• Mesenchymal stem cell medium was used in the control groups. (scielo.br)
  • During embryogenesis endothelial cells exhibit substantial plasticity that contribute to cardiac development by undergoing endothelial-to-mesenchymal transition (EndoMT). (surrey.ac.uk)
  • Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
  • As the major cell precursors in osteogenesis, mesenchymal stem cells (MSCs) are indispensable for bone homeostasis and development. (nature.com)
  • Mesenchymal stem cells (MSCs) show trilineage differentiation because these cells differentiate into osteocytes, chondrocytes and adipocytes. (nature.com)
  • Mesenchymal stem cells (MSCs) are multipotent cells with regenerative and immunomodulatory properties. (frontiersin.org)
  • Human mesenchymal stem cells (HMSCs) are multipotent somatic stem cells that can be isolated from a variety of tissues such as the bone marrow, adipose tissue, and dental pulp. (frontiersin.org)
  • NANOG regulates epithelial-mesenchymal transition via AMPK/mTOR signalling pathway in ovarian cancer SKOV-3 and A2780 cells. (nih.gov)
  • Human liver organoids are formed from the assembly of hepatocyte-like cells differentiated from iPS cells, human umbilical vascular endothelial cells and mesenchymal stem cells ( 9 ). (spandidos-publications.com)
  • The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
  • The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
  • Collectively, the metabolic interplay between tumor cells and adipocytes induces adipocyte mesenchymal transition and contributes to reconfigure the stroma into a more tumor-friendly microenvironment. (usda.gov)
  • Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocytes. (mdpi.com)
  • Zhou JQ, Wan HY, Wang ZX, Jiang N. Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells. (wjgnet.com)
  • Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating in specific directions. (wjgnet.com)
  • We have generated conditional knockout alleles to test whether AT1 cells may also signal to mesenchymal cells such as myofibroblasts. (mdanderson.org)
  • Gastrointestinal stromal tumors (GISTs) are a subset of GI mesenchymal tumors of varying differentiation. (medscape.com)
  • The CD34 protein is a hematopoietic progenitor cell antigen that occurs in a variety of mesenchymal tumors. (medscape.com)
  • Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)
  • The findings also help explain why the process of differentiating stem cells into specific lineages in the laboratory has been highly inefficient. (sciencedaily.com)
  • Second, altering the MSC state by inducing differentiation into multiple lineages did not affect the exosomal properties or endocytosis but triggered the expression of lineage-specific genes and proteins in vitro and in vivo respectively. (frontiersin.org)
  • As advancement in methods to differentiate iPSC into ocular lineages progresses, new non-integrative transfection strategies shows more promise for safe clinical application. (stanford.edu)
  • We hypothesize that iPSC reprogrammed from ocular epithelial cells will be more efficient in differentiating into ocular lineages and exhibit higher functionality than non-ocular sources such as fibroblasts or blood. (stanford.edu)
  • Upon activation, naïve CD4+ T-cells can differentiate into one out of few possible lineages, each invoking a specific immune response. (weizmann.ac.il)
  • While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on reduction in tumorigenicity are limited. (lu.se)
  • Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
  • It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
  • However, the primary mechanisms regulating osteogenic differentiation are controversial. (nature.com)
  • Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition of miR-103-3p showed the opposite results in NOR-MSCs. (techscience.com)
  • The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation, thereby providing possible target for the treatment of MDS pathogenesis. (techscience.com)
  • These stem cells come from developed organs and tissues in the body. (healthline.com)
  • Although different stem cells, morphogens and scaffolds can be combined to simulate natural odontogenic regeneration, it is crucial to determine which options most closely replicate the characteristics of human dental tissues. (scielo.br)
  • The advantages also include production of one cell type isolated from complexity of leaf tissues, accessibility for chemical manipulations and microscope observations, high potential and synchrony of TE differentiation, preservation of vessel element patterning in similarity to zinnia hypocotyls in vivo. (europa.eu)
  • A decrease in hemoglobin can lead to a shortage of oxygen in cells and tissues throughout the body. (medlineplus.gov)
  • of cells or tissues) to change from relatively generalized to specialized kinds, during development. (dictionary.com)
  • In this work, pathways governing mucus cell differentiation were investigated in lung tissues from patients with IPF and other chronic pulmonary disorders. (bmj.com)
  • Brown algae are unique among heterokonts in developing into multicellular forms with differentiated tissues , but they reproduce by means of flagellated spores and gametes that closely resemble cells of other heterokonts. (wikipedia.org)
  • Center for Regenerative Biotherapeutics protocols have been developed to generate adult stem cell-derived bonelike, nerve-like and heart-like tissues. (mayo.edu)
  • Transplanting organs, tissues or cells from one person to another. (mayo.edu)
  • Transplanting tissues or cells from one area of a person's own body to another. (mayo.edu)
  • Using specific types of stem cells to repair damaged tissues and treat disease. (mayo.edu)
  • Currently we are collecting and growing epithelial cells from the ocular surface of donor eye tissues. (stanford.edu)
  • The knowledge gained from separating and identifying different cells types of the eye will provide greater understanding into the physiology and overall function of the various eye tissues. (stanford.edu)
  • Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
  • In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)
  • This kit contains the following optimized proteins and reagents to drive the efficient differentiation of mouse monocytes into dendritic cells. (rndsystems.com)
  • Huang and Chang then looked at the proteins GATA1 and PU.1, transcription factors that normally favor differentiation into red and white blood cells, respectively. (sciencedaily.com)
  • Bone morphogenetic proteins (BMP), known as active components of odontogenic differentiation and tooth development, have been used as a growth factor in an appropriate medium. (scielo.br)
