Different bone diseases. Medical search. Frequent questions

And because the abnormal bone is weaker and more brittle than normal, it is prone to fractures. (mydr.com.au)
Researchers at the National Institutes of Health have discovered that a previously unexplained fatal form of Osteogenesis Imperfecta - a disorder that weakens bones and which may cause frequent fractures - results from a genetic defect in a protein involved in the production of collagen. (nih.gov)
People with OI are vulnerable to frequent bone fractures, brittle teeth, loose ligaments, muscle weakness, hearing loss, spinal curvature and skeletal dysplasia . (hss.edu)
Without the right amount of collagen, bones are weak and highly susceptible to trauma, causing frequent fractures and breaks. (cure.org)
With osteogenesis imperfecta, the goal is to keep the child walking, to protect the bone from breaking all the time so that they can walk, and also decrease the number of fractures that they have in a lifetime. (cure.org)
Osteoporosis is a disorder marked by weakened bones and an increased risk of fractures. (seniorwomen.com)
When low bone density is identified early through screening, lifestyle changes and therapies can help protect bone health and reduce the risk of fractures. (seniorwomen.com)
The women were participants in the Study of Osteoporotic Fractures, a long-term nationwide study supported by NIH's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Aging (NIA) and National Center for Research Resources (NCRR). (seniorwomen.com)
Hepatitis C virus (HCV) infection in people with HIV co-infection is associated with an increased risk of liver disease and liver-related death and also several important non-liver related disorders, including kidney disease and osteoporosis and fractures, according to data from the Swiss HIV Cohort published in the online edition of Clinical Infectious Diseases . (aidsmap.com)
The condition occurs when loss of bone mass leads to a high risk of fractures and affects millions of Americans yearly. (zmescience.com)
Although the bones are dense, fractures are common in osteopetrosis because of reduced bone quality. (biomedcentral.com)
Osteosclerotic patients also have increased BMD but fractures are rare, because bone quality is normal. (biomedcentral.com)
FIO manifests clinically with generalized bone pain and multiple fractures of both the axial and appendicular skeletons. (medscape.com)
Patient 1 was a 48-year-old Indian man who presented with a 10-year history of generalized bone pain, multiple fractures, and muscle weakness and was bed-bound at the time of presentation. (medscape.com)

Future directions are discussed, including the urgent need for studies both to determine the nature and extent of poor bone health, and to evaluate the therapeutic effect of available osteoporosis treatments in patients with NMD. (nih.gov)
Non-responders to the DMARDs in terms of progression of bone erosions could be indeed the consequences of a concomitant osteoporosis. (bmj.com)
Experts recommend that older women have regular bone density tests to screen for osteoporosis. (seniorwomen.com)
More than 40 million people nationwide either have osteoporosis or are at increased risk for broken bones because of low bone mineral density (osteopenia). (seniorwomen.com)
Osteoporosis is often called a "silent disease" because it usually progresses slowly and without symptoms until a fracture occurs. (seniorwomen.com)
To help doctors decide how often to repeat bone density tests in women who don't have osteoporosis at their initial screening, a research team led by Dr. Margaret Gourlay of the University of North Carolina at Chapel Hill analyzed data on nearly 5,000 women, age 67 or older. (seniorwomen.com)
As reported in the January 19, 2012, issue of the New England Journal of Medicine, the scientists found that less than 1% of women who initially had normal bone mineral density went on to develop osteoporosis during the study. (seniorwomen.com)
Only 5% of those with mildly low bone density at the start made the transition to osteoporosis. (seniorwomen.com)
Our study found it would take about 15 years for 10% of women in the highest bone density ranges to develop osteoporosis. (seniorwomen.com)
In this large nationwide community-based HIV cohort study HCV exposure was associated with an increased risk of kidney disease and osteoporosis," comment the authors. (aidsmap.com)
Some scientists say that observing how these stem cells interact when they transform into bone tissue could lead to new treatment and drugs for diseases such as osteoporosis. (zmescience.com)
Already, the Bone CLARITY method is being used in collaboration with a biotech company to test a new drug for osteoporosis. (zmescience.com)
The concept of peak bone mass has been widely used in developing strategies for the prevention of osteoporosis in the general population. (bmj.com)
Mount Sinai and The Yale School of Medicine have generated a mouse model that recapitulates all features of Gaucher Disease, including severe osteoporosis. (mssm.edu)
The most common form of bone disease is osteoporosis, which is characterized by reduced bone mineral density (BMD) and an increased risk of fracture. (biomedcentral.com)
If Osteoporosis is not your cup of tea, have you thought about macular degenerative eye disease - macular degeneration? (secrets-about-vitamins.com)

Paget's disease of bone is a chronic bone disorder. (medlineplus.gov)
Who is at risk for Paget's disease of bone? (medlineplus.gov)
What are the symptoms of Paget's disease of bone? (medlineplus.gov)
What other problems can Paget's disease of bone cause? (medlineplus.gov)
How is Paget's disease of bone diagnosed? (medlineplus.gov)
What are the treatments for Paget's disease of bone? (medlineplus.gov)

