Different formulations vaccines attenuated. Medical search. Frequent questions

A live attenuated influenza vaccine (LAIV) manufactured by MedImmune LLC is approved for persons aged 2--49 years ( 1 ). (cdc.gov)
Live, attenuated influenza vaccine (LAIV) is a nasal spray that can be given to non-pregnant people 2 through 49 years of age. (cdc.gov)
Also known as live, attenuated influenza vaccine (LAIV), this nasal spray contains live viruses. (cdc.gov)
FDA approved this live attenuated influenza virus (LAIV) nasal spray vaccine for persons 2 through 49 years of age. (cdc.gov)
This is the only LAIV nasal spray vaccine available for use during the 2021-2022 season. (cdc.gov)
Live attenuated influenza vaccine (LAIV) has been authorized for use in Canada since 2011, and was previously considered contraindicated by NACI in individuals with HIV. (canada.ca)
MedImmune, Inc. has announced clinical data showing that a live, attenuated intranasal influenza vaccine (LAIV) may help induce broader immunity in children against drifted influenza strains when compared to the traditional flu shot (TIV). (news-medical.net)
My research in the García-Sastre lab involves the formulation of a second-generation trivalent live attenuated influenza vaccine (LAIV) along with the development of methodologies for the development of influenza vaccines. (mssm.edu)
By combining both platforms together, we intend to device a LAIV vaccine and the pre-clinical trail experiments will be conducted in a mouse model and ferrets using representative challenge viruses along with highly pathogenic BSL-3 category level pathogens. (mssm.edu)

In addition, microscopic examination post-challenge showed animals immunized with the AS03-adjuvanted vaccines had the least signs of lung injury and inflammation, consistent with the greater relative efficacy of the adjuvanted vaccines. (nature.com)
Nevertheless, the high level of antigenic drift (genetic mutations) of some viruses, such as the influenza virus, reduces the efficacy of vaccines and needs to be addressed (1). (cmaj.ca)
Therefore, efficacy of vaccines need to be monitored including safety measures before one embarks on vaccinations (2). (cmaj.ca)
Because vaccine efficacy against DENV-2 has been historically poor, the genome representing this serotype is actually a DENV-2/DENV-4 chimera and consists of a DENV-4 backbone harboring the DENV-2 pre-membrane and envelope genes. (virology.ws)
Manufacturer(s) have sought approval of the vaccine(s) and provided evidence as to its safety and efficacy only when it is used in accordance with the product monographs. (canada.ca)
In the pivotal clinical trial, this vaccine was found to have an efficacy of 64% (95% CI, 56-71) in persons aged 60 to 69 against incident zoster but only 38% (95% CI, 25-48) in those aged 70 and older (median follow-up time: 3.1 years), and 66.5% against post-herpetic neuralgia unaffected by age. (bcmj.org)
The vaccine has performed well in clinical trials with 3-year vaccine efficacy against zoster at 97% in people aged 50 to 69 and 91% (a difference that is not statistically significantly lower) for those 70 and older. (bcmj.org)
3 A recent systematic review of the scientific literature reported a pooled efficacy of 83% (95% confidence interval: 69%-91%) for trivalent live attenuated influenza vaccine in children six months to seven years of age. (who.int)
4 The same review reported that trivalent inactivated influenza vaccines had an efficacy of 59% (95% confidence interval: 51%-67%) in healthy adults 18-65 years of age and provided significant protection against medically attended influenza. (who.int)
The method may incorporate novel administration devices, locations, volumes, formulations or other innovative approaches, and should be equivalent to the current gold standard, direct intravenous inoculation, as measured by sporozoite infectivity, vaccine immunogenicity or vaccine efficacy on subsequent malaria challenge. (sbir.gov)
Defining surrogate serologic tests with respect to predicting protective vaccine efficacy: Poliovirus vaccination. (who.int)
Recommendations to assure the quality, safety and efficacy of live attenuated poliomyelitis vaccine (oral). (who.int)
Like injected Covid vaccines, though, there are different types, and their efficacy might vary greatly. (plos.org)
The route can affect efficacy, too, and so could the person's current level of immunity - which previous vaccines they have had, for example. (plos.org)
This is also a method of increasing the efficacy of cancer vaccines. (oncolink.org)
Our research is directed to develop new approaches for viral vector design, novel vaccine formulations with improved efficacy and optimized preventive and therapeutic MVA-based immunization strategies (e.g. vaccination protocols for T cell-pillowed immunotherapy). (uniklinik-duesseldorf.de)
We have established or collaborate on preclinical animal models to test MVA vaccine efficacy for viral (e.g. (uniklinik-duesseldorf.de)
It remains unclear whether these mutations will seriously reduce vaccine efficacy. (cdc.gov)