  • Through its activity as a transcription factor and its interactions with other proteins, the GATA1 protein regulates the growth and division (proliferation) of immature red blood cells and platelet-precursor cells (megakaryocytes) and helps with their differentiation. (medlineplus.gov)
  • Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)
  • It was based on immunologic tests that identified the proteins that cancer cells made. (lymphomainfo.net)
  • By screening for proteins that colocalize with NHR-67 punctae, we identified new regulators of uterine cell fate maintenance: homologs of the transcriptional co-repressor Groucho (UNC-37 and LSY-22), as well as the TCF/LEF homolog POP-1. (elifesciences.org)
  • Deficiency in ClpP induces an overload of mitochondrial misfolded/unfolded proteins, suppresses mitochondrial respiratory activity, increases mitochondrial oxidative damage and causes cell death. (springer.com)
  • In recent years, scientists have discovered areas of DNA that do not give instructions on how to make proteins, are codes for making lncRNA molecules that help to control when genes are switched on and off inside cells. (medicalnewstoday.com)
  • Overexpressing the three proteins together allowed the researchers to generate haploid cells -- those with only one copy of each chromosome -- expressing proteins found in mature sperm. (sciencedaily.com)
  • This suggests that BOULE may play a larger role than the other proteins in the development of female germ cells. (sciencedaily.com)
  • Modulation of Basic Helix-Loop-Helix Transcription Complex Formation by Id Proteins during Neuronal Differentiation. (lu.se)
  • We found that the three Id proteins expressed in neuroblastoma cells (Id1, Id2, and Id3) were down-regulated during induced differentiation, indicating that Id proteins help keep the tumor cells in an undifferentiated state. (lu.se)
  • The ability of Id proteins to affect HES-1 activity is of particular interest in neuronal cells, where regulation of HES-1 is essential for the timing of neuronal differentiation. (lu.se)
  • Reijo Pera is a professor of obstetrics and gynecology at the medical school and the director of Stanford's Center for Human Embryonic Stem Cell Research and Education. (sciencedaily.com)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • Transplantation in Parkinson's disease using human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons is a promising future treatment option. (lu.se)
  • They have a higher odontogenic differentiation capacity compared to other cell groups due to their content of specific progenitor cells. (scielo.br)
  • CCN1 also induced Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cells to promote their differentiation into cholangiocytes. (jci.org)
  • this released a flood of progenitor cells, or cells which eventually create new cartilage. (forbes.com)
  • Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into forebrain neural progenitor cells. (lu.se)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • Overall, the results presented in this study show a common mechanism of endocytosis for MSC EVs across different cell types and the feasibility to generate functionally enhanced EVs by modifications to parental MSCs. (frontiersin.org)
  • Thus, the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs, significantly impacting MDS-MSCs differentiation. (techscience.com)
  • MSCs have a lower ability to differentiate into osteoblasts but a higher ability to differentiate into adipocytes, which could be linked to myeloid malignancies ( Woods and Guezguez, 2021 ). (techscience.com)
  • It is usually considered that the differentiation process of MSCs depends on specialized external stimulating factors, including cell signaling pathways, cytokines, and other physical stimuli. (wjgnet.com)
  • Recent findings have revealed other underrated roles in the differentiation process of MSCs, such as material morphology and exosomes. (wjgnet.com)
  • Novel Roles of Nanog in Cancer Cells and Their Extracellular Vesicles. (nih.gov)
  • Single-cell sequencing reveals that these de-differentiated adipocytes lose their original identities and transform into multiple cell types, including myofibroblast- and macrophage-like cells, with their characteristic features involved in immune response, inflammation, and extracellular matrix remodeling. (usda.gov)
  • Extracellular feedback occurs when a cell expresses receptors to a cytokine that it secretes. (weizmann.ac.il)
  • We study extracellular feedback by the cytokine IL-2 in the context of T-cell activation. (weizmann.ac.il)
  • The differentiating cells also actively alter these signals by producing relevant cytokines, thus influencing the differentiation process through extracellular feedbacks. (weizmann.ac.il)
  • Thrombospondin-1 is a secreted matricellular glycoprotein that modulates cell behavior by interacting with components of the extracellular matrix and with several cell surface receptors. (bvsalud.org)
  • Its presence in the extracellular matrix is induced by injuries that cause thrombospondin-1 release from platelets and conditions including hyperglycemia, ischemia, and aging that stimulate its expression by many cell types. (bvsalud.org)
  • In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)
  • NRG1α was detected in serous cells within normal submucosal glands and in epithelial cells lining honeycombing areas in IPF, and was not detected in other patients. (bmj.com)
  • Conclusion Expression of SOX2 and MUC5B and lack of SPDEF in atypically differentiated cells of bronchiolised distal airspaces are consistent with abnormal programming of airway epithelial cells in IPF. (bmj.com)
  • We intend to harness the inherent epigenetic memory of the ocular epithelial cells for superior and quicker protocol to regenerate cornea. (stanford.edu)
  • Some tubes had double layers, with inner layer of epithelial cells and outer layer of myoepithelial cells. (hindawi.com)
  • The luminal epithelial cells were positive for cytokeratin AE1/AE3, C-kit, and CEA, while the abluminal myoepithelial cells were positive for P63 and SMA (Figure 3 ). (hindawi.com)
  • Lung epithelial cells are located on the surface of the internal parts of the lung, and they are responsible for gas exchange (i.e., breathing). (lu.se)
  • Previously, our research team had found that two molecules, or more specifically, co-transcriptional regulators, known as YAP and TAZ, are involved in the damage of the lung epithelial cells. (lu.se)
  • Immature dendritic cells have the phenotype of CD11c + , with intermediate expression of B7-2/CD86, MHC class II, and little to no CD40. (rndsystems.com)
