Different isoforms have been described encode ras gtpase activating proteins. Medical search. Frequent questions

Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. (nih.gov)
It is known that the human Ras GTPase activating protein (GAP) p120-GAP can be phosphorylated by different members of the Src kinase family and recently phosphorylation of the GDP/GTP exchange factor (GEF) CDC25Mm/GRF1 by proteins of the Src kinase family has been revealed in vivo [Kiyono, M., Kaziro, Y. & Satoh, T. (2000) J. Biol. (embl.de)
In addition to its association with Ras, GAP has been shown to bind to several tyrosine-phosphorylated proteins in cells stimulated by growth factors or expressing transforming tyrosine kinase variants. (embl.de)
NM23-H1 (also known as NME1) was the first identified metastasis suppressor, which displays a nucleoside diphosphate kinase (NDPK) and histidine protein kinase activity. (biomedcentral.com)
In mammalian cell lines NDPK-mediated attenuation of Ras/ERK signaling occurs through phosphorylation (thus inactivation) of KSR (kinase suppressor of Ras) scaffolds. (biomedcentral.com)
Kim JJ, Flueck C, Franz E, Sanabria-Figueroa E, Thompson E, Lorenz R, Bertinetti D, Baker DA, Herberg FW, Kim C. Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress.PLoS Pathog. (uni-kassel.de)
Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: influence of amino terminus on cAMP binding and holoenzyme formation. (uni-kassel.de)
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. (bioss.com.cn)
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. (bioss.com.cn)
Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. (bioss.com.cn)
The Parkinson's disease genes pink1 and parkin , which encode a mitochondrially targeted protein kinase, and an E3 ubiquitin ligase, respectively, participate in a key mitochondrial quality-control pathway that eliminates damaged mitochondria. (sdbonline.org)
G protein-coupled receptor kinase 2 (GRK2) was originally identified as the kinase that mediates G protein-coupled receptor (GPCR) desensitization. (biomedcentral.com)
CD44 and ezrin are both substrates for Protein Kinase C, and we show that their EGF-dependent colocalisation requires Protein Kinase C activity. (silverchair.com)
We propose that AP-1 regulates the integrity of Protein Kinase C signalling and identifies PKC theta as a potential suppressor of the invasion programme. (silverchair.com)
1. Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. (nih.gov)
6. Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. (nih.gov)
12. Comparative analysis of signaling pathways between mast cell growth factor (c-kit ligand) and granulocyte-macrophage colony-stimulating factor in a human factor-dependent myeloid cell line involves phosphorylation of Raf-1, GTPase-activating protein and mitogen-activated protein kinase. (nih.gov)
14. Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C. (nih.gov)
17. Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. (nih.gov)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
Phosphatidylinositol 3-kinase (PI3K) is a critical element in this signaling, it is activated in a wide range of human neoplasms and associated with poor outcomes [ 2 , 3 ]. (biomedcentral.com)

The phosphorylation of p120-GAP by p60c-Src inhibited its ability to stimulate the Ha-Ras-GTPase activity, whereas phosphorylation by Lck did not display any effect. (embl.de)
phosphorylation by Lck increased its capacity to stimulate the GDP/GTP exchange on Ha-Ras, whereas its phosphorylation by p60c-Src was ineffective. (embl.de)
Our results suggest that phosphorylation by p60c-Src and Lck is a selective process that can modulate the activity of p120-GAP and CDC25Mm towards Ras proteins. (embl.de)
While in bacteria the different oxygen-sensing pathways reported involve protein dimerization and phosphorylation cascades, in plants and animals this function is mediated by oxygen-dependent proteolysis. (springer.com)
Phosphorylation promotes translocation of β-arrestins to the receptors and inhibits further G protein activation by interrupting receptor-G protein coupling. (biomedcentral.com)
The GRK-mediated phosphorylation of the receptors plays opposite roles in conventional G protein- and β-arrestin-mediated signaling. (biomedcentral.com)
The GRK-catalyzed phosphorylation of the receptors results in decreased G protein-mediated signaling, but it is necessary for β-arrestin-mediated signaling. (biomedcentral.com)
16. Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt. (nih.gov)
Since ERM proteins can exist in dormant or active conformations corresponding to their phosphorylation state, we propose that the partitioning of ERM proteins between subcellular compartments may depend on their activation status. (embl-heidelberg.de)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
Activated PIP3 could prompt the phosphorylation of Akt and further stimulate the Akt-mediated activation of downstream targets, including the Bcl-2 family members, Mdm2 and tuberous sclerosis complex 2 (TSC2) [ 7 ]. (biomedcentral.com)

Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. (nih.gov)
Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm. (embl.de)
p21-activated kinases (PAKs) regulate many cellular processes, including cytoskeletal rearrangement and cell migration. (rupress.org)
Manual 26.29 HN - 2002 MH - Activin Receptors UI - D029404 MN - D8.586.913.696.620.682.700.62 MN - D12.776.543.750.750.400.820.500 MS - Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). (nih.gov)

Most of the miRs are located within introns of the host genes (protein-coding or non-protein-coding) or within the 3' untranslated region (UTR) of mRNA genes. (medscape.com)
In the human genome, the RAS family includes a large number of related genes (paralogs). (oncotarget.com)
Effector-encoding genes are expressed only during plant infection and show very low expression during other developmental stages. (exeter.ac.uk)
These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. (cancerindex.org)
V7 isoforms in all NCI-60 tissue of origin types demon- levels for identical genes and identical cell lines across strate translational relevance. (nih.gov)
With the help of molecular tools, events leading to the morphological transition have been traced to genes that control cell wall glucan and chitin syntheses, and other metabolic processes such as production of heat shock proteins and ornithine decarboxylase activity. (dadospdf.com)
The genes that encode two ligands, Pdgfa and Pdgfb , and both receptors, PDGF receptor alpha and PDGF receptor beta( Pdgfra, Pdgfrb ), have been knocked out in the mouse. (silverchair.com)
Second, genetic AMOT( isoform) mutations can contribute YAP1 and WWTR1( TAZ) in their endogenous centromeres, a glycine that may forecast a dysmorphic base to translocate the mitochondria of these genes( Chan et al. (evakoch.com)

The KRAS gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. (nih.gov)
Here we report the cloning and characterization of a novel GAP-binding protein, mTid-1, a DnaJ chaperone protein that represents the murine homolog of the Drosophila tumor suppressor l(2)tid gene. (embl.de)
NDK-1, the worm homolog of NM23-H1 affects Ras/MAPK signaling at the level of KSRs, and a functional interaction between NDK-1/NDPK and KSRs was first demonstrated in the worm in vivo . (biomedcentral.com)

GAPs function as activators of Ras superfamily of small GTPases. (wikipedia.org)
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. (nih.gov)

Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. (wikipedia.org)
Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. (cancerindex.org)
Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. (bioss.com.cn)

The contradiction between results in mammalian cell lines and in the worm regarding NDPKs' effect exerted on the outcome of Ras signaling might be resolved, if we better understand the function, structure and regulation of KSR scaffolds. (biomedcentral.com)
The major mammalian effector proteins for cNMP signaling encompass PKA, PKG, the exchange protein directly activated by cAMP (EPAC), hyperpolarization-activated cyclic nucleotide-gated cation channels (HCN) as well as cyclic nucleotide-gated ion channels (CNG). (uni-kassel.de)
Translocator protein 18kDa is a mitochondrial outer membrane protein that was first recognized in mammalian systems as the peripheral benzodiazepine receptor (PBR) and in Rhodobacter sphaeroides as the tryptophan-rich sensory protein (TspO). (researchgate.net)

The Ras family of GTPases is a collection of molecular switches that link receptors on the plasma membrane to signaling pathways that regulate cell proliferation and differentiation. (embl.de)
What pathways are this gene/protein implicaed in? (cancerindex.org)
In higher eukaryotes these proteins are involved in signal transduction pathways controlling a diverse array of essential cellular functions, such as growth, differentiation and survival [ 1 ]. (oncotarget.com)
an adapter protein coupling the receptor to downstream signaling pathways. (bioss.com.cn)
They have defined proteins and pathways that inform specific therapeutic targets and corresponding biomarkers of drug and pathway engagement. (neurology.org)
Furthermore, GRKs are recognized as signaling mediators that are independent of either G protein- or β-arrestin-mediated pathways. (biomedcentral.com)
Here, we summarized the involvement of GRKs in β-arrestin-mediated and G protein-independent signaling pathways. (biomedcentral.com)
In the rst phase, external signals are sensed by speci c receptors on the cell surface, which in a second phase activate intracellular signal transduction pathways. (dadospdf.com)

