• MicroRNAs (miRNAs) regulate many physiological processes including body growth. (nature.com)
  • MicroRNAs (miRNAs) are endogenous noncoding RNAs that act as post-transcriptional regulators of gene expression by binding to the 3′-untranslated region (UTR) of target mRNAs. (nature.com)
  • The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
  • Moreover, we found that these differentially expressed exosomal miRNAs connect osteogenic differentiation to processes such as axon guidance, MAPK signaling, and Wnt signaling. (hindawi.com)
  • MicroRNAs (miRNAs) are single-stranded, endogenously expressed, short, noncoding RNAs with a length of 18-25 nucleotides. (nature.com)
  • Recently, much attention has focused on the impact of microRNAs (miRNAs) on tumorigenesis and cancer progression. (sarcomahelp.org)
  • miRNAs are approximately 22-nucleotide non-coding RNAs that participate in post transcriptional gene expression regulation through mRNA degradation, translational inhibition or chromatin-based silencing mechanisms. (sarcomahelp.org)
  • Pharmacologic manipulation of microRNA expression has been undertaken in the form of in vivo miRNA delivery of downregulated miRNAs and "antagomirs" targeting upregulated miRNAs. (sarcomahelp.org)
  • MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs, which act as key post-transcriptional regulators of target-gene expression. (spandidos-publications.com)
  • 1,000 human miRNAs have been identified that regulate ~1/3 of the coding genes in the human genome ( 9 ). (spandidos-publications.com)
  • EBV is the first human virus that has the capability to encode microRNAs (miRNAs). (ijbs.com)
  • microRNAs (miRNAs) are a large class of small non-coding RNAs with a length of 21-23 nucleotides (nt) [ 11 ]. (ijbs.com)
  • Exceptionally, a minority of miRNAs are derived from RNA Pol III transcripts. (ijbs.com)
  • For example, murine gammaherpesvirus 68 (MHV-68)-encoded miRNAs are located downstream of viral tRNAs and transcribed by RNA Pol III [ 2 ]. (ijbs.com)
  • Recent studies have shown that interleukin (IL)-1β is a key inflammatory mediator in acute gouty arthritis (GA), and its level is regulated by microRNAs (miRNAs). (biomedcentral.com)
  • microRNAs (miRNAs) are important regulators in plant growth and development. (biomedcentral.com)
  • Plant microRNAs (miRNAs) are 20-24 nucleotides (nt) long and widely exist as gene regulators. (biomedcentral.com)
  • Recent genome-wide molecular genetic studies have identified several protein-coding genes and microRNAs (miRNAs) significantly associated with BD. (en-journal.org)
  • MicroRNAs (miRNAs) are well-recognized for their abilities to regulate gene expression post-transcriptionally in plants and animals. (frontiersin.org)
  • The molecular alterations include epigenetic regulations such as regulation by microRNAs (miRNAs). (nitrkl.ac.in)
  • miRNAs are a group of small non-coding RNAs, about 18-25 nucleotides in length. (nitrkl.ac.in)
  • These miRNAs have the potential to regulate mRNA expression by suppressing the translational activity. (nitrkl.ac.in)
  • For this, we analyzed expression data of miRNAs and mRNAs in breast cancer tissues and identified the sets of miRNAs and mRNAs that are differentially expressed in breast cancer. (nitrkl.ac.in)
  • To confirm the expression of these miRNAs and mRNAs in breast cancer, we performed qRT-PCR of each of the mRNAs and miRNAs in MDA-MB-231 cell line and found that miRNAs- hsa-miR-27a-3p, hsa-miR-17- 5p that target ADAMTS5 and CX3CL1 respectively are up-regulated and the corresponding targets are down-regulated. (nitrkl.ac.in)
  • This inverse correlation in expression of these miRNAs and mRNAs supplemented with presence of target sites identified from target prediction indicate that these two miRNAs might be regulating the expression of these two mRNAs which in turn might be playing a crucial role in breast cancer. (nitrkl.ac.in)
  • MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression of their target genes. (biomedcentral.com)
  • We considered the expression of both miRNAs and messenger RNAs (mRNAs) at these time points to improve the identification of regulatory targets of miRNAs. (biomedcentral.com)
  • We identified 151 differentially expressed miRNAs with a strict dual nature of either upregulation or downregulation during the whole course of disease progression. (biomedcentral.com)
  • Among 82 newly discovered breast-cancer-related miRNAs, 35 can potentially regulate 271 protein-coding genes based on their sequence complementarity and expression profiles. (biomedcentral.com)
  • By integrating miRNA and mRNA expression profiles, we identified differentially expressed miRNAs and their target genes involved in several hallmarks of cancer. (biomedcentral.com)
  • In addition to numerous protein-coding genes, many microRNAs (miRNAs) also play important roles in breast cancer. (biomedcentral.com)
  • MicroRNAs (miRNAs) participate in arrhythmogenesis, and thus miRNA modulators may be applicable as therapeutic modalities for AF. (tmu.edu.tw)
