Different phages. Medical search. Frequent questions

Phage display was first described by George P. Smith in 1985, when he demonstrated the display of peptides on filamentous phage (long, thin viruses that infect bacteria) by fusing the virus's capsid protein to one peptide out of a collection of peptide sequences. (wikipedia.org)
A combination of bacteriophages (phages) may precisely target and suppress gut bacteria associated with inflammatory bowel diseases (IBD), says a new study from Israel that shows the potential of this emerging class of microbiome modulators. (nutraingredients-usa.com)
In the present study, we reconstructed large phage genomes from freshwater lakes known to contain bacteria that oxidize methane. (nature.com)
Bacteriophages (phages), viruses that infect and replicate within bacteria, are important in both natural and human microbiomes because they prey on bacterial hosts, mediate horizontal gene transfer, alter host metabolism and redistribute bacterially derived compounds via host cell lysis 1 . (nature.com)
found that the bacteriophage BPP-1 (Bvg plus tropic phage-1) had a tropism for the Bvg+ phase bacteria. (the-scientist.com)
When the phage hits the bacteria it has an immediate effect, if you apply it on the surface of chicken, within the first 30 minutes there is a 1 log reduction. (foodnavigator.com)
They are natural and safe for human consumption, phages kill specific bacteria. (foodnavigator.com)
Moreover, the speed of the phage lifecycle means that progeny phage production starts about 10 minutes after infection of the bacteria, so PACE can effectively mediate many generations of selective phage replication much faster than other laboratory evolution approaches. (genengnews.com)
Once doctors knew exactly what kind of infection she had, they did a worldwide search and found a phage that could match and potentially kill the bacteria. (abc.net.au)
Furthermore, the genome information of the bacteria and phages will be used to create mathematical models that allow conclusions to be drawn about phage/host specificity. (bund.de)
Lysogenic phages have evolved to insert their DNA into the genomes of specific strains of bacteria. (igem.org)
Then transform the plasmid into the host bacterial strain and expose the bacteria to the phage. (igem.org)
Bacteriophages - aka "phages" - are viruses that kill bacteria. (bigthink.com)
For as long as bacteria have existed, phages have been perfecting the art of destroying them. (bigthink.com)
Bacteriophages, known simply as " phages " for short, are viruses that infect and kill bacteria. (bigthink.com)
Desperate to find a cure after more than a dozen antibiotics had failed, Strathdee, an infectious disease epidemiologist at the University of California, San Diego, School of Medicine, stumbled upon phage therapy: a mostly forgotten treatment discovered 100 years ago that uses viruses to kill lethal bacteria. (today.com)
Phages are viruses that have naturally evolved to attack bacteria. (today.com)
In addition, sufficient conditions that a bacteria-phage community of arbitrary size with nested infection network can arise through a succession of permanent subcommunties each with a nested infection network by the successive addition of one new population are provided. (utoronto.ca)
However, acquisition of resistance by bacteria is a major issue in the successful development of phage therapies. (mit.edu)
In aquaculture settings, disease-causing bacteria are often transmitted through the water body, providing several applications for phage-based targeting of pathogens, in the rearing environment, and in the fish. (jyu.fi)
In the future, phage therapy may be used alone to eliminate antibiotic-resistant bacteria, or together with antibiotic therapy in cases where antibiotics still work. (bvsalud.org)
The irreversible increase in drug-resistant bacteria is cause for concern and has created a new role for phage therapy, especially in cases where the alternatives to control the signs and symptoms of drug-resistant infectious processes have been exhausted. (bvsalud.org)
A virus that infects bacteria is called a phage. (cdc.gov)
Phages infect specific species of bacteria. (cdc.gov)
The ability of lytic phages to rapidly kill and lyse infected bacteria, the specificity of phages for particular bacteria, and the ability of phages to increase in number during the infection process make phages excellent potential diagnostic and therapeutic agents for fighting bacterial disease. (cdc.gov)
Bacteriophages, commonly known as phages, are viruses that selectively target and kill bacteria. (medscape.com)
When DNA of the phage integrates into the host bacteria's genetic material, the bacteria develop the capacity to produce this polypeptide toxin. (medscape.com)

