Differential transcript expression. Medical search. Frequent questions

We used a genome-wide analysis which not only examined differential gene expression levels but could also detect differences in splice isoform usage. (jneurosci.org)

Results Transcript isoform signatures accurately separate early from late stage and metastatic from non-metastatic tumors, and are predictive of the survival of patients with undetermined lymph node invasion or metastatic status. (biorxiv.org)
Furthermore, we show frequent transcript isoform changes in breast tumors according to estrogen receptor status, and in melanoma tumors according to the invasive or proliferative phenotype, and derive accurate predictive models of stage and survival within each patient subgroup. (biorxiv.org)
Conclusions Our analyses reveal new signatures based on transcript isoform abundances that characterize tumor phenotypes and their progression independently of gene expression. (biorxiv.org)
Transcript isoform signatures appear especially relevant to determine lymph node invasion and metastasis, and may potentially contribute towards current strategies of precision cancer medicine. (biorxiv.org)
On the other hand, gene expression summarizes the output of RNA transcripts from a gene locus, which is mostly explained by one transcript isoform [ 10 ]. (biorxiv.org)
This prompts the question of whether transcript isoform changes, which remain largely unexplored as predictive signatures of tumor stage and survival, could hold relevant novel mechanisms of tumor progression. (biorxiv.org)
To understand the role of each cell in an organism, broad spectrum mRNA isoform and mutational gene expression analyses at the single-cell level is necessary. (elifesciences.org)
and thus may be most suited for the mutational isoform expression analyses. (elifesciences.org)
These results reveal numerous examples where neuron subtype-specific gene expression, as well as splice-isoform usage, can explain functional differences between neuron subtypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivity specification. (jneurosci.org)
In general, P450 and UGT expression was lower in hepatocyte cultures than that in liver, and CYP2C9 was found to be the most abundant P450 isoform expressed in cultured hepatocytes. (aspetjournals.org)
We also found an unexpectedly dynamic pattern of transcript isoform regulation, suggesting a critical regulatory role during HSC differentiation, and a cell cycle/DNA repair signature associated with multipotency in MPP2 cells. (lu.se)

In this study, we demonstrate that gDNA-based probe selection on the Affymetrix Human U133+2 GeneChip array can be used to study gene expression profiles in sheep tissues. (cambridge.org)
Gene ontology analysis of the differentially expressed genes revealed the expected differences in gene expression profiles between the two tissues. (cambridge.org)
Characterization of these factors is lacking in porcine conceptuses, therefore, the current study investigated mRNA expression of these factors in elongating conceptuses and primordial tissues as well as protein expression and cellular localization to better define their biological significance. (usda.gov)
This study focused on the expression and functionality of TRPV1, a nonselective cation channel that was found to be expressed in different carcinoma tissues. (dovepress.com)
Next-generation sequencing analyses revealed the expression of TRPV1 in several native breast cancer tissues, which was subsequently validated via reverse transcriptase-polymerase chain reaction. (dovepress.com)
In conclusion, the current study revealed the expression profiles of human TRP channels in 60 different breast cancer tissues and cell lines and furthermore validated the antitumor activity of TRPV1 against SUM149PT breast cancer cells, indicating that activation of TRPV1 could be used as a therapeutic target, even in the most aggressive breast cancer types. (dovepress.com)
Transcriptomes from the tissues of the brain-pituitary-gonad (BPG) axis of T10 samples revealed a differential gene expression profile compared to the other experimental groups, with clustering in a principal component analysis and in heat maps of all differentially expressed genes. (biomedcentral.com)
Examination of transcript expression across different RNA libraries revealed that expression patterns clustered based on tissues regardless of stress treatment. (figshare.com)
We reviewed published microarray and RNA sequencing studies in which gene expression profiles were compared between human RB and normal retina tissues. (molvis.org)
Expression of DCT was absent or barely detected in retina tissues, various human ocular cells, and major organs. (molvis.org)

Our analyses revealed new signatures that characterize tumor phenotypes and their progression largely independent of gene expression. (biorxiv.org)
Accurate identification of such artifacts can significantly impact quantification of transcript abundance, and subsequently affect differential expression analyses, especially for low-abundance genes. (neb.com)

