Differentiate into bone. Medical search. Frequent questions

Osteoblasts and chondrocytes are involved in building up the vertebrate skeleton and are thought to differentiate from a common mesenchymal precursor, the osteo-chondroprogenitor. (nih.gov)
Cells within the artificial scaffold successfully differentiated into chondrocytes within 2 weeks. (nih.gov)
Mesenchymal stem cells have the ability to differentiate into one of the three cell types: osteoblasts, chondrocytes, or adipocytes. (frontiersin.org)
The ability of MSCs to differentiate into chondrocytes has also made them the foremost option in cartilage repair studies. (aiche.org)
In vitro , recent studies have shown the existence of stem cells obtained by long-term culture of adherent cells from bone marrow cells 5 - 7 , and these cells differentiate into osteoblasts, chondrocytes, and adipocytes 8 , 9 . (medsci.org)

8 ] found that increased production of ROS in mice can lead to decreased osteoblasts and bone formation. (hindawi.com)
Mutual regulation of osteoblasts and osteoclasts is essential for bone remodeling [ 9 ], dominated by molecular signals [ 10 , 11 ]. (hindawi.com)
Studies revealed that exosomes are also secreted from bone-related cells (osteoclasts, osteoclast precursors, osteoblasts, and MSCs) [ 31 - 33 ]. (hindawi.com)
Immunohistochemical analyses revealed that osteoblasts and osteocytes involved in ectopic bone formation were GFP-negative, whereas osteoclasts and hematopoietic cells involved in bone formation were GFP-positive. (medsci.org)
These results indicate that bone marrow-derived cells might not differentiate into osteoblasts. (medsci.org)
Thus, the main role of bone marrow-derived cells in ectopic osteogenesis may not be to induce bone regeneration by differentiation into osteoblasts, but rather to contribute to microenvironment formation for bone formation by differentiating tissue stem cells into osteoblasts. (medsci.org)
Bone marrow MSCs can differentiate into bone cells, or osteoblasts, and fat cells, or adipocytes. (nih.gov)

Stem cells have required extensive treatment in the lab with growth factors in order to develop (or differentiate) into suitable specialized cells. (nih.gov)
A team led by Drs. Farshid Guilak and Charles Gersbach at Duke University set out to create an artificial scaffold that could direct stem cells within to differentiate and form extracellular matrix. (nih.gov)
The team used human mesenchymal stem cells, which are found in adult bone marrow. (nih.gov)
Accumulation of reactive oxygen species (ROS), which can be induced by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF- α ), can significantly inhibit the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). (hindawi.com)
In the skeletal system, bone marrow mesenchymal stem cells (BMSCs) play an important role in bone formation. (hindawi.com)
They can also come from a patient's own "hidden" adult stem cells, which are most often harvested from bone marrow and fat. (acsh.org)
This includes complications from harvesting bone marrow from the pelvis - which actually only contain less than 0.01 percent stem cells - including fracture and injury to adjacent structures and infection as detailed in The New York Times article. (acsh.org)
Stem cells are cells that have not yet fully differentiated. (brighthub.com)
Fully differentiated cells (non-stem cells) either cannot reproduce or can only reproduce a certain number of times. (brighthub.com)
Stem cells that are derived from a developed tissue, such as the umbilical cord, bone marrow, or skin, are called adult stem cells. (brighthub.com)
The development of new bone can be a multistep process: first, stem cells differentiate into cartilage cells. (nih.gov)
But that's not all: the cells must experience some mechanical stresses during the transformation in order to transform efficiently from stem cells to bone cells. (nih.gov)
Human dental pulp stem cells (hDPSCs) are mesenchymal stem cells that have been successfully used in human bone tissue engineering. (portlandpress.com)
Bone marrow mesenchymal stem cells (bMSCs) are a promising cell source for variety of tissue engineering applications due to their pluripotency and differentiation capacities. (aiche.org)
Thus, in recent years, treatment for bone defects using undifferentiated mesenchymal stem cells existing in vivo has attracted attention. (medsci.org)
In particular, among mesenchymal stem cells, bone marrow-derived stem cells are thought to be the major source of stem cells and are particularly attractive as donor cells in regenerative medicine because of their pluripotency. (medsci.org)
In vivo , bone marrow-derived stem cells have been reported to differentiate into various cells such as tracheal epithelium, intestinal mucosal epithelium, brain neurons, and salivary glands in normal tissues 1 , 2 . (medsci.org)
All the stem cells of blood originate in the marrow of the bones. (areasofmyexpertise.com)

