Diet alleviates diet induced insulin resistance. Medical search. Frequent questions

Application of the METTL3 methyltransferase inhibitor, STM2457, increased the level of insulin sensitivity in hepatocytes. (biomedcentral.com)
These findings offer unique insights into the role that METTL3-mediated m 6 A modifications of CYP2B6 play in regulating insulin sensitivity in hepatocytes and provide key information for the development of strategies to induce m 6 A modifications for the clinical treatment of NAFLD. (biomedcentral.com)
As ATP production plummets in the cell, the ratio of ATP to AMP is reduced, which triggers the nutrient sensing molecule AMPK to actively downregulate the synthesis of fat, increase the use of fat for energy, and increase insulin sensitivity. (lifespan.io)
Feeding mice a selenium-enriched high-fat diet alleviates diet-induced insulin resistance with increased insulin sensitivity, decreased tissue inflammation, and elevated IR expression in WAT. (publisso.de)
Consequently, decreasing GPx3 using siRNA technique reduced IR expression and insulin sensitivity in 3T3-L1 preadipocytes. (publisso.de)
Overall, our data identify GPx3 as a potentially novel regulator of IR expression and insulin sensitivity in adipose tissue. (publisso.de)
For example, after a resistance training workout, your insulin sensitivity is increased and your cells are primed to uptake nutrients in muscle rather than fat. (wacfitness.com)
What is insulin sensitivity? (wacfitness.com)
Insulin sensitivity is defined by how much insulin is required to remove glucose from the blood and into the cells. (wacfitness.com)
If you have low insulin sensitivity (insulin resistance), then you're going to have excess glucose in your blood . (wacfitness.com)
Glycemic Control contains well designed ingredients such as probiotic strains, ALA and galactomannan which can help restore the healthy bacteria, improve insulin sensitivity and help regulate blood sugar. (thegoodbug.com)
Chronic inflammation can impair insulin sensitivity and disrupt normal glucose regulation. (thegoodbug.com)
Furthermore, gut bacteria produce various metabolites, including lipopolysaccharides (LPS) and butyrate, which can affect insulin sensitivity and inflammation. (thegoodbug.com)
Decreasing the levels of lipopolysaccharide (LPS) and proinflammatory cytokines to increase insulin sensitivity, reducing the abundance of harmful flora related to insulin resistance and the inflammatory response. (thegoodbug.com)
In this state, your insulin levels remain low and help your body maintain insulin sensitivity. (dailyonoff.com)

The results of the animal experiment revealed that QLHQD alleviated lipid metabolism disorders, obesity, insulin resistance, and inflammation in rats with hyperlipidemia induced by high-fat diets. (bvsalud.org)
3] Since silymarin alleviates inflammation, this could be a mechanism responsible for its benefits against liver damage, insulin resistance, and weight loss. (theguerrilladiet.com)
Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF-кB pathway through microbiota-gut-brain axis - Phytother Res 2023 Apr 10 - 'Diabetic cognitive impairment (DCI) is a serious neurodegenerative disorder caused by diabetes, with chronic inflammation being a crucial factor in its pathogenesis. (qualitycounts.com)
Anti-inflammatory Activity of Isomaltodextrin in a C57BL/6NCrl Mouse Model with Lipopolysaccharide-induced Low-grade Chronic Inflammation (Doctoral dissertation). (inventbiotech.com)
A number of chronic conditions such as cancer, diabetes, cardiovascular disorders, autoimmune diseases, and neurodegenerative disorders emerge as a result of tissue injury and genomic changes induced by constant low-grade inflammation in and around the affected tissue or organ. (encyclopedia.pub)
According to the National Cholesterol Education Program's Adult Treatment Panel III (NCEP: ATP III), metabolic syndrome is associated with abdominal obesity, dyslipidemia, hyperglycemia, inflammation, insulin resistance, or diabetes mellitus, as well as an increased risk of developing cardiovascular disease. (encyclopedia.pub)
have reportedly shown that apigenin improves obesity and obesity induced inflammation [ 8 ] . (encyclopedia.pub)
Apigenin has also been reported to attenuate inflammation and the resultant pathological alterations in rats fed with a high fat, fructose diet [ 9 ] . (encyclopedia.pub)
Obesity is thought to promote CVD as a result of chronic low-grade inflammation and insulin resistance [ 13 ]. (biomedcentral.com)
Inflammation may be triggered by diets heavy in sugar, refined carbs, and saturated fats, whereas inflammation can be mitigated by eating foods rich in fibre, antioxidants, and healthy fats (3). (mofo.club)
Some of these include sugar, which can exacerbate acne by increasing inflammation, leading to rises in blood sugar and insulin resistance. (mofo.club)
Avoid processed foods at all costs because they are notorious for being loaded with inflammation-inducing ingredients including refined sugars, flours, and fats (3). (mofo.club)
Chronic inflammation produces a variety of issues in the human body and can cause leptin resistance. (bioptimizers.com)
Conversely, chronic inflammation blocks leptin signaling, causing leptin resistance. (bioptimizers.com)
Therefore, leptin resistance and chronic inflammation are like chicken and eggs that feed into each other. (bioptimizers.com)
Besides high insulin levels, inflammation can lead to declining brain health. (dailyonoff.com)
The ketones the body produces in this diet have shown the potential to be a long-term treatment for inflammation . (dailyonoff.com)

