• Crystal structure of UTP-glucose-1-phosphate uridylyltransferase from Burkholderia xenovorans Human UTP-glucose-1-phosphate uridylyltransferase isoform 1 subunit with UDP-glucose bound Human genes encoding proteins with UTP-glucose-1-phosphate uridylyltransferase activity include two isoforms with molecular weights of 56.9 and 55.7 kDa, respectively. (wikipedia.org)
  • One basic problem is how a decrease in tRNA levels, by downregulating Pol III efficiency, influences the expression pattern of protein-coding genes. (mdpi.com)
  • One-third of the 471 genes predicted to encode transcription factors are differentially expressed during sexual development of S. commune . (nature.com)
  • Oncotarget published " Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling " which reported that K69 and K285 regulate binding of DVL-1 to Wnt target gene promoters and modulate expression of Wnt target genes including CMYC, OCT4, NANOG, and CCND1, in cell line models and xenograft tumors. (oncotarget.com)
  • The canonical or β-catenin dependent branch of Wnt signaling relays information through secreted Wnt ligands, transmembrane Frizzled receptors, low-density lipoprotein receptor related protein 5/6 , DVL proteins, and active β-catenin to initiate transcription of Wnt target genes. (oncotarget.com)
  • This suggests that variants of other genes and proteins may also be involved in providing protection. (elifesciences.org)
  • H3.3 knockout followed by RNA-seq reveals large-scale transcriptional alterations in functionally important genes. (biomedcentral.com)
  • Genetic studies have clarified that most microcephaly genes encode ubiquitous proteins involved in mitosis and in maintenance of genomic stability, but the effects of their inactivation are particularly strong in neural progenitors. (cancerindex.org)
  • Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
  • Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
  • The fact that the Gimap genes are located together in a tight cluster on RNO4 (and in conserved synteny with many other species), combined with their sequence similarities, suggests the possibility that the proteins carry out similar function. (hindawi.com)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
  • Several molecular mechanisms with antifungal agents have been reported for C. albicans where insertions, deletions, and point mutations in genes codifying target proteins are frequently related to the antifungal drug resistance. (intechopen.com)
  • In addition, since the gene encoding the A56 protein is non-essential, it can be used as an insertion point for foreign genes and has been deleted in some viruses that are in clinical development as oncolytic agents. (microbiologyresearch.org)
  • In humans and in yeast, the enzyme is active as an octamer consisting of two tetramers stacked onto one another with conserved hydrophobic residues at the interfaces between the subunits. (wikipedia.org)
  • Dileucine motifs are variable (especially at their negatively charged positions and at the hydrophobic residues) and the various motif subtypes tend to have slightly different functions ( Mattera,2011 ). (eu.org)
  • Collectively, this study provides the first evidence that transient levels of the evolutionarily conserved factor RACK1 are critical for adult SC activation and proper skeletal muscle regeneration, favoring the efficient progression of SC from a committed to a fully differentiated state. (sdbonline.org)
  • Adaptin-binding acidic dileucine motifs and variants thereof occur almost exclusively on the cytosolic side of membrane proteins, mostly integral (transmembrane) proteins. (eu.org)
  • In the latter, they are frequently located near the protein N- or C-termini, with relative proximity (within 10-100aa) to a transmembrane segment. (eu.org)
  • Host interferon-induced transmembrane proteins (IFITMs) are broad-spectrum antiviral restriction factors. (life-science-alliance.org)
  • Interferon-induced transmembrane proteins (IFITMs) are antiviral factors that act uniquely and early in viral replication cycles to restrict the entry of a diverse range of primarily enveloped viruses into cells ( 1 ). (life-science-alliance.org)
  • Studies of IFITM topology suggest a type II transmembrane configuration with a cytosolic N terminus, cytosolic conserved intracellular loop (CIL) domain, transmembrane domain, and extracellular (or intraluminal) C terminus ( 4 , 5 ), although there is evidence that other IFITM topologies exist ( 6 , 7 , 8 ). (life-science-alliance.org)