Phage display is a laboratory technique for the study of protein-protein, protein-peptide, and protein-DNA interactions that uses bacteriophages (viruses that infect bacteria) to connect proteins with the genetic information that encodes them. (wikipedia.org)
The most common bacteriophages used in phage display are M13 and fd filamentous phage, though T4, T7, and λ phage have also been used. (wikipedia.org)
In addition, available Klebsiella bacteriophages from the consortium will be sequenced to provide detailed information on the genetic basis of the phages. (bund.de)
Bacteriophages (phages) are viruses capable of infecting and replicating within bacterial cells. (asm.org)
Control of bacterial diseases by bacteriophages (phages) is gaining more interest due to increasing antibiotic resistance. (jyu.fi)

The inspiration for this project was a recently published article reporting phage genome results obtained by high school and college students. (wikiversity.org)
The high diversity and relatively small genome sizes of these phages provide an ideal platform for introducing high school and undergraduate students to the research laboratory, isolating and naming novel viruses, and determining their genomic sequences. (wikiversity.org)
Near the bottom of that page there is a map of the L5 phage genome. (wikiversity.org)
To search for sequence similarities to the Mycobacterium phage L5 genome, click on the "GenBank: Z18946" link in the GenBank summary page for phage L5 (see Figure 3). (wikiversity.org)
A phenomenon that has recently come to light via metagenomic studies is the prominence of phages with genomes that are much larger than the average size of ~55 kilobases (kb) predicted based on current genome databases 2 . (nature.com)
For many years it has been known that (i) phage Φ29 DNA replication, as well as that of other prokaryotic genomes, occurs at the cytosolic membrane, and (ii) the lytic Φ29 cycle is suppressed in early sporulating cells and under these conditions the infecting phage genome becomes trapped into the spore. (bionity.com)
The integration of phage λ takes place at a special attachment site in the bacterial genome, called att λ . (wikidoc.org)
The original BOB' sequence is changed by the integration to B-O-P'-phage DNA-P-O-B'. The phage DNA is now part of the host's genome. (wikidoc.org)
The linear phage genome is injected into the cell, and immediately circularises. (wikidoc.org)
The objectives of our phage standard include negating the issues of genome size, exploiting phage characteristics for use as a vector, and developing a BioBrick compatible standard applicable to all lysogenic phages. (igem.org)
The phage standard describes the process of adding a given Biobrick part, which we will call source DNA into the genome of a lysogenic phage, referred to as host DNA . (igem.org)
This will require secondary DNA sequences including the phage genome integration site , some garbage DNA (flanked by essential restriction enzyme cut sites) and the low-copy number BioBrick plasmid . (igem.org)
The first step is to choose restriction enzymes using webcutter 2.0 that appear only once , closest to the region of the phage genome that is going to be modified (Fig. 1). (igem.org)
Current state of the low copy BioBrick plasmid containing the full phage genome. (igem.org)
Cut and ligate it all back together and viola, a modified phage genome is at your disposal. (igem.org)
Virulent or obligate lytic phages infect and quickly kill their bacterial host cell, whereas temperate or lysogenic phages may either stably integrate into their host's genome or enter into the lytic life cycle. (asm.org)
The researchers used mutant phages, genome sequencing, and in vitro experiments to show how one retron, Ec48, promotes this self-sacrifice. (weizmann-usa.org)
Genome-wide comparison of phage M13-infected and uninfected E. coli, 2 and 20 min after infection, was performed. (lu.se)