Similarly, obese adipocytes, high-cholesterol and diabetic situations disturb bone cell functions and bone health. (frontiersin.org)
The balance of these cell types in the bone marrow microenvironment is important for B cell formation and development because osteoblast cells support B cell development and adipocytes suppress it. (nih.gov)
TBT-treated mice had more adipocytes in bone marrow than controls and fewer early stage bone marrow B cells. (nih.gov)
Increased adipocytes in bone marrow occurs with aging and is associated with decreased immune response. (nih.gov)
Although more studies are needed, results from the BU SRP Center team suggest that exposure to TBT may worsen age-related changes and risks for disease both by directly causing B cell apoptosis and by altering the bone marrow microenvironment toward adipocytes that suppress B cell development and maturation. (nih.gov)
The image on the right shows an increased number of adipocytes in the bone marrow of TBT- treated mice, compared to the bone marrow of non-TBT-treated mice on the left. (nih.gov)

Bone metastases represent a frequent complication especially of follicular thyroid cancer and severely reduce the quality of life causing pain, fractures, and spinal cord compression. (endocrinology-journals.org)
Bone metastases are typically associated with elevated markers of bone turnover, but these markers have not been evaluated in differentiated thyroid cancer. (endocrinology-journals.org)
Patients with FTC are more likely to develop lung and bone metastases than are patients with papillary thyroid cancer. (medscape.com)

The approach could allow for the creation of orthopedic implants to replace cartilage, bone, and other tissues. (nih.gov)
Cartilage is the slippery tissue that covers the ends of bones in a joint. (nih.gov)
This includes osteoarthritis , the thinning of cartilage that causes bones to rub against one another - similar to a car tire going bald after 50,000 miles. (acsh.org)
This would make the joint even worse because bone creates a rough surface adjacent to the smooth articular cartilage. (acsh.org)
Secondary outcomes will include further MRI assessment of bone marrow lesions, bone area and T2 cartilage mapping, a 0-10 Numerical Pain Rating Scale, a Global Impression of Change score and a treatment satisfaction scale. (bmj.com)
Next, the cartilage cells become bone cells. (nih.gov)

Basic research on interactions between tumor cells and bone microenvironment are identifying potential novel targets for future more effective therapeutic interventions for less differentiated tumors. (endocrinology-journals.org)
Differentiating Enchondromas and Atypical Cartilaginous Tumors in Long Bones with Computed Tomography and Magnetic Resonance Imaging. (bvsalud.org)

[ 7 ] The investigators indicated this should be considered when evaluating immunostaining in the differential diagnosis of poorly differentiated malignancies, particularly NUT midline carcinoma. (medscape.com)

For well-differentiated lesions, iodine-PET scan combined 124 I-PET/CT is the newest imaging development and 131 I is the first line of treatment. (endocrinology-journals.org)
long-term infection can result in deformations of bone and nasopharyngeal tissue, aortitis, and other destructive lesions ( 1 ). (cdc.gov)
The association of bone disease and chronic cutaneous pustular lesions has been observed since the 1960s, but it was not until 1987 that Chamot et al 1 first used the acronym SAPHO to describe this rare group of chronic, relapsing, inflammatory osteoarticular disorders commonly associated with skin manifestations. (ajnr.org)

The creation of B cells in the body is supported by multipotent mesenchymal stromal cells (MSCs) in the bone marrow. (nih.gov)
Using cultured MSCs and B cells, the BU SRP team created a model of the bone marrow microenvironment. (nih.gov)

The bone metastases in FTC are osteolytic. (medscape.com)
Older patients have an increased risk of developing bone and lung metastases. (medscape.com)
It could improve quality of life in patients with bone metastases. (medscape.com)