  • A missense mutation (G115D) in the region of the enzyme containing the active site (which is conserved in eukaryotes) causes a dramatic decrease in enzymatic activity in vitro. (wikipedia.org)
  • Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)
  • Mutation of this residue in microbat IFITM3 impairs restriction of representatives of four different virus families that enter cells via endosomes. (life-science-alliance.org)
  • This mutant shows altered subcellular localization and reduced S-palmitoylation, a phenotype copied by mutation of conserved cysteine residues in microbat IFITM3. (life-science-alliance.org)
  • Furthermore, we show that microbat IFITM3 is S-palmitoylated on cysteine residues C71, C72, and C105, mutation of each cysteine individually impairs virus restriction, and a triple C71A-C72A-C105A mutant loses all restriction activity, concomitant with subcellular re-localization of microbat IFITM3 to Golgi-associated sites. (life-science-alliance.org)
  • Notably, the next SD includes an invariant lysine residue (K355), the substitute mutation which resulted in an entire lack of kinase activity [16,30,31]. (niepokorny.org)
  • Matrix metalloproteinases (MMPs) are a large family of extracellular enzymes, which function to remodel the pericellular environment, primarily through the cleavage of extracellular matrix proteins [ 16 , 17 , 18 ]. (biomedcentral.com)
  • AdamTS proteins are extracellular metalloproteases known to modify ECM proteins and promote cell migration, but demonstrated roles for AdamTS proteins in regulating CNS structure and ensuring cell lineages remain fixed in place have not been uncovered. (janelia.org)
  • The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
  • A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
  • CDKs are cyclin-dependent serine-/threonine-specific proteins kinases, the experience of which depends upon cyclin binding. (niepokorny.org)
  • The A56 protein is capable of binding two viral proteins, a serine protease inhibitor (K2) and the vaccinia virus complement control protein (VCP), and anchoring them to the surface of infected cells. (microbiologyresearch.org)
  • IFITMs belong to the CD225/pfam04505 or "dispanin" protein superfamily ( http://pfam.xfam.org/family/PF04505 ) ( 3 ) that contains more than 2,000 members, including both prokaryotic and eukaryotic proteins, all of which encode a conserved CD225 protein domain. (life-science-alliance.org)
  • BACKGROUND The histone methyltransferase (HMT) family includes histone lysine methyltransferases (HKMTs) and histone/protein arginine methyltransferases (PRMTs). (cancerindex.org)
  • To test this, we aligned 97 protein sequences consisting of homologs of UMAMIT clade I from 27 plant species and created sequence logos containing the 51 residues identified in the structural analysis ( Supplementary Figure 1 ). (frontiersin.org)
  • The predicted structures of the Gimap proteins show common sequences and motifs, such as GTP-binding domains in the N-terminal half, but with differing C-terminal ends [ 2 , 3 ]. (hindawi.com)
  • Our results illustrate how sequences outside of minimal enhancer regions can evolve functionally through mechanisms other than changes in transcription factor binding sites that drive patterning. (janelia.org)
  • These investigations report on identification of residues/sequences in the hRFVT-2 protein that is important for its physiological function and cell biology. (biomedcentral.com)
  • Functional proteomics and immunofluorescence analyses of H3.1 and H3.3 revealed a highly conserved role for Nrp1 and Asf1 histone chaperones in nuclear influx of histones. (biomedcentral.com)
  • Our results provide an evolutionary perspective on H3.3's conserved role in maintaining the transcriptional landscape of cells and on the emergence of specialized chromatin assembly pathways. (biomedcentral.com)
  • EvoRator: prediction of residue-level evolutionary rates from protein structures using machine learning. (tau.ac.il)
  • ADOS Proteins kinases are putative goals of brand-new herpesviral drugs because of their important function in the legislation of HCMV replication [3,4,5,6,7,8]. (niepokorny.org)
  • Its kinase area contains subdomains (SD) I-XI, that are conserved (aa 337C651) within herpesviral and mobile proteins kinases. (niepokorny.org)
