Differentiate into multiple cell types. Medical search. Frequent questions

Here, we report that adipocytes from tumor-invasive mammary fat undergo de-differentiation to fibroblast-like precursor cells during tumor progression and integrate into the tumor microenvironment. (usda.gov)
Single-cell sequencing reveals that these de-differentiated adipocytes lose their original identities and transform into multiple cell types, including myofibroblast- and macrophage-like cells, with their characteristic features involved in immune response, inflammation, and extracellular matrix remodeling. (usda.gov)
Collectively, the metabolic interplay between tumor cells and adipocytes induces adipocyte mesenchymal transition and contributes to reconfigure the stroma into a more tumor-friendly microenvironment. (usda.gov)
Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)
Most importantly stem cells possess the ability to differentiate into cell types of multiple lineages including adipocytes, chrondrocytes, and osteocytes. (vin.com)
Recently, a number of studies have confirmed that ADSCs possess the ability to differentiate into adipocytes, osteoblasts, and chondrocytes [ 16 - 18 ], suggesting that a broader source of stem cells is available for application in tissue engineering. (hindawi.com)

Neural stem cells (NSCs) are self-renewing, multipotent cells that firstly generate the radial glial progenitor cells that generate the neurons and glia of the nervous system of all animals during embryonic development. (wikipedia.org)
There are two basic types of stem cell: adult stem cells, which are limited in their ability to differentiate, and embryonic stem cells (ESCs), which are pluripotent and have the capability of differentiating into any cell type. (wikipedia.org)
During the embryonic development of vertebrates, NSCs transition into radial glial cells (RGCs) also known as radial glial progenitor cells, (RGPs) and reside in a transient zone called the ventricular zone (VZ). (wikipedia.org)
Adult NSCs differentiate into new neurons within the adult subventricular zone (SVZ), a remnant of the embryonic germinal neuroepithelium, as well as the dentate gyrus of the hippocampus. (wikipedia.org)
These old cells were reprogrammed in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated and human embryonic stem cells (hESC): cells of all types can again be differentiated after this genuine "rejuvenation" therapy. (eurekalert.org)
Human embryonic stem cells (hESC) are undifferentiated multiple-function cells. (eurekalert.org)
Since 2007, a handful of research teams across the world have been capable of reprogramming human adult cells into induced pluripotent cells (iPSC), which have similar characteristics and potential to human embryonic stem cells (hESC). (eurekalert.org)
This kind of reprogramming makes it possible to reform all human cell types without the ethical restrictions related to using embryonic stem cells. (eurekalert.org)
Using this new "cocktail" of six factors, the senescent cells, programmed into functional iPSC cells, re-acquired the characteristics of embryonic pluripotent stem cells. (eurekalert.org)
The rejuvenated iPSC cells were again differentiated to adult cells and compared to the original old cells, as well as to those obtained using human embryonic pluripotetent stem cells (hESC). (eurekalert.org)
Thus, telomerase activity and telomere maintenance are associated with the immortality of cancer cells, germ-line cells, and embryonic stem (ES) cells. (nature.com)
Stem cells are generally divided into two groups, embryonic stem cells and adult stem cells. (vin.com)
Human chorionic gonadotropin (hCG), produced primarily by differentiated syncytiotrophoblasts, is a key embryonic signal necessary for the maintenance of pregnancy. (actionext.com)
Commonly speaking, stem cells are the body's raw materials, present from the embryonic stage of life. (gattefosse.com)
The firm, which was co-founded in 2017 and has raised around $120m to date, is working with embryonic stem cells. (foodnavigator.com)
XI - embryonic stem cells: embryonic cells that are capable of modifying the cells of any organism tissue. (hinxtongroup.org)
Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark. (ox.ac.uk)
Here, we use human embryonic stem cells (hESCs) to show that the Activin-SMAD2/3 signaling pathway cooperates with the core pluripotency factor NANOG to recruit the DPY30-COMPASS histone modifiers onto key developmental genes. (ox.ac.uk)
Human Embryonic Stem Cells Express Elevated Levels of Multiple Pro-Apoptotic BCL-2 Family Members. (ca.gov)
The therapeutic potential of human embryonic stem cells is extraordinary. (ca.gov)
The reasons that these cells hold so much promise are two-fold: (1) embryonic stem cells can renew themselves indefinitely (divide and divide and. (ca.gov)
and (2) embryonic stem cells can be trained to become any cell type of the body (neurons, heart muscle, skin, liver, kidney. (ca.gov)
While we have made great strides in developing culture conditions that can support self-renewal of embryonic stem cells, we are a long way from mastering the conditions necessary for differentiating embryonic stem cells into every cell type of the body (of which there are about 200). (ca.gov)
However, one of the major challenges facing the growth of embryonic stem cells is the abundance of cell death that occurs. (ca.gov)
Two of the greatest challenges in regenerative medicine today remain (1) the ability to culture human embryonic stem cells (hESCs) at a scale sufficient to satisfy clinical demand and (2) the ability to eliminate teratoma-forming cells from preparations of cells with clinically desirable phenotypes. (ca.gov)
Unlike earlier transcriptomics analyses using single-cell technologies, we observe that cells derived from human embryonic stem cells (hESCs) in the grafts adopt mature dopaminergic signatures. (lu.se)

