MSCsProgenitor cellsNeuronsCardiomyocytesCells differentiatePhenotypeStemAssaysMacrophagesToxicityVivo modelsTissueNeuralAssayCardiacLineagesPopulationsProgenitorsDiagnosticStudyMethodsDifferentiationLiverCollaborationLymphocytesExperimentsNerveHumanFunctionalStudiesFormRapidEffectsResultsProductsBroadProcessExpression

MSCs5

• Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms. (hindawi.com)
• In this paper, we review the current literature on both in vitro and in vivo studies on the role of the immune system in fracture repair, the use of MSCs in the enhancement of fracture healing, and interactions between MSCs and immune cells. (hindawi.com)
• Multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have the capacity to differentiate into a variety of cell types (Figure 1 ), including adipocytes, chondrocytes, and osteocytes [ 9 , 10 ]. (hindawi.com)
• Bone marrow mesenchymal stem cells (MSCs) have been identified to have the potential to differentiate into multiple types of cells. (nih.gov)
• The primary objective of this study was to verify whether a natural antioxidant, lycopene, could protect MSCs from ischemia-induced apoptosis in vitro. (nih.gov)

Progenitor cells2

• Recent Accomplishments - Starting in 2013, we incorporated Fluidigm-based multiplex single cell PCR equipment HD Biomark to analyze the differentiation of single cardiac progenitor cells in vitro and found that Nkx2.5 expression marks a subpopulation of committed endocardial precursor cells in the mouse heart (Li et al, Development 2015). (stanford.edu)
• Scientists have coaxed differentiated cells to become neuronal progenitor cells many times in vitro. (the-scientist.com)

Neurons2

• These cells can differentiate into neurons, glia, keratinocytes, smooth muscle cells and melanocytes in vitro. (wikipedia.org)
• We also develop technologies for direct conversion of human fibroblasts into functional and subtype-specific neurons in vitro, and the conversion of endogenous glia into neurons in vivo. (lu.se)

Cardiomyocytes2

• The purpose of this study was (I) to validate a three-dimensional in vitro pacing model, (II) to examine the effect of rapid pacing on mitochondrial function in intact cells, and (III) to evaluate the involvement of L-type-channel-mediated calcium influx in alterations of mitochondria in cardiomyocytes during rapid pacing. (umn.edu)
• In vitro differentiated cardiomyocytes from P19 cells that formed embryoid bodies were paced for 24 h with 0.6 and 2.0 Hz. (umn.edu)

Cells differentiate1

• We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)

Phenotype6

• Previous studies have shown that human adipose stem cells (hASCs) are able to differentiate towards AF phenotype when treated with suitable growth factors. (utwente.nl)
• qRT-PCR confirmed the similarity of the differentiated hASCs with AF phenotype. (utwente.nl)
• Several markers for AF phenotype (aggrecan, collagen type I and glypican-3) were expressed in both hAFCs and differentiated hASCs. (utwente.nl)
• This is the first study that demonstrated that hASCs can be differentiated towards AF phenotype using serum free chondrogenic medium without growth factors. (utwente.nl)
• In vitro differentiated and mouse cell sorted Tfh phenotype was evaluated by flow cytometry and quantitative PCR (qPCR). (nih.gov)
• In vitro, these cells have a multipotent phenotype, which manifests as the ability to differentiate into several mesodermal lineages, especially adipocytes, chondrocytes and osteoblasts. (weizmann.ac.il)

Stem6

• When dissociated, they can be co-cultured with SC-like adipose-derived stem cells (ASC), providing a valuable model to study in vitro nerve regeneration and myelination, mimicking the in vivo environment at the injury site. (jove.com)
• Nestin, a protein marker for neural stem cells, is also expressed in follicle stem cells and their immediate, differentiated progeny. (wikipedia.org)
• 1. Development of a ML/AI pipeline for the prediction of subtypes and differentiation stage of developing mouse cardiac cells from mesoderm to birth and from in vitro differentiation of human induced pluripotent stem cells (hiPSCs). (stanford.edu)
• The recent development of stem cell research and the possibility of generating cells that can be stably and permanently modified in their genome open a broad horizon in the world of in vitro modeling. (wjgnet.com)
• Thanks to recent progresses, stem cells have been extensively employed to study Plasmodium liver and blood cycle in vitro . (wjgnet.com)
• Watch the lecture where Malin Parmar tells about the long history of transplantation trials in Lund and how they have been able to differentiate stem cells into specific dopaminergic cells in vitro. (lu.se)

