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  • fibroblasts
  • Differentiation, assessed by morphology and changes in gene expression, was accompanied by restricted and specific modifications to cell phospholipids, principally enrichments of shorter chain species of phosphatidylcholine (PC) and phosphatidylinositol, that were not observed in fetal lung fibroblasts. (biomedsearch.com)
  • genes
  • We identified numerous marker genes, which allowed alignment with known cell types, morphology, and location. (diva-portal.org)
  • STAT3 protein regulates genes that are involved in cell growth and division, cell movement, and the self-destruction of cells. (medindia.net)
  • In order to locate GDF6, researchers had to narrow down cancer-causing gene candidates from thousands of "copy number" genetic variations in melanoma cells to just a few hundred, because unlike noncancerous cells, cancer cells have large chromosomal areas where thousands of genes are repeated. (eurekalert.org)
  • The lab compared genes in zebrafish with melanoma to genes in human melanomas and found 374 that were altered in both fish and human cells. (eurekalert.org)
  • In melanoma cells, the lab discovered that GDF6 worked to turn off two genes, MITF and SOX9. (eurekalert.org)
  • Together, these genes help cells reach maturity and control cell death. (eurekalert.org)
  • Inhibition
  • We have recently reported, using isolated membrane vesicles, that these two types can be differentiated by their relative sensitivities to inhibition by clonidine and cimetidine [Kulanthaivel, Leibach, Mahesh, Cragoe & Ganapathy (1990) J. Biol. (biochemj.org)
  • The JAR cell Na(+)-H+ exchanger was found to be about 100 times more sensitive to inhibition by dimethylamiloride than the OK cell Na(+)-H+ exchanger. (biochemj.org)
  • Inhibition studies with clonidine and cimetidine were able to differentiate between these two exchangers very clearly. (biochemj.org)
  • It is concluded that the relative susceptibility to inhibition by clonidine and cimetidine offers an easy and efficient means of differentiating between the two types of Na(+)-H+ exchangers in cultured cells. (biochemj.org)
  • Inhibition of NFPC function in developing retinal ganglion cells (RGCs) severely reduces axon initiation and elongation and suppresses dendrite genesis. (jneurosci.org)
  • protein
  • The D-type cyclins form complexes with the cyclin dependent (CD) kinases CDK4 and CDK6 and promote the G1-S phase transition of the cell cycle by antagonizing the retinoblastoma suppresser protein pRB. (scielo.br)
  • Genetic deletion of Thy-1, a protein expressed on multiple cell types including MSCs, prevented MSC differentiation into osteoblasts but promoted differentiation into adipocytes. (sciencemag.org)
  • Looking at human melanoma cells, Ceol and Venkatesan found that 80 percent of patient tumors had elevated levels of GDF6 and the level of the protein in a tumor correlated to the aggressiveness of the cancer. (eurekalert.org)
  • Because GDF6 is a type of protein that acts outside the cell,it makes it much easier to target therapeutically. (eurekalert.org)
  • autologous
  • By definition, autologous cells are obtained from one's own body, just as one may bank his or her own blood for elective surgical procedures. (wikipedia.org)
  • Autologous cartilage is the gold standard for cartilage seed cells in regenerative medicine [ 4 ]. (hindawi.com)
  • As the donor source for autologous chondrocytes is limited, cells must be amplified in monolayers in vitro before implantation to meet the requirements of repair. (hindawi.com)
  • grown
  • The JAR human placental choriocarcinoma cell line and the opossum kidney (OK) cell line, when grown as confluent monolayer cultures on an impermeable plastic support, express Na(+)-H+ exchanger activity which is measurable by determining Na+ uptake into the cells from the culture medium. (biochemj.org)
  • characteristics
  • The cell type (i.e. alkaline, Ni-Cd, etc.) of a battery is determined by reference to characteristics of its electrical behavior during charging. (google.com)
  • mitochondria
  • During the process, mitochondria in the prespore cells were transformed dramatically: as the mitochondrion elongates, its central part becomes thinner and the cristae become localized at its 2 ends. (eurekamag.com)
  • ability
  • the ability to go through numerous cycles of cell division while maintaining the undifferentiated state. (wikipedia.org)
  • thus, the ability to detect and image cAMP in live cells would help to understand its mechanism of action. (sciencemag.org)
  • produces
  • 12. The apparatus of claim 8 wherein the indicating circuitry produces an output signal indicative of whether the monitored parameter corresponds to first or second cell technologies. (google.com)
  • dedifferentiation
  • However, the expansion of monolayers can cause rapid chondrocyte dedifferentiation, leading to loss of the original cell phenotype [ 7 ]. (hindawi.com)
  • comprises
  • 7. A method according to claim 1, wherein said host comprises B-cells comprising a functional immunoglobulin locus comprising a xenogeneic variable region and at least one human constant region. (freepatentsonline.com)
  • form
  • Within the leaf these vascular systems branch (ramify) to form veins which supply as much of the leaf as possible, ensuring that cells carrying out photosynthesis are close to the transportation system. (wikipedia.org)
  • secrete
  • Upon starvation some cells start to secrete a chemoattractant which has been identified as cAMP (1). (springer.com)
  • diabetic
  • Hathout EH, Thomas W, El-Shahawy M, Nahab F, Mace JW: Diabetic autoimmune markers in children and adolescents with type 2 diabetes. (amazonaws.com)
  • donor
  • Blood, which requires extraction through apheresis , wherein blood is drawn from the donor (similar to a blood donation), and passed through a machine that extracts the stem cells and returns other portions of the blood to the donor. (wikipedia.org)
  • help
  • These results could inform how diabetes is treated by identifying an agent to help re-differentiate these affected cells. (nyscf.org)
  • Scientists and doctors are interested in stem cells as they help to explain how some functions of the body work, and how they sometimes go wrong. (medicalnewstoday.com)
  • diabetes
  • Reinehr T, Schober E, Wiegand S, Thon A, Holl R: Beta-cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification? (amazonaws.com)
  • Libman IM, Becker DJ: Coexistence of type 1 and type 2 diabetes mellitus: "double" diabetes? (amazonaws.com)
  • CDC: Epidemiology of Type 1 and Type 2 Diabetes Mellitus Among North American Children and Adolescents. (amazonaws.com)
  • Dabelea D, Pettitt DJ, Jones KL, Arslanian SA: Type 2 diabetes mellitus in minority children and adolescents. (amazonaws.com)
  • Pozzilli P, Guglielmi C, Pronina E, Petraikina E: Double or hybrid diabetes associated with an increase in type 1 and type 2 diabetes in children and youths. (amazonaws.com)