  • Results: Among the differentially expressed miRNAs, 11 were down-regulated and 6 were up-regulated after ZFHX3 KD. (tmu.edu.tw)
  • These pieces of single-stranded RNA ― dubbed microRNAs or miRNAs ― have wide-ranging, subtle effects on the production of many different proteins without affecting a cell's underlying DNA code. (spectrumnews.org)
  • Studying postmortem brain tissue samples of 13 people with autism and 13 controls, the team found that out of the 466 miRNAs analyzed, 9 are either up- or down-regulated in people with autism compared with controls 5 . (spectrumnews.org)
  • In September, another team found that of 470 miRNAs analyzed, 9 are differentially expressed in people with autism, including 4 identified in the July report 6 . (spectrumnews.org)
  • In both studies, a computer algorithm predicted that a few of the differentially expressed miRNAs would target known autism-susceptibility genes. (spectrumnews.org)
  • DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)
  • Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
  • This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
  • Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
  • MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)
  • that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)
  • MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
  • Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)
  • Conclusion and Clinical Relevance: Examination of the pulmonary genetic profiles revealed differentially expressed genes and microRNAs following subchronic inhalation exposure to A. fumigatus. (cdc.gov)
  • When a signal is sent to express a specific gene, the DNA sequence encoding that gene is used as a template to produce single-stranded RNA in a process called transcription. (ernolaszlo.com)
  • Gene Ontology (GO) enrichment analysis of differentially expressed genes between wild type plants and STTM159 transgenic plants showed that genes involved in cell division, auxin, cytokinin (CK) and brassinosteroids (BRs) biosynthesis and signaling are significantly down-regulated in STTM159 plants. (biomedcentral.com)
  • Various cytokines, transcription factors, and other regulatory molecules have been found to be differentially methylated in CD8+ T cells in autoimmune diseases. (frontiersin.org)
  • Considering sets of up-regulated miRNA and down-regulated mRNAs, we constructed miRNA-target interaction map and screened few miRNA-target pairs (hsa-miR-27a-3p:ADAMTS5 & hsa-miR-17-5p: CX3CL1) that are hypothesised to play a role in breast cancer malignancy. (nitrkl.ac.in)
  • Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)
  • Structures of mammalian GLD-2 proteins reveal molecular basis of their functional diversity in mRNA and microRNA processing. (xenbase.org)
  • In this study, we performed an integrative network-based analysis using a publicly available data set studying the role of 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) in prostate cancer cells on mRNA and microRNA level. (biomedcentral.com)
  • The extendable network-based tools PathVisio and Cytoscape enable straightforward, in-depth and integrative analysis of mRNA and microRNA expression data in 1,25(OH) 2 D 3 -treated cancer cells. (biomedcentral.com)
  • Nowadays high-throughput technologies enable the measurements of mRNA and microRNA expression on a large scale. (biomedcentral.com)
  • In the present study, we will combine pathway- and network-based methods to decipher the regulatory action of 1,25(OH) 2 D 3 in prostate cancer cells on mRNA and microRNA level. (biomedcentral.com)
  • MicroRNAs Unveil Metabolic Imbalance in Spinocerebellar Ataxia Type-2 [abstract]. (mdsabstracts.org)
  • Since the insulin and growth phenotypes are rescued by expression of sNPFR1, we propose that the conserved miR-9a/miR-9 regulates body growth by modulating insulin signalling through its conserved sNPFR1/NPY2R target in both Drosophila and mammals. (nature.com)
  • MicroRNAs function is to regulate the expression levels of other genes by several mechanisms. (wikipedia.org)
  • Cardiac microRNA expression profile in response to estivation. (xenbase.org)
  • Thus, gene expression must be tightly regulated so that only appropriate genes are expressed in a particular cell type. (ernolaszlo.com)
  • Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure. (cdc.gov)
  • Total RNA was isolated from whole lung 24 and 48 hours post final exposure and was further processed for gene expression and microRNA array analysis. (cdc.gov)
  • It was revealed that cellular oncogenicity is positively regulated by miR-183 by inhibiting the expression of PTEN. (nature.com)
  • It has been proven that the miR-183 expression is up-regulated in tumor tissues and patient serum in BC, which indicates its possibly an oncogenic role 15 , 16 . (nature.com)
  • After selecting the data sets based on our criteria, quality control, and normalization, each data set of the microRNAs expression profile was analyzed. (nature.com)
  • Several studies demonstrate important associations between differential expression of micro-RNAs (miRs) and the prognosis of CRC. (biorxiv.org)
