculardevices.com)
  • Normal proliferative tissues contain multipotent stem cells (SCs) that drive tissue turnover. (medscape.com)
  • According to the cancer stem cell (CSC) concept, the cellular hierarchy in normal tissues is preserved in a number of hematological and solid malignancies. (medscape.com)
  • Tumors, like the tissues from which they originate, contain a unique SC population that is capable of self-renewal and of sustaining tumor growth indefinitely. (medscape.com)
  • CD56 is a sensitive marker of ovarian sex cord-stromal tumors and may also be useful in the diagnosis of this group of neoplasms, especially in cases that are inhibin or calretinin negative, and the differential diagnosis includes neoplasms that are CD56 negative. (medscape.com)
  • Although modern imaging techniques such as color Doppler sonography, helical or multidetector-row CT, and MRI have substantially improved the potential to image Wilms tumors, definitive diagnosis is still based on histology. (medscape.com)
  • Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
  • If you suspect a mast cell tumor, take your dog to the vet for diagnosis so that you can decide on the best treatment option. (dogsnaturallymagazine.com)
  • The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
  • Part of the problem was that the tumor appeared normal on an ultrasound a year before my diagnosis and given my age, my doctors though the mass was benign. (breastcancer.org)
  • Cytologic testing may not differentiate between a liposarcoma and a lipoma, so a surgical biopsy is recommended for diagnosis. (ivis.org)
  • Due to their vague and intermittent symptoms, diagnosis of carcinoid tumors may be delayed, especially in children, in whom the tumor is rare and the diagnosis is unexpected. (medscape.com)
  • Laboratory diagnosis of carcinoid tumors depends on the identification of the characteristic biomarkers of the disease. (medscape.com)
  • We have extended these findings to show that β1 integrin as well as CD47 are also expressed at lower levels in normal versus tumor cells, and that solid and hematologic tumor cells overexpress both CD47 and β1 integrin which correlate with poor prognosis in cancer. (bmj.com)
  • Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. (ajnr.org)
  • Perfusion imaging has been used to assess tumor grade and prognosis and, recently, to assess treatment response, which has attracted more attention due to the advent of newer therapeutic options, including antiangiogenic agents. (ajnr.org)
  • Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue neoplasm with a poor prognosis. (hindawi.com)
  • A benign tumor is a mass of cells (tumor) that does not invade neighboring tissue or metastasize (spread throughout the body). (wikipedia.org)
  • The health effects of benign tumor growth may be more prominent if the tumor is contained within an enclosed space such as the cranium, respiratory tract, sinus, or bones. (wikipedia.org)
  • A benign tumor made up of glandular tissue. (ucsfhealth.org)
  • A benign tumor means the tumor can grow but will not spread. (cancer.net)
  • Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
  • A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
  • In vivo perfusion imaging techniques provide additional information regarding tumor physiology and hemodynamics, which may help in better characterizing glioma malignancy and may also overcome some of the limitations of histologic grading and conventional morphologic imaging. (ajnr.org)
  • [ 1 ] Interestingly, according to Lydiatt et al, the histologic appearance and clinical behavior in postirradiation tumors do not appear significantly different from those in tumors arising de novo. (medscape.com)
  • Furthermore, even when standardized treatment is used and tumors are at the same stage and have similar histologic features, it is difficult to predict the outcome. (cdc.gov)
  • [ 2 ] In addition, some tumor types do not appear to adhere to the CSC concept at all [ 3 , 4 ] or may have multiple independent tumor-initiating cell populations. (medscape.com)
  • Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
  • However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)