The live attenuated vaccine BPZE1 was developed to mimic immunogenicity of natural infection without causing disease, and in preclinical models protected against pertussis disease and B. pertussis colonization after a single nasal administration. (mdpi.com)
The vaccine approved by the FDA is Dengvaxia, a live-attenuated formulation manufactured by Sanofi Pasteur that is administered in three doses, at six month intervals. (virology.ws)
Dengvaxia is based on an existing live-attenuated vaccine for yellow fever virus (YFV) and consists of four YFV genomes that have been chimerized by replacing the YFV pre-membrane and envelope structural genes with those of the four respective DENV serotypes. (virology.ws)
TV003, a live-attenuated tetravalent formulation developed by the National Institutes of Health, is currently being evaluated in phase 2 and phase 3 clinical trials. (virology.ws)
Using Jurata's thin film platform to stabilize CastleVax's live-attenuated, next-generation NDV-vectored COVID-19 booster vaccine is expected to result in a shelf-stable, needle-free vaccine capable of inducing mucosal immunity and protecting against breakthrough infection and transmission of the virus. (wtnh.com)
Launched from Mount Sinai, CastleVax is a clinical-stage biotechnology company whose two lead candidates, an inactivated NDV and a live-attenuated NDV, both against SARS-CoV-2, have already generated clinical results both domestically and abroad. (wtnh.com)
The awarded project aims to optimize Jurata's formulation to stabilize CastleVax's live-attenuated, next-generation COVID-19 booster vaccine and show in preclinical studies that the resulting thermostable vaccine elicits equivalent protection against SARS-CoV-2, compared to CastleVax's original vaccine formulation. (wtnh.com)
For younger people, including children afraid of needles, the nasal spray vaccine, which has live - but attenuated, or weakened - viruses, may be a good option, said Dr Gregory Poland, director of the Mayo Vaccine Research Group. (rtmagazine.com)
Both contain live but weakened (attenuated) rotavirus. (msdmanuals.com)
At present only Ontario offers publicly funded zoster vaccine, having introduced the live vaccine in 2016 for those aged 65 to 70. (bcmj.org)
The live attenuated zoster vaccine (Zostavax II, Merck Canada Inc.) approved in 2008 in a formulation requiring freezer storage, has been marketed as a fridge-stable formulation in Canada since April 2014 and continues to be available on the private market. (bcmj.org)
A non-live adjuvanted subunit vaccine (Shingrix, GlaxoSmithKline Inc., varicella zoster virus glycoprotein E recombinant [RZV]) was approved by Health Canada in October 2017 for adults aged 50 and older. (bcmj.org)
This vaccine is expected to have value for immunocompromised people who cannot receive the live vaccine, and while specific indications for this subpopulation are not yet listed in the product monograph with studies being conducted in people infected with HIV, solid tumors, organ transplant, and HSCT recipients, it is not contraindicated for the immunocompromised. (bcmj.org)
Live attenuated influenza vaccine (LAIV4) is not recommended for use during the 2017-18 season due to concerns about its effectiveness against (H1N1)pdm09 viruses during the 2013-14 and 2015-16 seasons. (medscape.com)
Inactivated influenza vaccines (IIVs), recombinant influenza vaccine (RIV4), and live attenuated influenza vaccine (LAIV4) are expected to be available. (cdc.gov)
Poliovirus vaccine- live. (who.int)
Inactivated and trivalent oral poliovirus vaccines contain either formalin- inactivated or live, attenuated poliovirus, respectively, of the three serotypes. (who.int)
History of Sabin attenuated poliovirus oral live vaccine strains. (who.int)
This vaccine is a live attenuated B. pertussis strain delivered nasally in order to mimic the natural route of infection. (frontiersin.org)
Varicella vaccine contains live virus and is less stable than most other vaccines. (biopharma.com)
During clinical testing by Merck using vaccine lots manufactured in 1982, 1984, 1987, and 1991, the manufacturing process was improved to increase the yield, viability and stability of the live attenuated virus in the final product. (biopharma.com)
Vaccine preparations used in clinical trials varied in terms of live virus titer (PFU) and the ratio of live:dead virus. (biopharma.com)
By understanding how these viruses resist antiviral environments, more effective rationally designed therapeutics and live-attenuated vaccines can be produced. (scitechnol.com)
The sixth mucosal vaccine in phase 3 is a live attenuated nasal spray from Codagenix (US), being manufactured by the Serum Institute of India. (plos.org)
The fungal vaccine identified by Dr. Del Poeta is a live attenuated strain that that induces protection against cryptococcal infection in immunocompetent and immunocompromised patients. (stonybrook.edu)
They will also test multiple formulations using only certain parts of the live attenuated strain, an important step to assess safety of the vaccine. (stonybrook.edu)
The technology used at AAHI does not require the "complex manufacturing techniques" or deep cold-chain storage that are associated with traditional live-attenuated vaccines. (vaccinenation.org)
The candidate will be a lyophilised, live-attenuated RNA vaccine candidate, delivering the full-length RNA genome of a weakened version of the virus complexed to the NLC. (vaccinenation.org)
This could have the benefit of increased availability and access and is, to the team's knowledge, the first attempt to advance an RNA-launched live-attenuated vaccine candidate to the clinic. (vaccinenation.org)
The 5-year project expands on previous research that demonstrated that a liquid presentation of the live-attenuated chikungunya RNA vaccine elicited strong immune responses in animals after a single dose. (vaccinenation.org)
Historically, vaccines against viral diseases have used live-attenuated (weakened) viruses or inactivated whole viruses to induce protective immune responses. (globalhealthnewswire.com)
Because this research does not require replicating "live" viruses, it does not need to be done in high-level containment facilities when developing vaccines for highly pathogenic viruses. (globalhealthnewswire.com)
Natural and synthetic biomaterials are increasingly being used for the development of vaccines and immunotherapies as alternatives to traditional live-attenuated formulations due to their improved safety profiles and no risk of reversion to virulence. (utmb.edu)
BCG vaccine contains live attenuated Bacillus Calmette-Guérin (BCG) strain of Mycobacterium bovis . (immune.org.nz)
Other live injected vaccine e.g. (immune.org.nz)
When not injected on the same day as BCG vaccine, other live vaccines must be delayed until four weeks after the BCG. (immune.org.nz)
BCG vaccine can be administered at any time before or after rotavirus vaccine because the BCG vaccine is an injectable live vaccine and rotavirus is an oral live vaccine. (immune.org.nz)
Vaccination is a key element to PRRS control and while both inactivated and live attenuated PRRS vaccines are widely used neither provides sufficiently effective protection against the diversity of circulating PRRSV strains. (pirbright.ac.uk)
Evaluating whether a synthetic live attenuated PRRSV expressing 'consensus sequence' glycoproteins provides enhanced cross-protection. (pirbright.ac.uk)
We are also exploring the potential for live attenuated PRRSV and pseudorabies virus to act as vaccine vectors for Nipah and thus provide a bivalent vaccine. (pirbright.ac.uk)