These compare the amino acid sequence of a gene to other sequenced or annotated phage genomes within the database for students in the SEA-PHAGES community to predict starts and functions of their proteins. (wikipedia.org)
The handful of marine phage genomes that have been sequenced to date, along with prophages in marine bacterial genomes, and partial sequencing of uncultivated phages are yielding glimpses of the tremendous diversity and physiological potential of the marine phage community. (nih.gov)
Finally, deciphering phage genomes is providing clues about the adaptive response of phages and their hosts to environmental cues. (nih.gov)
Clusters A through F contain phage with similar genomes. (wikiversity.org)
There is growing evidence that phages with unusually large genomes are common across various microbiomes, but little is known about their genetic inventories or potential ecosystem impacts. (nature.com)
Future work is needed to determine whether phage-associated PmoC has similar functions to additional copies of PmoC encoded in bacterial genomes, thus contributing to growth on methane. (nature.com)
The recently reported phage genomes range up to 735 kb in length and encode a diversity of genes involved in transcription and translation, as well as genes that may augment host metabolism 2 . (nature.com)
Augmentation of bacterial energy generation by auxiliary metabolic genes has been reported for phages with smaller genomes. (nature.com)
Phages with very large genomes were recently reported from a man-made lake that covers a deposit of methane-generating tailings from an oil sands mine in Canada 2 . (nature.com)
This is used to share the genomes of pmoC-phages, related phages without pmoC, and also the bacterial methanotrophs reconstructed from freshwater ecosystems. (figshare.com)
Lastly, lysogenic phage genomes are too large to be manipulated using normal BioBrick plasmids. (igem.org)

Applications of phage display technology include determination of interaction partners of a protein (which would be used as the immobilised phage "bait" with a DNA library consisting of all coding sequences of a cell, tissue or organism) so that the function or the mechanism of the function of that protein may be determined. (wikipedia.org)

Phage eluted in the final step can be used to infect a suitable bacterial host, from which the phagemids can be collected and the relevant DNA sequence excised and sequenced to identify the relevant, interacting proteins or protein fragments. (wikipedia.org)
Most of these phages infect Bacillus subtilis , but often they also infect other related species such as Bacillus amylolyquefaciens , Bacillus pumilus, and Bacillus licheniformis . (bionity.com)
The most distantly related phage of this family, GA-1, is unable to infect the standard B. subtilis strain 168 and has been placed in a third group. (bionity.com)
This will allow the phage to infect the bacterial cells as well as the integration site on the low-copy BioBrick plasmid. (igem.org)

In order to provide you with accurate and valuable pieces of information and reviews, we have conducted in-depth research for the best phage toy of 2023. (curee.org)

Of these 260 requests, only 15 patients received phage therapy. (mdpi.com)

The Westmead Institute for Medical Research (WIMR) laboratory that Dr Lin is part of is the first in Australia to run a clinical trial of phage therapy for people with superbug infections. (abc.net.au)
Effective cOmbination of Phages and Antibiotics for improved TheRApy. (bund.de)
There is a growing interest in phage therapy as a complementary tool against antimicrobial resistant infections. (mdpi.com)
In the last two years, external requests for phage therapy have increased significantly. (mdpi.com)
From April 2013 to April 2018, 260 phage therapy requests were addressed to the QAMH. (mdpi.com)
Phage therapy was pushed aside when penicillin came along, but it was the only treatment that helped a man overcome a superbug infection. (today.com)
Right before we administered the phage therapy, it was thought he was within hours of dying. (today.com)
I found phage therapy was one option. (today.com)
Although phage therapy was first implemented almost a century ago, it was brought to a standstill after the successful introduction of antibiotics. (asm.org)
Now, with the rise of antibiotic resistance, phage therapy is experiencing a well-deserved rebirth. (asm.org)
Among the admittedly vast literature recently published on this topic, this review aims to provide a forward-looking perspective on phage therapy and its role in modern society. (asm.org)
We cover the key points of the antibiotic resistance crisis and then explain the biological and evolutionary principles that support the use of phages, their interaction with the immune system, and a comparison with antibiotic therapy. (asm.org)
By going through up-to-date reports and, whenever possible, human clinical trials, we examine the versatility of phage therapy. (asm.org)
Finally, we discuss the benefits of phage therapy beyond the clinical perspective, including opportunities for scientific outreach and effective education, interdisciplinary collaboration, cultural and economic growth, and even innovative use of social media, making the case that phage therapy is more than just an alternative to antibiotics. (asm.org)
FIG 1 Timeline of major events in the history of research on phages, phage therapy, and antibiotics. (asm.org)
Background curves represent a qualitative measure of the overall interest, research, and use of phage therapy (yellow) and antibiotics (blue), showing how the introduction of antibiotics and the critical review of the early phage therapy studies coincided to bring phage therapy research and development to an almost complete standstill around the 1940s. (asm.org)
Our results show that successful phage therapy treatment in the aquaculture setting requires optimisation of phage delivery methods in vivo. (jyu.fi)
This dataset consists of three phage therapy experiments to prevent Flavobacterium columnare infections in rainbow trout. (jyu.fi)
Although research centers in the United States, France, and former Soviet States never stopped conducting studies on phage therapy, this concept was only rediscovered in the 1980s, again drawing the interest of the global scientific community. (bvsalud.org)
This chapter discuss about Rapid screening and Detection Methods Associated with Bacteriophage for Salmonella , commercially available phage products and regulatory status, Salmonella endolysins and future prospects of phage therapy . (bvsalud.org)

