AnatomyOrganismsChemicals and DrugsPhenomena and ProcessesInformation Science
DictyosteliumMolecular Sequence DataMyxomycetesHexanonesProtozoan ProteinsSpores, ProtozoanChemotaxisReceptors, Cyclic AMPGenes, ProtozoanCyclic AMPCell AggregationSporesAmino Acid SequenceActinsMyosins
DiscoideumAmoebaProteinSlime moldStrainsActinDifferentiationSpeciesGenomePurpureumFasciculatumOrganismDrosophilaSequencesResistant genesCellularPredictionsAmoebaeRegulationMutantsDevelopmentalGenomicChromosomeLocusGeneticSequenceSBDSOntologyRelationshipResearchersResistanceBiologyCellIdentifyReportActivityChainStudy
Discoideum13
  • We have cloned and characterized the Dictyostelium discoideum repE gene, a homolog of the human xeroderma pigmentosum (XP) group E gene which encodes a UV-damaged DNA binding protein. (nih.gov)
  • Dictyostelium discoideum is a species of soil-dwelling amoeba belonging to the phylum Amoebozoa, infraphylum Mycetozoa. (wikipedia.org)
  • We present a detailed sequence analysis of the 10 formins (ForA to J) identified in the genome of the social amoeba Dictyostelium discoideum . (biomedcentral.com)
  • Adiba found that one such predator - an amoeba called Dictyostelium discoideum - was very good at munching its way through harmless strains of E.coli , but a disease-causing strain known as 536 was too much to swallow. (nationalgeographic.com)
  • Dictyostelium discoideum is a useful model for molecular studies of cell biology and development. (bioone.org)
  • Min Zhao, dermatology professor at the University of California, Davis, Peter Devroetes of Johns Hopkins University, and colleagues hope to unravel how these responses work by studying body cells and Dictyostelium discoideum , an amoeba that lives in soil. (futurity.org)
  • In the paper titled "Cheater-resistance is not futile" ("Star Trek" fans take note), they found Dictyostelium discoideum, amoebas that thrive on rotting vegetation in forest soil, mutate to keep "cheaters" at bay, forcing them out of the reproductive chain. (scienceblog.com)
  • Sex hormone of Dictyostelium discoideum is volatile. (microbiologyresearch.org)
  • 1] "The genome of the social amoeba Dictyostelium discoideum. (tcdb.org)
  • The development of Dictyostelium discoideum to the multicellular stage and formation of fruiting bodies is largely determined by cAMP. (biomedcentral.com)
  • The three-dimensional structures of the truncated myosin head from Dictyostelium discoideum myosin II complexed with dinitrophenylaminoethyl-, dinitrophenylaminopropyl-, o-nitrophenylaminoethyl-, m-nitrophenylaminoethyl-, p-nitrophenylaminoethyl-, and o-nitrophenyl-N-methyl-aminoethyl-diphosphate.beryllium fluoride have been determined to better than 2.3-A resolution. (rcsb.org)
  • This video is composed of a sequence of time lapse films created by John Tyler Bonner in the 1940s to show the life cycle of the cellular slime mold, Dictyostelium discoideum. (asu.edu)
  • The major research interest of my laboratory is in the processes of chemotaxis and development in the cellular slime mould Dictyostelium discoideum. (ncku.edu.tw)
Amoeba4
  • Dictyostelium is unusual because it spends part of its life crawling around as a single-cell amoeba, but occasionally multiple amoebae will come together to form a fruiting body. (futurity.org)
  • The idea to study Dictyostelium discoiduem , a single-celled soil-dwelling amoeba, came from Kabnick's examination of literature on the microbe's genes and what best suited a course oriented around student-driven projects. (drexel.edu)
  • One of the main hallmarks and drawbacks of the course is how a new wave of students, each quarter, with no prior knowledge of the Dictyostelium amoeba, manages to pick up where others left off. (drexel.edu)
  • Much like the spores of the Dictyostelium amoeba, the course stands out in a realm of classes dominated by lectures and prepared labs. (drexel.edu)
Protein6
  • To speed-up the discovery process, we have developed a computational approach that can consider a vast array of data sets, including data on mutant-based phenotypes, gene expressions, protein interactions, gene functional annotations, literature, drugs, and effects of drug treatments. (uni-lj.si)
  • Protein kinases are one of the largest and most influential of gene families: constituting some 2% of the proteome, they regulate almost all biochemical pathways and may phosphorylate up to 30% of the proteome. (wormbook.org)
  • Protein kinases constitute one of the largest and most important of protein families, accounting for ~2% of genes in a variety of eukaryotic genomes. (wormbook.org)