More than 20 000 transcripts were detected in triplicate ovine skeletal muscle and liver samples, which is more than would be possible using the commercially available sheep-specific microarray. (cambridge.org)
A biotin labeled cRNA transcript was synthesized, fragmented and hybridized to Affymetrix U133A oligonucleotide microarray. (cdc.gov)
The differential gene expression data analysis was per-formed using Affymetrix microarray suite 5.0 software. (cdc.gov)
The Affymetrix software Microarray Suite 4.0 and 5.0 (MAS 4 and MAS 5) estimate expression from the average difference of PM and MM fluorescence. (biomedcentral.com)
The investigators combined eight microarray datasets from these brain regions and conducted a large-scale gene-expression analysis to probe for sex differences. (medscape.com)

It has become a prevalent technology, allowing an efficient genome-wide relative quantification of gene expression and, in particular, it is the method of choice to find differentially expressed genes between two or more biological conditions of interest. (frontiersin.org)

RNA-Seq is a widely used technology that allows an efficient genome-wide quantification of gene expressions for, for example, differential expression (DE) analysis. (frontiersin.org)

We provide a searchable web resource for exploring differential mRNA expression and splice form usage between excitatory, PV, SST, and VIP neurons ( http://research-pub.gene.com/NeuronSubtypeTranscriptomes ). (jneurosci.org)
We sorted excitatory neurons and key inhibitory neuron subtypes from mouse brains and assessed differential mRNA expression. (jneurosci.org)

Polymorphic variants at regulatory elements can cause differential allelic expression (DAE), thus using DAE as a quantitative trait could help identify such variation. (springer.com)
However, as the present case will illustrate, selective pressures in vivo may cause differential expression of certain GBS surface components during colonization or dissemination. (cdc.gov)

Ursuleac I, Colita A, Adam T, Jardan C, Ilea A, Coriu D. The concomitant occurrence of JAK2V617F mutation and BCR/ABL transcript with phenotypic expression - an overlapping myeloproliferative disorder or two distinct diseases? (medscape.com)

Altered gene expression patterns were observed in 187 RNA transcripts with a signal log ratio of at least 0.8 (1.7 fold change). (cdc.gov)
Stratifin and midkine proteins demonstrated more unique expression patterns within the conceptus. (usda.gov)
An alternative approach is gene coexpression analysis, which detects groups of genes with similar expression patterns across unrelated sets of transcriptomic data from the same organism. (mdpi.com)
The results showed evolutionary patterns of single molecule mutational gene expression from benign hepatocytes to liver cancer cells. (elifesciences.org)
The team validated that signature in three more groups of American or Finnish infants with lower respiratory infections, before narrowing in on expression patterns that proved useful for distinguishing the most serious RSV cases - in particular, those that involved extensive hospital stays or supplemental oxygen treatments. (genomeweb.com)
After dividing samples from the 135 cases with acute RSV infection into four different cohorts, they used Illumina arrays to assess expression patterns in the 45 samples from RSV-infected infants in one of the cohorts, designated the training cohort. (genomeweb.com)
Various patterns of differential splicing of CD8 alpha transcripts involve excision of the transmembrane or cytoplasmic domains. (lu.se)

Affymetrix GeneChip microarrays are a powerful tool to study global gene expression profiles and have been used on many species. (cambridge.org)
The most common approach in transcriptomics (RNA-seq and microarrays) is differential gene expression analysis (DGEA). (mdpi.com)
Transcribed RNA levels are often measured by hybridization to microarrays of oligonucleotide probes, in which each transcript is represented by multiple probes. (biomedcentral.com)

Our findings support the use of differential allelic expression in blood as a surrogate for breast tissue in future studies on predisposition to breast cancer. (springer.com)
We compared the distribution of allelic ratios of gene expression in fresh blood (B cells and total mononuclear cells), transformed lymphoblasts, and breast tissue from unmatched healthy individuals. (springer.com)
This allows for transcriptome-wide mapping of genes expression onto tissue sections, with concomitant H&E or IF staining. (gulbenkian.pt)
The dataset compares the expression of transcripts in lung cancer biopses versus normal tissue. (bioconductor.org)