In early blood cells, called hematopoietic stem cells, the methylation patterns established by DNA methyltransferase 3 alpha promote maturation (differentiation) into different blood cell types. (medlineplus.gov)
Researchers speculate that the altered gene activity prevents hematopoietic stem cells from differentiating normally, which leads to the overproduction of abnormal, immature white blood cells characteristic of acute myeloid leukemia. (medlineplus.gov)
Our approach focuses on Hematopoietic Stem Cells (HSCs) for their remarkable regenerative potential and Dendritic Cells (DCs) as key orchestrators of immunity. (lu.se)

Neural stem cell proliferation declines as a consequence of aging. (wikipedia.org)
The de-differentiated cells are metabolically distinct from tumor-associated fibroblasts but exhibit comparable effects on tumor cell proliferation. (usda.gov)
The upregulation of miR‑145 and miR‑221 was associated with the enhanced proliferation of periosteal cells and chondrogenic potential, respectively. (spandidos-publications.com)
Researchers first multiplied skin cells (fibroblasts) from a 74 year-old donor to obtain the senescence characterized by the end of cellular proliferation. (eurekalert.org)
Signs of aging were erased and the iPSCs obtained can produce functional cells, of any type, with an increased proliferation capacity and longevity," explains Jean-Marc Lemaitre who directs the Inserm AVENIR team. (eurekalert.org)
Among their other immunological properties, MSC inhibit lymphocyte proliferation and cytokine production, suppress dendritic cell function and alter DC cytokine production, and decrease IFN-g production by NK cells. (vin.com)
Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)
There were no significant differences in dental pulp cell proliferation patterns related to the absence or presence of GDF-5 after seven days of culture. (ispub.com)
These results indicate that, although GDF-5 may have no effect on cell proliferation in isolated dental pulp tissue, it could promote odontoblast differentiation. (ispub.com)
2003). A previous in-vitro study on the role of GDF-5 in periodontal ligament cells has shown that exogenous GDF-5 promotes cell proliferation while suppressing the activity of alkaline phosphatase (ALP), which is closely related to tissue calcification and which is secreted during the formation of tissue calcifications. (ispub.com)
Here, we investigated the effect of GDF-5 on the proliferation of dental pulp cells and their differentiation into odontoblasts by assaying the expression levels of odontoblast marker genes. (ispub.com)
Bone marrow examination showed the proliferation of hematopoietic cells were active, mainly granulocytes, and immature granulocytes increased. (frontiersin.org)
Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
G-MDSC are also referred to as polymorphonuclear (PMN)-MDSC, which differ from conventional neutrophils via expression of lectin-type oxidized LDL receptor 1 (LOX-1), which inhibits T cell proliferation [ 7, 8 ]. (iospress.com)

In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)
In lymphomas, immune cells called lymphocytes grow out of control and collect in lymph nodes , the spleen, in other lymph tissues or in neighboring organs. (cancercenter.com)
Hodgkin lymphoma is differentiated from the non-Hodgkin type by the presence of abnormal lymphocytes called Reed-Sternberg cells. (cancercenter.com)
Starting in lymphocytes- Multiple myeloma cells originate from lymphocytes, a normal type of white blood cell that resides in the bone marrow. (pethealthnetwork.com)
Some Lymphocytes become plasma cells- These lymphocytes differentiate into a variety of different types of cells, one of which is the plasma cell, an important component of the body's immune system. (pethealthnetwork.com)
CAR-T cell immunotherapy involves taking immune cells - usually T lymphocytes - from a person suffering from cancer, modifying them in the laboratory to increase their ability to recognise and fight tumour cells, then readministering them to the patient. (unige.ch)
And even, and this is the heart of our discovery, they tend to transform into memory T lymphocytes, a type of immune cell that retains the memory of the tumour elements that needs to be attacked. (unige.ch)

First, it was tested whether patient‑derived ADSCs could differentiate into chondrogenic and osteogenic lineages. (spandidos-publications.com)
MSCs are a population of nonhematopoietic adult stem cells that have the property of self-renewal and can differentiate into multiple lineages [ 8 - 10 ]. (hindawi.com)

