• Furthermore, treatment with the gamma-secretase inhibitor dibenzazepine and neurogenin-3 overexpression induced goblet cell and enteroendocrine cell differentiation, respectively, consistent with endogenous Notch signaling and lineage plasticity. (nih.gov)
  • To this end, we examined the effects on the whole intestinal tract (from duodenum to left colon) of a well-known γ-secretase inhibitor, dibenzazepine (DBZ), administrated to mice daily for 8 days at an efficient and nontoxic dose. (biologists.org)
  • Furthermore, using the Notch inhibitor dibenzazepine (DBZ) to drive cellular differentiation into secretory cell lineages, we show that although goblet cells resist E11 infection, enteroendocrine cells are permissive, suggesting that enteroviruses infect specific cell populations in the human intestine. (jove.com)
  • We analyzed Notch regulation by examining expression profiles (by quantitative reverse transcription PCR and RNAscope) of small intestinal organoids incubated with the Notch inhibitor DAPT, intestine tissues from mice given injections of the γ-secretase inhibitor dibenzazepine, and mice with intestine-specific disruption of Rbpj. (bvsalud.org)
  • It is unclear why a prudently planned guided stimulation technique should be seen whether physiological t levels, mid-normal range for psa varies with etiology of an ejaculation stimulator (8) through d2 receptors identied with immunochemistry and in some rapid ejaculators who seem to be sexual, whether out of the dibenzazepine group of functional disturbances of erectile dysfunction after radical prostatectomy after failed external-beam therapy. (healmyptsd.com)
  • A) Representative confocal microscopy images of MUC2 (green) in human cultures treated with 10 μM dibenzazepine (DBZ) show differentiation into the goblet cell-lineage as depicted by increased MUC2 expression (B) The number of goblet cells was quantified by counting the number of MUC2+ cells from 10 random fields at 63× magnification. (nih.gov)