  • We identified 438 protein kinase genes, including 20 atypical kinases, and an additional 25 kinase fragments or pseudogenes. (wormbook.org)
  • The existence of the Dictyostelium protein and a related protein in the plant Arabidopsis thaliana suggest that evolution of β-catenin may have been a prerequisite for all multicellular development. (biomedcentral.com)
  • For instance, Human Protein Atlas localization and expression information is only available for human gene entries. (gene-info.org)
Slime mold1
Strains5
  • Type I strains are specified by the gene called MatA, Type II strains have three different genes: MatB (homologous to Mat A), Mat C, and Mat D, and Type III strains have Mat S and Mat T genes (which are homologous to Mat C and Mat D). These sexes can only mate with the two different sexes and not with its own. (wikipedia.org)
  • Adiba confirmed that by pitting 31 different strains of E.coli against Dictyostelium . (nationalgeographic.com)
  • The resistant strains had several genes that allowed them to avoid death by digestion. (nationalgeographic.com)
  • The researchers found that cheater cells inserted into a population of mutants would "select" Dictyostelium strains that contained a particular resistor gene. (scienceblog.com)
  • Repeated experiments suggested the presence of cheaters inevitably gives rise to cheater-resistant mutations and that such spontaneous mutations were in fact the most robust (more so than when researchers inserted resistant genes into "wild" strains of Dictyostelium). (scienceblog.com)
Actin2
  • Our analysis allows some preliminary insight into the functionality of Dictyostelium formins: all isoforms might display actin nucleation activity and, with the exception of ForI, might also be susceptible to autoinhibition and to regulation by Rho GTPases. (biomedcentral.com)
  • Differential expression and 5' end mapping of actin genes in Dictyostelium. (wikidata.org)
Differentiation2
  • During early differentiation of Dictyostelium the attractant cAMP is released periodically to induce aggregation of the cells. (biomedcentral.com)
  • Knock-out* mutations in components of this system that have been generated by REMI (Restriction Enzyme-Mediated Integration) or by using lacZ-linked promoter trap approaches are currently being analysed by molecular genetic methods to identify the key genes that regulate development and differentiation of the cell types. (ncku.edu.tw)
Species4
  • Nature abounds with species that are highly resistant to pathogenic bacteria, including the popular model organism Dictyostelium, which is a bacterial predator. (uni-lj.si)
  • Some species do so using resistance genes that turn them from passive victims into aggressive fighters. (nationalgeographic.com)
  • A complete description of the Dictyostelium genome will open the way toward the application of genome-based experimental approaches to studies of cell biology and development in this organism, and allow detailed physiological and evolutionary comparisons to other species. (bioone.org)
  • Phylogeny of 5 Dictyostelid species: constructed from 32 orthologous genes in all species with genome sequence using Entamoeba histolytica as the outgroup. (dictybase.org)
Genome2
  • The 34-megabase Dictyostelium genome is currently being sequenced through the efforts of an international consortium. (bioone.org)
  • The genome is expected to encode 8-10,000 genes, including all those required for a free-living eukaryote capable of multicellular development. (bioone.org)
Purpureum2
Fasciculatum1
  • Dictyostelium fasciculatum: 50 kbp from DFA1457732:1. (dictybase.org)
Organism1
  • We use molecular genetic techniques to tag, isolate and manipulate the genes that are responsible for regulating the sequence of events that enables cells to aggregate together by chemotaxis from a dispersed population to form an organism 2-3 mm long containing up to 100000 cells. (ncku.edu.tw)
Drosophila1
  • Ovarian tumors are characteristically found in adult Drosophila melanogaster females homozygous for certain recessive genes (fes, nw and fu). (degruyter.com)
Sequences1
  • Construction of simple and efficient siRNA validation systems for screening and identification of effective RNAi-targeted sequences from mammalian genes. (ncku.edu.tw)
Resistant genes1
  • Our partners at Baylor College of Medicine took five years to discover four bacterial resistant genes. (uni-lj.si)
Cellular1