CDC's Advisory Committee on Immunization Practices has made recommendations previously for which persons should be the initial targets for immunization with influenza A (H1N1) 2009 monovalent vaccines and has issued guidelines on decisions for expansion of vaccination efforts to other population groups ( 6 ). (cdc.gov)
An immunogenicity study of an inactivated influenza A (H1N1) monovalent vaccine manufactured by CSL Limited (Parkville, Victoria, Australia) demonstrated that by day 21 after vaccination, antibody titers of 1:40 or more (hemagglutination-inhibition assay) were observed in 116 (97%) of 120 adults who received the 15 μ g dose. (cdc.gov)
This is because naïve vaccine recipients who have not had a prior natural infection with DENV can experience enhanced dengue disease if they are naturally infected after vaccination. (virology.ws)
CDC recommends annual influenza vaccination for everyone 6 months and older with any flu vaccine licensed by the Food and Drug Administration (FDA) that is appropriate for the recipient's age and health status. (cdc.gov)
Vaccine manufacturers are focusing on partnering with organizations such WHO, UNICEF, and GAVI Alliance to improve their vaccination programs, in order to reach the maximum population to offer vaccines. (openpr.com)
Furthermore, development of combinational vaccines could aid in reducing cost and adverse effects by reducing the number of vaccination programme. (openpr.com)
Giving influenza vaccine to people with heart disease, for example, is as important as giving them a statin," Schaffner says, yet many people living with chronic illness - and even many of their health care providers - don't realize how vital flu vaccination is to managing their condition. (kuer.org)
The rotavirus vaccine is part of the routine vaccination schedule recommended for children (see CDC: Child and Adolescent Immunization Schedule by Age ). (msdmanuals.com)
developed OLL/OLP within 6 days after COVID-19 vaccination (88 and 58 subjects experienced received mRNA- and adenovirus vector-based vaccines), whereas in cohort II, 59 individuals were newly diagnosed with OLL/OLP within 6 days after having went to the clinic for any additional reason. (fabretp.org)
Thus far, it remains unfamiliar if specific components of the formulations Yoda 1 cause a type IV hypersensitive reaction related to OLL, or if the immune response post vaccination causes a T cell-driven autoimmune reaction directed against the basal coating of keratinocytes of the oral mucosa in terms of OLP. (fabretp.org)
Zoster and its attendant complications are preventable by vaccination, and two vaccines are approved for use in Canada. (bcmj.org)
In light of the new WHO position paper on influenza vaccines published in 2012 and the increasing availability of country-specific data, countries and areas should consider reviewing or developing their seasonal influenza vaccination policies to reduce morbidity and mortality associated with annual epidemics and as part of ongoing efforts for pandemic preparedness. (who.int)
2 The most effective way to prevent seasonal influenza and its severe outcomes is through vaccination, and safe and effective vaccines have been used for more than 60 years. (who.int)
8,9 Despite the Western Pacific Region contributing more than 76% of the total virus isolates submitted to the WHO Global Influenza Surveillance Response and System (GISRS) between 1998 and 2010 for vaccine strain selection, 10 influenza vaccination programmes have not been established consistently throughout the Region. (who.int)
These programmes facilitate governments' health policies for influenza vaccination and provide the mechanisms for ensuring the target groups for vaccination actually receive vaccines. (who.int)
On vaccination and immunisation semuele price in South Africa deemed the vaccine not cost effective medication. (hybridnutrition.co.za)
The administration of vaccines is called vaccination . (webot.org)
[15] The terms vaccine and vaccination are derived from Variolae vaccinae (smallpox of the cow), the term devised by Edward Jenner (who both developed the concept of vaccines and created the first vaccine) to denote cowpox . (webot.org)
[25] Sometimes, protection fails for vaccine-related reasons such as failures in vaccine attenuation, vaccination regimens or administration. (webot.org)
Re-vaccination with BCG vaccine is not recommended in New Zealand. (immune.org.nz)
These revised recommendations of the Advisory Committee on Immunization Practices (ACIP) replace recommendations on poliomyelitis issued in 1982 and 1987, and present a new ACIP poliovirus vaccination policy that increases reliance on inactivated poliovirus vaccine (IPV). (cdc.gov)

Human infections with avian H7N9 subtype influenza viruses are a major public health concern and vaccines against H7N9 are urgently needed for pandemic preparedness. (nature.com)
In addition, heterologous antibody titers against older H7 subtype viruses of the North American lineage (H7N7, H7N3) and newer H7 subtype viruses of the Eurasian lineage (H7N9) were detected in the animals receiving the AS03-adjuvanted vaccines. (nature.com)
Currently, there is no licensed H7N9 vaccine available and people infected with H7N9 viruses are only treated therapeutically with neuraminidase inhibitors. (nature.com)
Her projects focus on studies of influenza antiviral treatment and antiviral effectiveness, vaccine effectiveness, pandemic preparedness, and development of CDC clinical guidance related to treatment and prevention of seasonal and novel influenza viruses. (cdc.gov)
Several promising vaccines are currently evaluated in the clinics for different respiratory viruses. (cmaj.ca)
These new vaccine formulations aim to be safer and more efficient compared to traditional vaccines based on attenuated viruses, killed pathogens and subunits. (cmaj.ca)
Influenza viruses evolve constantly, and twice a year WHO makes recommendations to update the vaccine compositions. (who.int)
For the 2016-2017 northern hemisphere influenza season, the vaccine formulation was updated in February 2016 to contain two types, A viruses (H1N1 and H3N2), and a type B virus. (who.int)
Vaccine viruses included in the 2017-18 U.S. trivalent influenza vaccines are an A/Michigan/45/2015 (H1N1)pdm09-like virus, an A/Hong Kong/4801/2014 (H3N2)-like virus, and a B/Brisbane/60/2008-like virus (Victoria lineage). (medscape.com)
Quadrivalent influenza vaccines contain these 3 viruses and an additional influenza B vaccine virus, a B/Phuket/3073/2013-like virus (Yamagata lineage). (medscape.com)
The Region currently has three WHO Collaborating Centres for Reference and Research on Influenza and 21 National Influenza Centres in 15 countries that monitor the impact and evolution of influenza viruses and provide isolates for global vaccine strain selection and formulation. (who.int)
Following the rapid and unpredicted spread of COVID-19 in the first seven months of 2020, the need to develop vaccines for pandemic viruses rapidly has been clearly established. (bvsalud.org)
While vaccine strategies have proven to be transformative against certain bacteria and viruses, there is yet to be an effective fungal vaccine. (stonybrook.edu)
Given the rapid genetic shift of zoonic influenza viruses, we still face difficulties maintaining the effectiveness of seasonal influenza virus vaccines especially in the context of controlling viruses with pandemic potential. (mssm.edu)
This warrants the need for a "Universal influenza vaccine" which would protect vaccine recipients from influenza viruses. (mssm.edu)
This project involves the use of attenuated influenza viruses which lack the interferon antagonist non-structural protein 1 (NS1) while retaining the nuclear export protein (NEP). (mssm.edu)
In addition, we are applying our expertise in porcine immunology and vaccinology to contribute to the development of vaccines to combat new and emerging zoonotic viruses, such as the Nipah virus and SARS-CoV-2. (pirbright.ac.uk)
Traditional vaccines against viruses contain portions of the virus that have been altered in some way so they cannot cause infection. (cdc.gov)