  • Mature dendritic cells have the phenotype of CD11c + , with increased expression of B7-2/CD86, MHC class II, and CD40. (rndsystems.com)
  • Previous studies have shown that human adipose stem cells (hASCs) are able to differentiate towards AF phenotype when treated with suitable growth factors. (utwente.nl)
  • qRT-PCR confirmed the similarity of the differentiated hASCs with AF phenotype. (utwente.nl)
  • Several markers for AF phenotype (aggrecan, collagen type I and glypican-3) were expressed in both hAFCs and differentiated hASCs. (utwente.nl)
  • This is the first study that demonstrated that hASCs can be differentiated towards AF phenotype using serum free chondrogenic medium without growth factors. (utwente.nl)
  • Finally, we found that transcription factors Jun , Fos , Atf3 , and Egr1 were upregulated in protective cells, especially Egr1 was predicted to be involved in the regulation of genes related to antioxidant stress and angiogenesis, suggesting a role in promoting differentiation into this cell phenotype. (hindawi.com)
  • These findings support a model by which decision under mixed conditions follows a fuzzy logic, where cells project their internal state onto the output phenotype stochastically, with probabilities which depend on the system's input. (weizmann.ac.il)
  • Here, we engrafted hESCs differentiated toward a ventral midbrain DA phenotype into the midbrain of a preclinical rodent model of Parkinson's disease. (lu.se)
  • If prostate biopsies are performed following hormonal therapy for prostatic adenocarcinoma, the appearance of residual tumor cells can mimic xanthoma cells. (medscape.com)
  • Tumor cells usually retain prostatic epithelial antigenicity, and immunohistochemical stains can be used for their identification. (medscape.com)
  • NANOG confers resistance to complement-dependent cytotoxicity in immune-edited tumor cells through up-regulating CD59. (nih.gov)
  • At higher magnification, the tumor cells showed minimal cytological atypia, scant cytoplasm, fine chromatin, small inconspicuous nucleoli, and rare mitotic figures (Figure 2 ). (hindawi.com)
  • The tumor cells were round to oval with fine chromatin, small inconspicuous nucleoli, indistinct cell borders, and light nongranular cytoplasm. (hindawi.com)
  • We take advantage of the similarity between neural developmental processes and cancer hierarchy to mitigate, if not completely abolish, the malignant nature of tumor cells and pave the way for new intervention strategies. (lu.se)
  • Eventually, the cells begin to differentiate, taking on a certain function in a part of the body. (healthline.com)
  • Under these conditions, iPS cells begin to differentiate into a hepatocyte lineage. (spandidos-publications.com)
  • The aim of this study was three-fold, firstly to identify new regulators of tendon development and to analyze their expression in Meox2 mutants, secondly, to analyze the intrinsic regulation of myogenic differentiation by Meox2 transcription factor, and thirdly to establish an in vitro assay to analyze tendon fibroblast-myoblast interactions. (confex.com)
  • These experiments demonstrated that expression of any of the Meox variants strongly inhibited myogenic differentiation, as measured by the fusion index. (confex.com)
  • In addition, OBEX induced a clear reduction of the lipid load in mature adipocytes obtained from 3T3-F442A cells. (nature.com)
  • In addition, its action on the 3T3-F442A cell line was tested in terms of regulation of proliferation capacity and differentiation into mature adipocytes as well as its effects on mature adipocytes. (nature.com)
  • In addition, on the 3T3-F442A cell line, OBEX inhibited proliferation of pre-adipocytes, blocked the differentiation of pre-adipocytes into new adipocytes, and decreased the lipid load in mature adipocytes. (nature.com)
  • Here, we report that adipocytes from tumor-invasive mammary fat undergo de-differentiation to fibroblast-like precursor cells during tumor progression and integrate into the tumor microenvironment. (usda.gov)
  • Stem cell technology offers a potential technique to repair the ruptured AF by enabling new matrix synthesis at the defect site. (utwente.nl)
  • How does a stem cell decide what specialized identity to adopt -- or simply to remain a stem cell? (sciencedaily.com)
  • When a stem cell divides, it can either remain a stem cell or turn into a differentiated cell, such as a muscle cell or a red blood cell. (healthline.com)
  • For example, hematopoietic stem cells are a type of adult stem cell found in bone marrow. (healthline.com)
  • Doctors have been performing stem cell transplants, also known as bone marrow transplants, for decades using hematopoietic stem cells in order to treat certain types of cancer. (healthline.com)
  • Our study also suggests that melanocyte stem cell localization may be altered during the course of aging. (medicalnewstoday.com)
  • Specifically, the division of a stem cell can result in the formation of identical daughter stem cells and/or cells that can differentiate to assume different fates. (medicalnewstoday.com)
  • A type of stem cell found in organs of the body that can be used for regenerative interventions. (mayo.edu)
  • The process by which an undifferentiated stem cell becomes a specialized cell type, such as a heart cell or brain cell. (mayo.edu)
  • A type of undifferentiated stem cell found in embryos. (mayo.edu)
  • Use of this type of stem cell has significantly decreased in recent years due to the discovery of induced pluripotent stem cells. (mayo.edu)
  • A stem cell that has been modified in the laboratory to give it specific properties. (mayo.edu)
  • Nanog, as a key cancer stem cell marker in tumor progression. (nih.gov)
  • Hematopoietic stem cell (HSC) replacement transplantation can ameliorate diseased hematologic system, thus inhibiting immune disorders including autoimmune diseases and immunodeficient disorders. (stanford.edu)
  • M, Peterson C. 2018 Haematopoietic stem suggests that during differentiation a stem cell approaches a stable equili- cells: entropic landscapes of differentiation. (lu.se)
  • Single cells in these populations exhibit different com- stem cell differentiation, Shannon information binations of regulator activity that suggest the presence of multiple theory, entropy configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)
  • AT1 cells are traditionally considered a passive structural component of the alveoli while attention has been focused on AT2 cells due to their proposed stem cell function. (mdanderson.org)
  • To this end, we overexpressed key transcriptional regulators of astroglial development in human GBM and GBM stem cell lines. (lu.se)