Quiescent stem cells are Type B that are able to remain in the quiescent state due to the renewable tissue provided by the specific niches composed of blood vessels, astrocytes, microglia, ependymal cells, and extracellular matrix present within the brain. (wikipedia.org)
In this paper, we discovered that certain fat cells change their identity when breast cancer spreads into the fat tissue. (usda.gov)
Although the overlying neural tissue is partly transparent, and the accompanying glial cells have been shown to act as fibre-optic channels to transport photons directly to the photoreceptors, [7] [8] light scattering does occur. (wikipedia.org)
In total, 1-10% of nucleated cells in adipose tissue are ADSCs, whereas only 0.0001-0.01% of nucleated cells in bone marrow are stem cells ( 5 ). (spandidos-publications.com)
Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
In particular, chimeric antigen receptor (CAR) - patient T cells genetically engineered to express antigen receptors targeting cancer cells - and organoid technologies (tiny, self-organized three-dimensional tissue cultures derived from stem cells) will continue to disrupt the cell and gene therapy and regenerative medicine fields, translating early successes with liquid cancers to solid tumors and beyond. (corning.com)
Organoids are generated using tissue-specific stem cells, which are typically undifferentiated epithelial cells. (corning.com)
We will use the latest state-of-the-art quantitative data-generation techniques (including Tomo-Seq and OPTiSPIM), to gather 3D data at multiple levels: gene expression patterns, cell signaling, cellular growth rates, intercalation patterns, and global tissue movements. (europa.eu)
Mesenchymal stem cells are multipotent but not pluripotent, which means they can differentiate into some, or "multiple," but not all tissue types. (vin.com)
Among these, adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cell isolated from adipose tissue, which has the advantages of abundant storage in vivo , easy acquisition, and expansion [ 13 - 15 ]. (hindawi.com)
While Aleph Farms is deploying tissue engineering techniques pioneered in regenerative medicine to make beef steaks, many other startups - under pressure from investors to get a minimum viable product (nuggets, burgers) out in front of consumers - are simply harvesting cell biomass (a slurry of cells that have not yet differentiated and matured into tissue) and adding extruded vegetable protein to create a meaty texture. (foodnavigator.com)
The economics of this approach may be more attractive than tissue engineering in the short term, says the team at Aleph Farms, which is co-culturing multiple bovine cell types around sheets of vegetable-based, porous sponge-like scaffolding to make thin strips of tissue containing muscle, fat, and extracellular matrix (collagen and other components). (foodnavigator.com)
The odontoblasts are differentiated from the dental papilla, which remains a soft connective tissue in the tooth interior also known as the dental pulp, even after development is complete. (ispub.com)
The cells used are derived from adult tissue such as fat, or bone marrow, thereby circumventing the ethical concerns raised by the use of cells derived from embryos. (ibtimes.com)
Advancements in organoid culture, such as the co-culture of different tissue types, further increases their utility as models of the in vivo organ and provides researchers a convenient platform to complement existing 2D culture and animal models. (stemcell.com)
Ewing sarcoma is a small, round, blue cell tumor that primarily affects bone and soft tissue. (logicalimages.com)
Drawing upon a history of using tissue interactions to understand differentiation, Kollar and Baird designed their experiments to understand how differentiated structures become specified. (asu.edu)
Conditional gene targeting has been extensively used for in vivo analysis of gene function in adipocyte cell biology but often with debate over the tissue specificity and the efficacy of inactivation. (diabetesjournals.org)
Here, we present spatial transcriptomics analysis of fully differentiated grafts in their host tissue. (lu.se)

The results represent significant progress for research into iPSC cells and a further step forwards for regenerative medicine. (eurekalert.org)
Stemedix, Inc provides effective Regenerative Medicine, known as Stem Cell Therapy in Saint Petersburg, Florida. (placidway.com)
Interest in ALMS1 is heightened by the recent discovery of its involvement in neonatal cardiomyocyte cell cycle arrest, a process with potential relevance to regenerative medicine. (springer.com)
Each year, the Lund Stem Cell Center recognizes notable scientific achievements made by our members in the fields of stem cell biology and regenerative medicine through our Article of the Year Award. (lu.se)
This recognition highlights the outstanding contributions made by our members in advancing the fields of stem cell biology and regenerative medicine. (lu.se)

Stem cells can self-renew and differentiate into multiple cell types. (ox.ac.uk)
Stem cells rely on extracellular signals produced by the niche, which dictate their ability to self-renew, expand and differentiate. (karger.com)

It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
Of note, we define OCT identities as a state with some characteristics of both osteoblasts and chondrocytes, instead of cell-type plasticity between osteoblasts and chondrocytes. (nature.com)

The neural retina consists of several layers of neurons interconnected by synapses and is supported by an outer layer of pigmented epithelial cells. (wikipedia.org)
In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)
4,6,7 It has been proposed that some of these MSC may actually differentiate into functional renal tubular epithelial cells, though this theory remains controversial. (vin.com)
ADAMDEC1 protein was mainly released from PDGFRalpha+ cells and accumulated in the mucosal layer lamina propria space near the epithelial basement membrane. (stanford.edu)
In squamous epithelia, this is defined as continuous strong nuclear, or nuclear plus cytoplasmic, staining of the basal cell layer with extension upward involving at least one-third of the epithelial thickness. (cancer.org.au)

CSCs derived from both CSCs and non-CSCs give rise to tumors through self-renewal and are able to differentiate into multiple cell types [6]-[9]. (exposed-skin-care.net)
Many malignancy therapies including chemotherapies that destroy the bulk of malignancy cells may ultimately fail as they do not get rid of CSCs that then cause a relapse of tumors [10]. (exposed-skin-care.net)
Ewing sarcomas may be differentiated from these other tumors by CD99 positivity, presence of rosettes on microscopy, and a t(11;22) translocation, which nearly all Ewing sarcomas contain. (logicalimages.com)
Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)
Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)

Some neural progenitor stem cells persist in highly restricted regions in the adult vertebrate brain and continue to produce neurons throughout life. (wikipedia.org)
NSCs primarily differentiate into neurons, astrocytes, and oligodendrocytes. (wikipedia.org)
Neural stem cells are more specialized than ESCs because they only generate radial glial cells that give rise to the neurons and to glia of the central nervous system (CNS). (wikipedia.org)
These neurospheres can differentiate to form the specified neurons, glial cells, and oligodendrocytes. (wikipedia.org)
One example is a neuroblast migrating towards the olfactory bulb to differentiate into periglomercular or granule neurons which have a radial migration pattern rather than a tangential one. (wikipedia.org)
Neural signals from the rods and cones undergo processing by other neurons, whose output takes the form of action potentials in retinal ganglion cells whose axons form the optic nerve. (wikipedia.org)
The vertebrate retina is inverted in the sense that the light-sensing cells are in the back of the retina, so that light has to pass through layers of neurons and capillaries before it reaches the photosensitive sections of the rods and cones. (wikipedia.org)
The study of how transcriptional control and cell signaling influence neurons and glia to acquire their differentiated properties is fundamental to understanding CNS development and function. (biologists.com)
Deconvolution shows dopamine neurons being the dominating cell type in many features beneath the graft area. (lu.se)