Preliminary data indicate that the immunogenicity and safety of these vaccines are similar to those of seasonal influenza vaccines. (cdc.gov)
Immunogenicity and safety study results similar to those observed for seasonal vaccines also have been reported by the other manufacturers (MedImmune LLC, Gaithersburg, MD and Novartis Vaccines and Diagnostics, Limited, Liverpool, UK, unpublished data, 2009). (cdc.gov)
A healthy volunteer receives the NIAID Zika virus investigational DNA vaccine as part of an early-stage trial to test the vaccine's safety and immunogenicity. (globalhealthnewswire.com)
The development process often takes 15 to 20 years or more and requires virus cultivation, animal model testing, product formulation, immunogenicity testing and years of costly clinical trials. (globalhealthnewswire.com)
VIENNA, 24-Sep-2020 - /EPR HEALTHCARE NEWS/ - Eveliqure Biotechnologies GmbH , an Austrian biotechnology company, today announces the initiation of clinical testing for its ShigETEC vaccine candidate, with the dosing of the first subject in a Phase 1 safety and immunogenicity study in Europe. (eprhealthcarenews.com)
And to support the development of COVID-19 vaccine candidates by utilising the pig as a preclinical model to study vaccine immunogenicity. (pirbright.ac.uk)
We are supporting the UK response to the COVID-19 pandemic by evaluating a range of vaccine candidates for immunogenicity in pigs to inform further clinical development. (pirbright.ac.uk)

However, because the DENV epitopes that the CD8+ T lymphocytes would recognize are absent in this vaccine, Dengvaxia does not confer any CD8-mediated immunity against DENV. (virology.ws)
Through the BLUE KNIGHT™ Resident QuickFire Challenge: Accelerating Project NextGen , Jurata and CastleVax have received funding to assist with the development of a next-generation booster vaccine against COVID-19 that does not require cold storage, can induce mucosal immunity, and can be administered without needles. (wtnh.com)
These funds will be used to further the development of a thermostabilized next-generation vaccine against SARS-CoV-2 that can be transported and stored without temperature control (refrigeration or freezing), then delivered without needles to induce mucosal immunity. (wtnh.com)
New combination vaccines should induce similar or superior levels of neutralizing antibody in serum for individual protection against paralytic disease and mucosal immunity that effectively decreases viral replication in the intestine and pharynx for population protection against transmission of poliovirus. (who.int)
As these resident memory T cells are long lived, vaccines that are able to induce them should provide long-lasting immunity. (frontiersin.org)
As of today, only one vaccine designed to induce potent mucosal immunity is in clinical development. (frontiersin.org)
Several reasons may account for this resurgence, including faster waning of immunity through acellular compared to whole-cell vaccines and potential strain adaptation to escape vaccine-induced immunity ( 9 ). (frontiersin.org)
The race for a vaccine that might be able to provide at least some "sterilizing" immunity just got a boost in the US: A new $5 billion program from the White House called "Project Next Gen" is partly dedicated to speeding up mucosal vaccines. (plos.org)
A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. (webot.org)
In this Review, we first introduce the concepts of CD8 + T cell activation, effector and memory functions, and cytotoxic activity, followed by vaccine design for eliciting robust and protective long-lived CD8 + T cell immunity. (utmb.edu)
We have a longstanding interest in understanding immunological mechanisms underlying protective immunity and the application of this knowledge to the development of new or improved vaccines. (pirbright.ac.uk)
However, knowledge about the biological properties of target antigens or modalities of antigen delivery to efficiently induce or expand MVA-vaccine-mediated immunity in vivo is still sparse. (uniklinik-duesseldorf.de)

Combinational MMR vaccines comprises mixture of two or more viral strains. (openpr.com)
Depends on the match of the strains in the vaccine with circulating strains, the age of the individual and whether they have any underlying medical conditions. (health.govt.nz)
The ful data concerning the history of attenuated poliovirus strains developed by one of us (Sabin, 1965) for vaccine production do not appear in a single journal. (who.int)
Over the past few years we have had frequent requests for the details such as isolation and attenuation and accordingly we felt that bringing the data together in the report below would be both helpful and informative to those involved in the production and control of poliovirus vaccine (oral) prepared from these strains. (who.int)
Typically, 3 virus strains (2 influenza A and 1 influenza B), which antigenically represent the influenza strains likely to circulate the next flu season, are included in the formulation each year. (medscape.com)
Quadrivalent vaccines that included 2 influenza A strains and 2 influenza B strains are available. (medscape.com)
The US Food and Drug Administration (FDA) makes the final decision about vaccine strains for influenza vaccines to be sold in the United States, based on year-round surveillance conducted by the US Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO). (medscape.com)
Identifying the key determinants of PRRSV proteins that mediate immune evasion or contribute to disease to provide rational targets for the production of attenuated vaccine strains. (pirbright.ac.uk)

Several important issues were addressed and a major part of the discussion focused on the need to develop new vaccines, especially to protect against pathogens that constitute a pandemic threat. (bvsalud.org)
Using killed or attenuated pathogens, many other vaccines have been developed. (oncolink.org)
The perspective notes that once a vaccine platform is established, such as that for DNA or mRNA vaccines, potentially it can be applied to multiple pathogens, especially within virus classes or families. (globalhealthnewswire.com)
Viral vector-based vaccines offer the potential to provide protection against virulent pathogens entering via the mucosal route. (pirbright.ac.uk)