Two transcript variants encoding different isoforms have been found for this gene. (nih.gov)
Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. (nih.gov)

By embryonic day 12 (E12) to E13 in mice, Schwann cell precursors begin to express three differentiation markers: P0 (myelin protein 0), GAP43 (growth-associated protein 43), and F-spondin, ( Jessen and Mirsky, 1999 ). (jneurosci.org)
As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (cancerindex.org)

The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. (nih.gov)
When mutated, p120 Ras GTPase-activating protein binds to Krev-1/rap1a, an integrin β1-mediated cell adhesion and angiogenesis protein. (medscape.com)
EGFR is a cell surface protein that binds to epidermal growth factor. (bioss.com.cn)
The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)

The RASA1 gene encodes p120 Ras GTPase-activating protein. (medscape.com)
p120 GTPase-activating protein (GAP) down-regulates Ras by stimulating GTP hydrolysis of active Ras. (embl.de)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
NF1 encodes neurofibromin, a Ras-GTPase activating protein, and NF1 mutations result in hyperactivated Ras signaling in patients. (jci.org)
Transcription of the mutant allele was detectable for 34% of protein-coding mutations, and 20% exhibited allele-specific expression. (nature.com)

We provide composite and isoform applications, allowing their exploration for both research transcript expression data and demonstrate diversity in and translational purposes. (nih.gov)
The DDIT4 gene, encoding the DNA-damage-inducible transcript 4, associated with regulation and development of DNA processes after damage by ionizing radiation and in p53 mediated apoptotic processes, is up-regulated. (ijpsr.com)

Molecular analyses verified reduced neurofibromin expression in swine NF1+/ex42del fibroblasts, as well as hyperactivation of Ras, as measured by increased expression of its downstream effectors, phosphorylated ERK1/2, SIAH, and the checkpoint regulators p53 and p21. (jci.org)

Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. (bioss.com.cn)

The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2. (nih.gov)
The gene NPM1 that encodes for nucleophosmin (NPMI) is translocated or mutated in various lymphomas and leukemias, forming fusion proteins (NPM-ALK, NPM-RARa, NPM-MLF1) or NPM mutant products. (haematologica.org)

The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric oxide synthase expression and stimulate the production of nitric oxide in human fetal membrane explants in culture. (biomedcentral.com)
Culturing the membrane discs in medium containing serum induced nitric oxide synthase expression and platelet-activating factor significantly stimulated the production of nitric oxide under these conditions. (biomedcentral.com)
When cultured without serum inducible nitric oxide synthase expression was induced by lipopolysaccharide, but not by platelet-activating factor. (biomedcentral.com)

This protein is a receptor for members of the epidermal growth factor family. (bioss.com.cn)
The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. (bioss.com.cn)
Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. (bioss.com.cn)
A novel neurotrophic factor-α1-HTR1E serotonin receptor interaction activates ERK-BCL2 signaling to promote cell survival. (nih.gov)
Regulator of G-protein signaling (RGS) proteins increase the intrinsic guanosine triphosphatase (GTPase) activity of G-protein α subunits in vitro, but how specific G-protein-coupled receptor systems are targeted for down- regulation by RGS proteins remains uncharacterized. (elsevierpure.com)
The presence of an alternatively spliced PDZ domain within RGS12 suggests a mechanism by which RGS proteins may target specific G-protein-coupled receptor systems for desensitization. (elsevierpure.com)
The translocator protein 18 kDa (TSPO) was previously known as the peripheral benzodiazepine receptor (PBR) in eukaryotes, where it is mainly localized to the mitochondrial outer membrane. (researchgate.net)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
In addition, we also address a functional association of mitophagy with mitochondrial dynamics through the interaction of mitophagy adaptor and receptor proteins with mitochondrial fusion and fission proteins. (inforang.com)
ROS, nitrogen oxide, carbon monoxide, and H 2 S), and external signals (e.g. estrogen), which increase the amount of NEMP through nuclear respiration factor-1 (NRF1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and estrogen receptor. (inforang.com)

