Differences genetic heterogeneity. Medical search. Frequent questions

However, substantial clinical and methodological heterogeneity present across neuroimaging experiments potentially hinders the identification of consistent neural biomarkers of BD. (nature.com)
Alzheimer's disease is a complicated neurodegenerative disorder with multiple phenotypic subtypes, including clinical and preclinical, that result from different genetic origins. (wikipedia.org)
However, the study of tumor immune heterogeneity holds great potential for clinical immunotherapy. (spandidos-publications.com)
This program supports basic and clinical research to determine the viral and host genetic factors involved in central nervous system (CNS) impairment caused by HIV-1 worldwide. (nih.gov)
Objective Elucidate the core clinical and genetic characteristics and identify the phenotypic variation between different regions and genotypes of fatal familial insomnia (FFI). (bmj.com)
The prevalence of clinical symptoms and genetic profile were obtained, and then the phenotypic comparison between Asians versus non-Asians and 129Met/Met versus 129Met/Val were conducted. (bmj.com)
This phase will identify the phenotypic, functional and molecular sources and patterns of B cell and PC diversity to determine candidate features potentially associated with clinical heterogeneity. (lupusresearch.org)
Autism is a neurodevelopmental disorder characterized by clinical, etiologic and genetic heterogeneity. (neurotransmitter.net)
Influenza A virus (IAV) is a famous example: in addition to their genetic diversity, clinical isolates of IAV adopt a filamentous morphology where particles can vary in length by over 100-fold. (mpg.de)
[ 16 ] Coupled with this genetic heterogeneity is considerable clinical heterogeneity, as illustrated by substantial differences in the extent and quality of symptoms. (medscape.com)
Genetic testing in children has traditionally focused on conditions with clinical actionability or utility. (cdc.gov)
Our aim is to create a clinical genetic risk score to be used already at the time of diagnosis to plan for an individualised treatment. (lu.se)

Genetic data are consistent with polygenic inheritance, allelic heterogeneity at most CAM loci, and pleiotropic influences on overlapping phenotypes. (uib.no)

Initial research on genetic heterogeneity was conducted using genetic linkage analyses, which map genetic loci of related individuals to identify genomic differences. (wikipedia.org)
Understanding the heterogeneity of GBM depends on the location of sampling and analysis of subclonal fractionation or indeterminate genomic status. (spandidos-publications.com)
In recent years, studies on the differences between genomic and epigenomic characteristics of MZs have led to the development of new approaches for elucidating the etiology of psychiatric disorders (Liang et al. (springer.com)
Moreover, our blood-tissue combined study revealed a significant difference in SNPs between blood and tumoral samples, probably due to glioma heterogeneity and genomic instability. (minervamedica.it)
We studied the associations between the stem quality, phenology, and genetic structure by genotyping the phenotypic variation at 15 genomic SSR makers of 208 mature European beech trees in four artificially established stands in Lithuania. (mdpi.com)

Genetic heterogeneity occurs through the production of single or similar phenotypes through different genetic mechanisms. (wikipedia.org)
Increased understanding of the role of genetic heterogeneity and the mechanisms through which it produces common disease phenotypes will facilitate the development of effective prevention and treatment methods for these diseases. (wikipedia.org)
New genetic technologies can enhance our understanding of the pathophysiological mechanisms, and aid in the identification of innovative strategies for the discovery of therapeutic drug targets. (nih.gov)
Examine molecular and genetic mechanisms of potential subtype/clade differences in HIV-1 neuropathogenesis. (nih.gov)
Examine the role of host genetic factors, including epigenetic mechanisms in regulating susceptibility to HIV-1 associated CNS dysfunction. (nih.gov)
This program brings together trainees and experts in epidemiology, genetic and sleep/respiratory physiology to identify biomarkers and molecular mechanisms for sleep apnea risk, models interactions between sleep disorders and genetic risk factors (G*E), and attempts to resolve the heterogeneity in sleep apnea that predicts differences in outcomes and treatment response. (harvard.edu)
Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in the consequences of both conditions and the mechanisms of action are poorly defined. (nih.gov)
Based on these numbers, it is not surprising that several psychiatric issues, including ASD, all share common underlying genetic mechanisms. (autismsciencefoundation.org)
Although the common genetic mechanisms underlying autism spectrum disorders (ASDs) may be varied and unknown, mounting evidence suggests that defects at the neuronal synapse may underlie the pathophysiology. (medscape.com)