Assays3

• Here, we demonstrate that sublethal doses ionizing radiation specifically promotes the migration and invasiveness of human GSC lines using in vitro and in vivo assays. (nature.com)
• Within the past 2 years, investigational peptide- and recombinant protein-based serologic assays that can more easily differentiate the antibodies to HTLV-I and HTLV-II have been developed (8,9). (cdc.gov)
• Tetrazolium reduction and resazurin assays are the mainstay of routine in vitro toxicity batteries. (cdc.gov)

Macrophages6

• To monitor phagocytosis of quantum dots by non-primed and primed alveolar macrophages (AM) in vitro, AM were collected by bronchoalveolar lavage (BAL) from untreated rats or rats that had been treated by pulmonary inoculation with L. monocytogenes. (cdc.gov)
• M-CSF and GM-CSF differentiated human blood monocytes are often used to generate monocyte-derived macrophages as a model for tissue macrophages. (biorxiv.org)
• Here, we report that bone marrow derived macrophages and human monocyte-derived macrophages differentiated with either M-CSF or GM-CSF show different levels of LRRK2 activation after membrane damage. (biorxiv.org)
• Notably, the membrane damaging agent LLOMe triggered LRRK2-dependent Rab8A and Rab10 phosphorylation primarily in GM-CSF differentiated macrophages. (biorxiv.org)
• Moreover, LRRK2 and Rab8A were recruited to damaged endolysosomes in GM-CSF differentiated macrophages. (biorxiv.org)
• Strikingly, GM-CSF differentiated macrophages recruited significantly more CHMP4B and Galectin-3 into damaged endolysosomes. (biorxiv.org)

Toxicity1

• Well-differentiated tumor cells showed higher toxicity than less-differentiated cells. (bioone.org)

Vivo models2

• To better understand Plasmodium biology, researchers can whether proceed to in vitro studies or use in vivo models. (wjgnet.com)
• In this thesis, human glia-to-neuron direct conversion and engineered viral vectors are explored using pre-clinical in vitro and ex vivo models. (lu.se)

Tissue2

• The main aim of this research project was to regenerate AF tissue in vitro using hASCs and serum free chondrogenic medium without supplementation of growth factors. (utwente.nl)
• Histopathology is often required to differentiate tissue invasion from airway colonization. (medscape.com)

Neural2

• In response to morphogens, the hONPs differentiate along several neural lineages. (scirp.org)
• Further studies in vitro should be useful for analysis of the role of muscle activity, of the local neural influence on the postsynaptic membrane, and of the mechanism of the muscle response. (aspetjournals.org)

Assay2

• On July 2, 2020, FDA granted an Emergency Use Authorization (EUA) for the CDC Influenza SARS-CoV-2 (Flu SC2) Multiplex Assay, a real-time RT-PCR test that detects and differentiates RNA from SARS-CoV-2, influenza A virus, and influenza B virus in upper or lower respiratory specimens. (cdc.gov)
• Since then, all donations of whole blood and blood components in the United States have been screened for antibodies to HTLV-I. The screening tests that were licensed, as well as the investigational supplementary tests used to confirm seroreactivity (Western immunoblot and radioimmunoprecipitation assay), do not reliably differentiate between antibodies to HTLV-I and the closely related HTLV-II. (cdc.gov)

Cardiac1

• In vitro generation of differentiated cardiac myofibers on micropatterned laminin surfaces. (gladstone.org)

Lineages1

• Second, altering the MSC state by inducing differentiation into multiple lineages did not affect the exosomal properties or endocytosis but triggered the expression of lineage-specific genes and proteins in vitro and in vivo respectively. (frontiersin.org)