  • Taken with the present results, this suggests that the potential use of inhibitors of prolyl 4-hydroxylase to control excessive collagen deposition in pathological fibrosis may be limited by the need to maintain continuous inhibition of collagen hydroxylation so as to facilitate intracellular degradation of the accumulated protein. (embl.de)
  • The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
  • These family proteins are known to play critical roles in mediating specific resistance to intracellular pathogens including protozoa bacteria and viruses18 19 20 Because IGTP localizes predominantly to the endoplasmic reticulum it is assumed to be involved in the processing and trafficking of immunologically relevant proteins21 22 IGTP has been found to be essential for host resistance to acute infections by the protozoans into TG cells. (techieindex.net)
  • MetT-PCP carried out deISGylation of the ISG15-conjugated cellular proteins, suggesting a possible role in combating cellular antiviral pathways. (microbiologyresearch.org)
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
  • We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. (lookformedical.com)
  • They are regulatory proteins that play a role in G-protein-coupled receptor densensitization. (lookformedical.com)
  • Here, we report that the microRNA miR-1 regulates the autophagy pathway through conserved targeting of the orthologous T re-2/ B ub2/ C DC16 (TBC) Rab GTPase-activating proteins TBC-7 and TBC1D15 in Caenorhabditis elegans and mammalian cells, respectively. (elifesciences.org)
  • A comparison of the putative substrate binding site of homologs within the brassicaceous-specific, glucosinolate-transporting clade with the non-brassicaceous-specific, non-glucosinolate-transporting UMAMIT32 clade identified 11 differentially conserved sites. (frontiersin.org)
  • Based on our model, we proposed a substrate-transporting cavity of UMAMIT29 defined by helix I to IV and VI-IX and selected 51 residues as putative substrate binding sites based on solvent accessibility ( Figure 1 ). (frontiersin.org)
  • Furthermore to people indirect results on cell routine legislation, the viral proteins kinase pUL97 straight cross-talks with CDKs since it mimics CDKs in phosphorylating partly-identical substrates and evidently possesses commonalities in protein framework and functionality. (niepokorny.org)
  • 1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
  • For the first time they demonstrate that all 3 DVL-1 residues differentially regulate canonical Wnt signaling. (oncotarget.com)
  • Therefore, this work provides a potential therapeutic strategy for protein aggregation disorders. (elifesciences.org)
  • Due to the central role of autophagy in the removal of aggregation-prone proteins, a better understanding of mechanisms controlling autophagy is essential for the identification of novel therapeutic opportunities for multiple disease states. (elifesciences.org)
  • This prompted us to investigate if mir-1 is required for preventing the accumulation of aggregation-prone proteins. (elifesciences.org)
  • The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
  • A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. (tcd.ie)
  • The CD4 binding site (CD4bs) of envelope glycoprotein (Env) gp120 is a functionally conserved, important target of anti-human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies. (biomedcentral.com)
  • This suggests that these residues are key for UMAMIT29-mediated glucosinolate transport activity and thus potential targets for blocking the transport of glucosinolates to the seeds. (frontiersin.org)
  • In contrast, the enzyme in plants has conserved charged residues forming the interface between subunits. (wikipedia.org)
  • Sigma subunits of AP complexes differ slightly in their surface charge densities and binding groove geometry, allowing for both generic and selective interactions with protein partners. (eu.org)
  • Elegant experiments using heat-shock inducible expression of inhibitory proteins have further refined these observations to establish epistatic relationships, in which BMP acts upstream of Wnt, which in turn acts upstream of FGF during regeneration of the limb bud and tail ( Lin and Slack, 2008 ). (frontiersin.org)
  • JNK specicity with the inhibitory result is more suggested by our nding that inhib itors of the mitogen activated protein kinase family, such as the ERK inhibitor U0126 or even the p38 inhibitor SB202190, exhibited no inhibitory exercise on HIV 1 reactivation. (alkpathway.com)