  • Upregulation of miR-488 and miR-920 could suppress MSU-induced IL-1β protein expression in THP-1 cells, but no significant difference in IL-1β messenger RNA levels was observed. (biomedcentral.com)
  • Further analysis from the RNA-seq data showed that the decreased cell divisions in STTM159 transgenic plants may result, at least partly from the lower expression of the genes involved in cell cycle and hormone homeostasis, which provides new insights of rice miR159-specific functions. (biomedcentral.com)
  • MicroRNAs are short noncoding RNA that regulate gene expression (Cannell et al. (asu.edu)
  • These results suggest that microRNA can be used to estimate the age of pupal samples as miRNA expression changes throughout pupation. (asu.edu)
  • microRNA (miRNA) expression level alterations between endometrial tissue and endometriotic lesions indicate their involvement in endometriosis pathogenesis. (mdpi.com)
  • It regulates Sp7 protein expression and induces expression of major bone matrix protein genes, such as Col1a1, Spp1, Ibsp, Bglap2, and Fn1 ( 7 , 8 ). (frontiersin.org)
  • In this study, using polyoma middle T antigen (PyMT) mice, a widely used luminal B breast cancer model, we profiled microRNA (miRNA) expression at four time points that represent different key developmental stages of cancer progression. (biomedcentral.com)
  • Moreover, after 1,25(OH) 2 D 3 treatment the gene expression in several cancer-related processes was down-regulated. (biomedcentral.com)
  • Promising regulatory molecules in this respect are small non-coding RNAs, like microRNAs, which regulate gene expression post-transcriptionally. (biomedcentral.com)
  • In addition, they examined the expression of microRNAs in these cells upon treatment with 1,25(OH) 2 D 3 . (biomedcentral.com)
  • OBJECTIVE To investigate the expression of differential expressed microRNAs and the predicted target gene in Lipopolysaccharides( LPS)-induced innate immune response of THP-1 macrophages at different time points( 4,8,12,24,48 h).And to explore the host immuno-inflammatory response regulatory mechanisms of bone grafting at early stage. (cnki.net)
  • The microRNAs expression was analyzed by real time quantitative PCR methods. (cnki.net)
  • Regarding the important role of microRNAs in breast cancer, investigating the molecular mechanisms of miRs and their impacts on breast cancer progression is critical. (nature.com)
  • BC-related differentially expressed microRNAs (DE-miRs) were recognized and assessed in the present study. (nature.com)
  • The present study aimed to identify differentially expressed tissue miRs associated with prognostic factors in CRC patients, through a systematic review of the Literature. (biorxiv.org)
  • Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. (biorxiv.org)
  • Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
  • TPX2 regulated by miR-29c-3p induces cell proliferation in osteosarcoma via the AKT signaling pathway. (xenbase.org)
  • This study demonstrates the roles of miR-488 and miR-920 in regulating the production of proinflammatory cytokines in the pathogenesis of GA. These findings suggest that miR-488 and miR-920 could serve as potential therapeutic targets in the treatment of GA. (biomedcentral.com)
  • To correlate differentially expressed non-coding microRNA of peripheral blood mononuclear cells (PBMCs) with SCA2 pathogenesis. (mdsabstracts.org)
  • MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
  • Total RNA from PBMCs of four confirmed SCA2 patients and four matched healthy controls was analysed for differential miRNA expressions using SurePrint-Human-miRNA-Microarrays (Agilent Technologies, USA). (mdsabstracts.org)
  • METHODS The differentiated THP-1 macrophage that induced by phorbol PMA were treated by LPS,and the total RNA was extracted at 4,8,12,24,48 h,respectively. (cnki.net)
  • Objective: The impact of fungal viability on the pulmonary microRNA and messenger RNA profiles that regulate murine immune responses was evaluated following subchronic inhalation exposure to Aspergillus fumigatus conidia. (cdc.gov)
  • MicroRNAs regulating genes involved in the pulmonary immune responses were those with the greatest fold change. (cdc.gov)
  • Wang M, Yu F, Wu W, Wang Y, Ding H, Qian L. Epstein-Barr virus-encoded microRNAs as regulators in host immune responses. (ijbs.com)
  • The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)
  • Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes, including osteogenic differentiation. (frontiersin.org)
  • MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
  • Furthermore, altered microRNAs may serve as potential biomarkers to evaluate fungal exposure. (cdc.gov)
  • The ATXN2 is involved in the regulation of cellular processes such as RNA metabolism/stabilization, translation regulation, calcium homeostasis, and cytoskeleton reorganization etc. (mdsabstracts.org)
  • Network algorithms were used to (1) identify active network modules and (2) integrate microRNA regulation in the network. (biomedcentral.com)