Osteopenia is referred to as a medical condition wherein bone mineral density is lower than the normal value. (ihealthdirectory.com)
Bone mineral density is a measurement of the level of minerals in the bones, indicating how dense and strong the bones are. (ihealthdirectory.com)
On the other side, from the bone point of view, we previously observed that low bone mineral density (BMD) at the cortical site was significantly associated with the presence of bone erosions, 8 and recently Zhu and colleagues reported alterations in the density and microstructure of the cortical bone of patients with RA, providing new insight into the microstructural basis of bone involvement in RA. (bmj.com)
Structures that are dense (such as bone) will appear white, air will be black, and other structures will be shades of gray depending on density. (mountsinai.org)
A study of nearly 5,000 women now reports that patients with healthy bone density on their first test might safely wait 15 years before getting rescreened. (seniorwomen.com)
That's why the US Preventive Services Task Force recommends routine screening of bone mineral density for women ages 65 and older. (seniorwomen.com)
Researchers divided the women divided into 4 groups based on initial bone density tests that were either normal or showed mild, moderate or advanced osteopenia. (seniorwomen.com)
They were given 2 to 5 bone density tests at varying intervals during the 15-year study period. (seniorwomen.com)
If a woman's bone density at age 67 is very good, then she doesn't need to be rescreened in 2 years or 3 years, because we're not likely to see much change," Gourlay says. (seniorwomen.com)
Bone disease characterised by a decrease in bone mineral density and bone mass, resulting in an increased risk of fracture (a broken bone). (aidsmap.com)
Azathioprine did not negatively influence the steroid effect on bone mineral density. (lu.se)
CONCLUSIONS: Azathioprine does not seem to affect bone mineral density by itself. (lu.se)
Mueller joined the School of Medicine in 1998 as a technologist, measuring bone mineral density. (wustl.edu)
METHODS In 22 prepubertal children with CF and mild lung disease, the relation between total body bone mineral density (BMD) and measures of body composition, biochemistry, lung function, and physical activity was studied. (bmj.com)
Bone strength is principally determined by bone density and bone volume, and several studies have shown the correlation between low bone mass and increased risk of fracture at, for example, the femoral neck. (bmj.com)
Femoral neck bone mineral density was obtained from DXA femur file. (cdc.gov)

Journal of Bone and Mineral Metabolism. (wikipedia.org)
Paget's disease of the bone is a rare condition affecting the elderly and it primarily involves a faulty bone metabolism. (news-medical.net)
Calcitonin: This hormone is involved in bone metabolism. (mountsinai.org)
Bone metabolism is affected by factors such as nutrition, exercise, medical illnesses and medications, as well as hormones including parathyroid hormone, vitamin D, estrogen, and testosterone. (rochester.edu)
Abnormalities in bone metabolism can result in bone disorders and imbalance of minerals such as calcium and phosphorus. (rochester.edu)
The Metabolic Bone Clinic at the University of Rochester Division of Endocrinology focuses on the evaluation and care of patients with conditions that affect bone and mineral metabolism. (rochester.edu)
Serum measures of mineral bone metabolism ( calcium , phosphate , parathyroid hormone , 25-hydroxy vitamin D , FGF23, osteopontin ) were measured at enrollment. (bvsalud.org)

Osteochondrodysplasia is a general term for a disorder of the development of bone and cartilage. (wikipedia.org)
KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)" (PDF). (wikipedia.org)
It is a genetic bone disorder which makes the bones fragile. (ihealthdirectory.com)
Osteogenesis imperfecta (OI) or "brittle bone disease" is a congenital disorder in which a person is born with very brittle bones, usually due to either a complete lack of or incorrectly formed type I collagen. (hss.edu)
Paget's disease, whose name has been derived from the famous British surgeon Sir James Paget, is a bone disorder. (herbs2000.com)
This bone disorder is characterized by acute degeneration of the bones and simultaneous formation of bones that are lacking in calcium and, hence, compared to the normal bones they are easily broken . (herbs2000.com)
Generally, people affected by Paget's disease do not have any symptoms, at least in the initial stages of developing this chronic bone disorder, and it is interesting to note that it is often identified when the X-rays of the patient are taken for diagnosing other medical conditions. (herbs2000.com)
Regeneron's rare disease drug outshone placebo in a phase 2 study, warding off the majority of new bone formation in adults with a disorder that causes the body's soft tissues to turn into bone. (fiercebiotech.com)
A localized disorder of bone remodeling. (mcw.edu)
Paget disease is a disorder that involves abnormal bone destruction and regrowth. (mountsinai.org)
According to the researchers, this condition is very similar to Paget's disease, a bone metabolic disorder that is characterized by a breakdown in communication between bone building cells and bone destroying cells. (earth.com)
say that future studies need to determine how to optimize the management of mineral and bone disorder in children with CKD. (isn-online.org)
The Brittle Bone Disorders Consortium (BBDC) brings together physicians, researchers, and educators to learn more about osteogenesis imperfecta (OI), a genetic disorder that mainly affects the development of the bones. (rarediseasesnetwork.org)
We study osteogenesis imperfecta (OI), which is a rare, genetic connective tissue disorder most characterized by bone fragility. (rarediseasesnetwork.org)
Gaucher Disease is a genetic disorder that has an incidence of up to one in 850 live births in the Ashkenazi Jewish population. (mssm.edu)
FIO is an ultra-rare skeletal disorder in which the collagen matrix (on which bone mineral is deposited) is disorganized, Dr. Matthew Drake of the Mayo Clinic told Reuters Health in an email, adding that no recognized therapy exists. (medscape.com)