  • The mammalian orthologs of Derailed and SRC64B also form complexes, suggesting that Src roles in RYK signaling are conserved. (biologists.com)
  • Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)
  • These data indicate that Nogo-A is a multifunctional protein with additional roles during CNS development that are disparate from its later role of neurite outgrowth inhibition in the adult CNS. (biomedcentral.com)
  • Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)
  • For this purpose, we developed and validated an annotation method (called pairwise comparative modelling) on the basis of a three-dimensional structure (homology comparative modelling), leading to the prediction of 6,095 ARDs in a catalogue of 3.9 million proteins from the human intestinal microbiota. (nature.com)
  • To predict ARDs in the intestinal microbiota, we developed a method based on protein homology modelling (see Methods) that we termed pairwise comparative modelling (PCM). (nature.com)
  • MMP-9, of special interest here, is a member of the MMP family and contains several conserved domains such as propeptide domain, catalytic domain with Zn 2+ -binding site, and hemopexin-like domain [ 17 ]. (biomedcentral.com)
  • Using recombinant variants of ppFhCL3 we demonstrated the critical importance of a pair of propeptide residues (Tyr 46 Lys 47 ) for the interaction with the propeptide binding loop (PBL) of the mature enzyme and other residues (Leu 66 and Glu 68 ) that allow the propeptide to block the active site. (biomedcentral.com)
  • Predicated on series evaluation and a 3D style of pUL97, the viral kinase displays structural similarity to CDK2 in the catalytic middle and in functionally essential residues from the ATP binding site [16]. (niepokorny.org)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. (elifesciences.org)
  • The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
  • A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions. (lookformedical.com)
  • In animals, CDK inhibitors are tightly regulated, especially by posttranslational mechanisms of which control of nuclear access and regulation of protein turnover are particularly important. (uni-bielefeld.de)
  • Here we address the posttranslational regulation of INHIBITOR/INTERACTOR OF CDK 1 (ICK1)/KIP RELATED PROTEIN 1 ( KRP1), an Arabidopsis ( Arabidopsis thaliana) CDK inhibitor. (uni-bielefeld.de)
  • To functionally characterize the affinity of OsCYB5-2 sHAK21 for K+ below salt treatment, kinetic parameters (inhibition continuous Ki for Na+) were assessed in yeast cells. (glucagon-receptor.com)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Nogo-A, a myelin-associated protein, inhibits neurite outgrowth and abates regeneration in the adult vertebrate central nervous system (CNS) and may play a role in maintaining neural pathways once established. (biomedcentral.com)
  • This degradation is mediated by at least two domains indicating the presence of at least two different pathways impinging on ICK1/KRP1 protein stability. (uni-bielefeld.de)
  • This protein is found in a cellular compartment called the mitochondria, which is responsible for supplying energy to the rest of the cell and therefore plays an important role in metabolic processes. (elifesciences.org)
  • A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. (le.ac.uk)
  • The latter dileucine motifs were implicated in membrane protein sorting to vacuoles or tonoplasts. (eu.org)
  • They serve to initiate clathrin-mediated endocytosis or protein sorting and can work synergistically with the adaptin mu subunit binding YxxPhi-type motifs ( TRG_ENDOCYTIC_2 ). (eu.org)
  • In fungi and plants, dileucine motifs are often responsible for the vacuolar or tonoplast localization of proteins carrying these motifs. (eu.org)
  • When each of the 11 residues of UMAMIT29 was individually mutated into the corresponding residue in UMAMIT32, five mutant variants (UMAMIT29#V27F, UMAMIT29#M86V, UMAMIT29#L109V, UMAMIT29#Q263S, and UMAMIT29#T267Y) reduced glucosinolate transport activity over 75% compared to wild-type UMAMIT29. (frontiersin.org)
  • Transport activity assays of mutant variants with a single point amino acid substitution in each site UMAMIT29 suggest that five of these residues are critical for glucosinolate transport. (frontiersin.org)
  • In the past few decades protein engineering allowed to generating artificial enzymes able to catalize unnatural reactions but also to become importnat tools for synthetic biology. (oist.jp)