Vaccines of these diseases are sold as attenuated viral vaccines, manufactured in a lyophilised formulation, which requires reconstitution with water for injection diluent and are available in two forms i.e. monovalent as well as combinational vaccines. (openpr.com)
All adults and adolescents should get the COVID-19 vaccine regardless of their CD4 count or HIV viral load. (hiv.gov)
The ability of cell culture systems to produce large quantities of attenuated viral particles has served as the basis for the production of both human and veterinary vaccines. (sigmaaldrich.com)
1 more vaccine has been authorized in China - Pneucolin, a viral vector nasal spray from Beijing Wantai BioPharm. (plos.org)
an inhaled viral vector vaccine from Wuhan BravoVax (China). (plos.org)
Most of the vaccines in clinical trials are viral vector vaccines. (plos.org)
1 more vaccine has progressed to phase 2 trial - an intranasal viral vector vaccine from CyanVac (US). (plos.org)
For the AstraZeneca viral vector vaccine in intranasal form. (plos.org)
Novel vaccine technologies: essential components of an adequate response to emerging viral diseases. (globalhealthnewswire.com)
We are evaluating a range of recombinant vaccine candidates, based on protein subunits as well as viral and mRNA vectors. (pirbright.ac.uk)
Our group focuses on the immunobiology of poxviruses and their development and characterization as viral vectors and recombinant vaccines. (uniklinik-duesseldorf.de)
Therefore, one focus of our work is the identification of key mechanisms essential for the efficient generation (priming) and expansion (recall) of anti-viral or vaccine-induced T cell responses. (uniklinik-duesseldorf.de)
First proposed in 1989, mRNA vaccines have been studied for years, with several ongoing clinical trials using mRNA vaccines for cancer and viral diseases, including rabies, influenza, and Zika . (cdc.gov)

These antibodies will then be used to identify highly conserved vaccine targets that may be engineered to induce cross-protection. (pirbright.ac.uk)

For instance, Daiichi Sankyo's VN-0102/JVC-001 is measles, mumps, and rubella vaccine in phase I clinical trials as of May 2016. (openpr.com)
Available at http://www.who.int/biologicals/vaccines/BS2185_OPV_Post_ECBS_DB_TZ_DBFinal12Feb2013.pdf, accessed February 2016. (who.int)

Influenza A (H1N1) 2009 monovalent vaccine approvals were made on the basis of standards developed for vaccine strain changes for seasonal influenza vaccines, adherence to manufacturing processes, product quality testing, and lot release procedures developed for seasonal vaccines. (cdc.gov)
Working model is the modified vaccinia virus Ankara (MVA) which is a highly attenuated vaccinia virus strain and currently tested as a vaccine vector against infectious diseases and cancer. (uniklinik-duesseldorf.de)

According to the CDC, "a study published in the New England Journal of Medicine [in August, 2014] indicated that the high-dose vaccine was 24.2% more effective in preventing flu in adults 65 years of age and older relative to a standard-dose vaccine. (wikipedia.org)
The CDC recommends the high-dose vaccine for people 65 and over but expresses no preference between it and standard vaccine. (wikipedia.org)
Proportion of children receiving at least 1 dose of influenza vaccine in school-located clinics, by age and vaccine formulation selected, Hawaii, USA, 2007-08 influenza season. (cdc.gov)
One dose of measles, mumps, and rubella vaccine is 93% effective against measles, 78% effective against mumps, and 97% effective against rubella. (openpr.com)
Claim 1 of the patent presents a distinguishing technical feature from exhibit 1, which is described as "the vaccine is formulated and administered subcutaneously in a first dose, orally in a second and third dose. (managingip.com)
Older people often have weaker immune responses to the vaccine, so experts suggest those 65 and older get either a high-dose shot, which has four times the regular dosage, or a shot with adjuvant, an ingredient that boosts immune response. (rtmagazine.com)
People who have had serious allergic reactions to a previous dose of the vaccine or to a vaccine component should not be given the rotavirus vaccine. (msdmanuals.com)
2 ] This vaccine is given as a single dose subcutaneously. (bcmj.org)
Second, recent licensures of two new influenza vaccines, Fluzone High-Dose Quadrivalent and Fluad Quadrivalent, are discussed. (cdc.gov)
Varivax is packaged as lyophilized powder in single-dose vials in both a newer "refrigerator stable" and original frozen formulation. (biopharma.com)
The nearly 2 µg of unmodified human DNA (from MRC-5 cells) present in each dose is reported to be the highest level in any approved pediatric vaccine. (biopharma.com)
In August 2023 the Access to Advanced Health Institute (AAHI) announced that it had received an $18 million award from the NIH in support of its efforts to develop a temperature stable, single-dose vaccine candidate against chikungunya. (vaccinenation.org)
Evaluating a novel solid dose vaccine formulation technology for delivery of PRRSV vaccines. (pirbright.ac.uk)

These measles, mumps, and rubella vaccines are administered by subcutaneous injection to children as well as adults. (openpr.com)

Effectiveness" only refers to the ability of the vaccine to prevent illness, and the vaccine does so much more than that," says Dr. LJ Tan , chief strategy officer for the nonprofit Immunization Action Coalition, based in St. Paul, Minn. (kuer.org)
Once it was clear that the effectiveness of the first generation of vaccines waned over time, and variants challenged them as well, interest in intranasal vaccines grew. (plos.org)
[1] [2] The safety and effectiveness of vaccines has been widely studied and verified. (webot.org)
A growing body of scientific evidence has shown the effectiveness of NA based vaccines and therefore I am exploring the possibilities of extracting catalytically active NA heads which can be used as a source of antigen for NA based vaccine. (mssm.edu)
A substance or combination of substances used in conjunction with a vaccine antigen to enhance (for example, increase, accelerate, prolong and/or possibly target) or modulate a specific immune response to the vaccine antigen in order to enhance the clinical effectiveness of the vaccine. (who.int)
An emerging concern is the possible impact of new SARS-CoV-2 variants (for example, the variants first identified in the United Kingdom, South Africa, and Brazil) on mRNA vaccine effectiveness. (cdc.gov)