This heterogeneity is referred to as 'polymorphism', as tumor cells rapidly undergo mitosis, resulting in the formation of numerous subclones and uncertainty regarding the state of the genome. (spandidos-publications.com)
Multiregional whole-exome or genome sequencing has revealed that there is significant variation in the genetic makeup of tumor cells across different anatomical locations and within the same tumor over time ( 4 ). (spandidos-publications.com)
This, together with genome instability, contributes to a significant heterogeneity which is further enhanced by the molecular differences of the underlying causes. (wjgnet.com)
The program encourages use of state-of-the-art approaches (e.g., transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequencing, single cell technologies, and systems biology) to identify and validate viral and host genetic factors that influence the pathophysiology of HIV-1 associated CNS dysfunction. (nih.gov)
There is considerable heterogeneity in the genome of the PRRS virus because of inherent errors common in transcription of RNA. (iastate.edu)
HBV is characterized by a genetic heterogeneity and 8 genotypes (A to H) can be classified based on comparison of complete HBV genomes and according to the criterion of ≥ 8% differences in the complete nucleotide sequence of the viral genome [4-6]. (who.int)
Patients enrolled in the pharmacokinetic studies within these 2 trials will be sampled for genetic analysis (genome-wide and targeted SNPs screening with in vitro confirmation of the biological plausibility of the association between pharmacokinetic and genetic characteristics). (h3africa.org)
Genome-wide association studies (GWAS) have implicated the region on chromosome 5p14.1 between CDH9 and CDH10 as the first potential common genetic risk factor in Caucasian populations. (medscape.com)

Genetic polymorphism in the intergenic region (HBS1L-MYB) between GTP-binding elongation factor HBS1L and myeloblastosis oncogene MYB on chromosome 6q is associated with high fetal hemoglobin levels. (scirp.org)

Host genetic variation is also a critical source of transmission heterogeneity, and this is an area research developed by Mike Stear and Louise Matthews (ovine nematodes), and Barbara Mable (effects of MHC on host-pathogen interactions). (gla.ac.uk)
Many systems balance between benefits and disadvantages of heterogeneity as variation can be tolerated, it can be harmful or beneficial. (researchsquare.com)
Heterogeneity is generated both passively, e.g. by differential gene expression in cells of a tissue, and actively, such as the generation of the immense variation for immunological recognition molecules. (researchsquare.com)
In this study, we compared the genetic variation of plant species occurring in different altitudinal zones. (uni-regensburg.de)
We first compiled a data set on genetic variation of 179 plant species occurring in Central Europe and the European Alps measured by AFLPs from the literature. (uni-regensburg.de)
Geographic distance among sampled populations, plant frequency and three plant traits (life span, mating system and pollination mode) were included into the models, to account for their potential effects on level of genetic variation. (uni-regensburg.de)
Our analysis revealed different patterns of genetic variation in plant species occurring in the alpine and non‐alpine zone. (uni-regensburg.de)
We argue that the observed pattern of genetic variation most likely results from restricted gene flow, both past and present, among spatially and environmentally isolated populations in alpine habitats. (uni-regensburg.de)
DEFF can be very different for different variables due to differences in variation by geography, by household intra class correlation, and by demographic heterogeneity. (cdc.gov)