Although PB remains the preferred source of cells for PNH detection, we and other authors have shown that a careful FC analysis of bone marrow (BM) aspirates can provide results for PNH detection and quantitation equivalent to those obtained with PB. (nih.gov)
These cells can differentiate into different types of musculoskeletal cells. (nih.gov)
Figure 3: Impact of WNT/β-catenin signaling on bone cells. (nature.com)
Figure 4: Crosstalk of WNT, PTH and BMP signaling between bone cells. (nature.com)
Further, experiments using an indirect technique to measure the sensitivity of normal mouse bone marrow indicated that these cells have a radiation sensitivity of similar magnitude ( 6 ). (bioone.org)
The relationship between the number of cells injected and the number of colonies appearing in the spleen has been determined and used to study the sensitivity to radiation of the proliferative capacity in vivo of normal adult mouse bone marrow cells irradiated in vitro . (bioone.org)
The results show that normal mouse bone marrow cells have a similar radiation sensitivity to other mammalian cells tested by very different methods. (bioone.org)
Multiple myeloma, also called myeloma, is a type of cancer where plasma cells in bone marrow replicate out of control. (healthline.com)
Multiple myeloma develops in plasma cells in your bone marrow. (healthline.com)
Multiple myeloma activates cells that break down bone called osteoclasts, which leads to elevated calcium in the blood, also called hypercalcemia . (healthline.com)
They may continue to differentiate into bone cells. (acsh.org)
Common side effects of FLT3 inhibitors can include fever, low levels of white blood cells (with increased risk of infection), nausea, vomiting, diarrhea, redness or sores in the mouth, muscle or bone pain, headache, abnormal liver tests, and respiratory infections. (cancer.org)
They are capable of developing into any of several types of cell, such as blood cells, bone cells, nerve cells, skin cells, etc. (brighthub.com)
Unipotent cells are differentiated cells that can reproduce indefinitely. (brighthub.com)
14. OP9 bone marrow stroma cells differentiate into megakaryocytes and platelets. (nih.gov)
It is now clear that hormones and growth factors produced by cells of other tissues are able to modulate bone modeling and remodeling by altering osteoblast, osteoclast, and osteocyte functions. (frontiersin.org)
Moreover, disseminated cancer cells also modulate the functions of bone resident osteoblast and osteoclast cells to deteriorate bone health. (frontiersin.org)
Fibrocytes are bone marrow-derived, circulating progenitor cells capable of differentiating into diverse mesenchymal cell types. (nih.gov)
Takabatake K, Tsujigiwa H, Song Y, Matsuda H, Kawai H, Fujii M, Hamada M, Nakano K, Kawakami T, Nagatsuka H. The Role of Bone Marrow-Derived Cells during Ectopic Bone Formation of Mouse Femoral Muscle in GFP Mouse Bone Marrow Transplantation Model. (medsci.org)
Multipotential ability of bone marrow-derived cells has been clarified, and their involvement in repair and maintenance of various tissues has been reported. (medsci.org)
However, the role of bone marrow-derived cells in osteogenesis remains unknown. (medsci.org)
In the present study, bone marrow-derived cells during ectopic bone formation of mouse femoral muscle were traced using a GFP bone marrow transplantation model. (medsci.org)
Bone marrow cells from C57BL/6-Tg (CAG-EGFP) mice were transplanted into C57BL/6 J wild type mice. (medsci.org)
Bone marrow transplantation successfully replaced hematopoietic cells with GFP-positive donor cells. (medsci.org)
Further, bone marrow-derived cells can be recruited from bone marrow adjacent to wound tissue during the wound healing process 3 , 4 . (medsci.org)
Hence, it has become clear that bone marrow-derived cells are involved in the maintenance and repair of various organs. (medsci.org)
These cells then differentiate into the red blood cells or white blood cells that the body needs. (areasofmyexpertise.com)
The team, led by Jennifer Schlezinger, Ph.D., found that TBT impacts bone marrow B cells directly by triggering cell death and indirectly by changing the microenvironment of bone marrow vital for supporting immune health. (nih.gov)
B cells are a type of white blood cell that develops and matures in the bone marrow and plays a critical role in the body's immune response to pathogens that may cause disease. (nih.gov)
They also found that TBT exposure changed the way that B cells mature and differentiate. (nih.gov)
Using cells and a model bone marrow microenvironment cell system, the authors revealed how TBT negatively affects B cells. (nih.gov)