  • To track differentiating cell populations, reporter cell lines generated by homologous recombination (knock-in) or via BAC transgenes have been widely used in mouse cells (5-8 ). (lu.se)
  • The objective of our research is to molecularly dissect known stem cell populations in order to discriminate between normal and malignant stem cells. (lu.se)
  • Prospective isolation of human HSCs is in its infancy and current views of the molecular ground state driving HSCs and how it is altered in leukemia is based on studies of heterogeneous populations where HSC and LSC molecular signatures are masked by contaminating cells. (lu.se)
  • Radiation therapy may provide palliative relief from symptomatic metastases, control recurrent tumors, and prevent recurrence of advanced resected tumors. (medscape.com)
  • Signs and symptoms of carcinoid tumors vary greatly and depend on the tumor location and size as well as on the presence of metastases. (medscape.com)
  • There are various different types of soft tissue sarcoma, and depending on the type of soft tissue the cancer started in, the cells will look different under a microscope. (curesarcoma.org)
  • This is a very common type of sarcoma, and is derived from the fat cells (adipocytes) of the body and, while it can occur anywhere, it is most frequent deep in the body near the kidneys (retroperitoneum), pelvis, and groin. (curesarcoma.org)
  • [ 5 ] According to Aust et al, less than 5% of soft-tumor sarcoma occurs in the head and neck, with only approximately 10% being angiosarcoma. (medscape.com)
  • Synovial sarcoma is a soft tissue tumor of uncertain origin. (bvsalud.org)
  • INTRODUCTION: Synovial sarcoma is an unusual tumor with an incidence of 1-3 cases per million. (bvsalud.org)
  • Introducción: El sarcoma sinovial es un tumor raro (incidencia de 1-3 casos por millón). (bvsalud.org)
  • Many types of benign tumors have the potential to become cancerous (malignant) through a process known as tumor progression. (wikipedia.org)
  • Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
  • There are other types of very rare tumors of the esophagus. (cancer.net)
  • Extragonadal germinal cell syndromes are rare tumors that predominantly affect young males. (medscape.com)
  • The latter are histologically similar to small cell or carcinoid tumors. (cancernetwork.com)
  • Distribution of carcinoid tumors. (medscape.com)
  • Findings range from no tumor-related symptoms (most carcinoid tumors) to full symptoms of carcinoid syndrome (primarily in adults). (medscape.com)
  • The etiology of carcinoid tumors is not known, but genetic abnormalities are suspected. (medscape.com)
  • If feasible, the treatment of choice for carcinoid tumors is surgical excision. (medscape.com)
  • The innate cell engager AFM24 showed greater efficacy in eliciting antibody-dependent cellular phagocytosis of EGFR wild-type and KRAS-mutant tumor cells compared with cetuximab. (onclive.com)
  • The innate cell engager ® (ICE) AFM24 showed greater efficacy in eliciting antibody-dependent cellular phagocytosis of EGFR wild-type and KRAS -mutant tumor cells compared with cetuximab (Erbitux), according to preclinical findings from a study presented in a poster during the 2021 SITC Annual Meeting . (onclive.com)
  • AFM24 enhances macrophage-mediated antibody-dependent cellular phagocytosis of various EGFR-expressing tumor cell lines, irrespective of the EGFR signaling pathway," wrote lead study author Sheena Pinto, PhD, translational project leader at Affimed, and coauthors, in the poster. (onclive.com)
  • However, AFM24 engages CD16A on NK cells and macrophages with a higher affinity than monoclonal antibodies, causing NK cell-mediated antibody-dependent cellular cytotoxicity and macrophage-mediated antibody-dependent cellular phagocytosis. (onclive.com)
  • In this analysis, investigators evaluated the ability of AFM24 to elicit antibody-dependent cellular phagocytosis in solid tumor cell lines expressing EGFR wild-type or EGFR signaling pathway mutations. (onclive.com)
  • Additional results showed that AFM24 increased antibody-dependent cellular phagocytosis of EGFR -positive tumor cells regardless of macrophage subtype. (onclive.com)