The obese model mice, induced by feeding high-fat diet (HFD), were treated with BMJ by gavage for 10 weeks. (nih.gov)
Consequently, these results sustain BMJ as a novel functional food for obesity, on the basis of its opposing effects on HFD-induced obesity in mice. (nih.gov)
In this study, the effects of R. oldhamii leaf extract on inhibiting the free fatty acid (FFA)-induced accumulation of fat in HepG2 cells and on improving fatty liver syndrome in mice with high fat diet (HFD)-induced NAFLD were investigated. (medsci.org)
For the in vivo assay, C57BL/6 mice were randomly assigned to three groups ( n = 5), including the normal diet group, the HFD group and the HFD+EtOAc group. (medsci.org)
In addition, the EtOAc fraction of R. oldhamii leaf significantly improved fatty liver syndrome and reduced total cholesterol (TC) and triglyceride (TG) in HFD-induced NAFLD mice at a dosage of 200 mg/kg BW. (medsci.org)
Thus, biochemical indexes related to diet-induced hyperglycemia were mainly detected using hematoxylin and eosin (H&E) staining, fluorescence quantitative PCR, and ultrahigh performance liquid chromatography-mass spectrometry (UPLC-MS). Then 16s rRNA gene sequencing was performed to analyze the effects of CEH on the gut microbiome in high-fat diet (HFD)-fed mice. (rsc.org)
CYP450 family members, especially Cyp2b10, whose homolog in humans is CYP2B6, led to a noticeable increase in m 6 A levels in HFD-induced mice livers. (biomedcentral.com)
In this study, transplantation of EVs from human induced pluripotent stem cell-derived MSCs (iPSC-MSC-EVs) resulted in significant restoration of ovarian follicle numbers, improved granulosa cell proliferation, and inhibition of apoptosis in chemotherapy-damaged granulosa cells, cultured ovaries, and in vivo ovaries in mice. (zoores.ac.cn)
Researchers at the University of Alabama in Birmingham (USA) demonstrated that treatment with nitric oxide alleviated disease progression in obese mice with type 2 diabetes. (sdam-svou-kvartiru.ru)
A novel therapy alleviated obesity and type 2 diabetes in mice fed a high-fat diet. (sdam-svou-kvartiru.ru)
A control group of mice received the same high-fat diet but no gel treatment. (sdam-svou-kvartiru.ru)
In addition, the mice from the nitric oxide group showed a improved glucose tolerance as well as a Decreases in fasting insulin and leptin levels . (sdam-svou-kvartiru.ru)
University of Alabama at Birmingham: A novel therapy ameliorates obesity and Type 2 diabetes in mice fed a high-fat diet (published: 29.04.2022), uab.edu - Guang Ren, Patrick Tae Joon Hwang, et al. (sdam-svou-kvartiru.ru)
Mice that were fed a diet to induce obesity lost weight after taking silymarin extracted from milk thistle. (theguerrilladiet.com)
High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice. (i4k.xyz)
gigasNakai alleviates hyperglycemia and hepatic steatosis in C57BL/KsJ-mice [12]. (euromedh2020.com)
sessiliflorusinhibits bodyweight gain in high-fat diet plan- (HFD-) induced mice without Olumacostat glasaretil symptoms of diarrhea [14]. (euromedh2020.com)
In a study conducted on high-fat-diet-induced mice, prophylactic use of low (15 mg/kg per day) and medium (30 mg/kg each day) doses of Vitamin C lowered the risk of NAFLD development, as evidenced by the significantly decreased weight in the physique, adipose tissue mass, and steatosis [25]. (atminhibitor.com)
Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity mice. (inventbiotech.com)
Saponins from Boussingaultia gracilis prevent obesity and related metabolic impairments in diet-induced obese mice. (inventbiotech.com)
To investigate the mechanism of cardiac injury induced by obesity and the cardioprotective effect of empagliflozin, we employed proteomic techniques to examine cardiac protein expression in obese mice and the changes in protein expression after empagliflozin intervention. (biomedcentral.com)
However, the team found that A. indistinctus administration in mice was able to improve lipid accumulation and alleviate IR, thereby suggesting the role that IS-associated bacteria could play in treating IR. (technologynetworks.com)