In the adult mammalian brain, the subgranular zone in the hippocampal dentate gyrus, the subventricular zone around the lateral ventricles, and the hypothalamus (precisely in the dorsal α1, α2 region and the "hypothalamic proliferative region", located in the adjacent median eminence) have been reported to contain neural stem cells. (wikipedia.org)
The most widely accepted model of an adult NSC is a radial, glial fibrillary acidic protein-positive cell. (wikipedia.org)
These Fgfr3-creER -marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre -marked stromal cells in adult stages. (nature.com)
They can divide and form all types of differentiated adult cells in the body (neurones, cardiac cells, skin cells, liver cells, etc. (eurekalert.org)
This research paves the way for the therapeutic use of iPS, insofar as an ideal source of adult cells is provided, which are tolerated by the immune system and can repair organs or tissues in elderly patients. (eurekalert.org)
Recent years have brought increased interest in the potential for adult stem cells to help in the treatment of many diseases through both their regenerative properties as well as their apparent ability to alter the environment in injured and diseased tissues. (vin.com)
In particular, adult stem cells called mesenchymal stem cells can migrate to affected areas and may be able to support the growth of other stem cells as well as moderate the response of the immune system. (vin.com)
Adult stem cells can be obtained from many differentiated tissues including but not limited to bone marrow, bone, fat, and muscle. (vin.com)
Obtaining adult stem cells also does not raise ethical concerns. (vin.com)
For most studies, the adult stem cell in question is actually a mesenchymal stem cell or mesenchymal stromal cell. (vin.com)
Dozens of adult stem cell treatments are moving through clinical trials and showing early success, raising hopes that some could reach the market within five years. (ibtimes.com)
Gurdon's experiment showed that differentiated adult cells could be induced to an undifferentiated state, where they could once again become multiple cell types. (asu.edu)

It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
However, stem cells are difficult to distinguish from multipotential progenitors, which may look and act like them. (karger.com)
Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)
They had a higher proportion of less differentiated CD34 + hematopoietic progenitors, and a subset of CD56 bright NK cells and γδ T cells characterized by distinct histone modifications associated with the gene transcription. (stanford.edu)

Because FOX proteins regulate neural stem cell homeostasis, FOX proteins have been used to protect neural stem cells by inhibiting Wnt signaling. (wikipedia.org)
By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
2) The surfaces of different cell types often display numerous molecular differences, particularly membrane-bound proteins. (bioinf.org)
Too many plasma cells lead to thick blood- Plasma cells produce proteins called immunoglobulins that are the foot soldiers of the immune system. (pethealthnetwork.com)
The patient's urine contains Bence-Jones proteins, a characteristic type of immunoglobulin (protein) produced by many dogs and cats with multiple myeloma. (pethealthnetwork.com)
To fit into the tiny cell nucleus, it is condensed around proteins called histones. (unige.ch)
Although there are more than 36 types of amyloid precursor proteins, only nine build up in the myocardium and cause cardiac amyloidosis. (medscape.com)

A 76-year-old woman with poorly differentiated endometrial adenocarcinoma. (medscape.com)
Nevertheless whether miR-200b regulates CSCs produced from docetaxel-resistant LAD cells continues to be poorly realized and must become further elucidated. (exposed-skin-care.net)
Yet it remains poorly understood how these factors can induce the various types of cells in the dental pulp to engage in a harmonized and coordinated process of dentin regeneration. (ispub.com)
It is considered a poorly-differentiated malignancy on the primitive neuroectodermal tumor (PNET) spectrum. (logicalimages.com)
While earlier work characterized PDAC as an immunologically privileged tumor poorly recognized by the immune system, recent studies revealed the important and nuanced roles of immune cells in the pathogenesis of PDAC. (stanford.edu)

NSCs are stimulated to begin differentiation via exogenous cues from the microenvironment, or stem cell niche. (wikipedia.org)
An immune cell in the tumor microenvironment that may be important for inhibiting the immune response against bladder cancer is the myeloid derived suppressor cell (MDSC). (iospress.com)

Differences in the size of the central nervous system are among the most important distinctions between the species and thus mutations in the genes that regulate the size of the neural stem cell compartment are among the most important drivers of vertebrate evolution. (wikipedia.org)
This purpose of the model is to help us address the deep scientific question: How are the complex interactions at multiple scales (genes, molecules, cells and tissues) coordinated so as to build a carefully constructed 3D organ? (europa.eu)
In this seminar, I will discuss our research efforts to develop "intelligent" pH-sensitive, membrane-destabilizing, and degradable polymeric carriers that can effectively deliver therapeutic nucleic acids past the endosomal membrane and into the cytoplasm of cancer cells to successfully suppress the expression of targeted genes. (usc.edu)
When T cells are activated, histone modifications take place which, on one hand, condense DNA and prevent transcription of genes ensuring longevity, while on the other hand open up and allow transcription of genes driving their inflammatory and killing function. (unige.ch)
The activities of transcription factors and other genes involved in cell fate decisions can be measured by a number of different gene expression quantification experiments. (lu.se)
At least one DNMT3A gene alteration that causes DNMT3A overgrowth syndrome deletes the entire DNMT3A gene and multiple neighboring genes. (medlineplus.gov)