  • Analyze cancer cells - Use cellular imaging analysis software to run quantitative analysis of the cell images to monitor the expression of different markers and to quantify biological readouts. (moleculardevices.com)
  • Similarly to normal hematopoiesis, leukemias are organized in cellular hierarchies where leukemic stem cells (LSCs) drive the tumor growth. (lu.se)
  • When compared with other malignant breast tumors, they show lower signal intensity on DWI and increased ADC values. (radiopaedia.org)
  • High-grade gliomas can be highly invasive and extremely vascular tumors. (ajnr.org)
  • Vascular tumors should be differentiated from vascular malformations, which present at birth, have a quiescent endothelium, and grow in proportion to the child. (nih.gov)
  • Together, vascular tumors and malformations comprise the field of vascular anomalies. (nih.gov)
  • I had a hard time finding information about mucinous tumors as well but google has been good to me. (breastcancer.org)
  • DGCs silenced for FMOD fail to cooperate with co-implanted GSCs to promote tumor growth. (tau.ac.il)
  • In monitoring patients for disease recurrence, tumor marker levels should be determined only when there is a potential for meaningful treatment. (aafp.org)
  • Anti-cancer drugs used in combination with surgery and/or radiation to destroy residual cancer cells to prevent or delay recurrence. (ucsfhealth.org)
  • Tumor in these nodes portends a high risk of recurrence. (ucsfhealth.org)
  • Curing cancer requires eliminating all cells capable of causing cancer recurrence in a person's lifetime. (msdmanuals.com)
  • Vascular tissue tumors can bleed, in some cases leading to anemia. (wikipedia.org)
  • In mammary gland development, Notch-dependent heterotypic signaling between resident tissue macrophages and mammary stem cells supports survival and function of the normal mammary stem cell 20 . (nature.com)
  • 3 - 5 However, PCT, which has also been used recently for glioma grading, 6 , 7 provides a linear relationship between tissue attenuation and tissue concentration of a contrast agent, unlike perfusion MR imaging, and, hence, probably provides a more robust and less biased estimation of hemodynamic (tumor blood volume) and physiologic (tumor vascular leakiness) parameters. (ajnr.org)
  • The current standard for tumor grading is histopathologic assessment of tissue, which has inherent limitations, such as sampling error, interobserver variation, and a wide variety of classification systems that are available, the most common of which is the WHO grading system. (ajnr.org)
  • ADI-270 has demonstrated a highly differentiated profile stemming from its unique engineering, including targeting via a CAR that incorporates CD27, addition of dominant negative TGF beta receptor armoring, complimentary innate anti-tumor activity of the gamma delta 1 T cells and tissue tropism to solid tumors. (businesswire.com)
  • This means that the tumor cells are organized and look more like normal tissue. (barnesjewish.org)
  • T describes the original tumor and how deep into nearby tissue it has spread. (barnesjewish.org)
  • The reintroduction of cells, tissue or organ previously removed from an individual, back into the same individual with continued function after reintroduction. (ucsfhealth.org)
  • A layer of cells that separate the epithelial cells and other tissue cells. (ucsfhealth.org)
  • The removal of a sample of abnormal tissue that is microscopically examined for cancer cells. (ucsfhealth.org)
  • The second explanation was more plausible, where neoplastic Schwann cells can transform into rhabdomyoblasts, suggesting the possibility of some mesenchymal tissue derivation from neuroectodermal cells. (hindawi.com)
  • In recent years, there has been significant progress in development of in vitro aggregates of tumor cells for use as models for in vivo tissue environments. (moleculardevices.com)
  • We are able to see cells in the center of the spheroid at this depth due to our specialized deep-tissue penetrating, confocal disk module. (moleculardevices.com)
  • In this paper, we discovered that certain fat cells change their identity when breast cancer spreads into the fat tissue. (usda.gov)