Empagliflozin reduces body weight, improves glucose and lipid metabolism, alleviates obesity-induced cardiac ventricular wall thickening, and lowers cardiac tissue collagen. (biomedcentral.com)
Further examination of DEPs revealed that following empagliflozin treatment, the expressions of Apoe, Apoc1, Saa2, Apoa2, and Pon1 altered dramatically, suggesting that these proteins may be the main proteins that empagliflozin uses to treat obesity-induced aberrant lipid metabolism. (biomedcentral.com)
However, larger, adequately powered, randomized, placebo-controlled, double-blind trials examining multiple measures of carbohydrate and lipid metabolism and insulin homeostasis are needed. (lww.com)

According to ELISA, Western blotting (WB) and reverse transcriptase polymerase chain reaction (RT-PCR), TFH significantly downregulates expression levels of diglyceride (DAG)-activated protein kinase C (PRKCA), mitogen activated protein kinase 10 (MAPK10), human nuclear factor κB subunit p65 (NF-κB p65) and tumor necrosis factor-α (TNF-α) in pancreas of STZ-induced rats. (bvsalud.org)
Gluten peptides enter the pancreas where they affect the morphology and might induce beta-cell stress by enhancing glucose- and palmitate-stimulated insulin secretion. (mdpi.com)
Human insulin is a peptide hormone produced by the beta-cells (β-cell) of the pancreas, and its release is dependent on glucose levels in the circulation, in addition amino acids, incretins and cholecystokinin also promote its release. (researchsquare.com)
Furthermore, apart from favoring insulin release in the pancreas, Vitamin D also induces adiponectin release from fat tissue [7]. (atminhibitor.com)
After a meal, insulin is secreted from the pancreas and signals to your cells in your liver, fat, and muscles to take in nutrients. (wacfitness.com)
The pancreas secretes the hormone insulin, which tells your cells to bring glucose into your cells. (bioptimizers.com)

Beneficial effects of pre-germinated brown rice treatment high-fat diet-induced metabolic syndrome. (greenmedinfo.com)

Moreover, it improved glucose tolerance, reduced insulin level and HOMA-IR value, and alleviated insulin resistance. (nih.gov)
RESULTS: After TFH intervention, the fasting blood-glucose level of T2DM rats induced by high-fat and high-glucose diet combined with streptozotocin (STZ) was downregulated significantly, while body weight, serum liquid level, insulin levels and homeostatic model assessment of insulin resistance (HOMA-IR) were improved. (bvsalud.org)
IR is calculated with the use of homeostasis model assessment insulin resistance index (HOMA-IR) using the formula: fasting plasma glucose (mmol/L) × fasting serum insulin (mU/mL)/22.5. (researchsquare.com)
They were assessed for insulin resistance, which was defined as a homeostatic model assessment of IR (HOMA-IR) of at least 2.5. (technologynetworks.com)

The researchers combined unbiased fecal metabolomics with metagenomics, host metabolomics and transcriptomics data to determine the role of the microbiome in insulin resistance. (technologynetworks.com)