For many years the musculature of vertebrates was known to derive from the somites, but the exact developmental lineage of axial and limb muscle progenitor cells remained a mystery until Nicole Le Douarin and Charles P. (asu.edu)

Malignancy stem-like cells (CSCs) or tumor initiating stem cells are a sub-population of tumor cells and play pivotal tasks in malignancy initiation progression recurrence and chemoresistance [2]-[5]. (exposed-skin-care.net)

Multiple myeloma may be referred to as just myeloma and is sometimes called plasma cell myeloma. (cancercenter.com)
Also referred to as myeloma and plasma cell myeloma, this disease is not curable, but it can be successfully treated in some cats. (pethealthnetwork.com)

Taken collectively the HDAC1/miR-200b/Suz-12-E-cadherin signaling might account SCH58261 for maintenance of CSCs and formation of chemoresistant phenotype in docetaxel-resistant LAD cells. (exposed-skin-care.net)
MiR-21 regulates EMT phenotype and hypoxia-inducible aspect-1α appearance in third-sphere developing breast SCH58261 cancer SCH58261 tumor stem cell-like cells. (exposed-skin-care.net)
To date, various studies have reported that cells isolated from the dental pulp of various animals can be induced to differentiate into cells of the odontoblastic phenotype by means of various chemicals, growth factors and signaling molecules both in vitro and in vivo ( reviewed in Nakashima and Akamine, 2005). (ispub.com)
These findings further support the preferred environmental niche of TH-positive cells and confirm their dopaminergic phenotype through the presence of multiple dopaminergic markers. (lu.se)

In the sensitization phase, allergens are captured by Langerhans cells (dendritic epidermal cells). (msdmanuals.com)

Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
In this study, we verified that exosomes derived from osteogenically differentiated ADSCs can promote osteogenic differentiation of ADSCs. (hindawi.com)

However, the rejection reaction often occurs in the transplantation of MSCs and could induce cell death. (nih.gov)
In the experiments, Gurdon conducted nuclear transplantation, or cloning, of differentiated cells, or cells that have already specialized to become one cell type or another, in tadpoles. (asu.edu)
Islet cell transplantation has shown curative potential for patients with type 1 diabetes, but the need for concurrent immunosuppression has led to side effects, limited efficacy, and decreased utilization. (pipelinereview.com)
Sana's hypoimmune platform has shown the potential to evade both allogeneic and autoimmune rejection in preclinical models, and we look forward to seeing if these insights translate into patients, providing a path to cell transplantation without immunosuppression," said Steve Harr, Sana's President and CEO. (pipelinereview.com)
The team at Uppsala has significant experience in primary islet cell manufacturing, transplantation, and clinical care of these patients, and we look forward to seeing the results from this clinical study and applying learnings to SC451. (pipelinereview.com)
Combining Sana's hypoimmune technology with primary islet cell transplantation therapy can generate important first-in-human data that may be a step to removing immunosuppression from allogeneic cell transplant in the type 1 diabetes setting. (pipelinereview.com)
Primary islet cell transplantation is an established procedure in type 1 diabetes, where allogeneic islet cells are isolated from a cadaver and transplanted into a patient with a goal of blood glucose control without the need for insulin. (pipelinereview.com)
If UP421 successfully overcomes immunologic rejection, it may result in engraftment, survival, and C-peptide production in patients with type 1 diabetes following transplantation without immune suppression. (pipelinereview.com)

The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
The Drosophila CNS midline cells are an excellent system for studying these issues because they consist of a small population of diverse cells with well-defined gene expression profiles. (biologists.com)
here, we use a combination of single-cell gene expression mapping and time-lapse imaging to identify individual MPs, their locations, movements and stereotyped patterns of division. (biologists.com)
In this context, in the undifferentiated state, the entropy would be large since fewer constraints exist on the gene expression programmes of the cell. (lu.se)
Until recently, and due to technical limitations, for a given cell type such experiments had to be done on an ensemble of many cells and, hence, gene expression quantifi- cations represented the average over a given population. (lu.se)
Colors this cell by a gene expression color. (lu.se)

Current understanding of histone post-translational modifications (histone modifications) across immune cell types in patients with inflammatory bowel disease (IBD) during remission and flare is limited. (stanford.edu)
We used epigenetic profiling by time-of-flight (EpiTOF) to investigate changes in histone modifications within peripheral blood mononuclear cells from IBD patients.We discovered substantial heterogeneity in histone modifications across multiple immune cell types in IBD patients. (stanford.edu)
Sana's hypoimmune technology seeks to overcome the immunologic rejection of allogeneic cells via disruption of human leukocyte antigen (HLA) class I and class II expression to allow cells to evade the adaptive immune system, including antibody and T cell responses, as well as overexpression of CD47 to allow cells to evade the innate immune cell system, in particular macrophages and natural killer (NK) cells. (pipelinereview.com)

Distinct lymphoid, myeloid, and stromal cell types in the TME exert opposing influences on PDAC tumor trajectory, suggesting a more complex organization than the classical "hot" versus "cold" tumor distinction. (stanford.edu)