The consideration of how material properties change in diseases could lead to a new paradigm in the study of genetic disorders that expands beyond the biochemical approach," said Buehler. (mit.edu)
The broader category of protein-based diseases contains even neuronal disorders such as Alzheimer's disease. (mit.edu)
Mineral bone disorders and kidney disease in hospitalized children with sickle cell anemia. (bvsalud.org)
Mineral bone disorders (MBD) are common in sickle cell anemia (SCA). (bvsalud.org)
They are disorders of growth and remodeling of bone and cartilage. (medscape.com)
Women generally have more work-related cases of carpal tunnel syndrome, tendonitis, respiratory diseases, infectious diseases, and anxiety and stress disorders. (cdc.gov)
Job stress has been linked with heart disease, muscle/bone disorders, depression, and burnout. (cdc.gov)

Periodontitis involves an elevated inflammatory response and greater bone resorption, or the breakdown of bone tissue, by osteoclasts. (newswise.com)
Succinate activates the succinate receptor to stimulate the development of osteoclasts and bone resorption. (newswise.com)
Increased numbers of larger than normal osteoclasts initiate the process at affected skeletal sites, and the increase in bone resorption is followed by an increase in new bone formation, altering bone architecture. (mcw.edu)
Osteopetrosis is characterised by increased BMD, and failure of osteoclastic bone resorption due to mutations in genes that encode proteins that are essential for osteoclast activity like the chloride pump and proton pump, or mutations in genes like cathepsin K, which breakdown bone matrix. (biomedcentral.com)

Urine tests also show signs of excess Calcium and rapid bone turnover. (news-medical.net)
Due to high blood levels of Calcium from increased bone breakdown kidney stones may occur. (news-medical.net)
This process, which is known as 'bone remodelling', is crucial to sustain the standard levels of calcium in the bones. (herbs2000.com)
As a general rule, individuals who have developed Paget's disease should be given calcium in a dosage of anything between 1,000 mg and 1,500 mg, sufficient exposure to sunlight and a minimum of 400 units of vitamin D every day. (herbs2000.com)
After they removed the calcium molecules from the bones which contribute to opacity, the team infused the bones with a hydrogel that locks cellular components in place and preserve the architecture of the sample. (zmescience.com)
these data provide a cautionary note regarding age-appropriate calcium requirements for optimal bone health in children," say the researchers. (isn-online.org)

Certain bones, such as weight-bearing bones, are involved and the risk of fracture is higher. (mountsinai.org)

The weak tendons and fragile bones characteristic of osteogenesis imperfecta, or brittle bone disease, stem from a genetic mutation that causes the incorrect substitution of a single amino acid in the chain of thousands of amino acids making up a collagen molecule, the basic building block of bone and tendon. (mit.edu)
Bone diseases are a common cause of morbidity and mortality in developed countries, and genetic factors play an important role in the pathogenesis of these diseases. (biomedcentral.com)
From a clinical standpoint, advances in knowledge about the genetic basis of bone disease offers the prospect of developing new markers for assessing fracture risk and the identification of new molecular targets that will form the basis for the design of new treatments. (biomedcentral.com)
Whether this study's findings will extend to other patients with FIO is uncertain, Dr. Drake cautioned, particularly because the subjects were brothers, "and thus may have had an unrecognized genetic basis for their disease which might be absent in others with FIO. (medscape.com)

CDC and the Council of State and Territorial Epidemiologists (CSTE) have established a policy that requires state health departments to report cases of selected diseases ( Table 1 ) to CDC's National Notifiable Diseases Surveillance System (NNDSS) (1,2). (cdc.gov)

The well-known forms of Osteogenesis Imperfecta (OI) result from a defect in the genes for type I collagen, which serves as a kind of molecular scaffolding that holds together bone, tendons, skin and other tissues. (nih.gov)
Osteogenesis Imperfecta or OI is also referred to as the Brittle Bone Disease. (ihealthdirectory.com)

Here various audiometry and hearing tests are performed to detect if hearing loss is due to nerve affliction or due to bone deformities. (news-medical.net)

To avoid complications, it is important to find and treat Paget's disease early. (medlineplus.gov)
Surgery is sometimes needed for certain complications of the disease. (medlineplus.gov)
Individuals who have developed Paget's disease are also likely to suffer from certain complications, such as the bones in the affected areas being inclined to breakage or fracture owing to even slight trauma. (herbs2000.com)
Paget's disease may also cause additional complications, including hypertension , sarcoma, gout , osteoarthritis , renal calculi, heart failure as well as a wobble walk attributable to softening of the pelvic bones. (herbs2000.com)
Emily Meier, MD, Director of the Sickle Cell Disease Program , discusses bone marrow transplants at Children's National and some of the complications of sickle cell disease. (childrensnational.org)
However, it is less clear if the infection is also associated with an increased risk of serious non-liver-related events, such as diabetes, cardiovascular disease, malignancies and bone complications. (aidsmap.com)

This creates a tiny rift in the tissue, which when repeated in many molecules, leads to brittle tissue, broken bones, deformity and, in the most severe form of the disease, death. (mit.edu)
This results in deformity of the affected bones. (mountsinai.org)