On September 15, 2009, four influenza vaccine manufacturers received approval from the Food and Drug Administration for use of influenza A (H1N1) 2009 monovalent influenza vaccines in the prevention of influenza caused by the 2009 pandemic influenza A (H1N1) virus. (cdc.gov)
Traditional vaccines often take years to develop and produce, which is not practical in emergency situations like the current COVID-19 pandemic. (cdc.gov)

According to a report by The Lancet, there were already 10 SARS-CoV-2 vaccine candidates in clinical trials as of June 2020. (ondrugdelivery.com)
Internationally, a handful of mucosal vaccines are already in use, more than a dozen others are in clinical trials, and results of preclinical studies have been released for well over a hundred more, including several developed with or by the US NIH. (plos.org)
4 more vaccines have entered clinical trials, bringing the total to 24. (plos.org)
The adoption of up-to-date methodology for convenient vector generation, vector quality control, and vector vaccine immune monitoring has increased the pace bringing recombinant MVA vaccines into clinical trials. (uniklinik-duesseldorf.de)

Serological analyses demonstrated that homologous hemagglutination inhibition and microneutralization antibody titers were detectable in the ferrets after the first immunization with the AS03-adjuvanted vaccines that were further boosted by the second immunization. (nature.com)
This document, the "Advisory Committee Statement: Canadian Immunization Guide Chapter on Influenza and National Advisory Committee on Immunization (NACI) Statement on Seasonal Influenza Vaccine for 2020-2021", updates NACI's recommendations regarding the use of seasonal influenza vaccines. (canada.ca)
Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices-United States, 2017-18 Influenza Season. (medscape.com)
Furthermore, studies in mouse models have revealed that B. pertussis infection, but not immunization with current acellular pertussis vaccines induces resident memory T cells, which may also contribute to protection against colonization by B. pertussis . (frontiersin.org)
Several factors have influenced the risk-benefit balance of the current immunization policy, including disease risk, risk for adverse vaccine reactions, and the cost of vaccines in the United States. (cdc.gov)

Fluarix Flulaval Fluarix Tetra Influvac and its quadrivalent formulation are surface antigen subunit vaccines marketed by Mylan. (wikipedia.org)
Optaflu is a trivalent surface antigen inactivated vaccine prepared in cell cultures manufactured by Novartis. (wikipedia.org)
The mechanism by which vaccine adjuvants enhance immune responses has historically been considered to be the creation of an antigen depot. (mdpi.com)
In certain lymphomas, the immunoglobulin antigen that the lymphoid cell is supposed to be producing becomes mutated, and hence a potential target for vaccines. (oncolink.org)
These findings demonstrate that MVA vaccine design can be essentially improved, as they point to the need for optimal adjustment of the target antigen properties to the intrinsic requirements of the delivering vector system. (uniklinik-duesseldorf.de)

The Lancet report suggests that the average development time for a vaccine is 10 years, but the hope is that current life science tools can shorten the process to allow covid-19 vaccines to be delivered in 2020. (ondrugdelivery.com)
First, the composition of 2020-21 U.S. influenza vaccines includes updates to the influenza A(H1N1)pdm09, influenza A(H3N2), and influenza B/Victoria lineage components. (cdc.gov)
In December 2020, less than a year after the SARS-CoV-2 virus was identified, two COVID-19 vaccines manufactured by Pfizer-BioNTech and Moderna were approved for use in the United States under an Emergency Use Authorization by the U.S. Food and Drug Administration (FDA). (cdc.gov)

Recombinant influenza vaccine (RIV) available in trivalent (RIV3) and quadrivalent (RIV4) formulations. (medscape.com)

While CastleVax's vaccine has shown compelling results in the clinic, it currently requires ultra-cold storage and administration via an intranasal spray device, making it logistically challenging to distribute and administer in low-resource regions, including low- and middle-income countries (LMICs). (wtnh.com)
Additionally, Jurata has evidence to suggest that their thin film technology could also change the route of administration of vaccines from intramuscular or intranasal to sublingual (under the tongue) or buccal (inside the cheek). (wtnh.com)
CIGB (Cuba), the manufacturers of Mambisa, an intranasal protein subunit vaccine, have reported to a conference that immune responses have been high in their trial. (plos.org)

Flublok and its quadrivalent formulation are recombinant subunit vaccines prepared in cell cultures. (wikipedia.org)
A new generation of vaccines based on nanoparticles has shown great potential to address most of the limitations of conventional and subunit vaccines. (cmaj.ca)

According to CDC, two doses of measles, mumps and rubella vaccine are 97% effective against measles and 88% effective against mumps. (openpr.com)
Quadrivalent vaccines are in wide use - between 114 million and 124 million of the 163 million to 168 million doses projected to be available for the current flu season, according to the CDC - but don't hold out for one. (rtmagazine.com)
Two or three doses are given, depending on the formulation: at age 2 months and 4 months or at 2 months, 4 months, and 6 months. (msdmanuals.com)
Children aged under 9 years who have not previously received inﬂuenza vaccine require 2 doses 4 weeks apart (funded for children with eligible conditions). (health.govt.nz)
1 With potentially hundreds of millions of doses to be administered annually, it is important to think carefully about the platform that will be used for covid-19 vaccine delivery. (ondrugdelivery.com)

All influenza vaccines available in the United States for the 2009--10 influenza season are produced using embryonated hen's eggs and contain residual egg protein. (cdc.gov)

For the 2017-18 season, quadrivalent and trivalent influenza vaccines available. (medscape.com)

In this study, two H7N9 split virion vaccines with or without AS03 adjuvant were tested in the naive ferret model. (nature.com)