Therefore, this study evaluated imaging criteria in a combination of computed tomography (CT) and magnetic resonance (MR) imaging for the differentiation between enchondromas and ACTs in long bones . (bvsalud.org)
Given the success of the previous collection, Bone Cell Differentiation in Health and Disease, and the new advances in the field, we are pleased to announce the launch of Volume II. (frontiersin.org)

Low bone mass and strength lead to fragility fractures, for example, in elderly individuals affected by osteoporosis or children with osteogenesis imperfecta. (nature.com)

Increased activation of osteoclasts causes the bones to break down. (healthline.com)
Bone mass is controlled by the coordinated action of osteoblast and osteoclasts, which form and resorb bone, respectively. (frontiersin.org)

The result is a clearer, more precise image that uses two colors to differentiate between benign abnormalities and those that are not. (nih.gov)

Likelihood of an ACT was significantly increased if either edema within the bone (p = 0.049), within the adjacent soft tissue (p = 0.006) or continuous growth pattern (p = 0.077) were present or if the fat entrapment (p = 0.027) was absent on MR images. (bvsalud.org)
This review provides theoretical references and evidences for further exploration of exosomes as noncoding RNA carriers to regulate bone tissue recovery through the following aspects: (1) basic characteristics of exosomes, (2) research progress of exosomal noncoding RNA in bone tissue engineering, (3) current status and advantages of engineering exosomes as nanocarriers for noncoding RNA delivery, and (4) problems and application prospects of exosome therapy in the field of orthopedics. (hindawi.com)
The process of bone remodeling is to repair bone damage and restore aging bone tissue [ 7 ]. (hindawi.com)
However, bone tissue for autogenous bone grafting is limited, and there is a risk of infection or invasion to donor tissue. (medsci.org)
Although practitioners can differentiate between normal and abnormal tissues, the dye will not discriminate between benign and diseased abnormal tissue and can only detect relatively large changes of about 1 cm. (nih.gov)

PORTLAND, OR, UNITED STATES, September 19, 2023/ EINPresswire.com / -- American-forged handcrafted kitchen knife company STEELPORT Knife Co. announces the launch of their sixth knife shape in their lineup of award-winning heirloom quality cutlery: The STEELPORT 6" Boning Knife . (bigcountryhomepage.com)

We conclude that differences in bone mass and geometry confer greater skeletal integrity in males, which may contribute to the lower incidence of stress and osteoporotic fractures in males. (researchgate.net)

Bone growth and metabolism are mainly regulated by a series of intracellular molecules and extracellular stimuli. (hindawi.com)

High bone density due to a mutation in LDL-receptor-related protein 5. (nature.com)
Your doctor may recommend taking medications to increase your bone density. (healthline.com)
Gender differences in fractures may be related to body size, bone size, geometry, or density. (researchgate.net)
We recently used a statistical appearance model, describing 70 variations in tibia-fibula geometry and density in a young physically active population, in 71 combination with the finite element method to evaluate sexual dimorphism and its influence on 72 bone strain [12]. (researchgate.net)
The purpose of this study was to cross-validate our previous findings of sex-related 78 differences in tibia-fibula bone geometry, density, and finite element-predicted bone strain in an 79 entirely new cohort of young physically active adults. (researchgate.net)
DXA scans are commonly used to determine bone density and body composition, as well as mass calculations. (cdc.gov)

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. (nature.com)

Destructive osteopathy is mainly due to the failure of the bone remodeling process, including enhanced osteoclast activity or reduced osteoblast generation [ 1 , 2 ]. (hindawi.com)
The status of the bone represents the net result of a balance between the activity of osteoclast and osteoblast, which results compromised as a consequence of endocrine disorders. (frontiersin.org)

Collagens are fibrous proteins that serve as the building blocks of skin, tendon, bone, and other connective tissues. (nih.gov)