  • Rita, Oligodendrogiloma, These tumors arise from oligodendrocytes, a type of supportive brain tissue. (cancer.org)
  • Our results suggest that ivacaftor promotes contrasting effects depending on target tissue post-MI, which may be largely dependent on its effects on different myeloid cell types. (lu.se)
  • Normal multipotent tissue stem cells (SCs) are the driving force behind tissue turnover and repair. (medscape.com)
  • By contrast, transit amplifying cells and differentiated cells are incapable of self-renewal and tissue regeneration. (medscape.com)
  • Use of human fetal tissue raises several ethical issues, but are there alternative cell sources that can substitute effectively? (lu.se)
  • Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)
  • In addition, we show that AO-176 is able to bind and occupy CD47/β1 integrin complexes to a greater extent at acidic versus physiologic pH such as would be found in tumor microenvironments, an observation that also contributes to the enhanced targeting of AO-176 to tumor cells. (bmj.com)
  • Most patients with cancer have non-inflamed tumor microenvironments that do not respond to checkpoint inhibitors. (biospace.com)
  • Imaging and analysis of spheroids are crucial to understanding the formation and behavior of tumor microenvironments. (moleculardevices.com)
  • Von Hippel-Lindau disease is a dominantly inherited cancer syndrome that significantly increases the risk of various tumors. (wikipedia.org)
  • Mechanistically, stemness is induced in non-stem cancer cells upon their direct contact with macrophages via Notch-Jagged signaling. (nature.com)
  • In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
  • 90% of cancer-related deaths, is a multi-step process involving cancer cell intravasation into the bloodstream, dissemination to distant sites, and seeding in new organs 1 . (nature.com)
  • At the apex of the hierarchy are the cancer stem cells (CSCs). (nature.com)
  • Because family physicians are assuming a greater role in caring for patients with cancer, an understanding of tumor markers is becoming increasingly important. (aafp.org)
  • Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)
  • REDWOOD CITY, Calif. & BOSTON--( BUSINESS WIRE )--Adicet Bio, Inc. (Nasdaq: ACET), a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer, today reported financial results and operational highlights for the third quarter ended September 30, 2023. (businesswire.com)
  • The grade of a cancer describes what the cancer cells look like using a microscope. (barnesjewish.org)
  • In general, cancer cells are graded using the scale below. (barnesjewish.org)
  • Each type of cancer tumor has its own, often complex, staging system. (barnesjewish.org)
  • These cells may become cancer over time, so it's good to find and treat them before that happens. (barnesjewish.org)
  • Stage I . Cancer is only in the cells where it first started, and the area is small. (barnesjewish.org)
  • The cancer cells in the liver look like the cancer cells in the colon and are treated like colon cancer. (barnesjewish.org)
  • Higher numbers usually mean more extensive disease, larger tumor size, or spread of the cancer beyond the organ where it first developed. (barnesjewish.org)
  • I also read that this type of cancer is slow growing (1/3 the growth rate of regular IDC) and doesn't tend to spread but they did find a few cancer cells in one lymph node. (breastcancer.org)
  • Abnormal amount of DNA in a cell, can correlate with a worse cancer. (ucsfhealth.org)
  • Investigators at St. Jude Children's Research Hospital have identified the cell that gives rise to the eye cancer retinoblastoma, disproving a long-standing principle of nerve growth and development. (science20.com)
  • The discovery that fully differentiated horizontal interneurons can multiply to form retinoblastoma also challenges the established scientific belief that cancer cells are most aggressive when they are undifferentiated, Dyer said. (science20.com)
  • On the contrary, we showed that when certain genes are inactivated in the retina, horizontal neurons that are already differentiated and fully integrated into the brain can start multiplying rapidly and produce a very aggressive cancer," Dyer said. (science20.com)