Populations2

• C ) Expansion of both the undifferentiated (A spermatogonia) and differentiated (A1 spermatogonia) spermatogonial populations occurs by mitosis of these cell types, regulated in part by FSH. (jci.org)
• In vitro systems are used to differentiate these cells into diverse macrophage subsets to mimic the populations observed in vivo . (biorxiv.org)

Progenitors2

• Journal Article] Identification and In Vitro Expansion of Adult Hepatocyte Progenitors from Chronically Injured Livers. (nii.ac.jp)
• Our findings were subsequently tested by in vitro experiments, where putative early and later-stage DN1 progenitors from the thymus were purified and their pro- gression into DN2 was measured. (lu.se)

Diagnostic1

• On July 7, 2020, CDC updated the LOINC In Vitro Diagnostic (LIVD) Test Code Mapping for SARS-CoV-2 Tests to include the LOINC test code and Vendor Specimen and Result Description SNOMED-CT codes. (cdc.gov)

Study1

• Considering that PTZ blocks the chloride channel coupled to the GABA A receptor complex, the present study aimed to analyze the possible modulation of GABAergic homeostasis within synaptic clefts in vitro . (hindawi.com)

Methods1

• Methods to isolate and expand the hONPs which form neurospheres in vitro have been developed in our laboratory. (scirp.org)

Differentiation1

• Three human colon carcinoma cell lines with variable degrees of differentiation and a normal colon fibroblast cell line were used to generate a suitable in vitro model for investigation of photosensitizer concentration as well as the applied light dose. (bioone.org)

Liver1

• ON the other hand, Grhl2 null cholangiocytes isolated from chronically injured liver differentiated into hepatocytes in vitro. (nii.ac.jp)

Collaboration2

• The aim of the collaboration between Vitra and the Dutch designer Hella Jongerius is to create a unique realm of Vitra colours and materials that augment contemporary designs and renew classic pieces in the collection. (vitra.com)
• ACX is the tenth office swivel chair that Vitra has developed in collaboration with Italian designer Antonio Citterio . (vitra.com)

Lymphocytes1

• Both belong to the oncovirus subfamily of retroviruses and can transform human lymphocytes so that they are self-sustaining in vitro. (cdc.gov)

Experiments1

• Using pharmacological approaches along with in vitro and in vivo experiments, we found that Nogo-A/NgR1 signaling regulates the pace of neuronal neogeneration by reducing NSC proliferation. (jneurosci.org)

Nerve1

• Nerve-muscle synapses form and the postsynaptic membrane begins to differentiate rapidly in vitro. (aspetjournals.org)

Human3

• In addition to the new in vitro systems, in recent years there were also significant advances in the development of new animal models that allows studying the entire cell cycle of human malaria. (wjgnet.com)
• In vitro, the mineralization ability of human rotator cuff cells from osteoarthritis donors was assessed by alizarin red or Von Kossa staining. (iasp-pain.org)
• Methanogen Abundance Thresholds Capable of Differentiating In Vitro Methane Production in Human Stool Samples. (harvard.edu)

Functional1

• The in vitro pacing model presented here reflects changes occurring during tachycardia and, thus, allows functional analyses of the signaling pathways involved. (umn.edu)

Studies1

• Previous studies have described that EPC do not differentiate in vitro. (utah.edu)

Form2

• has shown that nestin forms homodimers and homotetramers but does not form IF by itself in vitro. (wikipedia.org)
• This bacterium induces the neoplastic growth of plant cells that differentiate to form "hairy roots. (bioone.org)

Rapid1

• Rapid propagation technology was established and optimized in vitro for Chrysanthemum cinerariifolium (Trev. (bioone.org)

Effects1

• Eliminating ROS elimination or inhibiting AKT blocked the effects of the laser therapy in vivo and in vitro. (google.com)

Results1

• quantitative correlations between in vivo and in vitro results were highly significant. (elsevierpure.com)

Products1

• Vitra tests all products according to the GS criteria except for accessories. (vitra.com)

Broad1

• Vitra's office chair portfolio stretches between these poles, providing a broad range of differentiated solutions. (vitra.com)

Process1

• A biological evolutionary process now enables us to differentiate many shades. (vitra.com)

Expression1

• Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (nih.gov)