Diastolic function diabetic cardiomyopathies. Medical search. Frequent questions

One of the earliest signs is mild left ventricular diastolic dysfunction with little effect on ventricular filling. (wikipedia.org)
Diabetic cardiomyopathy is characterized functionally by ventricular dilation, enlargement of heart cells, prominent interstitial fibrosis and decreased or preserved systolic function in the presence of a diastolic dysfunction. (wikipedia.org)
Etiologically, four main causes are responsible for the development of heart failure in diabetic cardiomyopathy: microangiopathy and related endothelial dysfunction, autonomic neuropathy, metabolic alterations that include abnormal glucose use and increased fatty acid oxidation, generation and accumulation of free radicals, and alterations in ion homeostasis, especially calcium transients. (wikipedia.org)
Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, predisposed to the development of diabetic cardiomyopathy (DCM) in type 2 diabetes mellitus. (mdpi.com)
In diabetics, there is a predominant presence of „diastolic" left ventricle dysfunction or „diastolic" heart failure. (skp-casopis.sk)
Diabetic cardiomyopathy (DCM), a substantial contributor to morbidity and mortality in diabetics, is seen as a ventricular dysfunction, within the lack of coronary atherosclerosis and hypertension. (researchassistantresume.com)
The association between increased arterial stiffness and left ventricular diastolic dysfunction (LVDD) may be influenced by left ventricular performance. (medsci.org)
brachial-ankle pulse wave velocity, P wave dispersion, left ventricular diastolic dysfunction. (medsci.org)
The cardiac mortality and morbidity were increased in heart failure patients with left ventricular diastolic dysfunction (LVDD) [ 1 , 2 ]. (medsci.org)
Left ventricular (LV) diastolic dysfunction is known as an early marker of myocardial alterations in patients with diabetes. (biomedcentral.com)
Because microvascular disease has been regarded as an important cause of heart failure or diastolic dysfunction in diabetic patients, we tested the hypothesis that coronary flow reserve (CFR), which reflects coronary microvascular function, is associated with LV diastolic dysfunction in patients with type 2 diabetes. (biomedcentral.com)
Although the exact causes of LV myocardial damage in patients with diabetes (so called diabetic cardiomyopathy) remain unclear, several factors such as a metabolic abnormality, autonomic dysfunction, myocardial fibrosis and reduced perfusion due to small vessel disease, have been reported as potential mechanisms of myocardial damage in diabetic patients [ 11 , 12 ]. (biomedcentral.com)
Objective: The target of the present investigation is to echocardiographic grade of left ventricular diastolic dysfunction in grown-up patients with diabetes mellitus and hypertension over 30 years. (fortuneonline.org)
Conclusion: In present study examination exhibits that hypertension and diabetes mellitus have an independent positive impact on left ventricular diastolic dysfunction. (fortuneonline.org)
The occurrence of grade 3 left ventricular diastolic dysfunction and left ventricular systolic dysfunction increased with diabetes mellitus. (fortuneonline.org)
Diastole is the period during which the myocardium does not have its capacity to deliver power and continues to an unstressed measurement and quality bringing about deficiency of these courses causing diastolic dysfunction and the progressions in diastolic capacity can be available without cardiovascular breakdown with or without systolic function [2]. (fortuneonline.org)