Although the majority of expression quantitative trait loci (eQTLs) for the gene expression traits in the two environments are shared and have similar effects, analysis of the environment-specific eQTLs reveals enrichment of binding sites for two transcription factors. (nature.com)
Our offering includes DNA sequencing, as well as RNA and gene expression analysis and future technology for analysing proteins. (nanoporetech.com)
Methods Using information theory and machine learning methods, we integrated RNA sequencing and clinical data from The Cancer Genome Atlas project to perform the first systematic analysis of the prognostic potential of transcript isoforms in 12 solid tumors to build new predictive signatures for stage and prognosis. (biorxiv.org)
Serial analysis of gene expression identified genes involved in cellular differentiation/structure (cytokeratin-8 and -18) and growth/cell migration/mesoderm-epithelial interaction (stratifin and midkine), which could potentially be regulated by steroids like estrogen. (usda.gov)
This resource, combining a unique new dataset and novel application of analysis methods to multiple relevant datasets, identifies numerous potential drug targets for manipulating circuit function, reveals neuron subtype-specific roles for disease-linked genes, and is useful for understanding gene expression changes observed in human patient brains. (jneurosci.org)
In this vignette, we will be performing functional enrichment analysis on a differential gene expression dataset. (bioconductor.org)
Differential expression analysis has already been performed, generating log2foldchange and P-values for each gene. (bioconductor.org)
Although the transcript signatures unearthed in the analysis "were derived only from infants requiring hospitalization, which represents the tips of the iceberg of the disease spectrum caused by RSV," study authors noted, "it serves as a reference, and warrants future research including studies with earlier, sequential samples as well as samples from infants with milder RSV infection who are managed as outpatients. (genomeweb.com)
The analysis showed that in control individuals, expression of the examined genes was the same in men and women. (medscape.com)

However, it is not yet known whether the relative abundance of transcript isoforms may be informative for clinical stage and survival. (biorxiv.org)
We investigated the predictive potential of the relative abundances of transcript isoforms for tumor staging and clinical outcome in 12 different tumor types, integrating RNA sequencing and clinical annotation data for 12 tumor types from The Cancer Genome Atlas (TCGA) project. (biorxiv.org)
Knowledge about the relative abundance of transcript isoforms in tumors can potentially help predicting stage and clinical outcome and contribute towards current molecular strategies in precision cancer medicine. (biorxiv.org)
While protein expression is dictated by the level of gene expression, the structure and function of the protein is largely determined by the isoforms of the mRNA of a given gene and are impacted by mutations or other structural alterations to the amino acids ( Faustino and Cooper, 2003 ). (elifesciences.org)

Each promoter is associated with its own proximal exon (exon 0 for P0, exon 1 for P1) resulting in transcripts which are alternatively spliced in the 5' un-translated region. (wikipedia.org)
Alternatively, spliced mRNAs typically encode distinct proteins or harbor modified cis-regulatory elements, thereby altering the level of protein expression. (unil.ch)

These results reveal the potential for dissociation of mPer and mCry expression within the central oscillator during circadian resetting and a differential molecular response of the clock during advance and delay resetting. (jneurosci.org)
Our data reveal the differential expression landscape of 493 transcription factors and 682 lncRNAs and highlight specific expression clusters operating in HSCs. (lu.se)
Circulating microtranscriptome profiles reveal distinct expression of microRNAs in severe leptospirosis. (cdc.gov)

Confidently characterise and quantify full-length RNA transcripts, splice variants, and fusions using short to ultra-long fragment nanopore sequencing. (nanoporetech.com)

Alternative splicing involves the differential joining of exonic sequences within a nascent pre-mRNA transcript, to form distinct mature mRNAs. (unil.ch)
Results We report the generation and assembly of RNA sequences from 55 green ash samples into 107,611 putative unique transcripts (PUTs). (figshare.com)

In addition to providing a potential avenue for future RSV diagnostic and/or prognostic tests, study authors noted that the transcripts involved in the RSV infection and severity signatures are expected to help in understanding the immune system peculiarities associated with RSV infection. (genomeweb.com)