Biopsies should be obtained from any soft-tissue mass or, if no soft-tissue mass is present, from the most accessible bone in a mechanically safe area (eg, metaphysis vs diaphysis, acetabulum vs subtrochanteric femur). (medscape.com)
The bones that are usually affected by this health condition comprise the femur (thigh bone), the spine , the skull, the pelvis, the humerus (bone of the upper arm), and the clavicle (collar bone). (herbs2000.com)
The types of bones selected for the study were the femur and tibia, as well as some bones of the vertebral column. (zmescience.com)

The collagen defects result from dominant mutations, requiring only one copy of a mutant gene to cause bone disease. (nih.gov)
This approach to the study of disease, referred to as "materiomics" by the lead researcher on the project, Professor Markus Buehler of MIT's Department of Civil and Environmental Engineering, could prove valuable in the study of other diseases - particularly collagen- and other protein-based diseases - where a material's behavior and breakdown play a critical role. (mit.edu)
He sees the application of this approach to collagen-based diseases as a starting point that could lead to a similar analysis of the mechanical properties of tissue involved in other protein-based diseases. (mit.edu)
About 1 in 10,000 people are diagnosed with brittle bone disease annually, and defective collagen is implicated in many other medical conditions, including Alport syndrome (kidney disease) and Ehlers-Danlos syndrome (overly-flexible skin and joints). (mit.edu)
Several candidate genes have been identified that regulate BMD and susceptibility to fracture, including bone morphogenic protein 2, collagen type I alpha 1, the vitamin D receptor, the estrogen receptor and lipoprotein receptor related protein 5 (LRP5). (biomedcentral.com)
The underlying abnormality in FIO appears to be an acquired defect in bone collagen fibrillary arrangement. (medscape.com)

The mice had deformed brittle bones. (nih.gov)

Paget's disease of the bone (PDB) is characterised by focal abnormalities of increased bone turnover. (biomedcentral.com)
In addition, he commented, "whether rhGH can be used long-term is unclear, as we know that long-term exposure to high levels of growth hormone in adults may lead to adverse outcomes," such as an increased risk of diabetes, increased bone growth leading to joint abnormalities and increased pressure on nerves, which can result in carpal tunnel syndrome. (medscape.com)
We evaluated the prevalence of markers of SCA-related MBD (sMBD) in hospitalized children and assessed the relationship between sMBD and individual mineral abnormalities with kidney disease . (bvsalud.org)

There is excessive breakdown and regrowth of bone. (medlineplus.gov)
Normally, the building of new bone and the breakdown of old bone is in a state of balance, which is why, for most of us, our skeletons stay the same size once we have stopped growing. (mydr.com.au)
In people with Paget disease, there is an abnormal breakdown of bone tissue in specific areas. (mountsinai.org)
Drug therapy helps prevent further bone breakdown and formation. (mountsinai.org)

The muscles, bones and joints are usually called collectively the musculo-skeletal system. (healthy.net)
In adults, Paget's disease generally has an effect on the older skeletal bone and, according to rough estimate, approximately one per cent of the adult population in the United States, suffers from Paget's disease. (herbs2000.com)

However, this pain pattern can be present in patients with osteomyelitis and Paget disease, and in these instances, it is also nonspecific. (medscape.com)
Patients with metastatic bone disease are generally treated with surgery or radiation therapy. (medscape.com)
The goals of surgical intervention for spinal surgery in patients with metastatic bone disease includes decreasing or eliminating pain, decompressing neural elements to protect cord function, and mechanically stabilizing the spine. (medscape.com)
It is usually quite elevated in patients with Paget's disease. (news-medical.net)
A bone scan or a PET (Positron Emission tomography) scan is advised for patients with Paget's disease. (news-medical.net)
CDC recommends that all patients who received these products (#TDS222820) begin treatment for TB disease , even if they do not have any symptoms. (cdc.gov)
Patients affected by Paget's disease experience bone pain in the bones that have developed this condition. (herbs2000.com)
9 In particular, in patients with anticitrullinated protein antibodies, cortical thinning might be present even before the clinical onset of RA and it seems strictly related with the risk of bone erosions. (bmj.com)
Denosumab is a well-known, effective agent for increasing BMD, both at trabecular and cortical sites, 11 , 12 and has been showed to prevent metacarpal bone loss in patients with RA, 13 and improve cortical porosity. (bmj.com)
The patients in the study had varying disease severity-some had difficulty moving specific parts of their body while others had "near-total immobility. (fiercebiotech.com)
After 28 weeks of treatment, patients taking garetosmab saw a 25% reduction in number of bone lesions, Regeneron said in a statement. (fiercebiotech.com)
This disease is relentless and devastating, leaving many patients wheelchair-bound or locked in a position unable to move, with a dramatically curtailed lifespan," said Regeneron President and Chief Scientific Officer George Yancopoulos, M.D., Ph.D., in the statement. (fiercebiotech.com)
15 patients with Paget's bone disease were treated with varying schedules of porcine (3.8-157.5 MRCU/kg per wk) and/or salmon (1.5-210 MRCU/kg per wk) calcitonins over periods ranging from 4 to 24 months. (jci.org)
In spite of return of disease activity comparable to baseline levels, 3/5 resistant subjects treated with salmon calcitonin failed to develop hypocalcemia after injection of 300-1000 MRCU of salmon calcitonin, but two of these patients developed hypocalcemia in response to the porcine hormone. (jci.org)
We work with patients to create an individual diet, lifestyle and treatment plan to improve bone health. (rochester.edu)
OBJECTIVES: To ascertain whether patients with Crohn's disease treated with azathioprine maintained bone mineral mass better than patients treated with steroids alone. (lu.se)
SUBJECTS: A total of 59 patients with ileocolonic, ileocaecal or colonic Crohn's disease. (lu.se)
However, by being steroid-saving, it seems to conserve bone mineral mass in patients with Crohn's disease. (lu.se)
Patients who reached stringent remission according to the Simplified Disease Activity Index (SDAI≤3.3) were extracted to eliminate the activity related (ie, reversible) component of disability. (bmj.com)
Galileo Research Fact Sheet #142: Can Galileo Therapy improve bone parameters in Pompe disease patients? (galileo-training.com)
Bone pain resolved enough in both patients to allow them to perform most of their activities of daily living. (medscape.com)
Then when we developed a half-matched protocol, half of the patients eventually rejected the cells, and the disease came back. (medlineplus.gov)
Bone marrow transplants are not working in 100% of patients. (medlineplus.gov)
To quantify and compare the level of alveolar bone loss on panoramic and periapical radiographs of five (5) patients presenting periodontitis. (bvsalud.org)
On the panoramic and periapical radiographs of five patients, the measurements from the cement-enamel junction (CEJ) to the alveolar bone crest (ABC), at the mesial and distal surfaces of the upper and lower incisors, lower first premolars and first molars, were performed. (bvsalud.org)
Unlike those with achondroplasia or hypochondroplasia, patients with diastrophic dysplasia have epiphyseal involvement and are at risk for degenerative joint disease. (medscape.com)