The recurrence of diabetes mellitus is enormously expanding on the planet about 40% of patients with diabetes present with diastolic dysfunction and pervasiveness of diabetes in grown-ups overall was assessed to be 4% in 1995 and to ascend to 5.4% continuously 2025 and will be a 42% expansion in diabetic patients in the created nations and 70% expansion in the creating nations constantly 2025 [3]. (fortuneonline.org)
Diastolic dysfunction is related with low mortality which represents roughly 8% however high horribleness, in this manner the death rate hazard is expanded by two to four folds [4]. (fortuneonline.org)
Heart failure with preserved ejection fraction (HFpEF) and right ventricular (RV) dysfunction are frequent complications of diabetic cardiomyopathy. (unideb.hu)
Omecamtiv mecarbil evokes diastolic dysfunction and leads to periodic electromechanical alternans / Fülöp Gábor Á. (unideb.hu)
The author's aim to address the problem that [inaudible 00:03:47] approaches aimed at enhancing calcium current and inotropism in heart failure have also frequently been found to favor arrhythmogenesis and diastolic dysfunction. (libsyn.com)
Diastolic dysfunction has a major impact on symptom status, functional capacity, medical treatment, and prognosis in both systolic and diastolic heart failure (HF), irrespective of the cause. (bmj.com)
Diastolic dysfunction is the predominant cardiac abnormality in this syndrome, which is associated with increased risk of hospitalisation and death. (bmj.com)
Indeed, such a definition of diastolic HF has been adopted by the majority of previous reports, w5 and is supported by the results of recent studies which indicate that the presence of diastolic dysfunction may be assumed in patients presenting with HF and normal LV ejection fraction (LVEF). (bmj.com)
Nonetheless, a recent review has highlighted the disconnect between Doppler echo measurements and true diastolic properties of the left ventricle, and has questioned the prevailing assumption that HF with preserved systolic function is always caused by diastolic dysfunction. (bmj.com)
w8 For these reasons, recent guidelines have called for invasive determination of diastolic dysfunction to make a definite diagnosis of diastolic HF, 6 although the feasibility of this approach is limited. (bmj.com)
Echocardiographic assessment of diastolic function makes the diagnosis of diastolic HF more specific, allows serial assessment of the response of diastolic dysfunction to treatment, and facilitates inclusion of more homogeneous populations into intervention trials. (bmj.com)
This condition is known as left ventricular hypertrophy with diastolic dysfunction. (digidrs.com)
Cardiac causes of dyspnea include right, left or biventricular congestive heart failure with resultant systolic dysfunction, coronary artery disease, recent or remote myocardial infarction, cardiomyopathy, valvular dysfunction, left ventricular hypertrophy with resultant diastolic dysfunction, asymmetric septal hypertrophy, pericarditis and arrhythmias. (aafp.org)
Cardiorenal Syndrome is a specific condition which is characterized by a rapid or chronic worsening of cardiac function leading to acute or chronic kidney injury (A/CKI) and the reciprocal organ dysfunction sequence can be possible. (cardiologyresearchjournal.com)
The presence of systolic or diastolic dysfunction in people with diabetes, in the absence of common causes such as coronary artery disease, hypertension, or valvular heart disease, is termed "diabetic cardiomyopathy" ( 5 ). (diabetesjournals.org)
The development of diabetic cardiomyopathy is multifactorial, with insulin resistance, changes in cellular metabolism, and hyperglycemia-induced advanced glycation end products triggering a cascade of deleterious effects that contribute to hypertrophy, fibrosis, autonomic dysfunction, and ultimately impaired ventricular contraction and relaxation ( Figure 1 ) ( 5 - 10 ). (diabetesjournals.org)