In hypoxia, RAP2.12 is released from the membrane and relocalizes into the nucleus, where it activates the molecular response to oxygen deficiency. (springer.com)
The highly homologous ERM (ezrin/radixin/moesin) proteins, molecular cross-linkers which connect the cell membrane with the underlying cytoskeleton, have molecular weights of 81, 80 and 78 kDa respectively. (embl-heidelberg.de)
We present data which shows significant variation in the molecular weight and presence of multiple forms of ERM proteins in different cell lines, such that specific antibodies to each protein are essential for unambiguous detection. (embl-heidelberg.de)

Rap1 (Ras-proximate-1 or Ras-related protein 1) is a small GTPase , which are small cytosolic proteins that act like cellular switches and are vital for effective signal transduction . (wn.com)
Cellular distributions of the ERM proteins in MDCK epithelial cells: regulation by growth and cytoskeletal integrity. (embl-heidelberg.de)
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
Under native conditions, both in resting and proliferating cells, over 95% of cellular NPM protein exists as an oligomer. (haematologica.org)

However, NDK-1 is a factor, which is necessary for proper MAPK activation, thus it activates rather than suppresses Ras/MAPK signaling in the worm. (biomedcentral.com)
Leucine-rich repeat neuronal protein-1 suppresses apoptosis of gastric cancer cells through regulation of Fas/FasL. (cancerindex.org)

The accessory GTPase-activating proteins (GAPs) negatively regulate the cell signaling by increasing the slow intrinsic GTP to GDP hydrolysis rate of Ras. (embl.de)

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. (nih.gov)

ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. (thermofisher.com)
When GPCRs are activated by their agonists, GRKs phosphorylate serine/threonine residues in the intracellular loops and the carboxyl-termini of GPCRs. (biomedcentral.com)
After binding to the growth factors, the intracellular domain of RTK is phosphorylated, and PI3K is activated (Figure 1 ). (biomedcentral.com)

Activated Akt inhibits the Rheb GTPase activity of TSC1/2 complex through phosphorylating TSC2. (biomedcentral.com)
Akt inhibits the Rheb GTPase activity of TSC1/TSC2 dimer by phosphorylating TSC2. (biomedcentral.com)

Genetic studies in the nematode contributed substantially to our understanding of the function and regulation of the Ras pathway (i.e. (biomedcentral.com)
Our previous studies have demonstrated that down regulation of heat shock protein 70 (HSP70) contributed to the increased sensitivity of Burkitt lymphoma (BL) cells to chemotherapy through blocking this pathway [ 4 ]. (biomedcentral.com)

2. The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. (nih.gov)

As it still remains unclear how these phosphorylations can influence the Ras pathway we have analyzed the ability of p60c-Src and Lck to phosphorylate these two Ras regulators and have compared the activity of the phosphorylated and unphosphorylated forms. (embl.de)
Components of the RTK/Ras/ERK pathway seem to be highly conserved between mammals and worms. (biomedcentral.com)
The PI3K/Akt/mTOR pathway is constitutively activated in human cancers and is critical for tumor progression and chemo-resistance [ 10 ]. (biomedcentral.com)

The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. (cancerindex.org)

Allergic reactions commonly result from previous sensitization to the birch pollen allergen Bet v 1, followed by immunological cross-reactivity of IgE antibodies to structurally related proteins in peach. (bvsalud.org)
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). (thermofisher.com)

Cooperative antiproliferative effect of coordinated ectopic expression of DLC1 tumor suppressor protein and silencing of MYC oncogene expression on liver cancer cells: therapeutic implications. (nih.gov)

Proteins involved in cyclic nucleotide signaling need to be capable of sensing subtle changes in cNMP concentrations. (uni-kassel.de)
Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels ACS Chem Biol. (uni-kassel.de)

Birch-pollen-related food allergies are triggered by the immunologic cross-reactivity of IgE antibodies with structurally homologous PR-10 proteins that are present in birch pollen and various food sources. (bvsalud.org)
The structures of these homologous proteins are highly conserved, indicating their crucial role in biological processes in life [ 13 ]. (biomedcentral.com)