The condition is named after Sir James Paget, a British doctor who described the disease in the 1870s. (mydr.com.au)
In effect, Dr. Paget was the first to identify as well as explain this persistent bone disease in the latter part of the 19th century. (herbs2000.com)
Paget disease is a feature of several Mendelian diseases including Paget disease of bone 3 (OMIM:167250). (mcw.edu)
The cause of Paget disease is unknown. (mountsinai.org)
Paget disease is often diagnosed when an x-ray is done for another reason. (mountsinai.org)
Not all people with Paget disease need to be treated. (mountsinai.org)
Currently, there are several classes of drugs used to treat Paget disease. (mountsinai.org)

Additional information about OI is available from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, at http://www.niams.nih.gov/bone/oi.htm . (nih.gov)
Their intrinsic regenerative capacities are disturbed in many hematological and musculoskeletal diseases. (europa.eu)
Due to the limitations of such studies in human beings and animals, I propose to develop human in vitro models of healthy bone marrow, which can be induced to develop hematological and musculoskeletal diseases with high incidence, namely leukemia, multiple myeloma and bone metastasis. (europa.eu)

Rheumatoid arthritis is far less common than osteoarthritis and represents a completely different disease process. (healthy.net)
Takeuchi et al 1 demonstrate an additional inhibitory effect on the progression of bone erosions in rheumatoid arthritis (RA) with the addition to methotrexate of an anti-receptor activator of nuclear factor kappa-B ligand (RANKL) antibody, denosumab, confirming results already reported 8 years ago by Cohen and colleagues. (bmj.com)
Background Joint destruction in rheumatoid arthritis is comprised of cartilage and bone damage, which can be evaluated radiographically separately by the joint space narrowing (JSN) and erosion (ERO) scores. (bmj.com)

Proceedings: A simplified approach to metabolic bone disease. (bmj.com)

On X rays the affected bone shows up as large, dense white and deformed. (news-medical.net)

Sore joints or arthritis due to damage to the cartilage which lines the ends of bones. (mydr.com.au)
While pathogenetically the influx of immune and inflammatory cells signifies synovitis, its invasion into the adjacent bone and the consumption of cartilage constitute the destructive elements of the disease. (bmj.com)

Newswise - The National Institute of Dental & Craniofacial Research, part of the National Institutes of Health, has awarded a grant to researchers at New York University College of Dentistry (NYU Dentistry) to explore the biological mechanisms that contribute to poor oral health and related bone loss among people with diabetes. (newswise.com)
Diabetes may accelerate periodontitis through metabolic dysregulation, shifts in bacterial colonization, inflammation, and bone loss. (newswise.com)
Because bone loss and fracture risk are serious concerns for people with diabetes, Xin Li, PhD, associate professor of basic science and craniofacial biology at NYU College of Dentistry, has been working to understand the underlying mechanism for periodontal bone loss in people with diabetes. (newswise.com)
Using mouse models, the researchers will investigate whether succinate signaling alters the oral microbiome, study the role of succinate as an inflammatory and immune mediator, and determine whether blocking succinate signaling can thwart diabetes-related periodontal bone loss. (newswise.com)
Because we've found that succinate has significant implications for periodontal disease, we hope that by understanding this novel mechanism, we can help prevent periodontal bone loss in those with diabetes," said Deepak Saxena, PhD, associate professor of basic science and craniofacial biology at NYU College of Dentistry and one of the project's principal investigators. (newswise.com)
Restricting analysis to HCV-positive people showed that ongoing HCV replication was associated with liver disease and death and an increased risk of diabetes. (aidsmap.com)
The Endocrine Division uses technology, research, and novel gene therapies to enable physician-scientists in the Division of Endocrinology, Diabetes, and Bone Disease to identify new treatments. (mssm.edu)
Andrea Dunaif, MD, is the Chief of the Hilda and J. Lester Gabrilove Division of Endocrinology, Diabetes and Bone Disease. (mssm.edu)
Carol J. Levy, MD, CDE is a Professor in the Department of Medicine, Division of Endocrinology, Diabetes and Bone Disease, and a Professor in the Department of Obstetrics, Gynecology and Reproductive Science. (mountsinai.org)
As a child, she was diagnosed with type 1 diabetes and the patience and respect she received from clinicians along the way (including her obstetrician for her own pregnancies) reinforced her belief that a patient who understands the purpose of a treatment is one who is able to best able to manage his//her disease. (mountsinai.org)