expressed as mean +/- SD) without cardiac ischemia and 24 normoglycemic control subjects (age 54.5 +/- 7.1 years, body mass index 27.0 +/- 2.5 kg/m(2), glycosylated hemoglobin A(1c) 5.3 +/- 0.2%), we assessed myocardial left ventricular (LV) function by magnetic resonance imaging, and myocardial perfusion and substrate metabolism by positron emission tomography using (H2O)-O-15, carbon C-11-palmitate, and 18-fluorodeoxyglucose 2-fluoro-2-deoxy-D-glucose. (amsterdamumc.org)
Also, the diabetic patient may show subtle signs of diabetic cardiomyopathy related to decreased left ventricular compliance or left ventricular hypertrophy or a combination of both. (wikipedia.org)
Alterations of left ventricular systolic and diastolic function in pregnant women with insulin-dependent diabetes mellitus. (ihr-herz.de)
Left ventricular diastolic function parameters after PTCA and stent Implantation. (ihr-herz.de)
Left ventricular diastolic function in pregnancy in patients with arterial hypertension. (ihr-herz.de)
Prognostic relevance of left ventricular diastolic function parameters in dilated cardiomyopathy. (ihr-herz.de)
Left ventricular hypertrophy and cardiac diastolic function in a female rodent model of diabetes were improved by empagliflozin [ 5 ]. (jofem.org)
Diabetes can cause heart failure independently of ischemic heart disease by causing a diabetic cardiomyopathy that may manifest in the setting of normal or reduced left ventricular ejection fraction. (diabetes.ca)
Recent reports showed that myocardial TG accumulation is significantly higher in patients with diabetes and is associated with impaired left ventricular diastolic function. (elsevierpure.com)
Consequences are primary defects of cardiogenesis and asymmetric hypertrophic cardiomyopathy with a thickening of the interventricular septum and lower posterior ventricular wall [ 15 ]. (biomedcentral.com)
In particular among the 30% of infants without congenital cardiac diseases born from diabetic mothers, the echocardiographic exam presents an interventricular septum and ventricular walls hypertrophy with a ratio from interventricular septal / left posterior ventricle wall higher than 1,3 [ 17 ]. (biomedcentral.com)
Retinoid Receptor-Mediated Signaling in Cardiac Redecorating Cardiac remodeling includes a main role within the development to HF, that is associated with modifications within the ventricular framework and function, caused by myocardial damage, pressure or quantity overload. (researchassistantresume.com)
We hypothesized that the myocardial extracellular volume fraction (MECVF) could be used to detect myocardial matrix remodeling and its relationship to ventricular structure and function in diabetics without cardiovascular disease. (biomedcentral.com)
Well-controlled diabetics with normal ventricular structure, function, and no prior cardiac disease have diffuse interstitial myocardial fibrosis by CMR. (biomedcentral.com)
This study is designed to compare left ventricular diastolic function among patients divided by brachial-ankle pulse wave velocity (baPWV) and corrected P wave dispersion (PWDC) and assess whether the combination of baPWV and PWDC can predict LVDD more accurately. (medsci.org)
Assessment of left ventricular diastolic function is useful in risk stratification for patients with cardiovascular disease and can provide a diagnostic clue for heart failure with preserved ejection fraction. (medsci.org)
In this report, we present a rare case of a newborn of a diabetic mother with severe ventricular hypertrophy who developed myocardial infarction confirmed by elevated cardiac enzymes, electrocardiographic changes, and subendocardial ischemia on cardiac magnetic resonance imaging. (elsevierpure.com)
Follow-up revealed complete functional myocardial recovery with normalisation of ventricular systolic and diastolic functions on serial echocardiograms. (elsevierpure.com)
Typical hemodynamic characteristics include normal systolic function and equalization of increased ventricular end-diastolic pressures. (medscape.com)
Here we aimed to characterize RV and left ventricular (LV) remodeling and its prevention by vardenafil (a long-acting phosphodiesterase5A (PDE-5A) inhibitor) administration in a diabetic HFpEF model. (unideb.hu)
2 Thus, diastolic evaluation is an important component of the evaluation of the patient with systolic left ventricular (LV) impairment. (bmj.com)
Approximately 2 % of the adult population in high-income countries has clinical heart failure (HF), 1 and almost the same percentage again has impaired left ventricular (LV) function without symptoms. (aerjournal.com)