The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. (nih.gov)
Additionally, constitutively expressed ERF-VII proteins, such as RAP2.12, are bound to the acyl-CoA-binding proteins (ACBPs) at the plasma membrane and protected from aerobic degradation. (springer.com)
By immunocytochemistry, it was shown that podocalyxin and the actin binding protein ezrin are co-expressed in podocytes and co-localize along the apical plasma membrane, where they form a co-immunoprecipitable complex. (embl-heidelberg.de)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)

In collaboration with the company Biolog, we have identified numerous agonists and antagonists with high specificity and isoform selectivity to address PKA, PKG, EPAC and HCN channels. (uni-kassel.de)
Here, we describe the GTPase specificity of RGS12 and identify four alternatively spliced forms of human RGS12 mRNA. (elsevierpure.com)

To cause rice blast disease, the filamentous fungus Magnaporthe oryzae secretes a battery of effector proteins into host plant tissue to facilitate infection. (exeter.ac.uk)

This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). (wikipedia.org)

Then the activated Rheb promotes mTOR complex 1 (mTORC1) to phosphorylate p70S6 and 4E binding protein1 (4EBP1), resulting in dysregulation of protein synthesis and cell survival [ 8 ]. (biomedcentral.com)
Activated PI3K could phosphorylate PI (4,5) P2 (PIP2) to produce PI(3,4,5)P3 (PIP3). (biomedcentral.com)

RAS proteins are the founding members of the RAS superfamily of GTPases. (oncotarget.com)
The RAS protein family is a set of small GTPases that function as binary switches by alternating their activation state from GTP-bound (active) to GDP-bound (inactive). (oncotarget.com)

Despite its obvious importance for carcinogenesis, the role of Gln-61 in the GAP-stimulated GTPase activity of Ras has remained a mystery. (embl.de)
These results underscore the potential relevance of cross-talking in the RAS signaling network, which should be taken into account when considering the inhibitory activity of drugs targeting specific RAS oncoproteins. (oncotarget.com)
Activity of this protein is also involved in the generation of reactive oxygen species. (nih.gov)
Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
20 Through its N-terminal hydrophobic domain, NPM also exerts a chaperone activity, preventing protein aggregation in the nucleolus, favoring histone and nucleosome assembly, 21 - 23 and increasing acetylation-dependent transcriptional activity. (haematologica.org)

LRRN1 knockdown also resulted in upregulation of JUN, a subunit of the transcription factor AP-1 (activator protein-1). (cancerindex.org)

North et al highlighted the presence of human glucose transporter 1 (GLUT-1) isoform as a useful differentiating factor between infantile hemangiomas and other vascular anomalies. (medscape.com)
Mutants of Ras are found in 25-30% of human tumors. (embl.de)
With the exception of the relatively well-known KRAS, HRAS and NRAS proteins, little is known about how the interactions of the other RAS human paralogs affect cancer evolution and response to treatment. (oncotarget.com)
Our results show that many RAS proteins with divergent sequences are found close together in the human interactome. (oncotarget.com)
This study broadens our understanding of the human RAS signaling network and stresses the importance of considering its potential cross-talk in future therapies. (oncotarget.com)
However, with the exception of a few well-studied protein models, the precise functions of the thirty-five human RAS paralogs and their relation in terms of sequence conservation, gene expression and protein-protein interactions remain poorly understood [ 2 ]. (oncotarget.com)
Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. (biomedcentral.com)
In protein to build long, HSF1 is to promote various industry on human Ser hundreds social as Ser230, Ser326. (evakoch.com)

As allergies, especially those triggered by food, are becoming more and more prevalent, it is of increasing importance to fully understand the structures and dynamic behaviors of allergenic proteins along with their interactions with potential natural ligands. (bvsalud.org)

In this study we performed a comprehensive analysis of the relationship between the phylogeny of RAS proteins and their location in the protein interaction network. (oncotarget.com)
In this study, we report a direct and specific interaction of PAK1 with a 22-kD Ca 2+ -binding protein, CIB1, which results in PAK1 activation both in vitro and in vivo. (rupress.org)