In 1990, Jamie Scott and George Smith described creation of large random peptide libraries displayed on filamentous phage. (wikipedia.org)
In the case of M13 filamentous phage display, the DNA encoding the protein or peptide of interest is ligated into the pIII or pVIII gene, encoding either the minor or major coat protein, respectively. (wikipedia.org)
Here, we expand on the overall utility of the VLRB technology by introducing it into a filamentous phage display system. (usgs.gov)
The new system, called phage-assisted continuous evolution, or PACE, is based on the continuous culture and selection of the M13 filamentous bacteriophage commonly used in phage display. (genengnews.com)
The display of antibody repertoires on the surface of filamentous phage, together with efficient selection-amplification schemes, allows the isolation of good-quality human antibodies against virtually any molecular target. (chimia.ch)
Filamentous phage associated with recent pandemic strains of Vibrio parahaemolyticus. (cdc.gov)
To identify Escherichia coli genes potentially regulated by filamentous phage infection, we used oligonucleotide microarrays. (lu.se)
Thus, global transcriptional analysis and functional analysis revealed previously unknown host responses to filamentous phage infection. (lu.se)

Our latest study has shown we are able to safely administer intravenously these phages to patients who are not responding to specific types of antibiotics. (abc.net.au)
As superbugs become resistant to antibiotics, phages are seen as a promising alternative for patients who have run out of options. (abc.net.au)

Enterobacteria phage λ ( lambda phage ) is a temperate bacteriophage that infects Escherichia coli . (wikidoc.org)
CusabioAlternative Name(s): UVSX,Recombination and repair proteinGene Names: UVSXResearch Areas: OthersOrganism: Enterobacteria phage T4 (Bacteriophage T4)AA. (joplink.net)
CusabioAlternative Name(s): DsDNA-binding protein A (rpbB)Gene Names: dsbAResearch Areas: Cell BiologyOrganism: Enterobacteria phage T4 (Bacteriophage. (joplink.net)
Felix d'Herelle first coined the term "bacteriophage" ( 4 ), literally meaning "bacterium eater," and began using phages to treat bacterial infections in human patients ( Fig. 1 ). (asm.org)

M13 phage displaying an in vivo biotinylatable peptide (AviTag) genetically fused to the phage tail protein pIII were used as reporter particle scaffolds, with biotinylated aptamers attached via avidin-biotin linkages, and horseradish peroxidase (HRP) reporter enzymes covalently attached to the pVIII coat protein. (nih.gov)
I've got short, 9-15 AA long peptide sequences from phage display. (bio.net)

This project allows participants to access phage gene databases and participate in phage genomics research projects. (wikiversity.org)

CusabioAlternative Name(s): /Gene Names: ddaResearch Areas: NeuroscienceOrganism: Enterobacteria phage. (joplink.net)
CusabioAlternative Name(s): Gene Names: uvsYResearch Areas: OthersOrganism: Enterobacteria phage T4. (joplink.net)

Temperate phages are capable of protecting their host from phage reinfection and may change the bacterial phenotype through the expression of viral genes, a process known as lysogenic conversion ( 1 ). (asm.org)

In addition, pmoC-phage abundance patterns correlate with those of the coexisting bacterial methanotrophs, supporting host-phage relationships. (nature.com)
Additionally, we show a direct correlation between the CRISPR-Cas adaptive immunity and the metavirome of hypolith communities, suggesting the existence of dynamic host-phage interactions. (ugent.be)