Dapagliflozin successfully prevented the development of hypertrophic cardiomyopathy in a diabetic lipodystrophic mouse model [ 4 ]. (jofem.org)
Hypertrophic cardiomyopathy (HCM) in newborns is a rare condition with heterogeneous etiologies. (biomedcentral.com)
Hypertrophic cardiomyopathy (HCM) in newborns is a rare pathological condition in which disruption of the myocardial structures creates a thickening of the heart muscle [ 1 ]. (biomedcentral.com)
Fetal and neonatal hypertrophic cardiomyopathy is a complication of gestational diabetes and usually follows a benign course. (elsevierpure.com)
RCM may manifest as a solitary abnormality, although restrictive filling patterns of the left ventricle can also be seen in patients with dilated or hypertrophic cardiomyopathy . (medscape.com)

Objectives This study was designed to evaluate myocardial substrate and high-energy phosphate (HEP) metabolism in asymptomatic men with well-controlled, uncomplicated type 2 diabetes with verified absence of cardiac ischemia, and age-matched control subjects, and to assess the association with myocardial function. (amsterdamumc.org)
Background Metabolic abnormalities, particularly an excessive exposure of the heart to circulating nonesterified fatty acids and myocardial insulin resistance are considered important contributors to diabetic cardiomyopathy in animal models of diabetes. (amsterdamumc.org)
Diabetic cardiomyopathy is a disorder of the heart muscle in people with diabetes. (wikipedia.org)
Most heart failure in people with diabetes results from coronary artery disease, and diabetic cardiomyopathy is only said to exist if there is no coronary artery disease to explain the heart muscle disorder. (wikipedia.org)
Because of this, many studies have explored the clinical utility of screening people with diabetes for the presence of reduced LV function with BNP/NT-pro- BNP testing. (diabetes.ca)
Diabetic cardiomyopathy (DCM) is one of the most important complications of diabetes and is one of the major causes of death in diabetic patients. (ac.ir)
In the background of heart failure development in diabetes mellitus type 2 diabetics is ischaemic heart disease, developing under the influence of many (and usually intensively acting) risk factors, under the influence of nephropathy and other co‑ morbidities. (skp-casopis.sk)
Research have shown a reduced plasma degree of retinol in type 1 diabetics and in streptozotocin-induced diabetic pet versions [92,93] which eating supplementation of supplement A inhibits the introduction of type 1 diabetes [94]. (researchassistantresume.com)
We included 67 asymptomatic patients with type 2 diabetes and 14 non-diabetic controls in the final study population. (biomedcentral.com)
Therefore, we tested the hypothesis that CFR assessed by transthoracic echocardiography is associated with LV diastolic function in patients with type 2 diabetes without a history of heart failure. (biomedcentral.com)
Identification of a definite diabetic cardiomyopathy in type 2 diabetes by comprehensive echocardiographic evaluation: A cross-sectional comparison with non-diabetic weight-matched controls. (uib.no)
Neutral impact on systolic and diastolic cardiac function of 2 years of intensified multi-intervention in type 2 diabetes: The randomized controlled Asker and Bærum Cardiovascular Diabetes (ABCD) study. (uib.no)
To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. (spandidos-publications.com)
Coronary atherosclerosis appears in the majority of the diabetes population, with the mortality of up to 20% diabetic subjects caused by myocardial infarction ( 9 ). (spandidos-publications.com)
study: diabetes that proposes the Kallidin and diabetes of coronary B-cells and is well a excretion tissue for actions and functions. (siriuspixels.com)
In the United States, over 30 million people suffer from diabetes, and 84 million are pre-diabetic. (digidrs.com)
A disease of the muscle in your heart (cardiomyopathy) can happen if you have diabetes. (digidrs.com)
Recently, HF, including diabetic cardiomyopathy, has become a more well-recognized complication of diabetes, with a prevalence rivaling that of established cardiovascular disease (CVD). (diabetesjournals.org)

We found no direct relation between cardiac diastolic function and parameters of myocardial metabolism. (amsterdamumc.org)