  • Nearly two-thirds of patients with high-risk neuroblastoma -- a common tumor that forms in the nerve cells of children -- cannot be cured using tumor-killing cancer drugs. (sciencedaily.com)
  • A new study reveals a new genomic approach to screen for compounds that inhibit tumor growth by causing cancer cells to differentiate. (sciencedaily.com)
  • A study published by Cell Press in the May 23 issue of Chemistry & Biology reveals a new genomic approach to screen for compounds that could inhibit tumor growth by causing cancer cells to differentiate, or convert from immature cells to more specialized cell types. (sciencedaily.com)
  • One of the most significant objectives in cancer research is to understand tumor cell formation. (moleculardevices.com)
  • Culture spheroids - Cancer cells can be cultured directly in an ultra-low attachment (ULA), round bottom plate, or other labware to develop the typical morphology of a spheroid. (moleculardevices.com)
  • Cancer begins when healthy cells change and grow out of control, forming a mass called a tumor. (cancer.net)
  • Esophageal cancer, also called esophagus cancer, begins in the cells that line the esophagus. (cancer.net)
  • This type of esophageal cancer starts in squamous cells that line the esophagus. (cancer.net)
  • These transformed cells possess different metabolic states, act differently, and help the cancer cells grow. (usda.gov)
  • But, when we change the metabolism of these cells, we can slow down the growth of the breast cancer cells in our animal study. (usda.gov)
  • Additional studies are needed to better the association between fat and cancer cells. (usda.gov)
  • Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis. (cancerindex.org)
  • We investigated the homing-related chemokine expression levels of MSCs treated with a prostate cancer cell line (PC-3) -conditioned medium. (cancerindex.org)
  • This reprogramming process has also been reported in intestinal cancer cells. (genengnews.com)
  • Anaplastic oligodendrogliomas grow more quickly, and the cancer cells look very different from normal cells. (cancer.org)
  • At pathological examination, the dominant feature is the presence of mucin within and surrounding cancer cells. (radiopaedia.org)
  • Microscopically, it is formed by large mucin lakes surrounded by mucus-producing cancer cells. (radiopaedia.org)
  • An aberrant activation of the biological process, termed epithelial-mesenchymal transition (EMT) plays an important role for the acquisition of malignant phenotypes as well as cancer stem cells (CSC) properties by epithelial cancer cells. (tamu.edu)
  • The Cytotoxicity of Carbon Nanotubes and Hydroxyapatite, and Graphene and Hydroxyapatite Nanocomposites against Breast Cancer Cells. (tamu.edu)
  • Multifaceted entrancing role of glucose and its analogue, 2-deoxy-D-glucose in cancer cell proliferation, inflammation, and virus infection. (tamu.edu)
  • Induction of lung cancer stem-like cells by chronic exposure to carbon nanotube s. (cdc.gov)
  • Similar to human non-small cell lung cancer H460 cells, SWCNT-transformed lung epithelial BEAS-2B cells but not its passage-matched control cells formed tumor spheres in stem cell-selective conditions, indicating the existence of lung CSCs. (cdc.gov)
  • Lung CSCs have previously been reported to reside in the side population (SP) of parental lung cancer cells. (cdc.gov)
  • The introduction of HPV vaccines has also drawn more attention to the fact that HPV is associated not only with cervical cancer and genital warts but also with other tumors, such as head neck and anogenital cancers ( 3 ). (cdc.gov)
  • Cancer stem cell-associated proteins revealed by proteomics. (medscape.com)
  • La présente étude transversale a été menée auprès de 138 enfants atteints de cancer et traités dans l'Unité d'oncologie pédiatrique du Centre d'oncologie de l'Université de Mansoura, en Égypte. (who.int)
  • En revanche, les patients de moins de cinq ans et ceux avec un diagnostic de cancer provisoire posé initialement bénéficiaient du délai total médian le plus court. (who.int)