Vaxigrip Tetra Fluquadri Sanofi Pasteur produces the following vaccines: Fluzone Vaxigrip/Vaxigrip Tetra Flublok Fluzone and its quadrivalent formulation are split virus inactivated vaccines distributed by Sanofi Pasteur mainly in the United States. (wikipedia.org)
citation needed] Vaxigrip and its quadrivalent formulation Vaxigrip Tetra are split virus inactivated vaccines made by Sanofi Pasteur in Europe. (wikipedia.org)
Vaccine produced by CSL Limited is approved for use in persons aged ≥18 years ( 1 ), vaccine produced by Novartis Vaccines and Diagnostics Limited is approved for persons aged ≥4 years ( 2 ), and vaccine produced by Sanofi Pasteur, Inc. is approved for persons aged ≥6 months ( 3 ). (cdc.gov)

There are currently multiple covid-19 vaccine development programmes running across the world. (ondrugdelivery.com)

Zoetis Services LLC owns an invention patent, No. ZL200780048424.3, which relates to a vaccine for treating canine diseases. (managingip.com)
Flu kills more Americans than all other vaccine-preventable diseases, and as such, it deserves our respect and attention. (kuer.org)
He will also collaborate with Dr. Ojima and Stony Brook colleagues in the Department of Molecular Genetics and Microbiology, the Division of Infectious Diseases, and the Center for Biotechnology to advance the vaccine research. (stonybrook.edu)
Novel vaccine technologies are critical to improving the public health response to infectious disease threats that continually emerge and re-emerge, according to scientists at the National Institute of Allergy and Infectious Diseases (NIAID). (globalhealthnewswire.com)
Infectious diseases before and after a vaccine was introduced. (webot.org)
There is overwhelming scientific consensus that vaccines are a very safe and effective way to fight and eradicate infectious diseases. (webot.org)
By now, initial studies testing MVA vaccines for prophylaxis or immunotherapy of infectious diseases and cancer have been completed. (uniklinik-duesseldorf.de)

It is estimated that whooping cough causes globally around 200,000 deaths per year and more than 24 million new pertussis cases in children younger than 5 years were reported in 2014 ( 5 ), in spite of the wide usage of efficacious pertussis vaccines ( 6 ). (frontiersin.org)
There is therefore an urgent need to develop more efficacious vaccines to aid PRRSV control. (pirbright.ac.uk)
We also aim to develop a safe and efficacious Nipah virus vaccine for pigs that will aid the prevention and control of Nipah outbreaks. (pirbright.ac.uk)

Since the introduction of poliovirus vaccines in the 1950s and 1960s, poliomyelitis control has been achieved in the United States, the Americas, and elsewhere (1,2). (cdc.gov)

Seasonal influenza vaccine brands include Fluzone/Fluzone Quadrivalent and Vaxigrip/VaxigripTetra, Influvac and Optaflu. (wikipedia.org)
This safety profile is consistent with results from studies of the seasonal influenza vaccine manufactured by CSL Limited ( 8 ). (cdc.gov)
Flucelvax® Quad is a mammalian cell culture-based, inactivated seasonal influenza vaccine that has recently been authorized for use in Canada in adults and children ≥9 years of age. (canada.ca)

There have been preclinical studies released at least on most vaccine types, including Moderna's mRNA vaccine. (plos.org)
Additionally, our RNA vaccine platform uses standard manufacturing equipment and techniques employed by vaccine manufacturers worldwide that are easy to tech transfer and scale, unlike current mRNA vaccine technology. (vaccinenation.org)
The mRNA vaccine manufacturing process is more easily scaled up to produce large volumes of vaccine. (cdc.gov)

For more information, see the Centers for Disease Control and Prevention's (CDC) Rotavirus vaccine information statement . (msdmanuals.com)
When an older rotavirus vaccine was used, the risk of intussusception was increased. (msdmanuals.com)

The recently approved adjuvanted recombinant vaccine offers appreciably higher and durable protection rates and is associated with more, albeit tolerable, reactogenicity, and physicians should become familiar with these differences in order to provide appropriate counseling to patients who are considering the vaccine, which is available through the private market. (bcmj.org)

11 Those with severe immunosuppression may have a diminished immune response to the vaccine. (hiv.gov)

Because of this ongoing antigenic drift, seasonal influenza virus vaccine formulations are reviewed by the WHO bi-annually. (health.govt.nz)

Although achieving a robust tetravalent response has been a challenge, there are several vaccine candidates in the works that look promising. (virology.ws)

Current pertussis vaccines protect against disease, but not against colonization by and transmission of Bordetella pertussis , whereas natural infection protects against both. (mdpi.com)
Epidemiological and experimental evidence has shown that the vaccines fail to prevent B. pertussis infection and transmission, although they are very effective in preventing disease. (frontiersin.org)
Yet, compared to systemic responses, mucosal immune responses have attracted relatively little attention in the context of pertussis vaccine development. (frontiersin.org)
Although the pertussis incidence has dramatically decreased since the first introduction of these vaccines ( 7 ), whooping cough remains a major global public health problem, mostly in resource-poor countries. (frontiersin.org)
However, surprisingly, its prevalence is also strongly increasing in westernized countries ( 8 ), especially since the switch from the first-generation, whole-cell vaccines to the new-generation, acellular pertussis vaccines. (frontiersin.org)

Inactivated influenza vaccines (IIVs) available in trivalent (IIV3) and quadrivalent (IIV4) formulations. (medscape.com)

Vaccine- associated paralytic poliomyelitis: a review of the epidemiology and estimation of the global burden. (who.int)
Vaccine- associated paralytic poliomyelitis (VAPP) is a rare adverse event associated with oral poliovirus vaccine (OPV). (who.int)
Implementation of these recommendations should reduce the risk for vaccine-associated paralytic poliomyelitis and facilitate a transition to exclusive use of IPV following further progress in global polio eradication. (cdc.gov)
Vaccine-associated paralytic poliomyelitis (VAPP) has been the only indigenous form of the disease in the United States since 1979. (cdc.gov)

Fluenz, FluMist and their quadrivalent formulations are nasal attenuated vaccines by AstraZeneca. (wikipedia.org)
and an adenovirus vaccine, AZD1222 (under development by University of Oxford spinout Vaccitech, and AstraZeneca, with manufacturing support from Catalent's Cell & Gene Therapy division). (ondrugdelivery.com)