Following expression of the desired allergen in Escherichia coli in isotope-labeled minimal media, the three-dimensional solution structures of these proteins can be determined, and insight into ligand binding mechanics and structural dynamic properties are accessible through NMR spin relaxation experiments. (bvsalud.org)

All known oncogenic mutants of Ras map to a small subset of amino acids. (embl.de)
NPM is over-expressed in solid tumors of diverse histological origin 6 or is involved in tumor progression 7 - 9 In several hematologic malignancies, the NPM1 locus is lost 10 or translocated leading to the formation of oncogenic fusion proteins. (haematologica.org)

Subsequent studies revealed that GRK is a family composed of seven isoforms (GRK1-GRK7). (biomedcentral.com)

The NEXT3 synthesis of NOTCH3 is further well-insulated at the S3 matrix by the provirus protein membrane, leading the different integrin migration into the Werge( Groot et al. (evakoch.com)

In this study, we analyze the millisecond-timescale structural flexibility of thirteen PR-10 proteins from prevalent plant food sources by NMR relaxation-dispersion spectroscopy, in a comparative manner. (bvsalud.org)
14 B23.1, the prevalent isoform in all tissues, 15 contains 294 amino acids, 16 whereas B23.2, a truncated protein, lacks the last 35 C-terminal amino acids of B23.1 and is expressed at very low levels. (haematologica.org)

While the three-dimensional structures of PR-10 food allergens have been characterized in detail, only a few experimental studies have addressed the structural flexibility of these proteins. (bvsalud.org)
This analysis was integrated with the structural analysis of conserved positions in available 3D structures of RAS complexes. (oncotarget.com)
As the download Windows 7 Annoyances of times is to public end, defects can bind involved an phosphorylated citron of the IL1R and IL18R leading structures, capping dermatan medicine influencing to endothelial end proteins known by reverse isoforms( TLRs). (evakoch.com)

Two RGS12 isoforms of 6.3 and 5.7 kilobases (kb), encoding both an N-terminal PDZ (PSD-95/DIg/ZO-1) domain and the RGS domain, are expressed in most tissues, with highest levels observed in testis, ovary, spleen, cerebellum, and caudate nucleus. (elsevierpure.com)
The 18-kilodalton translocator protein (TSPO), proposed to be a key player in cholesterol transport into mitochondria, is highly expressed in steroidogenic tissues, metastatic cancer, and inflammatory and neurological diseases such as Alzheimer's and Parkinson's. (researchgate.net)
Traditional vaccine adjuvants activate innate immune cells, promote cell-mediated transport of antigen to lymphoid tissues, and promote antigen retention in LNs. (jci.org)

They interact normally with DNA binding proteins under heterodimer formation and are considered as negative regulators of transcription. (ijpsr.com)

Mitochondrial quality control systems actively function, both in physiological and pathological conditions, to protect the mitochondria from stress and damage at the protein and organelle level. (inforang.com)
Damage beyond the protein level activates a bigger response that includes mitochondrial biogenesis, fusion, fission and mitochondrial degradation, also known as mitophagy. (inforang.com)
DNA damage is repaired by mitochondrial DNA polymerase gamma (encoded by POLG ) that has base excision repair and exonuclease function. (inforang.com)

Anatomy32

Organisms14

Diseases1

Chemicals and Drugs118

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes64

Disciplines and Occupations1

Information Science4

Kinase21

Phosphorylation11

Kinases4

Genes8

Homolog3

Superfamily of small2

Alternatively spliced transcript variants3

Mammalian3

Pathways8

Variants2

Differentiation2

Binds4

P1202

Mutations3

Transcript2

Neurofibromin1

Cell proliferation1

Mutant2

Nitric oxide sy3

Receptor11

Molecular3

Cellular4

Suppresses2

Negatively regulate1

Cytoskeletal1

Intracellular3

Inhibits2

Regulation2

Cytoplasmic1

Pathway3

Phospholipase1

Structurally related2

Oncogene1

Nucleotide2

Homologous2

Plasma membrane4

Specificity2

Effector1

GAPs1

Phosphorylate2

GTPases2

Activity5

Activator1

Human8

Ligands1

Interaction2

Expression1

Oncogenic2

Family1

Membrane1

Prevalent2

Structures3

Tissues3

Regulators1

Mitochondrial3