  • Stem Cell Reports , 17 (1), 159-172. (lu.se)
  • Immunohistochemically, the tumor demonstrated epithelial-myoepithelial dual lineage differentiation, which confirmed the diagnosis of metastatic ACC. (hindawi.com)
  • [ 1 , 2 ] They can be defined as lymphoproliferative skin infiltrates of T-cell, B-cell, or natural killer cell lineage, which primarily occur in and remain confined to the skin in most patients, without detectable extracutaneous manifestations at diagnosis. (medscape.com)
  • Immature dendritic cells exhibit characteristic dendritic cell morphology. (rndsystems.com)
  • The de-differentiated cells are metabolically distinct from tumor-associated fibroblasts but exhibit comparable effects on tumor cell proliferation. (usda.gov)
  • Here, we investigated this dichotomy in vivo by examining two cell types in the developing Caenorhabditis elegans somatic gonad that derive from equipotent progenitors, but exhibit distinct cell behaviors: the post-mitotic, invasive anchor cell and the neighboring proliferative, non-invasive ventral uterine (VU) cells. (elifesciences.org)
  • In the nuclei of VU cells, residual NHR-67 protein is compartmentalized into discrete punctae that are dynamic over the cell cycle and exhibit liquid-like properties. (elifesciences.org)
  • Due to their diverse functions and plasticity, macrophages are able to exhibit markedly different phenotypes, depending on the external signals they receive, e.g., microbial products, damaged cells, or cytokines. (biorxiv.org)
  • Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)
  • And again, this variability was dynamic: the differences diminished over time, with gene activity in both the low- and high-Sca-1 cells becoming more like that in the middle group. (sciencedaily.com)
  • Together, the findings make the case that a slow fluctuation or cycling of gene activity tends to maintain cells in a stable state, while also priming them to differentiate when conditions are right. (sciencedaily.com)
  • These observations support the hypothesis that axonal influences affect oligodendrocyte survival, differentiation, and expression of proteolipid protein gene products. (rupress.org)
  • Different cell fates and groups were fully characterized by Gene Set Enrichment Analysis (GSEA) analysis and Transcription factor (TF) activity analysis. (hindawi.com)
  • Finally, we used Cytoscape (3.9.1) to extensively examine the gene regulatory network related to cell fate. (hindawi.com)
  • Analysis of dynamic gene expression revealed that Gpx3 was significantly upregulated during cell differentiation into protective cells. (hindawi.com)
  • The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. (nih.gov)
  • Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene. (nih.gov)
  • Correct development of the musculoskeletal system relies on intricate signaling pathways and gene regulation that facilitate cell differentiation. (confex.com)
  • This was likely due to the fact that we used transiently transfected cells, and so we started selection of stably transfected cells to isolate clones, which show permanent, and strong gene expression to carry out future experiments. (confex.com)
  • They also found that without Braveheart, MesP1, the master gene that regulates heart-cell differentiation in vertebrate animals, doesn't work . (medicalnewstoday.com)
  • In this context, in the undifferentiated state, the entropy would be large since fewer constraints exist on the gene expression programmes of the cell. (lu.se)
  • The programmes governing the function and fate of cells are to a large extent driven by the coordinated activity of transcription factors forming complex and dynamic gene regulatory networks (GRNs). (lu.se)
  • The activities of transcription factors and other genes involved in cell fate decisions can be measured by a number of different gene expression quantification experiments. (lu.se)
  • Until recently, and due to technical limitations, for a given cell type such experiments had to be done on an ensemble of many cells and, hence, gene expression quantifi- cations represented the average over a given population. (lu.se)
  • Subsequently, inadequate regulation of cell proliferation and defective oncogene and/or suppressor gene expression promote the transition from preneoplastic conditions to neoplasia. (medscape.com)
  • Morphology of Mouse Dendritic Cells Derived from PBMCs. (rndsystems.com)
  • Overexpression of ClpP reduces αSyn-induced mitochondrial oxidative stress through enhancing the level of Superoxide Dismutase-2 (SOD2), and suppresses the accumulation of αSyn S129 phosphorylation and promotes neuronal morphology in neurons derived from PD patient iPS cells carrying αSyn A53T mutant. (springer.com)
  • We have delineated a two-step AT1 cell morphogenesis process, cell flattening and cell folding, which leads to its ultrathin and yet expansive morphology. (mdanderson.org)
  • Treated cells undergo a remarkable shift in structure, acquiring an astrocyte-like morphology with star-shaped bodies and radial branched processes. (lu.se)
  • Examples of qualitative examinations include microscopic examinations for cell morphology or presence of parasitic organisms, serologic procedures for presence or absence of antigens and antibodies, some microbiological procedures, and some molecular techniques. (who.int)
  • Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)
  • We determined the presence of EndoMT in the pulmonary vasculature in vivo and the functional effects on pulmonary artery endothelial cells (PAECs) undergoing EndoMT in vitro. (surrey.ac.uk)
  • Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)
  • We are studying how lung endothelial cells respond to Vegfa during intussusceptive angiogenesis and whether and how the same Vegfa signaling elicits distinct responses from those during the well-characterized retinal sprouting angiogenesis. (mdanderson.org)
  • HMGCS2 protein expression is down-regulated preferentially in moderately and poorly differentiated carcinomas. (aacrjournals.org)
  • Recently, single cell RNA sequencing (scRNA-seq) analysis has been used to examine cellular fate and function during cellular differentiation and has contributed to elucidating the mechanisms of various diseases. (hindawi.com)
  • In an effort to advance the treatment strategies for the ocular surface diseases, I am focused on a regenerative medicine and single cell RNA sequencing based approaches to better comprehend the cellular biomarkers and molecular mechanisms involved in corneal tissue development and diseases. (stanford.edu)
  • The cellular source of iPSC is a key determinant in differentiation efficiency due to its epigenetic memory. (stanford.edu)