  • Adding microRNA regulation to the network enabled the identification of gene targets of significantly expressed microRNAs after 1,25(OH) 2 D 3 treatment. (biomedcentral.com)
  • Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)
  • Finally, IGF‑1R protein, phosphoinositide 3‑kinase/Akt signaling pathway‑associated proteins and cyclin pathway‑associated proteins were differentially expressed between miR‑497‑overexpressing cells and miR-497-silenced cells. (spandidos-publications.com)
  • Dorsoventral (DV) patterning of the Drosophila embryo is initiated by a broad Dorsal (Dl) nuclear gradient, which is regulated by a conserved signaling pathway that includes the Toll receptor and Pelle kinase. (sdbonline.org)
  • The changes in the G1-to-S cell cycle pathway showed that 1,25(OH) 2 D 3 down-regulates the genes influencing the G1-to-S phase transition. (biomedcentral.com)
  • The present study demonstrates how pathway analysis can be combined with network analysis to perform an integrated analysis of transcriptomics and microRNA-omics data. (biomedcentral.com)
  • In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
  • In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
  • The latter interact with the cytokines and growth factors, regulating their function [ 4 ]. (biomedcentral.com)
  • It's possible that microRNAs can have some kind of regulatory role over multiple targets and affect them a little bit differently in different people," says Kenneth Kosik , co-director of the Neuroscience Research Institute at the University of California, Santa Barbara. (spectrumnews.org)
  • Furthermore, microRNAs are also shown to be targets for asthma therapy in the future. (cdc.gov)
  • 2011 ) clearly showed that 1,25(OH) 2 D 3 can modulate gene and microRNA profiles in LCNaP cells and affects processes involved in cell cycle arrest, calcium ion homoeostasis and phosphoinositide-mediated signalling. (biomedcentral.com)
  • Targeted Transcriptomics of Frog Virus 3 in Infected Frog Tissues Reveal Non-Coding Regulatory Elements and microRNAs in the Ranaviral Genome and Their Potential Interaction with Host Immune Response. (xenbase.org)
  • Multiple miRNA-mRNA prediction databases were searched by differentially expressed genes (DEGs) to obtain pairs of a miRNA-DEG regulatory network. (frontiersin.org)
  • Methods: We performed small RNA deep sequencing on ZFHX3-KD and control HL-1 mouse atrial myocytes. (tmu.edu.tw)
  • Some small fragments of RNA are expressed differently in people with autism than in controls, according to two new studies. (spectrumnews.org)
  • By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
  • After transcription, the pre-mRNA transcript is spliced, joining coding exons together while excising introns and generating messenger RNA (mRNA), which is exported from the nucleus and read by ribosomes to produce polypeptides that fold into the final 3-dimensional structure of proteins ( Figure 1.1) . (ernolaszlo.com)
  • Six of the nine differentially expressed microRNAs target genes in the extended network, including CLSPN , an important checkpoint regulator in the cell cycle that was down-regulated, and FZD5 , a receptor for Wnt proteins that was up-regulated. (biomedcentral.com)
  • Our data suggests that in rice, miR159 positively regulates organ size, including stem, leaf, and grain size due to the promotion of cell division. (biomedcentral.com)
  • We selected miR-183 for study among the considerably dys-regulated microRNAs in breast cancer. (nature.com)
  • Recently, an increasing number of studies have revealed that microRNA-497 (miR-497) levels are decreased in tumors, and that it functions as a tumor suppressor in a number of types of human cancer, including colorectal, gastric, cervical and breast cancers, adrenocortical carcinoma and melanoma ( 12 - 20 ). (spandidos-publications.com)
  • Autism and schizophrenia might be disorders of synaptic plasticity, and emerging data suggests that these microRNAs are very important in regulating synaptic plasticity, so it may be that thatʼs the common link," she says. (spectrumnews.org)
  • Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
  • Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)
  • Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation. (xenbase.org)
  • Inhibition of interleukin-1β plays a protective role in Alzheimer's disease by promoting microRNA-9-5p and downregulating targeting protein for xenopus kinesin-like protein 2. (xenbase.org)
  • They are usually generated from either exons or introns of both protein-coding and non-coding transcripts that are processed by RNA polymerase II (Pol II) [ 12 - 14 ]. (ijbs.com)
  • Therefore, specific roles of miR159 in rice could be explored by down regulating miR159 through STTM. (biomedcentral.com)
  • The role of miR‑497 in regulating the proliferation of HCC‑derived cells was also investigated in vitro and in vivo. (spandidos-publications.com)
  • Results demonstrated that various miRNA sequences were differentially expressed across pupation. (asu.edu)