  • Nous suggérons de mettre en place des programmes de formation médicale continue, d'améliorer l'accès aux services de diagnostic, et de faciliter l'orientation-recours de façon à donner la priorité aux patients suspects de cancer et ainsi raccourcir le délai de diagnostic. (who.int)
  • Although various markers have been reported to stain sex cord-stromal tumors (eg, CD99, CD56, A103, müllerian inhibiting factor, vimentin), inhibin and calretinin have proven to be the most helpful to date. (medscape.com)
  • These tumor markers are most useful for monitoring response to therapy and detecting early relapse. (aafp.org)
  • With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
  • This article describes the use of common tumor markers in primary care practice. (aafp.org)
  • Nevertheless, tumor markers can play a crucial role in detecting disease and assessing response to therapy in selected groups of patients. (aafp.org)
  • The heterogeneous expression of markers, together with their rare frequency (1-10 CTCs in 8 mL of blood) are the main intrinsic factors hampering CTC isolation and limiting in-depth study of these cells in patients with melanoma. (nature.com)
  • It harbors few genetic alterations other than the initiating RB1 inactivation and corresponds to differentiated tumors expressing mature cone markers. (nih.gov)
  • The recognition of these two subtypes, one maintaining a cone-differentiated state, and the other, more aggressive, associated with cone dedifferentiation and expression of neuronal markers, opens up important biological and clinical perspectives for retinoblastomas. (nih.gov)
  • By contrast, subtype 2 tumors harbor frequent recurrent genetic alterations including MYCN-amplification. (nih.gov)
  • Recurrent tumors can be treated with a second surgury ratiation and chemo or biologic therapy. (cancer.org)
  • Binding of tumor CD47 to SIRPα on macrophages and dendritic cells triggers a 'don't eat me' signal that inhibits phagocytosis and allows escape from innate immune surveillance. (bmj.com)
  • The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
  • ICE is a bispecific engager of CD16A+ natural killer (NK) cells and macrophages and tumor antigens. (onclive.com)
  • To do so, monocyte-differentiated macrophages from healthy donor peripheral blood mononuclear cells were co-cultured for 4 hours with CMFDA-labeled, wild-type EGFR-expressing or KRAS -mutant tumor cells in the presence of 10 µg/mL of AFM24 or cetuximab. (onclive.com)
  • M0, M1, or M2 macrophages were co-cultured with CMFDA-labeled tumor cells in the presence of increasing concentrations of AFM24. (onclive.com)
  • Finally, M0 macrophages were co-cultured with pHRodo™-labeled tumor cells in the presence of 10 µg/mL of AFM24 or cetuximab. (onclive.com)
  • Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
  • Photodynamic therapy (PDT) is a new treatment modality for solid tumors as well as for flat lesions of the gastrointestinal tract. (bioone.org)
  • It has been estimated that 10% of these tumors are extensively or fully differentiated. (cancernetwork.com)
  • The St. Jude researchers showed that when the mouse retina had reduced Rb family function, fully differentiated horizontal neurons could multiply while retaining all of the differentiated features of normal horizontal neurons. (science20.com)
  • Compared to malignant (cancerous) tumors, benign tumors generally have a slower growth rate. (wikipedia.org)
  • This leads to the activation of genes and the production of proteins that increase cell growth. (wikipedia.org)
  • In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
  • In contrast, promoting lipid-storage capacity in adipocytes through MitoNEET overexpression curbs tumor growth despite greater adiposity. (usda.gov)
  • Park, B.H. Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells. (hopkinsmedicine.org)
  • The first suggests that fetal gonocytes whose development into spermatogonia is blocked may undergo abnormal cell division and then invasive growth mediated by postnatal and pubertal gonadotrophin stimulation. (medscape.com)
  • A. Tumor grossly limited to the true pelvis with negative nodes but with histologically confirmed microscopic seeding of abdominal peritoneal surfaces. (medscape.com)
  • B. Tumor of one or both ovaries with histologically confirmed implants of abdominal peritoneal surfaces, none exceeding 2 cm in diameter. (medscape.com)