Background Phenotypic changes during cancer progression are associated to alterations in gene expression, which can be exploited to build molecular signatures for tumor stage identification and prognosis. (biorxiv.org)
Although tumors originate primarily from genetic lesions, their progression involves other molecular transformations, which are related to the activation of specific aggressive phenotypes, like tumor spread and metastasis, and are often reflected in gene expression changes [ 4 , 5 ]. (biorxiv.org)
To understand the molecular-genetic basis of functional specialization and identify potential drug targets specific to each neuron subtype, we performed a genome wide assessment of both gene expression and splicing across EXC, PV, SST and VIP neurons from male and female mouse brains. (jneurosci.org)
To better represent true transcript abundance levels, Unique Molecular Identifiers (UMIs) can be used to distinguish PCR duplicates from reads that originate from distinct original molecules. (neb.com)
Cultured hepatocytes offer the possibility to assess long-term effects, such as enzyme induction (i.e., changes of the expression levels of molecular entities of the hepatocytes). (aspetjournals.org)
Investigators used molecular methods to examine the expression of genes in three brain regions implicated in MDD: the dorsolateral prefrontal cortex, the subgenual anterior cingulate cortex, and the basolateral amygdala. (medscape.com)
Examples of high molecular environmental factors are known to influence the development weight occupational allergens include proteases used in the and expression of asthma, and a vast array of triggers of asthma detergent industry, laboratory animal allergens, and ovalbumin have been identified. (cdc.gov)

The expression of photosynthesis and chlorophyll synthesis related genes were significantly reduced under both types of stresses, which limit the metabolic processes and thus help prolong survival under extreme conditions. (frontiersin.org)
In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
The combination of gene expressions, fusion gene transcripts, and mutation gene expressions significantly improved the classification of liver cancer cells versus benign hepatocytes. (elifesciences.org)
When blood samples are collected, the gene expression profile can change significantly within minutes. (qiagen.com)

Conclusion: Expression of ERh is an independent marker for favorable prognosis after adjuvant tamoxifen treatment in ERa-negative breast cancer patients and involves a gene expression program distinct from ERa. (lu.se)

Conversely, the HH and LH variants exhibited low capsule (LC) and high capsule (HC) expression, respectively. (cdc.gov)

Accurately analyse differential gene expression and transcript usage. (nanoporetech.com)

Differential allelic expression ratios were determined by Taqman assay. (springer.com)

These signatures show similar, and sometimes better, accuracies compared with known gene expression signatures, and are largely independent of gene expression changes. (biorxiv.org)

We also screened out 28 candidate genes from 762 DEGs and verified their expression by quantitative reverse transcription polymerase chain reaction (qRT-PCR). (researchsquare.com)
The Gel Beads were dissolved, and any respectively associated cells were lysed prior to reverse transcription, template switching and transcript extension. (elifesciences.org)
We investigated the expression of genes of interest using quantitative reverse transcription PCR. (molvis.org)

Transcript profiles involved in the starch and sugar metabolism pathways were also affected under both stress conditions. (frontiersin.org)
Real-time PCR was utilized to determine the transcript expression profiles. (usda.gov)
however, no study has examined the expression profiles of human TRP channels in breast cancer on a large scale. (dovepress.com)
and gain a deeper view of expression profiles of individual cells and increase sensitivity to detect rare cell populations. (bio-itworld.com)
There, they found that expression profiles at the 2,317 transcripts could correctly identify all but one of the samples from children with RSV infection. (genomeweb.com)

lncRNAs have been reported to possess multiple functions including regulation of gene expression, transcriptional activation and silencing of genes and thus play critical roles in a diversity of cellular process [ 14 , 15 ]. (researchsquare.com)
Starting with blood samples from hundreds of infants infected with RSV, human rhinovirus, or influenza over half a dozen cold and flu seasons, the Ohio State University College of Medicine's Octavio Ramilo and colleagues from the US and Finland used array-based gene expression profiling to track down a transcriptional signature coinciding with RSV infection. (genomeweb.com)
In this study, we investigated whether hypothalamic HTT expression causes transcriptional changes. (lu.se)
MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)

