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  • 1999
  • 1999) The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. (els.net)
  • adhesive
  • Together, these findings indicate that seizures activate integrin signaling and induce a turnover in adhesive contacts and that both processes contribute to lasting changes in circuit and synaptic function underlying epileptogenesis. (springer.com)
  • Sonnenberg
  • Professor Sonnenberg, head of the Division of Cell Biology at the Netherlands Cancer Institute in Amsterdam, is an expert in the field of Integrin research. (abcam.com)
  • Margadant C , Charafeddine RA and Sonnenberg A (2010) Unique and redundant functions of integrins in the epidermis. (els.net)
  • structural
  • Structural features of integrins. (els.net)
  • Schematic illustrations of the structural features of (a) non‐I‐domain and (b) I‐domain integrins. (els.net)
  • Fu G , Wang W and Luo BH (2012) Overview: structural biology of integrins. (els.net)
  • This paper provides readers with an overview of the molecular and structural bases of integrin activation as well as rationale for using anti-alpha4 integrin therapy for multiple sclerosis and then chronicles the rise and fall of this treatment strategy using natalizumab, a humanized anti-alpha4 integrin. (hindawi.com)
  • regulation
  • Integrin regulation. (nih.gov)
  • Here, we demonstrate key roles for αv integrins in regulation of mucosal immunity. (pnas.org)
  • Here, we report that αv integrins are central to the normal regulation of immune responses in the intestine and that deletion of αv in the immune system leads to spontaneous colitis, wasting, and autoimmunity. (pnas.org)
  • alpha4
  • Anti-alpha4 integrin therapy aiming to block infiltration of autoreactive lymphocytes to the inflamed brain has been validated in several clinical trials for the treatment of multiple sclerosis. (hindawi.com)
  • Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale. (semanticscholar.org)
  • Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. (semanticscholar.org)
  • Inhibition of alpha4 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in ApoE-deficient mice. (semanticscholar.org)
  • roles
  • Studies in mice have attributed roles to certain integrins already at very early stages of development while others play specific roles later in the adult. (hindawi.com)
  • Knockouts of most other αv-associated β integrins (β3, β5, and β6) are viable and reveal roles for αv in repair of tissue injury, inflammation, and immune responses ( 1 , 6 - 8 ). (pnas.org)
  • motif
  • These include coxsackievirus A9 (CV-A9), echovirus 9, and human parechovirus 1 that are among the most common and epidemic human picornaviruses and bind to α V-integrins via RGD motif that resides on virus capsid. (hindawi.com)
  • peptide
  • Moreover, intraperitoneal injection of the α V integrin blocking peptide cRGDfV (Calbiochem, United Kingdom) increased the growth response and also greatly reduced the calculated remodeling index. (ahajournals.org)
  • Thus, to the extent that the α V integrin blocking peptide is having a specific effect, and future experiments need to determine this, the results point to an important role for this integrin in the remodeling process. (ahajournals.org)
  • immunity
  • Thus, integrins provide cells with the capacity to sense and respond to their microenvironment and they control vital cellular functions for embryonic development, tissue homoeostasis, blood clotting and immunity. (els.net)
  • tissues
  • αv integrins are expressed in many tissues throughout development, and αv knockout mice die at midgestation from placental deficiencies or, immediately after birth, with cerebral and intestinal hemorrhage and cleft palate ( 2 ). (pnas.org)
  • Thus
  • Thus, it appears that the efficiency of coupling of β integrins to RhoA and the degree of cofilin activation appear to generate different types of cell movement. (sciencemag.org)
  • Thus, Mad1 is required for trafficking of α5 integrin during interphase. (sciencemag.org)
  • deletion
  • conditional deletion of Dnm2 in mouse embryos causes severe angiogenic phenotypes that are consistent with impaired integrin function. (biologists.org)