This is targeted to maintain a transferrin saturation level of 20% or higher and serum ferritin level of 100 ng/dL or higher in children with chronic kidney disease. (medscape.com)

Any bone in the body can develop Paget's disease, but it particularly affects the skull, spine, pelvis, legs and arms. (mydr.com.au)

MEDLINE and Embase were searched for cohort studies (January 1st 2010 to September 1st 2020) that reported the prevalence of cardiovascular, bone, renal and neurocognitive disease in WLWH >18 years. (natap.org)

Osteosarcoma is a type of bone tumor that is prevalent in children and the elderly, and many times it is commonly found in the knee area. (ihealthdirectory.com)
A small number of people may develop a cancer of the bone called osteosarcoma. (mountsinai.org)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
I'm Commander Ibad Khan and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)

Researchers do not know for sure what causes Paget's disease. (medlineplus.gov)
Remarkably, American researchers recently showed how to grow intact and transparent bones. (zmescience.com)
To determine stem cell populations in the bone, researchers usually slice the bone into thin sections then extrapolate the number of stem cells. (zmescience.com)

Common symptoms of the condition are frequent broken bones, gradual bending of the leg and arm bones, short stature, weak muscles, and, in time, loss of the ability to walk. (cure.org)
Once broken bones are stabilized, surgeons place metal rods and pins into the child's bones to prevent more breaks and abnormal bending. (cure.org)

Bisphosphonates: These drugs are the first treatment, and they help decrease bone remodeling. (mountsinai.org)

Metastatic bone disease occurs when cancer spreads from a primary organ site to bone. (medscape.com)
The spine is the most common location of metastatic disease. (medscape.com)
For the management of long-bone metastatic disease accompanied by an impending or completed fracture, open internal fixation is usually the preferred method of treatment. (medscape.com)

Ryan White Center for Pediatric Infectious Diseases and Global Health, Indianapolis, IN, United States. (bvsalud.org)
This report provides updated uniform criteria * for state health department personnel to use when reporting the nationally notifiable infectious diseases listed in Part 1 of this report. (cdc.gov)
This report supersedes the 1990 report, which included infectious diseases and one noninfectious condition (i.e., spinal cord injury). (cdc.gov)

Previously my team and I developed a simplified bone marrow analog that bases on macroporous, cell-laden biomaterials with tunable physical, biochemical and biological properties. (europa.eu)

Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group. (wikipedia.org)
To address this paucity of data, Denburg and colleagues evaluated fracture burden in 537 children aged 1-16 years enrolled in the prospective Chronic Kidney Disease in Children study to determine the gender-specific incidence of fracture and to identify risk factors for fracture in this population. (isn-online.org)
In adults with chronic kidney disease, interventions to slow the progression of kidney disease that have been proven to be effective include strict blood pressure control and angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor-blocker (ARB) therapy, lipid lowering therapy, and correction of anemia. (medscape.com)
In addition, antihypertensive therapy is used for both renal protection and cardiovascular protection, because chronic kidney disease is associated with a marked increase in cardiovascular risk. (medscape.com)
According to the recommendations of the Pediatric Work Group of Kidney Disease Outcomes Quality Initiative (KDOQI) for chronic kidney disease (CKD), all children with evidence of CKD should be referred to a pediatric nephrologist for consultation and comanagement. (medscape.com)
Recombinant human erythropoietin (rHuEPO) has been used for chronic kidney disease (CKD)-associated anemia since 1986. (medscape.com)
The Kidney Disease Improving Global Outcomes (KDIGO) guidelines were used to define SCA-associated acute kidney injury (AKI). (bvsalud.org)
Acute kidney disease (AKD) was defined as a composite of AKI, an eGFR Cystatin C GFR equation, or evidence of structural injury (positive biomarker test or albuminuria ). (bvsalud.org)
Biomarkers of kidney injury and bone health may help risk stratify children at risk of sMBD. (bvsalud.org)
if your child has ever had or still has a liver disease (such as hepatitis) · if your child is suffering from or has ever suffered from kidney disease. (who.int)

It is well known that chronic HCV infection is associated with an increased risk of serious liver disease and liver-related death. (aidsmap.com)
The CDC Surveillance Coordination Group has established a steering committee that is charged with the development of a broad range of case definitions for noninfectious conditions (e.g., environmental or occupational conditions, chronic diseases, adverse reproductive health events, and injuries). (cdc.gov)