Some studies have linked intake of a GF diet to reduced obesity and T2D and suggested a role in reducing leptin- and insulin-resistance and increasing beta-cell volume. (mdpi.com)
The story with leptin, however, is not straightforward, as excess body fat can lead to leptin resistance . (bioptimizers.com)
Other factors can also contribute to leptin resistance, and leptin resistance can make fat loss very challenging. (bioptimizers.com)
What Is Leptin Resistance? (bioptimizers.com)
The more body fat you have, the more leptin you have, and elevated levels are correlated with leptin resistance. (bioptimizers.com)
Leptin resistance has numerous unhealthy effects, such as promoting fat gain and related metabolic and poor inflammatory health. (bioptimizers.com)
Leptin resistance is worth addressing whether you want to look better, perform better, or live a long and healthy life. (bioptimizers.com)
What Causes Leptin Resistance And Low Leptin Function? (bioptimizers.com)
While excessive body fat can cause leptin resistance, there's more to the story. (bioptimizers.com)

These findings suggested that the protective effects of BMJ on diet-induced obesity may be involved in gut microbiota-SCFAs-LPS-inflammatory axis. (nih.gov)
The mechanism of action in this regard might involve regulating the IRE1-α/IKKB-ß/NF-κB signaling pathway in the liver, thereby attenuating inflammatory responses and insulin resistance. (bvsalud.org)
Vitamin D and Vitamin D receptors take part in the liver, adipose, and gut homeostasis, owing to its notable insulin-sensitizing, anti-inflammatory, and anti-fibrotic CXCR4 Source effects [11]. (atminhibitor.com)
High levels of LPS are associated with insulin resistance, while butyrate may have anti-inflammatory and beneficial effects. (thegoodbug.com)
Diet can benefit acne by lowering inflammatory levels, for example. (mofo.club)
Acne can produce redness and swelling, but retinol's anti-inflammatory properties can help alleviate such symptoms. (mofo.club)

A new therapeutic approach using nitric oxide resulted in far-reaching positive changes in metabolism and alleviated the effects of obesity and type 2 diabetes. (sdam-svou-kvartiru.ru)
IR alters glucose metabolism, resulting in an elevation in insulin production by beta-cells. (researchsquare.com)
Insulin resistance (IR) is clinically characterized as the inability of insulin to enhance glucose uptake and metabolism. (researchsquare.com)
Therefore, if we take into consideration the repercussions of IR on the different organs, it is interesting to differentiate between the outcomes secondary to over activation of signaling pathways that remain sensitive to insulin versus changes that are a consequence of an impaired ability of insulin to regulate glucose metabolism. (researchsquare.com)
A multi-institutional study led by Dr. Tadashi Takeuchi at Stanford University and published in Nature , demonstrates the specific role that various species within the gut microbiota play in carbohydrate metabolism, suggesting the potential for insulin-sensitive (IS) gut bacteria to combat insulin resistance (IR) and serve as a treatment for individuals with Type 2 diabetes. (technologynetworks.com)
Previous studies have indicated that many species in the gut microbiota are involved in carbohydrate metabolism, which can contribute to insulin resistance when unregulated. (technologynetworks.com)

The T2DM model was evaluated through fasting blood glucose level, body weight, serum biochemical indicators, insulin levels and homeostatic model assessment of insulin resistance. (bvsalud.org)

Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of the mechanisms underlying this relationship. (nature.com)
Suppression of Gut Dysbiosis Reverses Western Diet-Induced Vascular Dysfunction. (inventbiotech.com)

Insulin receptor signaling is crucial for white adipose tissue (WAT) function. (publisso.de)
By using multiple mouse models of obesity and insulin resistance, we identify a common downregulation of IR with a reduction of mRNA expression of selenoproteins Txnrd3, Sephs2, and Gpx3 in gonadal adipose tissue. (publisso.de)
Consistently, GPX3 is also decreased in adipose tissue of insulin-resistant and obese patients. (publisso.de)

