The two active ingredients, 4-vinylcyclohexene diepoxide (VCD) and triptolide, deplete all stages of follicles in the female and disrupt spermatogenesis in the male. (escholarship.org)
Compromised fertility in free feeding of wild-caught Norway rats Rattus Novergicus with a liquid bait containing 4-Vinylcyclohexene Diepoxide and Triptolide. (contrapeststore.com)
It contains two ingredients, 4-vinylcyclohexene diepoxide (VCD) and triptolide, which eliminate immature ovarian follicles, prevent sperm maturation and reduce sperm motility. (parkerecopestcontrol.com)
Exposure1
A study employing a perimenopause model induced by chronic exposure to 4-vinylcycloxene diepoxide explored how estradiolAuthor Manuscript Author Manuscript Author Manuscript Author ManuscriptAlcohol. (ck2inhibitor.com)
Chemical2
Atorvastatin lactone diepoxide is a chemical compound that is commonly used as a cholesterol-lowering drug. (clearsynth.com)
Surface chemical analysis of RO membranes grafted with poly(ethylene glycol) diglycidyl ether (PEG diepoxide) indicates that PEG is present on the surface. (doe.gov)
Properties2
Finally, the curing properties of the diepoxide with lysine-based α-amino-ε-caprolactam were analyzed by rheological measurements. (beilstein-journals.org)
We present an experimental investigation of the mechanical properties of solid vitrimer samples obtained by incorporating a diepoxide into a commercial PBT in the presence of a Zn(II) catalyst using batch compounder and injection molding machines. (hal.science)
High2
In conclusion, atorvastatin lactone diepoxide is a useful medication for the treatment of high cholesterol levels in the blood. (clearsynth.com)
G35 A high molecular compound of a polyethylene glycol and a diepoxide that is esterified with nitroterephthalic acid. (rajanalytical.com)
Presence1
The mechanism of diepoxide and adipic acid (AA) reaction in the presence of benzyltriethylammonium chloride and 1,4-diazobicyclo[2,2,2] octane has been proposed. (edu.ua)
Ovarian8
Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition. (wakehealth.edu)
Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. (cdc.gov)
This study was performed to determine the effects of LIPUS on granulosa cells (GCs) apoptosis and protein expression of B-cell lymphoma-2 (Bcl-2) and BCL2-Associated X (Bax) in 4-vinylcyclohexene diepoxide (VCD)-induced POF mice and investigate the mechanisms of LIPUS on ovarian function and reserve capacity. (biomedcentral.com)
Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes. (wakehealth.edu)
ContraPest works by using a chemical known as 4-vinylcyclohexene diepoxide, or VCD, to destroy female rats' ovarian follicles in their most immature form, each of which contains one egg. (arizona.edu)
In rodents, accelerated ovarian failure (AOF) induced by systemic injection of 4-vinylcyclohexane diepoxide mimics the estrogen fluctuations seen in human menopause including the perimenopause transition (peri-AOF) and postmenopause (post-AOF). (cornell.edu)
In order to prevent female rats from reproducing, a substance known as 4-vinylcyclohexene diepoxide, or VCD, which is the ingredient used in rat birth control, is used to kill the ovarian follicles in their immature state, each of which carries one egg. (bestnewsfit.com)
In the present study, accelerated ovarian failure (AOF) in estrogen receptor beta (ERβ) reporter mice was induced by 4-vinylcyclohexene diepoxide (VCD) in young mice to model early-stage ovarian failure (peri-AOF) characteristic of peri-menopause. (cornell.edu)
Butadiene5
Mutagenicity of a glutathione conjugate of butadiene diepoxide. (nih.gov)
We confirmed our previous work showing that expression of rat glutathione (GSH) transferase 5-5 enhances the mutagenicity of butadiene diepoxide in Salmonella typhimurium TA1535. (nih.gov)
A GSH-butadiene diepoxide conjugate was isolated and fully characterized by mass spectrometry and nuclear magnetic resonance as S-(2-hydroxy-3,4-epoxybutyl)GSH. (nih.gov)
The conjugate had a t(½) of 2.6 h (pH 7.4, 37 °C) and was considerably more mutagenic than butadiene diepoxide or monoepoxide in S. typhimurium. (nih.gov)
To initiate studies designed to identify the mutagenic spectrum associated with butadiene diepoxide-induced N 2 -N 2 guanine intrastrand cross-links, site specifically adducted oligodeoxynucleotides were synthesized in which the adducted bases were centrally located within the context of the human ras 12 codon. (elsevierpure.com)
Salmonella1
Genetic Toxicity Evaluation of 4-Vinyl-1-cyclohexene Diepoxide in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
Mice1
Our present study was performed on the POF mice model induced by 4-vinylcyclohexene diepoxide (VCD). (biomedcentral.com)