NCs are an almost invariant feature of some cancers, including well- and de-differentiated liposarcoma (WDLPS), parosteal osteosarcoma and dermatofibrosarcoma protuberans. (sarcomahelp.org)

The pathway is now the target for therapeutic intervention to restore bone strength in millions of patients at risk for fracture. (nature.com)
If the spine becomes weak from loss of bone mass, there's an increased risk of a spinal fracture. (healthline.com)

For example, steroids are artificial hormones whereas SARMs differentiate as chemicals. (outlookindia.com)
In the head and neck region, autogenous bone grafting and artificial biomaterials are currently being used to treat bone defects due to trauma, tumor, or surgical invasion. (medsci.org)

Figure 2: WNT signaling pathway members regulate bone mass: lessons from mouse genetics. (nature.com)

Despite its well-differentiated characteristics, FTC may be overtly or minimally invasive. (medscape.com)
In addition, we focused on elaborating the feasible clinical application of bone exosomes and the characteristics of exosomal noncoding RNAs in the regulation of bone reconstruction. (hindawi.com)

In conclusion, both CT and MR imaging show suggestive signs which can help to adequately differentiate enchondromas from ACTs in long bones and therefore can improve diagnostics and consequently patient management. (bvsalud.org)

The scan is an inexpensive, low radiation scan that can differentiate between bone, muscle, and fat. (cdc.gov)

Furthermore, the changes in bone turnover markers in the three groups with DTC are expressed as z - scores versus the REF group. (medscape.com)

Recent studies reported that the key factor for bone reconstruction was exosome [ 13 ]. (hindawi.com)

The relationships of the normal ranges (mean ± 2 SD) given by the manufacturers (dotted lines) to the normal ranges according to our own control group represented by group REF (gray background) are depicted in Figures 1-3 for the three markers of bone metabolism. (medscape.com)

These chemicals activate androgen receptors that are only available in the muscles and bones. (outlookindia.com)
It can help improve cardiovascular health, strengthen muscles and bones, and enhance flexibility and endurance. (bacchusgamma.org)

Mouse genetics confirmed the importance of canonical Wnt signaling in the regulation of bone homeostasis, with activation of the pathway leading to increased, and inhibition leading to decreased, bone mass and strength. (nature.com)

3) Drug Therapy: Investigations of the mechanisms of action of eltrombopag and clinical applications in patients with inherited bone marrow failure (Fanconi anemia, Diamond Blackfan Anemia). (nih.gov)

Moreover, ROS can also enhance adipogenesis of BMSCs and ultimately cause bone formation disorders through inhibition of Wnt/ β -catenin and Hedgehog signaling [ 1 ]. (hindawi.com)

With its unique design and functional details, the STEELPORT 6" Boning Knife allows for superior control, agility, and protection, making it an essential tool for confidently and efficiently breaking down and trimming cuts of meat. (bigcountryhomepage.com)

0.001) and expansion of bone (p = 0.002) were present and if matrix calcifications were observed in less than 1/3 of the tumor (p = 0.013). (bvsalud.org)

common sites of involvement are the lungs, liver, and bone. (medscape.com)
On the other hand, fitness is a state of both physical and mental health, where a person is physically able to complete tasks without getting tired and possesses a healthy heart, lungs, bones, and muscles. (bacchusgamma.org)

Two time-trend studies using the Surveillance, Epidemiology, and End Results (SEER) Program database have shown a 2% and 3.8% annual increase in the incidence of differentiated thyroid carcinoma in the United States among children, adolescents, and young adults in the 1973 to 2011 and 1984 to 2010 periods, respectively. (cancer.gov)
Increase in the incidence of differentiated thyroid carcinoma in children, adolescents, and young adults: a population-based study. (cancer.gov)

A decade ago, rare human mutations affecting bone negatively (osteoporosis-pseudoglioma syndrome) or positively (high-bone mass phenotype, sclerosteosis and Van Buchem disease) have been identified and found to all reside in components of the canonical WNT signaling machinery. (nature.com)