A twin study revealed that the genetic heritability of alcoholism was between 40% and 60% in Caucasian populations 16 . (nature.com)
This observation suggests that the genetic background of amyotrophic lateral sclerosis differs between different populations, countries and regions. (bmj.com)
There is also little evidence on sex differences and non-Western populations are underrepresented. (plos.org)
Genetic differentiation was significantly higher among populations of species from the alpine than subalpine, montane or lowland zone. (uni-regensburg.de)
In contrast, genetic diversity was significantly lower within populations from the alpine zone compared to the other zones. (uni-regensburg.de)
This has drawn attention to possible benefits of studying populations where genetic heterogeneity might be reduced. (lu.se)

69 genes and 145 loci have been discovered to be involved in the genetic heterogeneity of non-syndromic hearing loss, and the phenotype of the disorder is largely associated with its pattern of inheritance. (wikipedia.org)
The genes/mutations could act alone or interact with other genetic and/or epigenetic or environmental factors, causing autism or related disorders. (neurotransmitter.net)
The first stage involved identifying, in unrelated subjects showing linkage to 2q24-q33, genetic variants in exons and flanking sequence within candidate genes and comparing the frequency of the variants between autistic and unrelated nonautistic subjects. (neurotransmitter.net)
To circumvent this, we supplemented the group differential profile with a novel individual-level analysis by deriving individual fold-change differences from the group's significant genes. (auburn.edu)
The field of pharmacogenetics encompasses the study of the heterogeneity in genes related to drug transporters, drug metabolising enzymes and drug targets, in the context of efficacy of treatment and adverse drug reactions. (h3africa.org)
Inherited cataracts demonstrate extreme genetic heterogeneity, with more than 20 genes identified to date. (molvis.org)

and locus heterogeneity, which occurs when a similar phenotype is produced by mutations at different loci. (wikipedia.org)
In addition, intrinsic differences in subclonal tumor cells that arise from random mutations can create distinct niches within limited lesions. (spandidos-publications.com)
These studies reveal a wide range of genetic tumor heterogeneity in both spatial and temporal dimensions, encompassing diverse single-nucleotide mutations, insertions, deletions and copy number variations ( 9 , 10 ). (spandidos-publications.com)
Other genetic and environmental factors are also likely to affect the risk of cancer in people with TP53 mutations. (medlineplus.gov)

Depending on tumor type and genetic profile, there are differences on how tumors look internally. (tum.de)
A new technique developed by Munich researchers, known as multi-spectral optoacoustic mesoscopy (MSOM), has now been shown capable of resolving optical contrast through tumor volumes that are at least 1,000 times larger than those possible with optical microscopy, enabling high-resolution visualization of tumor heterogeneity patterns. (tum.de)
The heterogeneity of glioblastoma can suppress immune cell function and lead to immune evasion, which presents a challenge in developing effective molecular therapies for tumor cells. (spandidos-publications.com)
Liquid biopsy is a useful tool for accurately monitoring dynamic changes in tumor immune heterogeneity and the tumor microenvironment. (spandidos-publications.com)
Glioblastoma (GBM) is characterized by significant genetic heterogeneity among tumor cells. (spandidos-publications.com)
Tumor cells are influenced by both genetic factors and environmental elements in the microenvironment, resulting in a complex regulation process ( 1 ). (spandidos-publications.com)
Furthermore, tumor heterogeneity has a significant impact on both the immune microenvironment and the infiltration of various immune cells within tumors, such as cytotoxic T lymphocytes (CTLs) ( 5 ), myeloid antigen-presenting cells ( 6 ) and cancer-associated fibroblasts (CAFs) ( 7 ). (spandidos-publications.com)
It has been discovered that the genetic structure of tumor cells and the components of the immune microenvironment interact with each other. (spandidos-publications.com)
This interaction results in a more complex alteration of both the heterogeneity of tumor cells and the heterogeneity of the tumor microenvironment. (spandidos-publications.com)
Consequently, the heterogeneity of tumor cells is constantly evolving. (spandidos-publications.com)
Thus, tumor heterogeneity has an important role in tumor development. (spandidos-publications.com)
Differential gene expression analysis represents one approach to analyzing important differences in the molecular profiles between normal and tumor tissue. (auburn.edu)