Telomeric DNA consists of short guanine-rich repeat sequences in all eukaryotes with linear chromosomes, and its length in human somatic cells is remarkably heterogeneous among individuals ranging from 5 to 20 kb, according to age, organ, and the proliferative history of each cell ( Wright and Shay, 2005 ). (nature.com)

The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)
Inserm's AVENIR "Genomic plasticity and aging" team, directed by Jean-Marc Lemaitre, Inserm researcher at the Functional Genomics Institute (Inserm/CNRS/Université de Montpellier 1 and 2), has recently succeeded in rejuvenating cells from elderly donors (aged over 100). (eurekalert.org)
A stem cell is a generic term referring to any unspecialized cell that is capable of long-term self-renewal through cell division but that can be induced to differentiate into a specialized, functional cell. (vin.com)
Furthermore, the fate of stem cells is crucial to their use in new therapies - in other words, these cells must be kept alive and functional to have benefit to human patients. (ca.gov)
The goal of UP421 treatment is to provide proof of concept for transplanting functional islet cells without immunosuppression. (pipelinereview.com)

The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
The term "transitional" emphasizes the unique feature of these cells that are particularly abundant in the young bone marrow. (nature.com)
Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
Bone marrow mesenchymal stem cells (MSCs) have been identified to have the potential to differentiate into multiple types of cells. (nih.gov)
Over the last decades, mesenchymal stem cells (MSCs) have attracted extensive attention in the field of bone regeneration [ 4 - 7 ]. (hindawi.com)
We're actually developing products now," said Timothy Mayleben, chief executive of Aastrom, which is using cells derived from a patient's own bone marrow to develop treatments for cardiovascular disease. (ibtimes.com)
In leukemia, the bone marrow produces mutated cells that spread to the blood, where they grow and crowd out healthy blood cells. (cancercenter.com)
This cancer develops in the bone marrow and affects plasma cells, which produce antibodies that attack infections and diseases. (cancercenter.com)
When plasma cells become cancerous, they may accumulate in the marrow and damage or weaken bone and cause pain. (cancercenter.com)
Sometimes, there are too many plasma cells- In cases of multiple myeloma, plasma cells developing within the bone marrow undergo a "malignant" transformation, and way too many plasma cells are manufactured. (pethealthnetwork.com)
The malignant cells spread- Once released from the bone marrow, the malignant plasma cells often spread to other sites. (pethealthnetwork.com)
The major symptoms associated with multiple myeloma are caused by the spread of cancer cells, hyperviscosity syndrome (thick blood), and the underproduction of normal cells within the bone marrow (see explanations above). (pethealthnetwork.com)
Nonunion and segmental bone loss after fracture, reconstructive surgery, or lesion excision can present complex orthopedic problems, and the multiple surgical procedures often needed are associated with patient morbidity and reduced quality of life. (who.int)

The cells in the dental pulp comprise a heterogeneous mixed population, made up of odontoblasts, fibroblasts, stem cells, and macrophages and other immunocompetent cells. (ispub.com)

In the multicellular theory, each tumor type is associated with a specific differentiated cell of origin within the salivary gland unit. (medscape.com)

When a naive T cell recognizes its antigen via binding to its T-cell receptor, it expands clonally and differentiates into memory/effector T cells. (msdmanuals.com)

The researchers have successfully rejuvenated cells from elderly donors, some over 100 years old, thus demonstrating the reversibility of the cellular aging process. (eurekalert.org)
They have the physiological characteristics of "young" cells, both from the perspective of their proliferative capacity and their cellular metabolisms. (eurekalert.org)
In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
Total cellular RNA was extracted from infected B95a cells or in the elimination phase of measles control, the goal is to col- directly from clinical specimens, if virus isolation was not suc- lect a specimen for viral isolation along with a serum sample at cessful, by the guanidinium acid-phenol method (25). (cdc.gov)
Instead, once given a "go" signal, cells utilize their own energy and cellular machinery to dismantle themselves, a process known as programmed cell death. (ca.gov)
In addition, catalases are also involved in multiple cellular processes, such as cell development and differentiation, as well as metabolite production. (erasingdavid.com)
In this limitless virtual environment, multiple 3D cellular maps can be visualized and compared simultaneously using simple hand controllers. (lu.se)

Epidermal growth factor (EGF) and fibroblast growth factor (FGF) are mitogens that promote neural progenitor and stem cell growth in vitro, though other factors synthesized by the neural progenitor and stem cell populations are also required for optimal growth. (wikipedia.org)
Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
Single cells in these populations exhibit different com- stem cell differentiation, Shannon information binations of regulator activity that suggest the presence of multiple theory, entropy configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)
But when it comes to studying diverse populations of cells, this approach can fall short and an extra dimension is needed. (lu.se)

The different types of amyloidosis are named by the letter "A" followed by an abbreviation for the type of precursor protein that has misfolded. (medscape.com)

In the present study, the potential of using exosomes isolated from adipose‑derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient‑derived primary cells. (spandidos-publications.com)

They undergo symmetric or asymmetric cell division into two daughter cells. (wikipedia.org)

Additionally cell surface marker characterization via flow cytometry differentiates them from hematopoetic cells, though no truly unique MSC molecule has been identified. (vin.com)
Additionally, bound aptamers and unbound oligonucleotides can be separated easily through BLU9931 supplier washing or centrifugation during the SELEX process, because target molecules are anchored on the surface of cells naturally. (bioinf.org)