  • Expression of forC, D, I and J increased during transition to multi-cellular stages, while the rest of genes displayed less marked developmental variations. (biomedcentral.com)
Predictions2
  • For eight of these genes, our predictions were confirmed in the wet lab. (uni-lj.si)
  • Please use the gene predictions with caution! (dictybase.org)
Amoebae1
  • In the video above, amoebae with and without the PiaA gene crawl around in the presence of weak electric fields. (futurity.org)
Regulation1
  • PKA in turn is involved in an oscillatory loop of adenylyl cyclase activation as well as in gene regulation. (biomedcentral.com)
Mutants1
  • In mutants lacking the β-catenin, most of the fruiting bodies collapse, and there is an additional signaling defect: a cell-autonomous failure to induce certain aspects of prespore gene expression. (biomedcentral.com)
Developmental2
  • The data indicate that potential developmental roles for XP-related genes can be profitably studied in this system. (nih.gov)
  • In Dictyostelium , the interaction of secreted cAMP with specific cell surface receptors regulates the activation/de-activation of GSK3, which mediates developmental cell patterning. (biologists.com)
Genomic1
  • The repE gene is not expressed by mitotically dividing cells, and repE mRNA is first detected during the aggregation phase of development when the cells have ceased dividing and replicating genomic DNA. (nih.gov)
Chromosome3
  • The repE gene maps to chromosome 4 and it is the first gene identified in Dictyostelium that is homologous to those involved in nucleotide excision repair and their related XP diseases in humans. (nih.gov)
  • In 90% of cases, SDS is associated with mutations in the Shwachman-Bodian-Diamond syndrome ( SBDS ) gene, located on chromosome 7. (medscape.com)
  • Also, Shwachman-Diamond syndrome has been associated with mutations in the SBDS gene, located on chromosome 7. (medscape.com)
Locus1
  • Genes may also have a locus and ORF associated with them that can be used for querying. (gene-info.org)
Genetic2
  • Dictyostelium fascinate researchers because so many of them willingly give up their lives to save others of their colony - a characteristic seen at all rungs on the ladder of life, but only recently studied at the genetic level. (scienceblog.com)
  • It starts by developing a series of simple quantitative genetic models to illustrate the importance of GSEIs to the evolutionary process and how they differ from standard GEIs when the environment is abiotic and therefore does not contain genes. (bath.ac.uk)
Sequence1
  • A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. (ensembl.org)
SBDS1
  • The SBDS gene may not be required for neutrophil maturation but may act to maintain survival of granulocyte precursor cells. (medscape.com)
Ontology1
  • should we capture the cell type in which the apototic genes are expressed and hence request new cell types if not already in cell type ontology? (geneontology.org)
Relationship1
  • To establish the relationship between formins of Dictyostelium and other organisms we constructed a phylogenetic tree based on the alignment of FH2 domains. (biomedcentral.com)
Researchers1
  • The screening technique could be used to identify more genes linked to electrotaxis and help researchers piece together exactly how electrical signals are detected and turned into action. (futurity.org)
Resistance1
  • For bacterial resistance, we have predicted the role for nine new genes. (uni-lj.si)
Biology1
  • Among other biology courses, Kabnick oversees an entirely student-driven research course called "Dictyostelium. (drexel.edu)
Cell2
  • Results: By live imaging of single-gene transcriptional events in individual cells, we have directly recorded the potential for mitotic inheritance of transcriptional states down cell lineages. (dundee.ac.uk)
  • I am particularly interested in the components of the signal transduction system and the way in which they control cell movement and gene activity. (ncku.edu.tw)
Identify1
  • The resulting compressed data system is then used to identify genes with high probability of a target phenotype. (uni-lj.si)
Report1
Activity1
  • Although methylated H3K4 is usually associated with active transcriptional units, the modification was not required for gene activity but stabilized transcriptional frequency between generations. (dundee.ac.uk)
Chain1
  • A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. (wikidata.org)
Study1
  • Real-time PCR was used to study the expression pattern of formin genes. (biomedcentral.com)