Disorders on the Autism spectrum have high levels of genetic heterogeneity and result from multiple genetic pathways including single gene mutation disorders (such as Fragile X Syndrome), regional and submicroscopic variations in the number of gene copies (either heritable or de novo), rare and common genetic variants, and chromosomal aberrations. (wikipedia.org)
The calculation of PRSs is based on genetic variants and effect sizes obtained from large studies using many different cohorts of patients. (ecco-ibd.eu)
However, PRSs usually do not incorporate functional information about causal variants, and the potential for heterogeneity in effect sizes among subgroups of individuals is disregarded entirely. (ecco-ibd.eu)
Taken together, human association, human brain and mouse model data now provide strong support for the idea that the neuropathology of many common, heritable brain disorders that lack gross microscopic neuropathologies will be identified in differences in patterns of brain connections that are mediated, in part, through common allelic variants in these "signaling related" CAMs. (uib.no)
Li-Fraumeni syndrome: not a straightforward diagnosis anymore-the interpretation of pathogenic variants of low allele frequency and the differences between germline PVs, mosaicism, and clonal hematopoiesis. (medlineplus.gov)

The heterogeneity LOD (HLOD) at the 6q, 2p and 14q loci in all families was 3.27, 1.66 and 1.24, respectively. (lu.se)

Cystic fibrosis is an inherited autosomal recessive genetic disorder that occurs through a mutation in a single gene that codes for the cystic fibrosis transmembrane conductance regulator. (wikipedia.org)
Sickle cell disease is an inherited genetic disorder, resulting from homozygous and compound heterozygote mutation in the β globin gene as a single base-pair point mutation (GAG to GTG) results in the substitution of glutamic acid (hydrophilic) to Valine (hydrophobic) in the 6th position of the β-chain of hemoglobin resulting in hemoglobin S formation [7]. (scirp.org)
Genetic heterogeneity is a common phenomenon with both single-gene diseases and complex multi-factorial diseases. (handlebar-online.com)
One copy of a mutated (changed) gene from one parent can cause the genetic condition. (handlebar-online.com)
While much of the variability to anti-tuberculosis drugs remains unexplained, one likely reason is genetic, in other words that different people respond differently to a drug because of their gene differences. (h3africa.org)
In addition, although a number of genetic causes of autosomal dominant pulverulent cataracts have been identified (including CRYBB1 ) this is the first gene to have been implicated in autosomal recessive nuclear pulverulent cataract. (molvis.org)
14 Also, critical research from brains of people with autism compared to schizophrenia and bipolar disorder show that while gene are expressed similarly, the tiniest differences lead to different outcomes. (autismsciencefoundation.org)

Using HOMOG, no evidence was found for heterogeneity with the five Japanese families in whom linkage was reported. (nih.gov)
Evidence for linkage was supported by linkage analysis with the two SNPs, with a maximal multipoint nonparametric linkage score of 1.57 and a maximal multipoint heterogeneity lod score of 2.11. (neurotransmitter.net)

Individuals with BD showed functional differences in the right posterior cingulate cortex during resting-state experiments, the left amygdala during emotional experiments, including those using a mixed (positive/negative) valence manipulation, and the left superior and right inferior parietal lobules during cognitive experiments, while hyperactivating the left medial orbitofrontal cortex during cognitive experiments. (nature.com)
Differences in age-at-onset and many untyped individuals seem to explain the lower lod scores. (nih.gov)
This information can be used to estimate genetic risk and detect individuals with several higher odds of developing the disease during their lifetime. (ecco-ibd.eu)
First, looking at the genetic profile of brain tissue obtained from the cortex of individuals affected by ASD, schizophrenia, bipolar depression and major depressive disorder, scientists revealed overlap in genetic expression. (autismsciencefoundation.org)