  • The perturbances in cellular redox homeostasis leads to high free radical burden thereby causing oxidative stress in the cells. (stanford.edu)
  • A growing body of evidence suggests that cell division and basement membrane invasion are mutually exclusive cellular behaviors. (elifesciences.org)
  • We propose a model in which association of NHR-67 with the Groucho/TCF complex suppresses the default invasive state in non-invasive cells, which complements transcriptional regulation to add robustness to the proliferative-invasive cellular switch in vivo . (elifesciences.org)
  • A growing body of evidence suggests that cell cycle progression and invasion through a basement membrane are mutually exclusive cellular behaviors in both development and disease states (reviewed in Kohrman and Matus, 2017 ). (elifesciences.org)
  • During development of the hermaphroditic reproductive system, the proximal granddaughters of the Z1 and Z4 somatic gonad progenitors, Z1.pp and Z4.aa, give rise to four cells that will adopt one of two cellular fates: a proliferative ventral uterine (VU) cell or the terminally differentiated, invasive anchor cell (AC) ( Figure 1A ) ( Kimble and Hirsh, 1979 ). (elifesciences.org)
  • Downloaded from plays a mechanistic role in cellular decision-making processes ( a ) 2 during differentiation is currently the object of intense study. (lu.se)
  • We have identified a key transcriptional regulator of this process, without which AT1 cells lose their molecular and cellular characteristics and the lung undergoes alveolar simplification as in BPD. (mdanderson.org)
  • Direct cellular reprogramming has recently gained attention of cancer researchers for the possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell types. (lu.se)
  • Here, we employ cellular reprogramming to induce astrocytic differentiation as a therapeutic approach in GBM. (lu.se)
  • Roles for thrombospondin-1 signaling, mediated by specific cellular receptors or by activation of latent TGFß, have been defined in T and B lymphocytes, natural killer cells, macrophages, neutrophils, and dendritic cells. (bvsalud.org)
  • While macrophage phagocytosis is an immune defense mechanism against invading cellular organisms, cancer cells expressing the CD47 ligand send forward signals to repel this engulfment. (bvsalud.org)
  • 3,4 The zygote and cells derived from the first two cellular divisions constitute the most primitive cells (totipotent cells) that are capable of forming the embryo and the embryonic annexes (e.g. placenta, amniotic membranes etc). (bvsalud.org)
  • Consequently, PLDL and PDL seemed to be promising scaffold candidates for odontogenic regeneration at least as HA-TCP, when they were applied with the DPSC induced for odontogenic differentiation. (scielo.br)
  • Our study suggests that melanocyte stem cells are mobile but can start the regeneration of hair melanocytes only when they are present in a specific area within the hair follicle (hair germ compartment). (medicalnewstoday.com)
  • Stem cells in the body are responsible for the regeneration of tissue in the body and can differentiate to form an array of specialized cells. (medicalnewstoday.com)
  • These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis as well as the development of new teeth. (bvsalud.org)
  • Upon activation, immature dendritic cells mature and increase the expression of class II MHC and co-stimulatory molecules important for effective antigen presentation to naïve T cells. (rndsystems.com)
  • Chimeric antigen receptor T (CART) cell therapy targeting the B cell specific differentiation antigen CD19 has shown clinical efficacy in a subset of relapsed/refractory (r/r) diffuse large B cell lymphoma (DLBCL) patients. (frontiersin.org)
  • Surface calreticulin activates macrophages and triggers dendritic cell maturation, promoting effective antigen presentation and therefore activating antitumor T cells. (bvsalud.org)
  • A high recurrence rate of non-Hodgkin's lymphoma (NHL) following chimeric antigen receptor T (CAR T) cell treatment remains a bottleneck, and immunosuppressive tumor microenvironment (TME) compromising CAR T cell efficacy in NHL is the primary cause of relapse. (bvsalud.org)
  • Of note, anti-CD47 scFv secreting CAR T cells exert a more potent immune response following specific antigen stimulation compared with parental CAR T cells, characterized by more efficient degranulation and cytokine production with polyfunctionality. (bvsalud.org)
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
  • A nerve fiber that transmits signals away from the neuronal cell body and to the next nerve synapse. (mayo.edu)
  • In vitro analysis with 3T3-F442A cells revealed anti-proliferative and anti-differentiation effects of OBEX. (nature.com)
  • How cells switch between proliferative and invasive states is not well understood. (elifesciences.org)
  • We show that the fates of these cells post-specification are more plastic than previously appreciated and that levels of NHR-67 are important for discriminating between invasive and proliferative behavior. (elifesciences.org)
  • Differentiated cells express typical glial markers and show a marked decrease in their proliferative state. (lu.se)
  • Specific properties, such as proliferative and differentiation potential, are slightly different among DSCs. (bvsalud.org)
  • Pseudotime analysis showed that CFs differentiated into two distinct cell fates, one of which produced activated myofibroblasts, and the other which produced protective cells that were associated with reduced fibrosis levels, increased antioxidative stress responses, and the ability to promote angiogenesis. (hindawi.com)
  • The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
  • Plasmids encoding these reporters were transfected into C2C12 myoblasts and fluorescence was analyzed as these cells underwent in vitro differentiation. (confex.com)
  • As C2C12 cells differentiated the fluorescence of all reporters diminished. (confex.com)
  • MCP-1) and adhesion molecules (VCAM-1), in proliferating or differentiating C2C12 cells and primary myoblasts. (cdc.gov)
  • The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. (scielo.br)
  • Herein, we engineered CD19-CAR T cells to secrete an anti-CD47 single-chain variable fragment (scFv) and validated their function in enhancing antitumor efficacy, regulating T cells differentiation, modifying phagocytosis and polarization of macrophages by in vitro and in vivo researches. (bvsalud.org)
  • Instead, it supports the idea that cells differentiate through the collective behavior of multiple genes in a network that ultimately leads to just a few endpoints -- just as a marble on a hilltop can travel a nearly infinite number of downward paths, only to arrive in the same valley. (sciencedaily.com)