Aortic valve disease can lead to heart failure, arrhythmia, infections in the heart, and sudden death may occur in 15 to 20 percent of people who have symptoms. (sciencedaily.com)
In Australia, about 2-4% of people over the age of 55 will have some degree of Paget's disease, although for most people it will cause no symptoms or major problems. (mydr.com.au)
Many people with Paget's disease are unaware they have the condition because they have no symptoms or only mild symptoms. (mydr.com.au)
The symptoms of Paget's disease depend on where in the body the abnormal new bone is being produced. (mydr.com.au)
Because most people with Paget's disease have no symptoms, the disease is often diagnosed by chance after tests have been carried out for another reason. (mydr.com.au)
The disease has a wide spectrum of signs and symptoms ( 4 ). (cdc.gov)
Ten days later, high-grade fever up to 40°C developed, without any other signs or symptoms of disease. (cdc.gov)
It is worth mentioning here two main factors - the affected bones as well as the severity of the condition determine the symptoms of Paget's disease. (herbs2000.com)

This enzyme measures the bone turnover. (news-medical.net)
These are areas of more bone turnover than usual. (news-medical.net)

Rare bone diseases such as osteopetrosis and hereditary osteoscleroses are also caused by mutations in genes that affect bone cell function. (biomedcentral.com)

However, the condition has been around for thousands of years, with some skeletons from ancient Egypt known to have evidence of large, misshapen bones. (mydr.com.au)

Our work is focused on the pathophysiology and development of novel cellular therapies to cure severe combined immunodeficiencies caused by RAG genes and inherited bone defects due to osteoclast dysfunction. (hsr.it)

Affected bones become enlarged, misshapen and weaker than normal. (mydr.com.au)
As a result of new abnormal bone being produced, affected bones become enlarged and misshapen. (mydr.com.au)
In effect, when the affected bones become enlarged they may squeeze the nearby nerves, thereby resulting in lack of sensation and tingling in the area. (herbs2000.com)

By maximising peak bone mass in adolescence or young adulthood, along with strategies to reduce the rate of bone mineral loss, fracture risk and development of thoracic kyphosis may be substantially reduced. (bmj.com)

Sickle cell disease (SCD) specialists have performed bone marrow transplants in children since the 1990s. (medlineplus.gov)

Andrews' Diseases of the Skin: Clinical Dermatology. (wikipedia.org)
2 Insufficient inhibition of structural joint damage by disease-modifying antirheumatic drugs (DMARDs) was reported despite clinical improvement, 3-5 and recently two meta-analysis 6 , 7 showed that methotrexate combined with biologics is statistically superior to methotrexate in inhibiting radiographic progression, but the estimated mean change with all treatments was less than the minimal clinically important difference. (bmj.com)
Cheryl Marie Mueller, clinical administrator in the Division of Bone and Mineral Diseases at Washington University School of Medicine in St. Louis, died Dec. 17, 2015, after a 12-year battle with cancer. (wustl.edu)
The Bone Research Society (BRS) is one of the largest national scientific societies in Europe dedicated to clinical and basic research into mineralised tissues, and is the oldest such society in the world. (oife.org)
The OI Foundation (OIF) and Children's Brittle Bone Foundation (CBBF) committed to establishing and funding a network of linked clinical research centers. (rarediseasesnetwork.org)
In addition to the clinical orthodontic trial mentioned, we completed a phase I clinical trial of an anti-TGF beta antibody in adults with OI as well as a multi-omic study of OI human bone. (rarediseasesnetwork.org)
At Mount Sinai Morningside, The New York Obesity Research Center is the only federally funded obesity research center and the mission is to reduce the incidence of obesity and related diseases through leadership in basic obesity research, clinical research, epidemiology and public health, patient care, and public education. (mssm.edu)

I'm hoping our research can go beyond sickle cell disease to have a bigger impact. (medlineplus.gov)
We are trying to create a state where instead of completely replacing bone marrow with that of their donors, we are creating a mixture of donor and patient cells because we now know that as low as 20% donor cells is enough to reverse sickle cell disease. (medlineplus.gov)
It's an exciting time for sickle cell disease research. (medlineplus.gov)
The number one disease among newborn babies is sickle cell disease. (medlineplus.gov)

Osteomalacia is a condition where there is softening of the bones which is caused by defective bone mineralization. (ihealthdirectory.com)
Bone biopsies showed "dramatic improvement" in mineralization. (medscape.com)

Non-isomerised C-telopeptide fragments are also monitored to provide clues regarding disease activity and progression as well as treatment efficacy . (news-medical.net)
For this purpose we need to understand the early events of disease onset and progression. (europa.eu)
The new NIDCR grant will fund research to determine whether elevated levels of succinate accelerate the progression of periodontal disease. (newswise.com)

When disease or damage occurs to this system it nearly always results in pain, and most people use words such as rheumatism or arthritis to describe this type of pain. (healthy.net)
The disease occurs worldwide, but is more common in Europe, Australia, and New Zealand. (mountsinai.org)