Transcriptomics data from Lake Rotsee (Switzerland) showed that some phage-associated pmoC genes were highly expressed in situ and, of interest, that the most rapidly growing methanotroph was infected by three pmoC-phages. (nature.com)
Thus, augmentation of bacterial methane oxidation by pmoC-phages during infection could modulate the efflux of this potent greenhouse gas into the environment. (nature.com)
Hereafter, we refer to these phages as pmoC-phages. (nature.com)

Surface swabs were tested for lytic phages and bacterial isolates for mitomycin C-inducible prophages. (mdpi.com)
Diagnostic and therapeutic applications of lytic phages. (cdc.gov)

Firstly, lysogenic phages are natural vectors that have evolved to integrate and propagate their DNA through specific bacterial strains. (igem.org)
This specificity allows the integration sites of different lysogenic phages to be used as insertion vectors . (igem.org)

The thrill of discovering new viruses and previously unidentified genes, coupled with ownership of individual phage projects, provides strong motivations for students to engage in and pursue scientific research. (wikiversity.org)
In the present study, we searched the unreported phage genomic fragments from this lake for genes involved in methane oxidation. (nature.com)
PACE essentially comprises a system by which E. coli cells continuously flow through a fixed-volume vessel, or lagoon, which contains a replicating population of phage DNA vectors (the selection phage) encoding the gene or genes of interest. (genengnews.com)
The analysis revealed altered transcription levels of 12 E. coli genes in response to phage infection, and the observed regulation of phage genes correlated with the known in vivo pattern of M13 mRNA species. (lu.se)
The significantly upregulated genes encode proteins involved in reactions of the energy-generating phosphotransferase system and transcription processing, which could be related to phage transcription. (lu.se)

In this technique, a gene encoding a protein of interest is inserted into a phage coat protein gene, causing the phage to "display" the protein on its outside while containing the gene for the protein on its inside, resulting in a connection between genotype and phenotype. (wikipedia.org)
The proteins that the phages are displaying can then be screened against other proteins, peptides or DNA sequences, in order to detect interaction between the displayed protein and those of other molecules. (wikipedia.org)
Phage display technology was further developed and improved by groups at the Laboratory of Molecular Biology with Greg Winter and John McCafferty, The Scripps Research Institute with Richard Lerner and Carlos Barbas and the German Cancer Research Center with Frank Breitling and Stefan Dübel for display of proteins such as antibodies for therapeutic protein engineering. (wikipedia.org)
Like the two-hybrid system, phage display is used for the high-throughput screening of protein interactions. (wikipedia.org)
If a "phagemid" vector is used (a simplified display construct vector) phage particles will not be released from the E. coli cells until they are infected with helper phage, which enables packaging of the phage DNA and assembly of the mature virions with the relevant protein fragment as part of their outer coat on either the minor (pIII) or major (pVIII) coat protein. (wikipedia.org)
By immobilizing a relevant DNA or protein target(s) to the surface of a microtiter plate well, a phage that displays a protein that binds to one of those targets on its surface will remain while others are removed by washing. (wikipedia.org)
Both Int and IHF bind to attP and form an intasome , a DNA-protein-complex designed for site-specific recombination of the phage and host DNA. (wikidoc.org)
They found that Ec48 is activated by inhibition of a protein complex called RecBCD, an early responder in a bacterium's anti-phage defenses-and a common target for invading phages. (weizmann-usa.org)
When bound to phage GA coat protein, the bulged adenine loops out of the helix and occupies a binding pocket on the surface of the protein, forming a nucleation complex for phage assembly. (rcsb.org)
We have studied this RNA motif in a 21 nucleotide hairpin containing a GA coat protein-binding site whose four nucleotide loop has been replaced by a more stable loop from the related phage Ms2. (rcsb.org)
Thus, while the adenine site preferences of the spliceosome and of phage GA may be due to protein factors, the preferred adenine is predisposed in the free RNA to conformational rearrangement involved in formation of the active complexes. (rcsb.org)
Through natural evolution and structural modeling, we identified host-range-determining regions (HRDRs) in the T3 phage tail fiber protein and developed a high-throughput strategy to genetically engineer these regions through site-directed mutagenesis. (mit.edu)
To investigate the relation between protein stability and the predicted stabilities of individual secondary structural elements, residue Pro86 in an alpha-helix in phage T4 lysozyme was replaced by ten different amino acids. (rcsb.org)