If you've been diagnosed with a blood cancer, such as leukemia, lymphoma or multiple myeloma, and have questions about your treatment plan, or if you're interested in a second opinion on your diagnosis, call us or chat online with a member of our team. (cancercenter.com)
Multiple myeloma is a relatively rare cancerous process that occurs in cats. (pethealthnetwork.com)
What is multiple myeloma? (pethealthnetwork.com)
Myeloma patients often have dangerously low numbers of these normal cells within their bloodstream. (pethealthnetwork.com)
An overabundance of plasma cells, as is the case with multiple myeloma, translates into an overabundance of immunoglobulin found in the bloodstream. (pethealthnetwork.com)
According to a study found on PubMed.gov , multiple myeloma in people has been associated with exposure to toxic chemicals present in tobacco smoke and emissions from petroleum refinery waste dumps and industrial operations. (pethealthnetwork.com)
The cause of multiple myeloma in companion animals is unknown, and there is no breed or sex predilection. (pethealthnetwork.com)
Because multiple myeloma cells can wreak havoc in so many ways, the symptoms associated with this disease vary from patient to patient. (pethealthnetwork.com)
The key to successful treatment of multiple myeloma is getting therapy started as soon as possible, so as to eliminate the excess plasma cells before they manage to cause a life-threatening problem such as a stroke, hemorrhage, infection or kidney failure. (pethealthnetwork.com)
To investigate the role of reductive carboxylation, the scientists inhibited this mechanism in CAR-T cells in mouse models of leukaemia and multiple myeloma, two blood cancers. (unige.ch)

For example, MSC are poor antigen presenting cells and do not express MHC class II or co-stimulatory molecules and only low levels of MHC class I molecules. (vin.com)
When antigen-presenting cells present the antigen to the sensitized T cells, the T cells can expand and trigger an inflammatory reaction at that location (elicitation phase of ACD), resulting in the characteristic symptoms and signs of ACD. (msdmanuals.com)

More precisely, research show that UVA is very likely to induce DNA lesions in the epidermal basal layer, which hosts the keratinocytes stem cells. (gattefosse.com)
The downregulated DEGs were mainly enriched in digestion, basal part of the cell, and aldo-keto reductase (NADP) activity. (hindawi.com)

Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)
Somatic DNMT3A gene mutations are also found relatively frequently in another form of blood cancer called T-cell acute lymphoblastic leukemia. (medlineplus.gov)
The emergent ability to directly reprogram somatic cells into desired hematopoietic cell-types is opening avenues to the discovery of new therapies for immune and blood diseases. (lu.se)

The treatment centers in Thessaloniki adopt a holistic approach, combining stem cell therapy with complementary therapies and rehabilitation programs. (placidway.com)
The case sent a chill through the scientific community when it came to light 15 years ago and typifies some of the hurdles researchers have faced while trying to bring stem cell therapies to the market. (ibtimes.com)
Ultimately, if therapies based on stem cells are to be realized, these cells will have to be grown in massive quantities, with an unprecedented level of quality control to ensure that only one cell type can be found in the lot. (ca.gov)

Stem cell therapy in particular is an innovative new field of scientific investigation and clinical application that holds promise for a variety of diseases in veterinary medicine as well as human medicine. (vin.com)
In addition, it is also important to keep the immune modulatory properties of MSC in mind when interpreting the results of many stem cell therapy studies. (vin.com)
GMTP Group - St. Luke's Hospital, located in Thessaloniki, offers comprehensive stem cell therapy treatment packages tailored to the needs of MS patients. (placidway.com)
The center provides a multidisciplinary approach to care, combining stem cell therapy with specialized rehabilitation programs and personalized support. (placidway.com)
You can get stem cell therapy for multiple sclerosis packages in Greece with the price starts at 10,667 Euro or $11,419 . (placidway.com)
These facilities adhere to international standards and provide a safe and comfortable environment for patients undergoing stem cell therapy for Multiple Sclerosis. (placidway.com)
The medical personnel in Thessaloniki have extensive experience in the field of stem cell therapy and Multiple Sclerosis. (placidway.com)
Thessaloniki offers cost-effective stem cell therapy packages, making it a feasible choice for patients seeking affordable yet high-quality treatment options for Multiple Sclerosis. (placidway.com)
The stem cell therapy packages in Thessaloniki generally exclude airfare expenses. (placidway.com)

This specific type of cell holds the potential to differentiate into multiple cell types and tissues. (gattefosse.com)
Finally Suz-12 was inversely correlated with miR-200b positively correlated with HDAC1 and up-regulated in docetaxel-resistant LAD cells compared with docetaxel-sensitive tissues. (exposed-skin-care.net)
To date, various studies have reported that BMP-family growth factors can induce cells isolated from dental pulp tissues to differentiate into odontoblasts. (ispub.com)
The Adipoq-Cre exhibited no observable recombination in any other tissues examined, whereas both aP2-Cre lines resulted in recombination in endothelial cells of the heart and nonendothelial, nonmyocyte cells in the skeletal muscle. (diabetesjournals.org)

These have distinct advantages as they are naturally pluripotent, so can grow and divide indefinitely in cell culture in the right conditions, and differentiate into multiple different cell types, Toubia explains. (foodnavigator.com)
Somites are blocks of cells that contain distinct sections that diverge into specific types (axial or limb) of musculature and are an essential part of early vertebrate development. (asu.edu)