  • Again, they found tremendous variability within the apparently uniform cell population: more than 3,900 genes were differentially expressed (turned "on" or "off") between the low- and high-Sca-1 cells. (sciencedaily.com)
  • Composed of multiple constituent enhancers, super enhancers (SEs) are powerful cis-regulatory elements that identify genes that ensure sequential differentiation. (nature.com)
  • Then, we constructed the pseudotime trajectory of cell development and identified key regulatory genes using the Monocle R package (v2.22.0). (hindawi.com)
  • While the observation that NHR-67 forms punctae associated with transcriptional repressors in non-invasive cells is intriguing, the work does not yet established a clear link between the formation and dissolution of NHR-67 condensates with the activation of downstream genes that NHR-67 is actively repressing. (elifesciences.org)
  • It appears that Braveheart controls the cascade by influencing the PRC2 protein complex, which normally sits on top of DNA, blocking MesP1 and other genes that are essential for developing heart cells. (medicalnewstoday.com)
  • Researchers know that neural stem cells called neuroblasts divide multiple times to sequentially produce neurons of specialized function, but the mechanisms of this process, and how the timing varies for different genes and neuron types, is still not fully understood. (nih.gov)
  • Until now we've relied on studies in mice to understand human germ cell differentiation, but the reproductive genes are not the same. (sciencedaily.com)
  • In addition to expressing key genes, these cells also began to remove modifications, or methyl groups, to their DNA that confer cell-specific traits that would interfere with their ability to function as germ cells. (sciencedaily.com)
  • She received the Jean Brachet Memorial Award of the International Society of Developmental Biology (now called the International Society of Differentiation) and gave the 1996 Jean Brachet Memorial Lecture. (wikipedia.org)
  • 2.DEVELOPMENTAL BIOLOGY: Cells (etc.) become more specialized (differentiated) in time. (behavior.net)
  • Alokananda Ray, a postdoctoral researcher in the Li lab (left) with Xin Li, an assistant professor of cell and developmental biology. (nih.gov)
  • n a new paper published in eLife , Alokananda Ray, a Ph.D candidate during the time of the study and now graduated, and Xin Li (GNDP), an assistant professor of cell and developmental biology at the University of Illinois Urbana-Champaign, shed light on the process in the optic medulla of Drosophila melanogaster , the fruit fly. (nih.gov)
  • Results In IPF, the bronchiolised and enlarged distal airspaces stained for SOX2 are consistent with epithelial differentiation characteristic of conducting airway epithelium. (bmj.com)
  • Beta cell dysfunction is a characteristic of both type 1 and type 2 diabetes. (mayo.edu)
  • This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. (scielo.br)
  • Dental pulp stem cells (DPSC) seem to be the most appropriate cell group for the regenerative approach. (scielo.br)
  • Dental pulp stem cells: state of the art and suggestions for a true translation of research into therapy. (scielo.br)
  • Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells. (scielo.br)
  • Cytokines produced by DCs can also promote the differentiation of CD4 + T helper cells as part of immune activation. (rndsystems.com)
  • In vitro , CD3 + CD8 + CD27 - CD28 - compared to CD3 + CD8 + CD27 + CD28 + CART cells displayed similar CD19 + target cell-specific cytotoxicity, but were hypoproliferative and produced less cytotoxic cytokines (IFN-γ and TNF-α). (frontiersin.org)
  • This decision is influenced by the spectrum of cytokines that the cells sense. (weizmann.ac.il)
  • While differentiation is usually studied under polarizing conditions, applying only one signal at a time, cells in vivo are expected to sense a more complex environment, in which they may be simultaneously exposed to combinations of cytokines. (weizmann.ac.il)
  • We explore differentiation under mixed input conditions by exposing cells to varied combinations of cytokines, experimentally mapping the "decision space" of the differentiation process at the single cell level. (weizmann.ac.il)
  • Once activated, M1-like macrophages release cytokines that inhibit the proliferation of nearby cells (including cancer cells) and initiate inflammation and an immune response. (biorxiv.org)
  • At the other extreme, M2-like macrophages are induced by the interleukins (IL)-4 and −13, cytokines secreted by activated Th2 cells [ 16 ]. (biorxiv.org)
  • The CellXVivo ™ Mouse Dendritic Cell Differentiation Kit contains the media and cytokine components to generate immature and mature dendritic cells from mouse bone marrow. (rndsystems.com)
  • Opened or reconstituted Mouse Dendritic Cell Base Media, Recombinant Mouse GM-CSF, Recombinant Mouse IL-4, or Recombinant Human TNF-alpha should be stored at 2-8 ° C under sterile conditions for up to 30 days or at -20 ° C to -70 ° C in a manual defrost freezer for up to 3 months. (rndsystems.com)
  • Immature dendritic cells (left, blue) and TNF-α-treated mature dendritic cells (right, red), derived from bone marrow cells cultured with the CellXVivo ™ Mouse Dendritic Cell Differentiation Kit, were stained for flow cytometry with antibodies for CD11c, B7-2/CD86, MHC class II (I-A/I-E), or CD40 (open histograms). (rndsystems.com)
  • Described here are some of the general requirements of in vitro test methods for skin sensitization, and progress that has been made in developing suitable approaches with particular emphasis on the utility of dendritic cell culture systems. (cdc.gov)
  • The results show that lysophosphatidic acid signalling pathways influence retraction of processes in oligodendrocyte precursors but that this effect changes as oligodendrocytes differentiate. (nih.gov)
  • The conventional view of how stem cells differentiate assumes that cells are "instructed" to progress along prescribed signaling pathways. (sciencedaily.com)
  • A new study suggests that the conventional view, which assumes that cells are "instructed" to progress along prescribed signaling pathways, is too simplistic. (sciencedaily.com)
  • Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
  • Processes of differentiated central glia-4 oligodendrocytes were insensitive to lysophosphatidic acid treatment but cell bodies became phase dark, indicating cell spreading on the poly-l-lysine substratum. (nih.gov)
