Dicoumarol (INN) or dicumarol (USAN) is a naturally occurring anticoagulant drug that depletes stores of vitamin K (similar to warfarin, a drug that dicoumarol inspired). (wikipedia.org)
Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs. (wikipedia.org)
Coumarin derivatives include warfarin, dicumarol, phenprocoumon and acenocoumarol. (nih.gov)
Finally, they used a chemical inhibitor of NQ01 (dicoumarol), which is a relative of warfarin, to successfully sensitise tamoxifen-resistant cells. (sciencedaily.com)
Its fermentation product dicoumarol is a potent anti-clotting agent and forms the basis of warfarin. (vin.com)
Dicoumarol is a naturally occurring anticoagulant that functions as a functional vitamin K depleter (similar to warfarin, a drug that dicoumarol inspired). (hemostasis.com)
Inhibitor2
Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor. (researchmap.jp)
Herein, we have used hydrogen/deuterium exchange monitored by mass-spectrometry (HDXMS) to investigate the structural dynamics of NQO1 in three ligation states: without ligands (NQO1apo), with FAD (NQO1holo) and with FAD and the inhibitor dicoumarol (NQO1dic). (preprints.org)
Heparin1
Dicoumarol was used, along with heparin, for the treatment of deep venous thrombosis. (wikipedia.org)
Anticoagulant1
Identified in 1940, dicoumarol became the prototype of the 4-hydroxycoumarin anticoagulant drug class. (wikipedia.org)
Toxicity2
These compounds are not antagonists of Vitamin K directly-as they are in pharmaceutical uses-but rather promote depletion of vitamin K in bodily tissues allowing vitamin K's mechanism of action as a potent medication for dicoumarol toxicity. (wikipedia.org)
The mechanism of action of Vitamin K along with the toxicity of dicoumarol are measured with the prothrombin time (PT) blood test. (wikipedia.org)
Oxidoreductase2
Dicoumarol inhibits rat NAD(P)H:quinone oxidoreductase in vitro and induces its expression in vivo. (nel.edu)
Stiborova M, Levova K, Barta F, Dracinska H, Sulc M, Hodek P, Frei E, Arlt V, Schmeiser H. Dicoumarol inhibits rat NAD(P)H:quinone oxidoreductase in vitro and induces its expression in vivo. (nel.edu)
Chemical1
Dicoumarol is a natural chemical substance of combined plant and fungal origin. (wikipedia.org)
Agent1
This discovery remained unnoticed until twenty years later the 'hemorrhagic agent' was identified as dicoumarol, 3,3-methylene-bis. (eur.nl)
Blood1
Dicoumarol was isolated by Karl Link's laboratory at University of Wisconsin, six years after a farmer had brought a dead cow and a milk can full of uncoagulated blood to an agricultural extension station of the university. (wikipedia.org)
Anticoagulant drug3
Dicoumarol (INN) or dicumarol (USAN) is a naturally occurring anticoagulant drug that depletes stores of vitamin K (similar to warfarin, a drug that dicoumarol inspired). (wikipedia.org)
Identified in 1940, dicoumarol became the prototype of the 4-hydroxycoumarin anticoagulant drug class. (wikipedia.org)
Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs. (wikipedia.org)
Inhibition1
Inhibition by dicoumarol and enhancement in viral hepatitis B. (nih.gov)
Prothrombin2
The mechanism of action of Vitamin K along with the toxicity of dicoumarol are measured with the prothrombin time (PT) blood test. (wikipedia.org)
When toxic hay or silage is consumed for several weeks, dicumarol alters proenzymes required for synthesis of prothrombin, resulting in hypoprothrombinemia (by preventing formation of the active enzyme). (merckvetmanual.com)
Coagulation2
It is a derivative of coumarin, a bitter-tasting but sweet-smelling substance made by plants that does not itself affect coagulation, but which is (classically) transformed in mouldy feeds or silages by a number of species of fungi, into active dicoumarol. (wikipedia.org)
Dicoumarol does affect coagulation, and was discovered in mouldy wet sweet-clover hay, as the cause of a naturally occurring bleeding disease in cattle. (wikipedia.org)
Sweet clover4
The analysis and biosynthesis of dicoumarol in spoiled sweet clover. (uregina.ca)
During the process of spoiling, the coumarins in sweet clover are converted to toxic dicumarol, a potent vitamin K antagonist and anticoagulant. (merckvetmanual.com)
Any method of hay storage that allows molding of sweet clover promotes the likelihood of formation of dicumarol in the hay. (merckvetmanual.com)
The time between consumption of toxic sweet clover and appearance of clinical disease varies greatly and depends on the dose (dicumarol concentrations of the sweet clover variety and amount eaten), duration of exposure, and age of the animals. (merckvetmanual.com)
Potent1
These compounds are not antagonists of Vitamin K directly-as they are in pharmaceutical uses-but rather promote depletion of vitamin K in bodily tissues allowing vitamin K's mechanism of action as a potent medication for dicoumarol toxicity. (wikipedia.org)
Compound1
In this study, we used the ovarian cancer cell line SKOV3 as the model system and examined whether dicumarol (DIC), a coumarin compound, could inhibit ovarian cancer through targeting PDK1. (researcher-app.com)
Exposure1
PC-91MC4 cell line did not show collateral resistance to KW-2149 In PC-9 cells, MMC-sensitivity was significantly Inhibited by dicumarol under aerobic, but not under hypoxic condition Sensitivity to KW-2149 was not altered by dicumarol treatment or exposure to hypoxia. (dokumen.tips)
Effect2
This effect could also be reversed by dicumarol. (aspetjournals.org)
To evaluate the role of DT-diaphorase (DT-D) as a bioactivator of MMC and its newly developed analogue, KW-2149, in the non-small cell lung cancer (NSCLC) cell lines under aerobic or hypoxic condition, we examined the inhibitory effect of dicumarol. (dokumen.tips)
Oral1
Anticoagulante oral que interfiere con el metabolismo de la vitamina K. También se utiliza en experimentación bioquímica, como inhibidor de las reductasas. (bvsalud.org)
Content1
If the dicumarol content of the ration is low or variable, animals may consume it for months before signs of disease develop. (merckvetmanual.com)