CONCLUSION: QLHQD is able to significantly mitigate hyperlipidemia induced via high-fat diets in rats. (bvsalud.org)
moschataDuchesne, known as pumpkin also, assists improve lipid profile, insulin level of resistance, and additional related complications in obese rats [11]. (euromedh2020.com)
Germinated brown rice ameliorates obesity in high-fat diet induced obese rats. (greenmedinfo.com)
Comparative study between atorvastatin and losartan on high fat diet-induced type 2 diabetes mellitus in rats. (livedna.net)
Mechanisms of the protective effects of curcumin against indomethacin-induced gastric ulcer in rats. (livedna.net)
The possible antidotal effect of alpha-lipoic acid against acetaminophen induced hepatotoxicity in rats. (livedna.net)
Protective effect of hydrogen sulfide against cold restraint stress-induced gastric mucosal injury in rats. (livedna.net)
Potential protective role of quercetin against chronic doxorubicin induced cardiotoxicity in rats. (livedna.net)
Enhanced Nitric Oxide Synthase-nitric oxide (NOS-NO) signaling underlies sildenafil amelioration of cyclosporine-induced nephrotoxicity in rats. (livedna.net)
Atorvastatin protects against aorta contractility impairment in insulin-resistant rats. (livedna.net)
The antihyperglycemic effect of curcumin in high fat diet fed rats. (livedna.net)
Evaluation of hepatoprotective and anticancer properties of aqueous olive leaf extract in chemically induced hepatocellular carcinoma in rats. (livedna.net)
Hepatocyte lysosomal membrane stabilization by olive leaves against chemically-induced hepatocellular neoplasia in rats. (livedna.net)

In our recent research, we observed that adipocytes express MHC class II molecules and co-stimulatory molecules CD80/CD86, and that their expression significantly increases in response to high fat diet (HFD) challenges ( 8 ). (frontiersin.org)
Analysis using dot blot and epitranscriptomic chips revealed that the m 6 A modification pattern of the transcriptome in high-fat diet (HFD)-induced fatty liver and free fatty acid (FFA)-induced fatty hepatocytes showed significant changes. (biomedcentral.com)
Furthermore, the nitric oxide gel also protected the animals from non-alcoholic fatty liver, which often develops in the context of a high-fat diet. (sdam-svou-kvartiru.ru)
Using proteomic techniques the impact of the sodium-glucose transport protein 2 inhibitor empagliflozin on cardiac protein expression in a mouse model was assessed under normal and high-fat diet (HFD) conditions. (biomedcentral.com)
Researchers believe that propolis could be a possible treatment for high-fat diet induced obesity. (fitgreenvibes.com)
Whether losing some weight or improving other physical conditions, this low-carb and high-fat diet has become the go-to for many. (dailyonoff.com)

Pterostilbene alleviated neuroinflammation by suppressing oxidative stress and carbonyl stress damage, astrocyte and microglia activation, and dopaminergic neuronal loss. (qualitycounts.com)

Proteins involved in the fatty acid synthesis pathway interact with those involved in the insulin signaling pathway. (biomedcentral.com)
We selected articles from the PubMed database that featured the terms 'insulin resistance' and 'signaling pathway. (researchsquare.com)
The intracellular signaling pathway of IR is complex, involving several factors and molecules, and activation of specific points has been demonstrated in individuals with insulin resistance. (researchsquare.com)

A novel therapy alleviated the effects of severe obesity and type 2 diabetes due to the use of Nitric Oxide . (sdam-svou-kvartiru.ru)
Consequently, lack of insulin receptor (IR) in WAT results in a diabetes-like phenotype. (publisso.de)
2 Deficiency of insulin production or activity results in diabetes mellitus (DM), which can be either type 1 (T1DM) when there is a destruction of the β-cell by an autoimmune process, or type 2 (T2DM) in which there is a failure of the β-cell to produce insulin. (researchsquare.com)
Clinical studies suggest that type 2 diabetes mellitus (T2DM) is a risk factor for cognitive decline and dementia, and have found evidence that insulin resistance (IR) occurs in the brain of patients with T2DM and Alzheimer disease (AD). (nature.com)
IR, which is when cells are unable to respond to insulin and extract glucose from the blood, is one of the key factors responsible for the development of Type 2 diabetes. (technologynetworks.com)
On top of controlling diabetes , this diet can improve your brain health and cognitive functions. (dailyonoff.com)

Reduced insulin receptor expression and altered DNA methylation in fat tissues and blood of women with GDM and offspring. (inventbiotech.com)

1 The main function of insulin is to maintain glucose homeostasis, enabling glucose absorption and inhibiting hepatic gluconeogenesis, besides acting as an anabolic hormone that favors not only the absorption of amino acids and fatty acids, but also promotes cell growth and energy storage. (researchsquare.com)