A classic example is the heat shock protein system, particularly Hsp90 , whose expression is environmentally plastic and increases under thermal stress, but buffers phenotypic changes induced by mutations to maintain homeostasis 2 , a process termed canalization 3 . (nature.com)
Cells of the conceptus were highly proliferative at all stages and the embryonic disc of the ovoid conceptus was already polarized as indicated by the protein expression of Ki67 and brachyury, respectively. (usda.gov)
Western blotting and/or immunohistochemistry were utilized to examine protein expression and cellular localization. (usda.gov)
Midkine protein expression was prominent in the embryonic disc of ovoid conceptuses. (usda.gov)
Accurate Long-read transcriptome sequencing at single-cell level is required to decipher the spectrum of protein expressions in mammalian organisms. (elifesciences.org)
Functional annotation of the PUTs by comparison to the Uniprot protein database identified matches for 63Â % of transcripts and for 98Â % of transcripts with ORFs. (figshare.com)
The effects of culture format (i.e., sandwich culture versus conventional culture) and of dexamethasone (DEX) media concentrations on mRNA, protein, and activity levels were determined for three donors, and protein expression was compared with that in liver. (aspetjournals.org)
The sandwich culture format and 0.1 μM DEX in media retained the protein expression in the hepatocytes closest to the levels found in liver. (aspetjournals.org)
However, higher in vitro expression was observed for drug transporters, especially for multidrug resistance protein 1 and breast cancer resistance protein. (aspetjournals.org)
Osteonectin expression was evaluated using immunohistochemistry with anti-secreted protein acidic and rich in cystein (anti-SPARC) antibody. (bvsalud.org)
MicroRNAs (miRNAs) are small, noncoding RNAs that bind to the 3' UTR of target mRNAs, and silence gene expression by inducing degradation of target mRNAs or inhibition of protein translation [ 10 ]. (cdc.gov)

Recent advances in genetic manipulation of Chlamydia were employed to inactivate rsbV1 , as well as to increase the expression levels of rsbW or rsbV1 , in vivo . (plos.org)

Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
Regulatory polymorphisms in cis-acting elements result in the unequal expression of alleles. (springer.com)
Differential allelic expression (DAE) in heterozygote individuals could be used to develop a new approach to discover regulatory breast cancer susceptibility loci. (springer.com)
We aimed to perform a more extensive evaluation of differential allelic expression between blood and breast in order to assess the potential usefulness of LCL and fresh blood in association studies, to identify regulatory polymorphisms related to susceptibility to breast cancer. (springer.com)
The regulatory elements required for this cell-specific gene expression are likely located within its proximal promoter. (molvis.org)

This transcription factor is most noted for its use in the interspecifically induced expression of ectopic eyes and is of medical importance because heterozygous mutants produce a wide spectrum of ocular defects such as aniridia in humans. (wikipedia.org)
Representative σ 66 -dependent gene transcription was repressed in the absence of rsbV1 or upon increased expression of RsbW, and increased upon elevated expression of RsbV1. (plos.org)
Anticoagulants such as EDTA prevent blood clotting, but do not prevent changes in gene expression due to induced transcription or regulated turnover of mRNA. (qiagen.com)

whereas human epidermal growth factor receptor 2 (HER2)-positive breast cancers can be targeted by specific drugs, the triple-negative breast cancer phenotype is defined by chromosomal instability and low expression levels of estrogen receptor (ER) alpha, progesterone receptor (PR), and HER2, rendering treatment rather difficult. (dovepress.com)
On the other hand, environmental factors have been reported to modulate epigenetic modifications and thereby affect gene expression and phenotype [ 11 , 12 ]. (researchsquare.com)

Reads cover complete transcripts and can be used to detect alternative splicing, in addition to regular differential expression. (gulbenkian.pt)

Aberrant expression of many specific lncRNAs was reported to be correlated to the pathogenesis of various diseases in human and model animals [ 16 , 17 ]. (researchsquare.com)

In this study, we have investigated the effect of SWCNT on alterations in gene expression. (cdc.gov)

We have tested heritability-weighted averages to define expression of a transcript and found that these allow detection of more QTLs than previously described methods. (biomedcentral.com)
Several alternative methods have been proposed to combine multiple probe-specific values into a single expression estimate. (biomedcentral.com)
Also, methods to examine sex-specific gene expression on a large scale have only recently been developed, he said. (medscape.com)

Accordingly, the development of gene expression signatures has been instrumental to complement and improve stage identification and prognosis [ 6 - 9 ]. (biorxiv.org)
[ 10 ] In addition, gene expression profiling studies support the concept that radial glial cells from different neuroanatomic sites may be predisposed to acquiring particular genetic aberrations that result in ependymomas with site-specific genetic signatures and biologic potential. (medscape.com)