Doctors use the presence of these symptoms to differentiate from precancerous disease and to guide treatment. (healthline.com)
Autologous transplantation of genetically modified HSCs offers a potentially curative treatment for inherited blood disorders, such as bone marrow failure syndromes and immuno-deficiencies. (nih.gov)
Using MSC aggregates which are differentiated prior to implantation, can overcome the drawbacks of the current treatment methods. (aiche.org)

The subanalysis evaluating the influence of LT 4 dosage per kilogram of body weight showed that the patients in the DTC-ES group demonstrated a tendency toward increasing S-CTx, U-NTx, and OC values with higher LT 4 /per kilogram doses, although this correlation was not significant for either of the investigated bone markers (Figs. 4-6). (medscape.com)
bacteremia was nosocomial for 7 patients and poly- cardiovascular disease, diabetes mellitus, bone and joint microbial for 5. (cdc.gov)

Human temporal bone specimens, from normal and disease-state subjects, are particularly difficult to retrieve and prepare for postmortem study, as are smaller samples from living humans. (nih.gov)
Can we differentiate between pathologic fibrosis and that of normal aging? (nih.gov)

With the STEELPORT Boning Knife, home cooks can feel inspired to buy and experiment with different cuts of meat, and have the self-sufficiency to break down high quality proteins from scratch at home. (bigcountryhomepage.com)
It is specifically designed for deboning and trimming, for example breaking down bone-in proteins, trimming fat and removing silverskin, etc. (bigcountryhomepage.com)

Fitness is the result of consistent exercise and encompasses the body's ability to perform daily tasks without fatigue, maintain healthy cardiovascular function, and possess strong bones and muscles. (bacchusgamma.org)

Once a cell has become differentiated, it cannot change further into another type of cell. (brighthub.com)
There are many kinds of blood cell, and a multipotent blood stem cell (hematopoietic cell) can become any kind of blood cell, but not another kind of cell such as a bone cell. (brighthub.com)

In order to better understand the mechanism of exosomes as noncoding RNA vectors regulating bone remodeling, we reviewed the newest findings on the feature and role of exosomes in bone formation. (hindawi.com)

The study, which focuses on how to discriminate this aspect through the medullary bone of these birds, was recently published in Polar Biology, and was led by CONICET doctoral fellow at the Instituto de Investigación en Paleobiología y Geología (IIPG, CONICET-UNRN), Luis Garat. (conicet.gov.ar)

In humans, the spinal cord is a continuation of the brainstem and anatomically begins at the occipital bone, passing out of the foramen magnum and then enters the spinal canal at the beginning of the cervical vertebrae. (wikipedia.org)
Encased within the thick temporal bone, the auditory and vestibular systems are also difficult to view in living humans. (nih.gov)

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. (nature.com)
This is the prerequisite for maintaining mass and mechanical strength of bone [ 8 ]. (hindawi.com)

After transplantation, insoluble bone matrix (IBM) was implanted into mouse muscle. (medsci.org)
Calcium is critical for maintaining bone health, muscle movement, and nerve impulses. (nih.gov)

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. (nature.com)
Ectopic bone formation was histologically assessed at postoperative days 7, 14, and 28. (medsci.org)

Anatomy68

Organisms10

Diseases42

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Psychiatry and Psychology1

Phenomena and Processes35

Disciplines and Occupations1

Technology, Industry, Agriculture8

Health Care5

Chondrocytes5

Osteoblasts7

Stem cells18

Adipocytes6

Thyroid cancer3

Cartilage6

Tumors2

Poorly differentiated1

Lesions3

MSCs2

Metastases3

Cells31

Differentiation2

Osteogenesis1

Osteoclasts2

Abnormalities1

Tissue5

20231

Skeletal1

Extracellular1

Density6

Osteocytes1

Osteoblast2

Tissues1

Cancers1

Fracture2

Artificial2

Regulate bone1

Characteristics2

Long Bones1

Scan1

Turnover1

Factor1

Markers of bone1

Muscles and bones2

Regulation of bone1

Clinical1

BMSCs1

Functional1

Tumor1

Lungs2

Adolescents2

Mutations1

Treatment3

Patients2

Normal2

Proteins2

Cardiovascular1

Cell2

Mechanism1

Birds1

Humans2

Mass2

Muscle2

Formation2