This paper explores the heterogeneity of glioblastoma and the immune microenvironment, providing a therapeutic basis for individualized treatment. (spandidos-publications.com)
New classifications based on genetic characteristics of the tissue microenvironment have been proposed and key carcinogenic signaling pathways have been described. (wjgnet.com)

While pathogenesis and heterogeneity in SLE are mediated by genetic, epigenetic, environmental and immunological factors, B cells and plasma cells (PC) are central contributors and a major therapeutic target. (lupusresearch.org)

Marked genetic heterogeneity is correlated to multiple levels of causation in many common human diseases including cystic fibrosis, Alzheimer's disease, autism spectrum disorders, inherited predisposition to breast cancer, and non-syndromic hearing loss. (wikipedia.org)
OBJECTIVE: Autism/autistic disorder (MIM number 209850) is a complex, largely genetic psychiatric disorder. (neurotransmitter.net)
Another landmark study included genetic information over 1 million people worldwide, including those with 17 different psychiatric (such as autism) and neurological (like Parkinson's Disease) disorders. (autismsciencefoundation.org)
Psychiatric disorders were more similar to each other in genetic profiles than they were to neurological disorders, and while autism showed distinct genetic features, it overlapped with schizophrenia 16 . (autismsciencefoundation.org)

The role of this spatial heterogeneity is not well understood or studied in living tumors. (tum.de)
Typically used to understand biological functions in tumors, optical microscopy, for example, gives limited insights into the spatial heterogeneity of tumors as it only accesses volumes of less than a cubic millimeter. (tum.de)

Poikilosis indicates that all systems display intrinsic heterogeneity, which is a normal state. (researchsquare.com)

These observations indicate a large degree of disease heterogeneity with underlying mechanistic differences in the quality, intensity and regulation of the B cell compartment. (lupusresearch.org)
In addition, we will investigate the plasma microbiome to determine the heterogeneity of a compartment of importance in lupus pathogenesis and B cell regulation. (lupusresearch.org)

What is the difference between autosomal dominant and autosomal recessive inheritance? (handlebar-online.com)

Furthermore, it is characterized by extreme genetic complexity and significant intra- and inter-tumoral heterogeneity. (auburn.edu)

Rowland Kao has similar interests in using genetic markers in bovine Tb to inform the transmission dynamics of this bacterial pathogen. (gla.ac.uk)
Next generation sequencing (NGS) is revolutionizing molecular ecology by simplifying the development of molecular genetic markers, including microsatellites. (datadryad.org)
Here we summarize the results of the large scale development of microsatellites for 54 non-model species using NGS and show there are clear differences amongst plants, invertebrates and vertebrates for the number and proportion of motif types recovered that are able to be utilised as markers. (datadryad.org)

High exposure to VPA can lead to carnitine depletion causing a misbalance between the intra-mitochondrial beta-oxidation and the microsomal co-oxidation, a pathway that produces toxic metabolites such as 4-en-VPA which inhibits ammonia elimination. (unav.edu)

In recent years there has been a rapid development in the understanding of the genetics underlying interindividual differences in drug metabolism and treatment efficacy. (h3africa.org)

However, the same considerations may apply to a broader range of genetic testing applications in various settings - preconception, prenatal, neonatal, or early childhood. (cdc.gov)

Therefore, although ASDs are known to be extremely heritable, their common genetic causes remain largely elusive because of the complex behavioral phenotypes and multigenic etiology of these disorders. (medscape.com)

Coordinates showing significant activation and/or connectivity differences between BD participants and controls during resting-state, emotional, or cognitive tasks were extracted. (nature.com)
In contrast to T cells, which did not exhibit a significant difference, B cells from PPARγ +/- showed an enhanced proliferative response to stimulation by either lipopolysaccharide or cross-linking of antigen receptors. (jci.org)
There are significant genetic and antigenic differences between these initial isolates. (iastate.edu)
There was a significant genetic influence on initial level of GCA (h[superscript 2] = 0.67), but not change (h[superscript 2] = 0.23). (ed.gov)
Finally, the authors found no significant differences by demographic strata - gender and race/ethnicity. (cdc.gov)