In most cases, diabetic cardiomyopathy is detected with concomitant hypertension or coronary artery disease. (wikipedia.org)
Given that diabetic cardiomyopathy's definition excludes concomitant atherosclerosis or hypertension, there are no changes in perfusion or in atrial natriuretic peptide levels up until the very late stages of the disease, when the hypertrophy and fibrosis become very pronounced. (wikipedia.org)
Diffuse myocardial damage occurs early in the course of diabetic cardiomyopathy independent of hypertension and obesity, and may be a potential target for early intervention in at-risk diabetic patients with subclinical myocardial disease. (biomedcentral.com)
The meaning of "3H care" attain and maintain adequate controls over hypertension, hyperlipidemia, and hyperglycemia in type 2 diabetic patients. (e-dmj.org)
These authors looked at the voltage dependent [inaudible 00:03:31] calcium channel which is a key mediator of interest [inaudible 00:03:34] calcium entry associated with various cardiovascular conditions such as hypertrophy, atrial fibrillation, hypertension and diabetic cardio myopathy. (libsyn.com)
Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)

The ratio of mitral velocity to early diastolic velocity of the mitral annulus (E/e′) was used as a surrogate marker of diastolic function. (biomedcentral.com)

Four pathways, enumerated below all explain part of the diabetic complications. (wikipedia.org)
How do diabetic complications occur? (digidrs.com)

50%, but also referred to as preserved systolic function or heart failure with preserved EF). (diabetes.ca)
Restrictive cardiomyopathy (RCM) is a rare disorder in children that is characterized by restrictive filling and reduced diastolic volume of one or both ventricles with normal or near-normal systolic function and wall thickness. (medscape.com)
While uniform patterns in cGMP, 3-NT and Fpassive levels predict identical effects of vardenafil therapy for the diastolic function in both ventricles, the uneven cTnI, cMyBP-C phosphorylation levels and pCa50 values implicate different responses for the systolic function. (unideb.hu)
3 However, the American College of Cardiology/American Heart Association guidelines for the evaluation and management of HF w4 support a diagnosis of exclusion-that is, clinical evidence of HF with preserved systolic function. (bmj.com)
4 w6 w7 Zile and colleagues demonstrated that at least one abnormal index of diastolic function was present in patients with HF and normal systolic function. (bmj.com)
These data suggest that a diagnosis of diastolic HF may accurately be made as a diagnosis of exclusion, 4 albeit in a highly selected population of relatively young, predominantly male patients who were scheduled to undergo cardiac catheterisation (contrasting with the large clinical population of elderly, hypertensive, predominantly female patients with HF and preserved systolic function). (bmj.com)
These patients present with exertional dyspnoea in the context of normal systolic function, and in this situation, symptoms may be ascribed to diastolic HF. (bmj.com)

Documentation of systolic and diastolic myocardial function is recommended at the time of diagnosis of heart failure or with any significant change in clinical stability. (diabetes.ca)

Expression of cardiac copper chaperone encoding genes and their correlation with cardiac function parameters in goats. (ufl.edu)
Diabetics without any history of MI (by clinical grounds or by evidence of subendocardial LGE) or heart failure underwent 3T CMR imaging and assessment of MECVF and assessment of biochemical parameters of insulin sensitivity. (biomedcentral.com)

Diabetic cardiomyopathy may be associated with restrictive (HFPEF) and dilated phenotypes (HFREF). (wikipedia.org)

Doppler echocardiography is ideally suited for assessment of diastolic function, being widely available, non-invasive, and less expensive than other techniques. (bmj.com)
In selected cases where the test results are inconclusive or require clarification, complete pulmonary function testing, arterial blood gas measurement, echocardiography and standard exercise treadmill testing or complete cardiopulmonary exercise testing may be useful. (aafp.org)

One particularity of diabetic cardiomyopathy is the long latent phase, during which the disease progresses but is completely asymptomatic. (wikipedia.org)
These changes are accompanied by a variety of electrocardiographic changes that may be associated with diabetic cardiomyopathy in 60% of patients without structural heart disease, although usually not in the early asymptomatic phase. (wikipedia.org)
Heart failure has an asymptomatic form (26% of diabetics above the age of 60), and a symptomatic form (28% of diabetics above the age of 60), thus only 46% of the people have no disorder of the left ventricle function. (skp-casopis.sk)