  • If a Wilms tumor is suspected or if the primary tumor is histologically confirmed, it should be staged by using CT or MRI. (medscape.com)
  • Background Overexpression of CD47 by tumor cells exploits an immune checkpoint preventing tumor recognition and destruction by innate immune cells. (bmj.com)
  • The induction of the dedifferentiation occurs only when two hits occur in the same cell: either H-Ras overexpression and loss of p53 or loss of tumor suppressors NF1 and p53. (genengnews.com)
  • In occasional cells, this crossing over may lead to increased 12p copy number and overexpression of cyclin D2. (medscape.com)
  • For the past 100 years, it's been ingrained among scientists that differentiated mature nerves are so elaborate that they can't divide, and if they try to divide, they undergo apoptosis," Michael Dyer, Ph.D., an associate member in the St. Jude Department of Developmental Neurobiology, said. (science20.com)
  • This is the first time that anyone has shown that under certain conditions, a fully mature and differentiated nerve can undergo cell division and multiply. (science20.com)
  • The prelimanary thoughts from the drs are to undergo radiation to shrink the tumor. (cancer.org)
  • Hence, there is a need for noninvasive in vivo clinical imaging tools that can study perfusion in the entire tumor, can be used to assess much larger volumes than small biopsy samples, and can probably guide biopsy and excision sites for better results. (ajnr.org)
  • Sensitivity to irinotecan was assessed in vitro and in tumor-bearing mice. (knaw.nl)
  • Tumorigenic ALDHhigh/ABCB1negative cells generated nontumorigenic ALDHlow/ABCB1positive daughter cells in vitro and in tumor xenografts. (knaw.nl)
  • Subsequent studies described a VEGFR2 and AC133 expressing subpopulation of these CD34 positive circulating cells that could form endothelial colonies in vitro [ 14 , 15 ]. (hindawi.com)
  • We studied the relationship between resistance to the topoisomerase I inhibitor irinotecan and tumor-initiating potential in human colonosphere cultures and in mice with colorectal xenograft tumors. (knaw.nl)
  • Clone- and tumor-initiating capacities were assessed by single-cell cloning and in immune-deficient mice. (knaw.nl)
  • RESULTS: Colonosphere cultures had a high capacity to initiate tumors in mice and were resistant to irinotecan. (knaw.nl)
  • Here, we employ high-resolution intravital microscopy using a CSC biosensor to directly observe CSCs in live mice with mammary tumors. (nature.com)
  • Nov. 9, 2022 Researchers have found a new theranostic compound that effectively shrinks prostate tumor in mice. (sciencedaily.com)
  • The tumor phenotype in mice takes eight weeks to develop from the H-Ras and shp53 model. (genengnews.com)
  • The tumor phenotype is revealed when mice appear lethargic and have an enlarged head. (genengnews.com)
  • Systemically, ivacaftor leads to higher frequencies of circulating Ly6C + and Ly6C hi cells compared to vehicle-treated MI mice. (lu.se)
  • I also describe the development of a novel behavioural task that is predictive of mesDA neuron cell loss in mice. (lu.se)
  • Sex cord-stromal tumors are groups of tumors composed of granulosa cells, theca cells, Sertoli cells, Leydig cells, and fibroblasts of stromal origin, singly or in various combinations. (medscape.com)
  • [ 1 ] sex cord-stromal tumors are classified into the following categories. (medscape.com)
  • Sex cord-stromal tumors account for approximately 8% of all ovarian tumors. (medscape.com)
  • MRI diffusion studies have been shown to help differentiate Wilms tumor from neuroblastoma, with the apparent diffusion coefficient (ADC) being substantially higher for Wilms tumor. (medscape.com)
  • Using this screening method, the researchers identified a compound that causes neuroblastoma cells to differentiate, uncovering promising new treatment strategies. (sciencedaily.com)
  • By focusing on an alternative strategy to treating neuroblastoma tumors, we identified a compound class that in early testing in neuroblastoma cells in the laboratory shows promise for treating children with this disease. (sciencedaily.com)