We want to describe differences in the phenotype, the genetic upset and immunological-pattern in this group of children and link these data to the risk of developing comorbidities and late complications. (lu.se)

Study the role of HIV-1 sequence diversity in understanding neurovirulence, neurotropism, discordant and compartmentalized viral evolution, CNS cell type-specific infection, regional genetic heterogeneity, and associated functional effects. (nih.gov)
What we hope might be neutral genetic differences in pathogens are useful as tracers of pathogen movement, but non-neutral genetic differences are increasingly appreciated to play a critical role in transmission heterogeneity. (gla.ac.uk)
Thus, genetic factors are thought to play a major role as compared to environmental factors (Rutter 2006 ). (springer.com)
The similarity of the genetic information in MZs provides a useful means for determining the disorder-causing role of environmental factors. (springer.com)
We will also determine the role of the microbiome in disease heterogeneity and its correlation with heterogeneous B cell variables. (lupusresearch.org)
The heterogeneity of the depression concept seems to play a differentiating role: metabolic syndrome and inflammation up-regulations appear more specific to the atypical depression subtype, whereas hypercortisolemia appears more specific for melancholic depression. (biomedcentral.com)
While the importance of genetic diversity in viral persistence and adaptation is well-established, the role of phenotypic heterogeneity - differences in the size, shape, and molecular composition of virus particles that may be otherwise genetically identical - remains unclear. (mpg.de)
however genetic factors play an important role in its etiology. (molvis.org)

Cyclospora cayetanensis is more closely related genetically to Eimeria species than to Cryptosporidium species (5) , and the two organisms have biological differences. (cdc.gov)
Recently, biological studies based on molecular methods are now being increasingly applied to examine the differences between MZs discordance for psychiatric disorders to unravel their possible causes. (springer.com)
Consequences of non-lagom extent of heterogeneity are introduced, along with a novel idea for therapy by reconstituting biological processes to lagom extent, even when the primary effect cannot be treated. (researchsquare.com)

These progeny can vary widely in their genetic sequence as well as in their structural and molecular characteristics. (mpg.de)
The study asked 1,289 parents of young children to compare profiles of hypothetical genetic tests with different characteristics. (cdc.gov)

Autosomal dominant inheritance is a way a genetic trait or condition can be passed down from parent to child. (handlebar-online.com)

I examine the effects of cognitive ability and personality traits on college graduation in a recent cohort of young Americans, and how the returns to these traits vary by family background, and find very substantial differences across family background groups in the personality traits that predict successful completion of college, particularly for men. (repec.org)

For traits related to emotional functioning, we also detected substantial overlapping genetic influences with depressive symptoms. (plos.org)
In this longitudinal study we examined the stability of general cognitive ability (GCA), as well as heterogeneity and genetic and environmental influences underlying individual differences in change. (ed.gov)
Genetic factors primarily contribute to stability, while change reflects the influence of nonshared environmental influences. (ed.gov)

Today we understand that type 1 diabetes affects children with different genetic background and that children with type 1 diabetes have an increased risk of developing comorbidities in other autoimmune diseases, such as celiac disease and thyroid disease, and also developing late complications (such as retinopathy). (lu.se)

The encouraging first results with molecular - genetic signatures should be validated and clinically applicable. (wjgnet.com)
2017 ). The current paper focuses on epidemiological and molecular genetic research studies in MZs with the purpose of unravelling useful insights on factors that can lead to SCZ and ASD. (springer.com)
A consanguineous family of Somali origin with four affected children was ascertained and recruited for molecular genetic analysis. (molvis.org)

As a result, twin studies of psychiatric disorders are greatly contributing to the elucidation of genetic and environmental factors in the etiology of psychiatric conditions. (springer.com)