In comparison to cancers that occur in organs, or that spreads to bone tissue, bone cancer can be considered fairly uncommon. (ihealthdirectory.com)
Bone marrow is the tissue found in the center of the bone. (ihealthdirectory.com)
In what may be the first detailed molecular-based multi-scale analysis of the role of a materials' failure in human disease, a paper in the Aug. 5 issue of Biophysical Journal describes exactly how the substituted amino acid repels other amino acids rather than forming chemical bonds with them, creating a radically altered structure at the nanoscale that results in severely compromised tissue at the macroscale. (mit.edu)
They learned that the mutations creating the most severe form of the disease also correlate with the greatest magnitude of adverse effects in creating more pronounced rifts in the tissue, which lead to the deterioration and failure of the tissue. (mit.edu)
Just like skin, bone sheds old tissue and grows a new one from stem cells sourced from the bone marrow. (zmescience.com)
The bones in our bodies are living tissue. (rochester.edu)
In addition, OI is a pleiotropic connective tissue disease that affects more than bone, and the phenotype can be highly variable depending upon genotype. (rarediseasesnetwork.org)
No relation was found between BMD and anthropometric indices, fat free soft tissue, degree of lung disease, degree of fat malabsorption, dietary energy intake, or level of physical activity. (bmj.com)
Since the 1990s, to do a bone marrow transplant, a patient had to have a sibling with a complete tissue match and take a medication that suppresses their immune system (Cyclophosphamide), as well as high dose chemotherapy. (medlineplus.gov)

Vision loss , if Paget's disease in the skull affects the nerves. (medlineplus.gov)
Hearing loss may be the first to be detected in Paget's disease affecting the skull bones. (news-medical.net)
In case the disease affects the skull bones, the patient may experience headaches , lack of eyesight as well as impaired hearing . (herbs2000.com)
For example, hormones from bone send the brain signals to regulate appetite, and studying the interface between the skull and the brain is a vital part of neuroscience. (zmescience.com)

In some cases, the affected bones may impinge the cranial nerves leading to hearing loss as well as loss of vision accompanied by vertigo and tinnitus . (herbs2000.com)

Nevertheless, people enduring this health condition may possibly suffer from bone pains, fracture, and malformation of bones as well as arthritis . (herbs2000.com)
In some cases, the legs may even bend over, whereas if the hip or knee is affected by Paget's disease, it may result in limping, arthritis and even aches and rigidity of the bones in these body parts. (herbs2000.com)
Method: Descriptive, univariate, and multivariate regression analyses were employed to assess key psychosocial, disease, and host factors among the sample (N =141) of adults with arthritis, aged [UNKNOWN] 50 years old. (cdc.gov)

We hypothesize that targeting succinate signaling will prevent the acceleration of periodontal disease. (newswise.com)
Periapical radiograph can be considered the best radiographic method to evaluate the alveolar bone loss level and, consequently, to help the diagnosis of the periodontal disease. (bvsalud.org)
However, the panoramic radiograph is still a valid method for evaluating the level of bone loss caused by the periodontal disease, although the dentist should be aware of the limitation and characteristics of this radiographic technique. (bvsalud.org)

In severe Paget's disease, the heart has to work harder to pump blood to affected bones. (medlineplus.gov)
Heart failure is detected in severe Paget's disease. (news-medical.net)

Less commonly, Paget's disease can affect the heart, because the abnormal new bone needs its own blood supply. (mydr.com.au)
As a result, the body absorbs old bone and forms abnormal new bone. (earth.com)

Paget's disease is a treatable condition that affects the bones, mainly in older people. (mydr.com.au)
Create healthcare diagrams like this example called Diseases Treatable with a Bone Marrow or Cord Blood Transplant in minutes with SmartDraw. (smartdraw.com)

It is important to confirm the diagnosis of Paget's disease. (news-medical.net)
Retrieved on October 01, 2023 from https://www.news-medical.net/health/Diagnosis-of-Pagets-disease-of-the-bone.aspx. (news-medical.net)

The data suggests a high burden of cardiovascular, bone, renal and neurocognitive disease in WLWH compared to HIV negative women. (natap.org)
How about cardiovascular or heart disease? (secrets-about-vitamins.com)

Anatomy12

Diseases25

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes8

Technology, Industry, Agriculture1

Fractures14

Osteoporosis16

Paget's Dise6

Density16

Metabolism7

Disorder16

Disorders7

Resorption4

Calcium6

Risk of fracture1

Genetic4

Notifiable Diseases Surveillance System1

Osteogenesis2

Deformities1

Complications6

Deformity2

Femur3

Collagen6

Brittle bones1

Abnormalities3

Breakdown4

Skeletal2

Patients26

Paget7

Musculoskeletal3

Rheumatoid arthritis3

Metabolic Bone Di1

Dense1

Cartilage2

Diabetes10

Serum1

Pelvis1

20201

Osteosarcoma2

Centers for Diseas3

Researchers3

Broken bones2

Bisphosphonates1

Metastatic3

Infectious Diseases3

Simplified bone marrow1

Kidney10

Chronic2

Symptoms8

Turnover2

Affect bone1

Misshapen bones1

Osteoclast1

Affected bones become enlarged3

Fracture risk1

Marrow transplants1

Clinical7

Sickle4

Mineralization2

Progression3

Occurs2

Tissue9

Skull4

Hearing loss1

Arthritis3

Periodontal disease3

Severe Paget's disease2

Abnormal new bone2

Treatable2

Diagnosis2

Cardiovascular2