  • Well-differentiated tumor cells showed higher toxicity than less-differentiated cells. (bioone.org)
  • Dinorah Friedmann-Morvinski, a post-doctoral fellow in Inder Verma's lab at the Salk Institute, has shown how tumors originated from mature neurons dedifferentiate into glioma stem-like progenitor cells. (genengnews.com)
  • We provide detailed protocols for the generation of lentiviral vectors, the transduction of hES-cells, and their differentia- tion into neurons. (lu.se)
  • CRT aims to replace neurons that have degenerated in PD, with donor cells that have the potential to functionally re-integrate into the host circuitry. (lu.se)
  • This involves transplantation of developing midbrain cells from aborted fetuses, (the part that form mesDA neurons), into the striatum of a PD patient. (lu.se)
  • A potentially pre-clinical aspect of this thesis is detailed in paper №4 where I describe a robust protocol for the generation of functional mesDA neurons from human embryonic stem cells that are functional in a rat model of PD. (lu.se)
  • LSIL is the morphologic expression of acute HPV infection and is characterised by cells with increased nuclear to cytoplasmic ratios and irregular nuclear membranes. (cancer.org.au)
  • Angiosarcoma is a vascular tumor, the cells of which manifest many of the morphologic and functional properties of normal epithelium. (medscape.com)
  • 13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
  • The production of blood cells, hematopoiesis, is maintained by a small number of hematopoietic stem cells (HSCs) that have the capacity to differentiate into all hematopoietic lineages, and at the same time self-renew to maintain the HSC pool. (lu.se)
  • Conversely, tumor-initiating cells were ABCB1-negative and were identified by high ALDH activity. (knaw.nl)
  • Conversely, tumor marker levels may rise after effective treatment (possibly related to cell lysis), but the increase may not portend treatment failure. (aafp.org)
  • PTEN hamartoma syndrome encompasses hamartomatous disorders characterized by genetic mutations in the PTEN tumor suppressor gene, including Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, Proteus syndrome and Proteus-like syndrome. (wikipedia.org)
  • The APC gene is a tumor suppressor. (wikipedia.org)
  • This protein activates two transcription factors: T-cell factor (TCF) and lymphoid enhancer factor (LEF). (wikipedia.org)
  • CMP-001 is a differentiated TLR9 agonist that activates a tumor-specific T cell response. (biospace.com)
  • Amplification of CCND2 activates cdk4/6, allowing the cell to progress through the G1-S checkpoint. (medscape.com)
  • It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. (cancerindex.org)
  • Our previous studies have shown that chronic exposure to single-walled carbon nanotube s (SWCNTs) induces malignant transformation of human lung epithelial cells. (cdc.gov)
  • In this study we investigated whether SWCNT-transformed lung epithelial cells present CSC traits. (cdc.gov)
  • Together, our results indicate the ability of SWCNT to transform human lung epithelial cells and induce CSCs which could represent a novel mechanism of carcinogenesis induced by CNTs. (cdc.gov)
  • Here we compared two microfluidic devices for the recovery of circulating melanoma cells. (nature.com)
  • In this study, we compared the recovery and purity of melanoma cells isolated through different microfluidic devices, Parsortix (Angle plc, Surrey, United Kingdom) and ClearCell® FX1 system (Biolidics, Singapore), which enrich CTCs based on their differential cell size, density and deformability. (nature.com)
  • The melanoma cell lines A2058 and SK-MEL-5 were used in spiking experiments due to their differential cell size. (nature.com)
  • When combined with checkpoint inhibitors, CMP-001 can induce deep and durable systemic anti-tumor responses," said Dr. Art Krieg, Checkmate's Founder and CSO. (biospace.com)
  • Proteomic analysis showed a higher abundance of the extracellular matrix small leucine-rich proteoglycan fibro-modulin (FMOD) in the conditioned medium of differentiated glioma cells (DGCs), the equivalent of glioma non-CSCs, compared to that of glioma stem-like cells (GSCs). (tau.ac.il)