Study the HBS1L-MYB (rs4895441 and rs9376090) genetic polymorphisms in Egyptian patients with β -thalassemia major and sickle cell disease and its relation to Hb F and severity of the disease. (scirp.org)
Study host genetic factors involved in regulating responsiveness to antiretroviral therapy and neuroprotective adjuvant therapies (pharmacogenomics). (nih.gov)
The aim of this study is to uncover genetic variations that influence differences in cooperative behavior. (repec.org)
Through this study we aim to explore and determine host genetic factors contributing to pharmacokinetic (i.e. drug concentration) and dynamic (i.e. treatment outcome) variability in TB patients. (h3africa.org)
The more specific aim of our research is to study the heterogeneity of childhood type 1 diabetes. (lu.se)

In this talk, I will describe our efforts using these tools to understand how phenotypic heterogeneity in evolutionarily divergent human respiratory viruses contributes to aspects of virus replication and transmission. (mpg.de)

Case-control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, regardless of their onset age. (nature.com)
Using these methods to analyse a dichotomous disease event alone ignores the probability of later disease onsets in currently healthy subjects and incorrectly considers that all subjects with diseases equally contribute to the likelihood for inference, irrespective of differences in their onset age. (nature.com)
In sickle cell disease patients, Genetic polymorphisms in HBS1L-MYB (rs9376090 & rs4895441) affect the level of Hb F which could improve the prognosis of these patients. (scirp.org)
Genetic and antigenic variability between isolates, even within a country, remains a continuous challenge to control of the disease. (iastate.edu)
Our goal is to elucidate the B cell undergirding of SLE heterogeneity in unique cohorts of Black patients, a population with the highest concentration of severe disease. (lupusresearch.org)

Viral and host genetic factors contribute to pathophysiology of HIV-1 associated CNS dysfunction. (nih.gov)
Identify viral and host genetic signatures associated with HIV-1 associated CNS dysfunction. (nih.gov)

Laboratory experiments have documented substantial heterogeneity in social preferences, but little is known about the origins of such behavior. (repec.org)

This meta-analysis aims to comprehensively reassess brain activation and connectivity in BD in order to identify replicable differences that converge across and within resting-state, cognitive, and emotional neuroimaging experiments. (nature.com)
Understanding these differences can help identify unmet needs in AMI prevention and management to guide targeted interventions. (cdc.gov)

The perturbation-lagom-TATAR countermeasures-regulator (PLTR) model combines the effects of perturbation and lagom (allowed and sufficient extent of heterogeneity) in a system with tolerance, avoidance, repair, attenuation and resistance (TARAR) countermeasures, and possible regulators. (researchsquare.com)

For genetic counselling it would seem important to resolve the mode of genetic interaction. (lu.se)

This heterogeneity can vary greatly between different types of immune cells, leading to further complexity in understanding the immune response to tumors. (spandidos-publications.com)

Associations of genetic factors with malignant gliomas have been modest. (aacrjournals.org)
Delineate the genetic basis of host restriction factors in CNS cell types. (nih.gov)
The genetic factors involved in these cases are unclear. (medlineplus.gov)

Anatomy24

Diseases43

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Psychiatry and Psychology4

Phenomena and Processes70

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena4

Information Science6

Named Groups5

Health Care11

Geographicals3

Clinical12

Allelic heterogeneity1

Genomic5

Mechanisms9

Genome8

Polymorphism1

Variation9

Populations6

Genes6

Mutations4

Tumor12

Variants5

Loci1

Gene7

Linkage2

Individuals4

Microenvironment2

Epigenetic1

Autism4

Spatial2

Intrinsic1

Regulation2

Recessive1

Extreme genetic1

Markers3

Intra1

Genetics1

Range of genetic1

Phenotypes1

Significant5

Phenotype1

Role8

Biological3

Characteristics2

Autosomal dominant1

Substantial differences1

Influences3

Different genetic1

Molecular genetic3

Etiology1

Study5

Contributes1

Disease5

Viral2

Origins1

Identify2

Extent1

Resolve1

Understanding1

Factors3