Detecting and understanding changes in cell conditions on the molecular level is of great importance for the accurate diagnosis and timely therapy of diseases. (bioinf.org)
These diseases affect the cells in the lymphatic system. (cancercenter.com)

These transformed cells possess different metabolic states, act differently, and help the cancer cells grow. (usda.gov)

Endometrial cancer is the most common female genital cancer, with the most common type being adenocarcinoma. (medscape.com)
Endometrial biopsy, usually using an aspiration-type curet or other device, is generally accepted as the first-step office procedure for the diagnosis of endometrial cancer and should be coupled with endocervical curettage. (medscape.com)
But, when we change the metabolism of these cells, we can slow down the growth of the breast cancer cells in our animal study. (usda.gov)
Additional studies are needed to better the association between fat and cancer cells. (usda.gov)
It is also possible to generate organoids from patient cells to investigate the genetic alterations within an individual's cancer cells. (corning.com)
The current presence of cancer stem-like cells (CSCs) is one of the mechanisms responsible for chemoresistance that has been a major hindrance towards lung adenocarcinoma (LAD) treatment. (exposed-skin-care.net)
The use of these aptamers as targeting moieties has led to the development of numerous nanotools for the efficient cancer diagnosis and therapy.29-34 Here we present an overview of DNA aptamer development against different cell types using cell-SELEX technology, mainly based on the experiments and results of our lab. (bioinf.org)
We used quantitative PCR to compare the steady-state expression profile of all human BCL-2 family members in hESCs with that of human primary cells from various origins and two cancer lines. (ca.gov)
Our findings indicate that hESCs express elevated levels of the pro-apoptotic BH3-only BCL-2 family members NOXA, BIK, BIM, BMF and PUMA when compared with differentiated cells and cancer cells. (ca.gov)
Their favorite place to set up housekeeping is within bones where the damage caused by the cancer cells can create significant pain for the patient. (pethealthnetwork.com)
Among these are: improved nutritional value of food, control of intestinal infections, improved digestion of lactose, control of some types of cancer, and control of serum cholesterol levels. (erasingdavid.com)
A team from the Universities of Geneva (UNIGE), Lausanne (UNIL), the Geneva University Hospitals (HUG) and the Vaud University Hospital (CHUV), all part of the Swiss Cancer Center Léman (SCCL), has discovered how to prolong the functionality of CAR-T cells. (unige.ch)
Immune cells and cancer cells have a fairly similar metabolism, which enables them to proliferate very rapidly. (unige.ch)
The data presented in this edition of Cancer Incidence in Five The CI5 data include all invasive malignant neoplasms and Continents (CI5) are mainly organised according to anatomical some non-invasive malignant neoplasms For most morphology site However, for some sites, the histological type of cancer codes, a fifth digit /1 or /2 automatically excludes the data entry. (who.int)

The term 'microinvasive carcinoma' is no longer recommended, and the term 'superficially invasive squamous cell carcinoma' (SISCCA) should be used instead. (cancer.org.au)
Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)

Of particular interest is the ability to culture precancerous cells that are not fully transformed, which have not previously been accessible to the research community. (corning.com)
Gurdon's first experiment in 1958 showed that the nuclei of Xenopus cells maintained their ability to direct normal development when transplanted. (asu.edu)

Our results reveal the mechanisms by which extracellular factors coordinate chromatin status and cell fate decisions in hESCs. (ox.ac.uk)
Notch signaling also promoted midline glial and median neuroblast cell fate. (biologists.com)
By contrast,the other daughter cell asymmetrically acquired Numb, which inhibited Notch signaling, leading to a different fate choice. (biologists.com)
The programmes governing the function and fate of cells are to a large extent driven by the coordinated activity of transcription factors forming complex and dynamic gene regulatory networks (GRNs). (lu.se)
This averaging effect hampered the analysis of finer regulatory mechanisms at the single-cell level, the fundamental unit for any fate decision process. (lu.se)

If we could somehow block the cell death that occurs in these cultures or if we could change the conditions to remove the components that trigger cell death, we could achieve growth of hESCs of a greater scale. (ca.gov)
The published work identifies some of the key molecules inside hESCs that are responsible for driving cell death in standard growth conditions. (ca.gov)
Limiting apoptosis could aid scaling efforts, whereas triggering selective apoptosis in hESCs could eliminate unwanted teratoma-forming cells. (ca.gov)

Anatomy65

Organisms17

Diseases8

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes67

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science5

Adipocytes6

Embryonic26

Hematopoietic Stem3

Proliferation15

Lymphocytes7

Lineages2

Tissue19

Regenerative medicine5

Self-renew2

Osteoblasts2

Epithelial5

Tumors6

Neurons9

Adult12

Progenitors4

Proteins7

Poorly5

Microenvironment2

Genes6

Progenitor cells1

Malignancy1

Plasma cell my2

Phenotype4

Dendritic1

Osteogenic2

Transplantation8

Gene expression6

Immune cell3

Stromal cell1

Human somatic cells1

Functional5

Bone14

Fibroblasts1

Tumor type1

Receptor1

Cellular8

Populations4

Precursor1

Isolated from adipose1

Undergo1

Additionally2

Myeloma10

Antigen prese2

Basal2

Somatic3

Therapies3

Stem cell th9

Tissues4

Distinct2

Diseases2

Possess1

Cancer14

Squamous3

Ability2

Fate5

HESCs3