  • 2.3 Topic: Are epistatic patches in Rossmann Fold enzymes conserved? (oist.jp)
  • Heme/iron-binding proteins, protease inhibitors, proteases, lipocalins and immune-related proteins were the categories most abundantly expressed in females, while glycolytic enzymes, protease inhibitors and lipocalins were the most abundantly expressed in males. (biomedcentral.com)
  • A multiple alignment of the amino acid sequence across divergent species, identified five previously undescribed, Nogo-A specific conserved regions that may be relevant for development. (biomedcentral.com)
  • Using a gene editing tool to selectively substitute some of the building blocks, also known as amino acids, that make up the ATP5G1 protein revealed that improvements to the mitochondria were caused by switching specific amino acids. (elifesciences.org)
  • We used comparative protein-structure modelling to predict residues that interact with two amino acids known to be critical for hRFVT-2 function (the clinical mutants L123 and L339), site-directed mutagenesis, and truncation approach in the human-derived brain U87 cell model. (biomedcentral.com)
  • Our aim in this study was to expand our knowledge in these areas, and we used a comparative protein-structure modelling to predict residues that interact with two amino acids known to be critical for hRFVT-2 function, i.e. (biomedcentral.com)
  • Here, through combined use of cortical layer markers and transgenic mouse lines, we show that Kv2.1 and Kv2.2 are localized to functionally distinct cortical cell types. (jneurosci.org)
  • These findings confirm important quantitative differences between sexes in the O. erraticus saliva proteome, unveil novel salivary proteins and functions at the tick-host feeding interface and improve our understanding of the physiology of feeding in O. erraticus ticks. (biomedcentral.com)
  • Here, we show that bat IFITMs are characterized by strong adaptive evolution and identify a highly variable and functionally important site-codon 70-within the conserved CD225 domain of IFITMs. (life-science-alliance.org)
  • Besides that, there is little known about structural features of the hRFVT-2 protein that are important for its function and cell biology. (biomedcentral.com)
  • Finally, these authors report that conserved DVL-1 lysines modulate various oncogenic functions such as cell migration, proliferation, cell-cycle progression, 3D-spheroid formation and in-vivo tumor growth in breast cancer models. (oncotarget.com)
  • AP2 is chiefly involved in endocytosis of cell surface proteins and their trafficking to early or late endosomes. (eu.org)
  • This control is propagated through the alpha-subunit of prolyl 4-hydroxylase where protein levels were previously shown to rise fivefold with increasing cell density. (embl.de)
  • Using a fluorescent sulfhydryl probe as well as a sulfhydryl inhibitor, one observes a strong cell density response, supporting the hypothesis that cellular redox potential could alter protein stability. (embl.de)
  • This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. (cancerindex.org)
  • Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation. (tcd.ie)
  • while both proteins have biologically relevant functions at the cell surface, neither one can locate there on its own. (microbiologyresearch.org)
  • With 19 Wnt ligands, 10 Frizzled receptors and 3 Dishevelled proteins participating in signaling, the amount of information relayed is enormous. (oncotarget.com)
  • A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
  • A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (lookformedical.com)
  • A genome-wide resource for the analysis of protein localisation in Drosophila. (tcd.ie)
  • EvoRator2: predicting site-specific amino acid substitutions based on protein structural information using deep learning Journal of Molecular Biology: 435(14):168155. (tau.ac.il)
  • Similarly, how the mechanisms by which reduced Gimap5 transcript levels and the absence of the Gimap5 protein [ 2 , 7 , 8 ] contribute to lymphopenia and T1D are still being elucidated [ 9 - 13 ]. (hindawi.com)
  • A Rossman fold motif participates in binding of the UTP nucleotide and a sugar-binding domain (residues T286-G293) coordinates with the glucose ring. (wikipedia.org)
  • Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral properties of the green fluorescent protein (GFP). (cipsm.de)
  • These proteins contain two related domains known as the chromo- and the chromoshadow-domain. (cipsm.de)