Histological examination with oil red O staining showed marked lipid deposition in the hearts of diabetic fatty db/db mice. (elsevierpure.com)

As a precursor to overt heart failure, diabetics experience a unique alteration in myocardial architecture marked by diffuse interstitial fibrosis. (biomedcentral.com)

About 50% of diabetics with diabetic cardiomyopathy show pathologic evidence for microangiopathy such as sub-endothelial and endothelial fibrosis, compared to only 21% of non-diabetic heart failure patients. (wikipedia.org)
In this issue (P94), Kutoh reports type 2 diabetic patients who showed changes in cardiac function which is concomitant with changes in ketone bodies by using one of sodium glucose cotransporter 2 inhibitors (SGLT2i), tofogliflozin [ 1 ], proposing a possible mechanism for SGLT2i-mediated prevention of heart failure. (jofem.org)
Further, the CVD-REAL Study, the large multinational study, concluded that treatment with SGLT2i was associated with a lower risk of hospitalization for heart failure and death as compared with other glucose lowering drugs, suggesting that the benefits seen in empagliflozin in a randomized trial may be a class effect applicable to a broad population of type 2 diabetic patients in real-world practice [ 3 ]. (jofem.org)
Mudaliar et al postulated that the cardiorenal benefits of SGLT2i are due to a shift in myocardial and renal fuel metabolism away from fat and glucose oxidation, which are energy inefficient in diabetic heart and kidney, toward an energy-efficient super fuel like ketone bodies, which improve myocardial/renal work efficiency and function as a "Unifying Hypothesis" [ 11 ]. (jofem.org)
The aim of this study was to investigate the effect of 4 weeks of high intensity interval training (HIIT) on gene expression of calcium channel of ryanodine receptors (RyR2), SERCA2a and phospholamban (PLB) in the heart of diabetic male rats. (ac.ir)
Heart failure in diabetic patients. (skp-casopis.sk)
Diabetics also have diabetic cardiomyopathy, which contributes significantly to the development and progression of heart failure. (skp-casopis.sk)
[ 1 ] The heart is grossly normal, although histologic abnormalities are often present, depending on the etiology of the restrictive cardiomyopathy. (medscape.com)
Myocardial fibrosis, characterized as interstitial fibroblast proliferation and excessive collagen deposition, is the structural basis of myocardial stiffness and the key process of cardiac function transformation from the compensatory phase to heart failure. (dovepress.com)
Structural heart disease via cardiac ischemia and infarction, also known as ischemic cardiomyopathy, is a documented complication of hyperglycemia. (diabetesjournals.org)

RA signaling continues to be implicated within the legislation of cell differentiation, proliferation and apoptosis [116,117], and a considerable body of understanding has gathered on its function in the legislation of cardiomyocyte development, apoptosis and mobile function in response to different pathophysiological stimuli. (researchassistantresume.com)
In vitro force measurements, biochemical and histochemical assays were employed to assess cardiomyocyte function and signaling. (unideb.hu)

Diffuse fibrosis is associated with LAVI, a marker of diastolic function, but not with other markers of clinical or cardio-metabolic risk. (biomedcentral.com)
These disorders include metabolic conditions such as anemia, diabetic ketoacidosis and other, less common causes of metabolic acidosis, pain in the chest wall or elsewhere in the body, and neuromuscular disorders such as multiple sclerosis and muscular dystrophy. (aafp.org)

Infants of diabetic mothers show an incidence of congenital cardiac disease of about 3.6%, compared to 0.8% in the general population [ 16 ]. (biomedcentral.com)
We assessed pro(renin) receptor expression in the setting of disease and blockade of the renin-angiotensin system, using the TGR[m(Ren2)-27] model of diabetic cardiomyopathy and the direct renin inhibitor, aliskiren. (ncl.ac.uk)
This result suggests a possible link between coronary microvascular disease and LV diastolic function in these subjects. (biomedcentral.com)