Thus, the EtOAc fraction of R. oldhamii leaf and its derived phytochemicals have great potential in preventing FFA-induced fat accumulation. (medsci.org)

Muscles that are glycogen depleted make you more insulin sensitive because there is more "room" for carbs in the muscle. (wacfitness.com)
This condition happens when the body produces too much insulin from excessive carbs and becomes less responsive to the substance. (dailyonoff.com)

For instance, VDR in pancreatic beta cells regulates the insulin gene [11]. (atminhibitor.com)
Firstly, the body regulates pleasure and induces motivation and reward through the dopamine neurotransmitter. (dailyonoff.com)

This Review highlights these observations and discusses intervention studies which suggest that the restoration of insulin activity in the hippocampus may be an effective strategy to alleviate the cognitive decline associated with T2DM and AD. (nature.com)
Dementia and cognitive decline are common consequences of constant high insulin levels . (dailyonoff.com)

Insulin resistance (IR) in hepatocytes endangers human health, and frequently results in the development of non-alcoholic fatty liver disease (NAFLD). (biomedcentral.com)

While it's unlikely that specific detox diets will help you to lose weight or detoxify any more than an otherwise good diet based on whole, natural, and unrefined foods, some nutrients might help the body to support its own innate detoxification processes and reduce the damage that toxins may cause. (nuzest.com)
The nutrients in your diet are responsible for the acne-fighting benefits it provides. (mofo.club)

Can Creatine Supplementation Alleviate Long COVID Symptoms? (medicaldaily.com)
High sugar and insulin levels can cause the body to release too much cortisol and adrenaline, resulting in increased heart rate, blood pressure, and other "hypoglycemic" symptoms. (dailyonoff.com)

Inducing Gpx3 expression via selenite treatment enhances IR expression via activation of the transcription factor Sp1 in 3T3-L1 preadipocytes and improves adipocyte differentiation and function. (publisso.de)
cocosWolf, offers insulin-sensitizing activity in ST13 preadipocytes [15] as well as the chloroform small fraction ofZ. (euromedh2020.com)

Several mechanisms have been suggested to justify the development of IR, among which are genetic alterations in proteins of the insulin action cascade, visceral fat thickening and fetal malnutrition. (researchsquare.com)
Alterations in normal insulin signaling pathways contribute as increased risk factors for the development of dysfunctions on the various organs. (researchsquare.com)

Detox diets and programs were once more commonly known as liver cleanses . (nuzest.com)

When it comes to fat loss, insulin is the mother of all hormones. (wacfitness.com)
Research suggests that following a keto diet may increase the production of happy hormones or dopamine and serotonin neurotransmitters. (dailyonoff.com)

In contrast, low-carb or keto diets limit a person's carbohydrate intake, prompting the body to turn to fat for energy. (dailyonoff.com)

Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)

2012. Platelet-derived growth factor-BB induces cystathionine γ-lyase expression in rat mesangial cells via a redox-dependent mechanism. (livedna.net)

Importantly, both lifestyle (diet and exercise) and pharmacological interventions that are known to alleviate peripheral IR effectively restore hippocampal neuroplasticity in rodent models of T2DM and AD, and this effect may be due to restoration of insulin signalling in the hippocampus. (nature.com)

However, how do low-carb and keto diets work, and how do they help a person's mental and brain health? (dailyonoff.com)

Anatomy20

Organisms13

Diseases36

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Psychiatry and Psychology2

Phenomena and Processes84

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture14

Information Science3

Health Care16

Sensitivity15

Inflammation17

Mice22

Lipid metabolism3

Pancreas6

Metabolic syndrome1

HOMA-IR4

Microbiome1

Leptin9

Inflammatory6

Metabolism6

Homeostatic model asse1

Dysfunction2

Adipose3

Rats13

High-fat diet6

Oxidative1

Pathway3

Diabetes6

Receptor expression1

Homeostasis1

Accumulation1

Carbs2

Regulates2

Cognitive decline2

NAFLD1

Nutrients2

Symptoms2

Preadipocytes2

Alterations2

Liver1

Hormones2

Carbohydrate1

Protein1

Mechanism1

Pharmacological1

Person's1