  • The forming of pUL97 oligomers and ADOS dimers is dependant on a self-interaction domain, located within proteins 231-280, that facilitates solid autophosphorylation taking place at N-terminal residues [35 generally,36,37]. (niepokorny.org)
  • The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. (cancerindex.org)
  • In humans, each enzyme subunit contains several residues (L113, N251, and N328) that are highly conserved in eukaryotes. (wikipedia.org)
  • Based on a predicted model of UMAMIT29, we propose that the substrate transporting cavity consists of 51 residues, of which four are highly conserved residues across all the analyzed homologs of UMAMIT29. (frontiersin.org)
  • We hypothesised that the transport cavity contains highly conserved residues that are key for the transport activity. (frontiersin.org)
  • Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response. (lookformedical.com)
  • Co-expression of Ov-phy-1 with the O. volvulus homologue of protein disulfide isomerase in a baculovirus system resulted in the production of enzymatically active O. volvulus prolyl 4-hydroxylase. (embl.de)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Early specification of central epiblasts to a neural fate is influenced by fibroblast growth factor (FGF) production while induction of non-neural epithelium in the periphery occurs through wingless-type (Wnt) and bone morphogenic protein (BMP) expression. (biomedcentral.com)
  • First we showed that the defect in the function of the L123 and L339 hRFVT-2 clinical mutants is related to a reduction in protein stability/translation efficiency and to retention of the protein in the ER. (biomedcentral.com)
  • this inhibition was associated with changes in protein stability/translation efficiency (in the case of V120A and L342A) and an impairment in transport function (in the case of L121). (biomedcentral.com)
  • Truncating the N- and C- terminals of hRFVT-2 led to significant inhibition in RF uptake, which was associated with changes in protein stability/translation efficiency (it was also associated with a partial impairment in membrane targeting in the case of the N-terminal truncation). (biomedcentral.com)
  • Emerging powerful bioinformatics tools assign function to new protein based on structure, sequence and binding pocket similarities. (oist.jp)
  • We subsequent investigated if AS601245 would inhibit the induction of phosphorylation of AP 1 proteins that are reportedly JNK substrates. (alkpathway.com)
  • The protein encompassing the predicted MetT-PCP domains of HEV ORF1 was tested for deubiquitinating activity using fluorogenic substrates - ubiquitin-7-amino-4-methylcoumarin (AMC), IFN-stimulated gene 15 (ISG15)-AMC, Nedd8-AMC and SUMO-AMC. (microbiologyresearch.org)
  • We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)
  • The structure of UTP-glucose-1-phosphate uridylyltransferase is significantly different between prokaryotes and eukaryotes, but within eukaryotes, the primary, secondary, and tertiary structures of the enzyme are quite conserved. (wikipedia.org)
  • Eye proteins are the biological molecules that make up the various structures of the eye and are essential for its proper function. (lookformedical.com)
  • Levels of proteins, including Cyt C, Bcl-2/BAX, and Nrf2 /HO-1-associated proteins, were determined by western blotting and immunofluorescence. (sdbonline.org)
  • Gene Dosage in the Dysbindin Schizophrenia Susceptibility Network Differentially Affect Synaptic Function and Plasticity. (tcd.ie)
  • These findings provide the first evidence of a protein variant that is responsible for protecting cells during the metabolic stress conditions caused by hibernation. (elifesciences.org)
  • could be used to identify and study other proteins that increase resilience to metabolic stress. (elifesciences.org)
  • Such reactions are involved in carbohydrate, protein and lipid metabolism as well as in the metabolic conversion of vitamins B 6 and B 9 into their biologically active forms [ 1 ]. (biomedcentral.com)
  • Autophagy is a degradation system that involves sequestration of cytoplasmic proteins and organelles by double-layered membranes that form vesicles called autophagosomes. (elifesciences.org)
  • Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)
  • There was no processing of the Hel and RdRp domains having the conserved (1205) LXGG site by the protein. (microbiologyresearch.org)