We have therefore identified and characterised conserved T cell antigens from PRRSV and are evaluating their vaccine potential using a novel vaccine vector platform based on an attenuated herpesvirus. (pirbright.ac.uk)

Jurata and CastleVax have received funding to assist the development of a next-gen booster vaccine against COVID-19. (wtnh.com)
With so many candidate vaccines in development, there is potential to scale needle-free technologies in parallel with ongoing vaccine development programmes, safe in the knowledge that it has maximum potential to reliably deliver whichever vaccine(s) are proven to be effective. (ondrugdelivery.com)
It highlights that the typical success rate for vaccine development is only 6% and that even an 18-month development programme is considered very aggressive by infection experts. (ondrugdelivery.com)
Proof-of-concept should be established in animal models using cryopreserved malaria sporozoites as the Phase I objective, with pre-clinical development, clinical testing and FDA licensure of a P. falciparum sporozoite vaccine (administered by this novel method) projected for later development phases. (sbir.gov)
The requirement has been updated by the document"Capability Development Document For Plasmodium Falciparum Malaria Vaccine"issued by the Army Medical Research and Materiel Command and approved 01 April 2010 by the US Army Deputy Chief of Staff. (sbir.gov)
The updated cost of coccidiosis in chickens will inform debates on the value of chemoprophylaxis and development of novel anticoccidial vaccines. (huvepharma.com)
Dr. Evans works in collaboration with colleagues and post-doctoral fellows to understand complex mechanisms in virus-host interactions with goals toward vaccine development. (scitechnol.com)
Dr. Evans has also expanded his vaccine research efforts to include the development of virus-like particle formulations derived from a novel yeast platform. (scitechnol.com)
The funding from the National Institutes of Health (NIH) recognize the widespread need for better antifungal treatments and the promise of Dr. Del Poeta's work, which could result in the development of new drugs and a first vaccine. (stonybrook.edu)
Effective this July, Dr. Del Poeta and colleagues will receive another $3 million five-year NIH grant to support the development a fungal vaccine his lab has created. (stonybrook.edu)
The award is intended to support development, preclinical development, and human clinical evaluation of a vaccine to meet the "increasingly urgent need" for a "reliable, abundant supply" of a chikungunya vaccine. (vaccinenation.org)
In a perspective in The Journal of the American Medical Association , the experts highlight innovations that could significantly shorten the typical decades-long vaccine development timeline. (globalhealthnewswire.com)
Platform technologies enable scientists to apply a standardized manufacturing process to multiple vaccines and create a collective database on their safety as well, which can shorten the preclinical development period to as little as several months, according to the authors. (globalhealthnewswire.com)
[17] The science of vaccine development and production is termed vaccinology . (webot.org)
Our major research focus is the development of improved vaccines for porcine reproductive and respiratory syndrome (PRRS). (pirbright.ac.uk)
We are working with colleagues and collaborators on ambitious complimentary approaches aimed at the development of improved PRRS vaccines. (pirbright.ac.uk)
Development of a Nipah virus vaccine to eliminate porcine reservoirs and safeguard human health. (pirbright.ac.uk)

In studies of other seasonal inactivated influenza vaccines, rates of adverse events were not significantly different from placebo injections except for arm soreness and redness at the injection site ( 9 ). (cdc.gov)
In the United States, there are currently two ways someone can get a flu vaccine-by injection (a shot) or nasal spray. (cdc.gov)
The collegial panel opined that the language attests that claim 1 is not a mere feature of the drug administration method but a feature that would indirectly affect the product's preparation, suggesting that the product is a combination of two dosage forms, namely the injection formulation and the oral formulation, and their respective excipients thereof. (managingip.com)
The vaccine has been shown to be 85% effective for protecting against all cases of chickenpox and nearly 100% effective in preventing severe cases, with only rare, mild side effects, such as soreness and swelling at the injection site. (biopharma.com)
The vaccine is given as an intradermal injection over the left deltoid muscle. (immune.org.nz)

Vaccine, 2008 26 (Suppl. (cmaj.ca)

Agents include vaccines and antiviral drugs. (medscape.com)

The vaccine formulations targeting these antigens have caused a relatively weak immune response. (oncolink.org)

4 ] The adjuvant is unique to this vaccine (AS01 B ), and is composed of liposomes containing two immunostimulants: 3-O-desacyl-4'-monophosphoryl lipid A from Salmonella minnesota combined with 1 mg of dioleoyl phosphatidylcholine (DOPC) and 0.25 mg cholesterol, and Quillaja saponaria Molina. (bcmj.org)

There are now more than 150 published reports of preclinical studies of mucosal Covid vaccines. (plos.org)
Vaccines generated by us are being studied in vitro and in vivo in preclinical animal models as well as in collaborative clinical studies. (uniklinik-duesseldorf.de)

Anatomy12

Organisms27

Diseases16

Chemicals and Drugs123

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes30

Disciplines and Occupations3

Technology, Industry, Agriculture10

Information Science3

Health Care12

Geographicals1

LAIV9

Efficacy18

Live40

Vaccination21

Viruses18

Immunogenicity7

Immunity12

Strains8

Pathogens4

Viral13

Induce1

20162

Strain2

Dose13

Subcutaneous injection1

Effectiveness6

Pandemic2

Clinical trials4

Immunization5

Antigen5

20203

RIV41

Intranasal3

Subunit vaccines2

Doses5

Influenza season1

Quadrivalent and trivalent1

Split virion1

Sanofi Pasteur3

Covid-19 vaccine1

Diseases7

Efficacious3

Poliovirus vaccines1

Seasonal influenza vaccine3

MRNA vaccine3

Rotavirus vaccine2

Recombinant vaccine1

Immune response to the vaccine1

Antigenic drift1

Candidates1

Pertussis5

IIVs1

Paralytic poliomyelitis4

AstraZeneca2

Novel vaccine1

Development17

Injection5

Suppl1

Antiviral1

Antigens1

Adjuvant1

Preclinical2