However, it is unclear how cerebral ischemic stroke regulates cardiac function, what are the direct effects of stroke on cardiac function, and what are the underlying molecular mechanisms. (justia.com)

MECVF in diabetics was 0.36±0.05 (as compared to normal controls 0.29±0.04, P = .0004 by unpaired t-test). (biomedcentral.com)

Experimental evidence suggests that these factors may be causally related to CVD, but the direction of causality is difficult to determine, as a major confounder is their reduced renal clearance or metabolism with reduced kidney function. (biomedcentral.com)

Paradoxically, the role of diastolic function assessment is more difficult to define in patients with diastolic HF. (bmj.com)

While implicated in a broad range of diseases, studies to date have focused on the kidney, particularly in the diabetic context. (ncl.ac.uk)
We found that reduced kidney function resulted in the expansion of cardiac macrophages, in particular through local proliferation of resident populations. (biomedcentral.com)
40% of people with severely reduced kidney function (not on dialysis) are not aware of having CKD. (cdc.gov)

These results suggest that reduced ATGL and CGI-58 expression and increased TG synthesis may exacerbate myocardial steatosis and oxidative stress, thereby promoting cardiac apoptosis in diabetic mice. (elsevierpure.com)

Patients with type 1 DM face a two to four times higher mortality rate than non-diabetic people ( 7 - 10 ). (spandidos-publications.com)

Left atrial volume index (LAVI) and emptying function, as well as LV and RV volumes and function, were determined by standard techniques. (biomedcentral.com)

Some investigators have divided RCM into the following subtypes: (1) pure restrictive cardiomyopathy, (2) hypertrophic-restrictive cardiomyopathy, and (3) mildly dilated restrictive cardiomyopathy. (medscape.com)
Therapy for idiopathic restrictive cardiomyopathy (RCM) is limited to symptomatic treatment and is often ineffective in improving outcome. (medscape.com)
Most cases of RCM (including idiopathic ones) are not known to be inherited, although there have been reports of families in whom multiple members are affected by a combination of hypertrophic and restrictive cardiomyopathies. (medscape.com)
6] Additionally, some inherited infiltrative disorders can cause restrictive cardiomyopathy. (medscape.com)

Sirtuin-3 (SIRT3) performs a vital role in regulating metabolism, mitochondrial function, and oxidative stress. (mdpi.com)

Defects in cellular processes such as autophagy and mitophagy are thought to contribute to the development of diabetic cardiomyopathy. (wikipedia.org)
Therefore, we investigated the roles of ATGL and CGI-58 in the development of myocardial steatosis in the diabetic state. (elsevierpure.com)

These findings were supported by changes in cardiac function which is concomitant with changes in ketone bodies by SGLT2i observed in the report by Kutoh [ 1 ]. (jofem.org)

Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), also known as lysine (K)-specific demethylase 6A (KDM6A), functions as a tumor suppressor gene or oncogene depending on the tumor type and context. (bvsalud.org)
This was a retrospective study of 200 type 2 diabetic patients who received "3H care" for one year or more in our diabetic clinic. (e-dmj.org)

Anatomy9

Organisms4

Diseases42

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes25

Anthropology, Education, Sociology and Social Phenomena1

Health Care10

Dysfunction32

Ventricular22

Hypertrophic cardiomyopathy5

Diabetes18

Cardiac diastolic function1

Hypertension6

Early diastolic1

Complications2

Systolic function7

Myocardial function1

Parameters2

HFPEF1

Echocardiography2

Asymptomatic3

Hearts of diabetic1

Overt heart1

Heart10

Cardiomyocyte2

Metabolic2

Disease3

Mechanisms1

0.361

Renal1

Assessment1

Kidney3

Apoptosis1

Mortality1

Atrial1

Restrictive4

Oxidative stress1

Development2

Concomitant1

Type2