Phage Φ29 has also been proven to be a versatile system to study in vitro transcription regulation in general and the switch from early to late phage transcription in particular. (bionity.com)
The detailed knowledge of in vitro phage Φ29 DNA replication and transcription regulation makes it an attractive model to study these processes in vivo . (bionity.com)
As an innovative addition, the in vitro production of phages will be investigated to enable their use without complex purification steps in the field of human medicine. (bund.de)

[1] These phages, which form part of the Podoviridae family , are the smallest Bacillus phages isolated to date and are among the smallest known dsDNA phages. (bionity.com)

The phage gene and insert DNA hybrid is then inserted (a process known as "transduction") into E. coli bacterial cells such as TG1, SS320, ER2738, or XL1-Blue E. coli. (wikipedia.org)
Common gene modules in diverse phages are providing the information necessary to make evolutionary comparisons. (nih.gov)
The system achieves continuous selection by linking the desired activity to the production of infectious progeny phage containing the evolving gene(s). (genengnews.com)
The repressor found in the phage lambda is a notable example of the level of control possible over gene expression by a very simple system. (wikidoc.org)
Toxin production is encoded on the tox gene, which, in turn, is carried on a lysogenic beta phage. (medscape.com)

Those that remain can be eluted, used to produce more phage (by bacterial infection with helper phage) and to produce a phage mixture that is enriched with relevant (i.e. binding) phage. (wikipedia.org)
On initial infection, the stability of cII determines the lifestyle of the phage. (wikidoc.org)
Phages for treatment of Salmonella spp infection. (bvsalud.org)

The life cycle of lambda phages is controlled by cI and Cro proteins. (wikidoc.org)
The lambda phage will remain in the lysogenic state if cI proteins predominate, but will be transformed into the lytic cycle if cro proteins predominate. (wikidoc.org)

Lambda gtll recombinant phages w. (bvsalud.org)

Since 2007, phages have been used sporadically to treat bacterial infections in well-defined cases in the Queen Astrid military hospital (QAMH) in Brussels, Belgium. (mdpi.com)
When phages were discovered 100 years ago, they were used to treat bacterial infections, but then when penicillin came on the scene, it was considered to be a wonder drug. (today.com)

Marine phages are the most abundant biological entities in the oceans. (nih.gov)

Access to live virus stocks would be needed during the initial stages of monoclonal antibody production or if, for example, phage display systems were to be developed. (who.int)

The rapid emergence of antibiotic-resistant infections is prompting increased interest in phage-based antimicrobials. (mit.edu)

Lambda phage was discovered by Esther Lederberg in 1951. (wikidoc.org)

We further utilized the system to isolate target-specific "lampribodies" from phage display libraries from immunized animals and observed an amplification of binders with relative high affinities by competitive binding. (usgs.gov)

Selected phages will be evaluated on a wide range of infections in which PHAXIAM already benefits from considerable expertise, such as lung, blood and urinary tract infections. (krqe.com)
We tested delivery of phages by different methods (via baths, in phage-coated material, and via oral delivery in feed) to prevent and treat Flavobacterium columnare infections in rainbow trout fry using three phages (FCOV-S1, FCOV-F2, and FCL-2) and their hosts (FCO-S1, FCO-F2, and B185, respectively). (jyu.fi)

Phages replicate through two primary life cycles, the dynamics of which have important implications for their therapeutic application. (asm.org)

2020. "Phages Actively Challenge Niche Communities in Antarctic Soils. (ugent.be)
Bacterial retrons function in anti-phage defense," Cell , 183:1551-61.e12, 2020. (weizmann-usa.org)

For our project, these insertion vectors will be low-copy BioBrick plasmids containing the integration site of a given phage, flanked by chosen restriction sites. (igem.org)