  • Previous studies have indicated that newly formed oligodendrocytes are dynamic cells whose production, survival, and differentiation depend upon axonal influences. (rupress.org)
  • Oligodendrocytes, the myelin-forming cell in the central nervous system (CNS) 1 , are neuroepithelial in origin. (rupress.org)
  • They began by examining populations of seemingly identical blood stem cells, and found that a cell marker of "stemness," a protein called Sca-1, was actually present in highly variable amounts from cell to cell -- in fact, they found a 1,000-fold range. (sciencedaily.com)
  • which is the iron-containing protein in red blood cells that carries oxygen. (medlineplus.gov)
  • The GATA1 protein is involved in the specialization (differentiation) of immature blood cells. (medlineplus.gov)
  • An abnormal GATA1 protein causes immature red blood cells to undergo a form of programmed cell death called apoptosis. (medlineplus.gov)
  • The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. (nih.gov)
  • Here, we show that the protein level of ClpP is selectively decreased in αSyn-expressing cell culture and neurons derived from iPS cells of PD patient carrying αSyn A53T mutant, and in dopaminergic (DA) neurons of αSyn A53T mice and PD patient postmortem brains. (springer.com)
  • Simultaneously, RRX-001 reduces CD47 protein levels, aiding in preventing immune escape by calreticulin-rich cancer cells. (bvsalud.org)
  • We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)
  • We demonstrate here that lysophosphatidic acid induces process retraction in central glia-4 cells and oligodendrocyte precursors. (nih.gov)
  • This process is called differentiation. (healthline.com)
  • During the process of harvesting embryotic stem cells, the embryo is destroyed. (healthline.com)
  • The authors sought to identify mechanisms driving the differentiation of mucus cells during the bronchiolisation process. (bmj.com)
  • It was previously thought that once McSCs differentiated into melanocytes, this process was irreversible. (medicalnewstoday.com)
  • The process of removing all the cells from a donor organ, such as a heart or lung, leaving behind just a tissue scaffold. (mayo.edu)
  • Cell differentiation is the process in which immature cells become specialized, mature cells. (lymphomainfo.net)
  • This averaging effect hampered the analysis of finer regulatory mechanisms at the single-cell level, the fundamental unit for any fate decision process. (lu.se)
  • Although low CD47-expressing cancer cells still allow phagocytosis, the reverse signaling delays the process, leading to incomplete digestion of the entrapped cells and subsequent tumor hybrid cell (THC) formation. (bvsalud.org)
  • The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)
  • Such epigenetic reprogramming is a hallmark of germ cell formation. (sciencedaily.com)
  • Since stem cells have the ability to turn into various other types of cells, scientists believe that they can be useful for treating and understanding diseases. (healthline.com)
  • There are several types of stem cells that can be used for different purposes. (healthline.com)
  • They make new red blood cells, white blood cells, and other types of blood cells. (healthline.com)
  • They can differentiate into all types of specialized cells in the body. (healthline.com)
  • To function properly, these immature cells must differentiate into specific types of mature blood cells. (medlineplus.gov)
  • Hair follicles contain several different types of cells, including melanocyte stem cells that generate cells that produce the pigment melanin responsible for hair color. (medicalnewstoday.com)
  • Our first important observation is that, MSC EVs possess a common mechanism of endocytosis across multiple cell types. (frontiersin.org)
  • Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
  • There are many types of lymphoma , all classified based on their cell type, cell markers, location of the cancerous mutation, and how they grow. (lymphomainfo.net)
  • The only way to tell the cell types apart was by looking under a microscope, and the updated tissue tests available nowadays can categorize cancerous cells much better. (lymphomainfo.net)
  • In the United States, a similar system, called the Lukes and Collins Classification, was the first to classify based on B-cell and T-cell types. (lymphomainfo.net)
  • Employing this specific strategy, we wish to explore the transdifferentiated or partially reprogrammed state in ocular epithelial cell types by giving pulsed reprogramming factors. (stanford.edu)
  • The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
  • In a new study published this week, a team describes how some of it codes for a genetic snippet of "long non-coding RNA" (or lncRNA) that controls the destiny of stem cells that differentiate into various types of heart cell. (medicalnewstoday.com)
  • It opens a new door to what we could do, and how we could use lncRNAs to induce specific cell types, that's been completely unexplored. (medicalnewstoday.com)
  • Yet, when these brains form during embryonic development, there is initially only a small pool of cell types to work with. (nih.gov)
  • Although GISTs may differentiate along either or both cell types, some show no significant differentiation at all. (medscape.com)
  • Objective: the aim of this study was to conduct a literature review of the types of stem cells of dental origin and their applications in Dentistry. (bvsalud.org)
  • Stem cells (SCs) are undifferentiated cells with self-renewal ability and capacity to differentiate into specialized cell types. (bvsalud.org)
  • Singularly, SPDEF, a transcription factor associated with mucus metaplasia, was rarely detected in mucus cells in IPF. (bmj.com)
  • Mucus cells lining abnormal airways from patients with IPF expressed MUC5B and SOX2 but lacked SAM pointed domain containing ETS transcription factor (SPDEF) and forkhead box A3(FOXA3). (bmj.com)
  • After 7 days of culture, the cells were subjected to reverse transcription‑quantitative PCR analysis. (spandidos-publications.com)
  • Transcription of nhr-67 is downregulated following post-translational degradation of its direct upstream regulator, HLH-2 (E/Daughterless) in VU cells. (elifesciences.org)
  • As neuroblasts divide and differentiate, they express transcription factors which ultimately direct the daughter cells on what kind of neuron to be. (nih.gov)
  • Such heterogeneity could originate from extrinsic factors, such as cell-to-cell signalling and surrounding temperature and pressure, but also from the intrinsic noise generated by having few copies of molecules involved in transcription and translation. (lu.se)