And based on the extent of the expression shift for 1,536 transcripts in the RSV-related signature, the group reported, it was possible to begin making predictions about which cases would progress to the point of requiring lengthy hospital stays and/or treatments such as supplemental oxygen. (genomeweb.com)

Collection of animal blood in RNAprotect Animal Blood Tubes prevents changes in transcript levels. (qiagen.com)
When they looked at the nature of the genes behind the expression signature, the investigators saw that inflammation and innate immune genes were among those showing a jump in expression in those with RSV infections, while levels of genes contributing to adaptive immune functions often waned. (genomeweb.com)

The format of this lung cancer dataset should look familiar to anyone who has worked with differential gene expression results. (bioconductor.org)

A recent study of the disparity in breast cancer mortality between AA and EA women concluded that differences in mortality are driven by higher hazard rates of breast cancer death in AA women, irrespective of ER expression [ 9 ]. (cdc.gov)

therefore, it is imperative to assess the expression of genes involved in response to flood and drought stress. (frontiersin.org)
The changes in expression of genes involved in regulating the flux of cell wall precursors and starch/sugar content can serve as an adaptive mechanism for soybean survival under stress conditions. (frontiersin.org)

We show that differential allelic expression is common among these 12 candidate genes and is comparable between breast and blood (fresh and transformed lymphoblasts) in a significant proportion of them. (springer.com)

Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)

Data from these define genetic and non-genetic variation, define a measure of heritability for expression of individual genes, and provide the basis for a new method of data reduction for genetical genomics. (biomedcentral.com)

The primary data for 1-step growth, 2-step growth and gene expression summarized in Figs 4 and 5 are available in the S1 Dataset in the supplementary information. (plos.org)

The unit offers RNA-seq library preparation, with multiple options such as ribo-depletion (Bacterial and Eukaryotic), poly-A enrichment, 3′-Tag-Seq (QuantSeq) libraries All the libraries are constructed to retrieve the full transcript, exception for QuantSeq (3′-end sequencing). (gulbenkian.pt)

Microplastic-associated PCBs are placed in a differential bioavailability framework by comparing the results to several other natural and anthrogenic particles, including wood, coal, and biochar. (researchgate.net)
In particular, results of the study suggest that infants with especially low expression of genes coding for adaptive immune contributors and high expression of inflammation-related transcripts tended to have more severe RSV infections, while those with milder infections showed an extra boost in innate immune gene expression. (genomeweb.com)

T]his study provides evidence of the profound systemic dysregulation of both the innate and adaptive immune response induced by RSV infection in children," Ramilo and his co-authors wrote, "and confirms the value of gene expression profiling as a practical and powerful strategy to objectively stratify children with acute RSV [lower respiratory tract infections]. (genomeweb.com)
For instance, investigators found that expression of genes related to synapse function was decreased in men but increased in women, and expression of immune genes was increased in men and decreased in women. (medscape.com)
GBS β-h/c expression is linked to expression of an orange pigment with antioxidant properties ( 6 , 15 ), and these 2 factors act in concert to impair macrophage-based immune clearance ( 16 ). (cdc.gov)
Both genetics and environmental factors influence the expression of asthma, and not all asthma is the result of a specific immune response to allergen. (cdc.gov)

A comprehensive understanding of gene expression in human RB is essential for the development of safe and effective new therapies. (molvis.org)

Anatomy4

Organisms2

Diseases1

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes33

Disciplines and Occupations1

Information Science4

Examined differential gene expression1

Isoform11

Tissues10

Analyses2

Microarray5

Differentially expressed1

Quantification1

MRNA expression2

Cause differential2

Phenotypic expression1

Patterns7

Microarrays3

Tissue4

Analysis9

Isoforms4

Alternatively2

Reveal3

Fusions1

Sequences2

Prognostic1

Molecular7

Significantly4

Distinct1

Variants1

Accurately1

Ratios1

Gene expression changes1

Reverse transcription3

Profiles5

Transcriptional4

Protein11

Vivo1

Regulatory5

Transcription3

Phenotype2

Reads1

LncRNAs1

Alterations1

Methods3

Signatures2

Extent1

Levels2

Lung1

Differences1

Genes involved2

Candidate genes1

Affect gene expression1

Genomics1

Data1

Libraries1

Results2

Immune4

Human1