Of the 11 isolates tested (10 obtained from ill persons and one from the sauce), all were phage type 8. (cdc.gov)
Toxigenic isolates of Vibrio cholerae, biotype eltor, serotype Inaba, phage-type 2, were obtained from the index case, a companion of the patient, the reticulated water supply of their place of residence, and a stretch of the neighbouring river that was being used to supplement fully treated water piped from Brisbane. (who.int)

We are a technology and research-driven company, the phage needs to kill the entire species of Listeria and Salmonella, you don't want to kill 80% and leave the rest intact. (foodnavigator.com)

Phages are commonly found in sewage. (abc.net.au)

This will enable the Company to capitalize on preclinical models validated with its three historical phage families, mutualize certain developments within the same indication and accelerate the progression to clinical phases. (krqe.com)

Much remains to be discovered about the diversity, evolution and ecological impact of phage. (wikiversity.org)
By modulating the structure, diversity, and trophic outputs of microbial communities, phages play crucial roles in many biomes. (ugent.be)
Although the past two decades have revealed substantial insights regarding the diversity and structure of microbiomes, we lack mechanistic insights regarding community interactions and how phages may affect these. (ugent.be)

GenBank - Search the GenBank database for the accession number for one of the phages from the Hatfull article such as phage L5 (number Z18946). (wikiversity.org)

Although phages may substantially govern trophic interactions in cold deserts, relatively little is known regarding the precise ecological mechanisms. (ugent.be)
We provide evidence suggesting that the regulatory role played by phages in this system is an important determinant of bacterial host interactions in this environment. (ugent.be)

Once the phage has injected its DNA into its host , the phage DNA may integrate itself into the host cell chromosome. (wikidoc.org)

Smith and Winter were awarded a half share of the 2018 Nobel Prize in chemistry for their contribution to developing phage display. (wikipedia.org)
MARVEL COMIC-INSPIRED DESIGN: Phage figure features premium design, detail, and articulation for posing and display in a Marvel collection. (curee.org)

For the example shown, the mouse cursor was over the sequence with greatest similarity to phage L5, another phage called Che12. (wikiversity.org)
Clicking on that link should show a tree that indicates the types of sequences with similarity to the L5 phage (see Figure 6, below). (wikiversity.org)

Marvel Hasbro Legends Series Venom 6-inch Collectible Action Figure Toy Phage, Premium Design and 1. (curee.org)
6-INCH-SCALE COLLECTIBLE PHAGE FIGURE: Fans, collectors, and kids alike can enjoy this 6-inch-scale figure, inspired by the character from the Marvel. (curee.org)
PREMIUM ARTICULATION AND DETAILING: This quality 6-inch Hasbro Marvel Legends Series Venom Phage figure features multiple points of articulation and. (curee.org)

We discuss conventional approaches as well as novel strategies, including the use of phage-antibiotic combinations, phage-derived enzymes, exploitation of phage resistance mechanisms, and phage bioengineering. (asm.org)

We first tested the efficacy of isolating phage into which known VLRB molecules were cloned after a series of dilutions. (usgs.gov)

This article illustrates how antibody phage technology has been used in our laboratory for the isolation of tumour targeting agents. (chimia.ch)

Phages isolated from the feces could potentially be incorporated into dressings for ulcers, creating a novel treatment modality that is both effective and cost-saving. (medscape.com)

Organisms21

Diseases1

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes14

Information Science3

Bacteria27

Bacteriophages5

Genome18

Genomes11

Coding sequences1

Infect4

20231

Received phage therapy1

Therapy20

Filamentous8

Antibiotics2

Bacteriophage4

Peptide2

Genomics1

Enterobacteria2

Temperate1

Host-phage2

PmoC-phages3

Lytic phages2

Lysogenic phages2

Genes5

Protein13

Vitro3

DsDNA1

Gene5

Infection3

Proteins2

Recombinant1

Treat bacterial infections2

Abundant1

Monoclonal1

Antibiotic-Resistant1

Lambda1

Libraries1

Infections2

Replicate1

20202

Plasmids1

Isolates2

Salmonella1

Commonly1

Clinical1

Diversity3

Search1

Interactions2

Integrate1

Display2

Similarity2

Marvel3

Enzymes1

Efficacy1

Isolation1

Potentially1