  • It is inhibited by pre-treatment of cells with C3 exoenzyme, a specific inhibitor of Rho, or with Y-27632, a specific inhibitor of ROCK, a downstream kinase of Rho. (nih.gov)
  • Accordingly, immunohistochemistry with specific antibodies shows that HMGCS2 is expressed mainly in differentiated cells of human colonic epithelium. (aacrjournals.org)
  • These cells can only serve a specific purpose in a particular organ. (healthline.com)
  • This differentiation of stem cells to a cell type that performs a specific function is thought to be irreversible. (medicalnewstoday.com)
  • Moreover, we show that cell state can be tuned into a specific state in this continuum by altering input signal combinations. (weizmann.ac.il)
  • TNFa delivers its signals to target cells by binding to specific cell surface membrane receptors (TNFR1 and TNFR2). (cdc.gov)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • We then injected a novel DA-neurotropic retrograde MNM008 adeno-associated virus vector capsid, into specific DA target regions to generate starter cells based on their axonal projections. (lu.se)
  • Mouse PBMCs were differentiated into immature mouse dendritic cells by culturing for 5 days in reagents included in the CellXVivo ™ Mouse Monocyte-derived Dendritic Cells Differentiation Kit. (rndsystems.com)
  • Phenotypic Analysis of Cultured Immature and Mature Mouse Dendritic Cells. (rndsystems.com)
  • In affected individuals, immature red blood cells are unusually shaped and cannot develop into functional mature cells, leading to a shortage of healthy red blood cells. (medlineplus.gov)
  • A lack of immature red blood cells results in decreased amounts of specialized, mature red blood cells, leading to anemia . (medlineplus.gov)
  • In one of the locations-called the bulge- these McSCs undergo self-renewal to maintain a population of immature stem cells. (medicalnewstoday.com)
  • We revealed that as melanocyte stem cells move within the hair follicle, stem cells can reversibly alter cell state from immature to mature state, and this reversibility is critical for the proper maintenance of these stem cells. (medicalnewstoday.com)
  • Unlike previous research, which yielded primarily immature germ cells, the cells in this most-recent study functioned well enough to generate sperm cells. (sciencedaily.com)
  • Why Differentiate Dendritic Cells ex vivo ? (rndsystems.com)
  • Although MSC EVs show great promise for regenerative medicine applications, insights into their uptake mechanisms by different target cells and the ability to control MSC EV properties for defined function in vivo have remained elusive knowledge gaps. (frontiersin.org)
  • Most importantly, forced differentiation substantially reduces tumorigenicity of GBM cells in an in vivo xenotransplantation model. (lu.se)
  • Activation of abnormal respiratory epithelial differentiation programs may contribute to the expression of MUC5B and bronchiolisation of the distal lung, a salient feature of IPF. (bmj.com)
  • After two days of culture in HSM, the expression levels of α-fetoprotein (AFP) and albumin, which are hepatocyte markers, were upregulated, suggesting that hepatocyte differentiation was initiated ( 19 ). (spandidos-publications.com)
  • Through a series of transcriptome analyses, we have identified a Wnt ligand specifically expressed in AT1 cells but not AT2 cells, an expression pattern similar to that of Vegfa. (mdanderson.org)
  • For TNFa induced inhibition of myoblast differentiation myogenin expression was reduced. (cdc.gov)
  • The scRNA-seq analysis was used to characterize the dynamic changes associated with fibroblast differentiation and identified Gpx3 as a factor that might be involved in the regulation of myocardial fibrosis under cardiac pressure overload. (hindawi.com)
  • In differentiating neuroblastoma cells, HASH-1 is down-regulated, and there is coincident up-regulation of the transcriptional repressor HES-1, which is known to bind the HASH-1 promoter. (lu.se)
  • Sex cord-stromal tumors are groups of tumors composed of granulosa cells, theca cells, Sertoli cells, Leydig cells, and fibroblasts of stromal origin, singly or in various combinations. (medscape.com)
  • The tendon fibroblasts we attempted to isolate are from Scleraxis-GFP transgenic mice, so all tendon cells are GFP positive. (confex.com)
  • For the differentiation of dendritic cells from mouse bone marrow. (rndsystems.com)
  • Hard tissue formation in a porous HA/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrow. (scielo.br)
  • A medical procedure in which healthy bone marrow stem cells are injected into the body to replace damaged or diseased bone marrow. (mayo.edu)
  • A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
  • Treated cells undergo a remarkable shift in structure, acquiring an. (lu.se)
  • Although many related studies have been performed, differences in cell lines, experimental conditions and downstream mechanisms have generally resulted in contradictory findings. (nature.com)
  • However, many of the mechanisms that govern their differentiation, maturation, and integration into the host circuitry remain elusive. (lu.se)
  • The efficacy was analogous or preferable to the combination of CAR T cells and CD47 antibody. (bvsalud.org)
  • Instead, a recent study published in Nature suggests that the McSCs can migrate back and forth between the two aforementioned locations, differentiating to produce hair pigment-producing melanocytes in the hair germ area and then translocating to the bulge and dedifferentiating to ensure the maintenance of an adequate supply of stem cells. (medicalnewstoday.com)
  • Nervous systems diversify from a small pool of neural stem cells to the great diversity of neurons we see in adult brains of higher ordered animals," said Ray. (nih.gov)
  • To circumvent these obstacles, we have developed two methods for the investigation of human neural cells in culture. (lu.se)
  • 2012). In an additional work, performed in collaboration with Yuval Hart and Uri Alon from the department of molecular cell biology, we show that IL-2 pleiotropic activity can result in homeostasis of cell numbers, where the final cell concentration is independent of initial concentration over a large range (Hart et. (weizmann.ac.il)
  • We are also interested in its role in AT1 cell homeostasis and injury in the adult lung. (mdanderson.org)
  • We are also interested in the role of AT1 cell-derived VEGFA during homeostasis and tumorigenesis. (mdanderson.org)
  • Blood cell and serum markers, along with clinical data of DLBCL patients who were scheduled for CART cell therapy were evaluated to search for biomarkers predicting CART cell responsiveness. (frontiersin.org)
  • 2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)