TumorsMixed tumorNeoplasmsLesionsNeoplasmEffusionsLymphomaMelanomaComputed tomographySuspected malignant mesotheliomaPathologySpecificityEvaluation of malignantMajority of malignantUltrasoundPositron emission tDiagnosisDifferentiate between benignMetastaticSpecimensPrognosticTumoursAtypicalNodulesImagingPeripheralAsbestosDifferentialCancer DiagnosticsOncologyMesotheliomaCytologyLungVitroBiomarkerSoft-tissueDiseasePleural fluidCytopathologyChondrosarcomaSignificantlyMelanomas
Tumors13
- Thirty-two of 48 malignant peripheral nerve sheath tumors (67%) were SOX10-positive. (eurekamag.com)
- The majority of malignant peripheral nerve sheath tumors showed ≥2+ staining, but staining did not correlate with grade. (eurekamag.com)
- Furthermore, the stain needs to be interpreted with caution in intraneural tumors in order to avoid a potential diagnostic pitfall. (eurekamag.com)
- Liposarcomas are malignant tumors of the lipocytes ( fat cells ) and are not commonly found in pet birds. (ivis.org)
- Slightly more common in men than in women, malignant brain tumors (gliomas, meningiomas, and schwannomas) have an overall incidence of 4.5 per 100,000. (online-family-doctor.com)
- Treatment for malignant brain tumors also includes chemotherapy with nitrosoureas, which cross the blood-brain barrier and allow other chemotherapeutic drugs to go through as well. (online-family-doctor.com)
- Globa A.G., Alekseev Y.I., Varlamov D.A., Vishnevsky A.A. (2011) The diagnostic value of RNA oncomarkers in evaluation of malignant breast tumors. (msk.ru)
- Primary malignant melanoma of the lung is extremely rare and only accounts for 0.01% of all primary lung tumors [ 1 ]. (biomedcentral.com)
- 4 cm, and 337 (38.29%) of these tumors were found to be malignant. (ijbcp.com)
- I am an author for 25 book chapters in breast disease including the WHO blue book and Fletcher Diagnostic Histopathology of Tumors new editions and I am acting as a reviewer to 20 indexed and high profile international journals and editor to three journals. (nottingham.ac.uk)
- CONCLUSION: The biomarker panel suPAR(II-III), HE4, CA125 and age in premenopausal women improved discrimination of malignant and benign ovarian tumors. (lu.se)
- Bone tumors may be cancerous (malignant) or noncancerous (benign). (msdmanuals.com)
- Primary bone tumors may be noncancerous (benign) or cancerous (malignant). (msdmanuals.com)
Mixed tumor1
- True malignant mixed tumor (carcinosarcoma) of tonsillar minor salivary gland origin: diagnostic imaging and endovascular therapeutic embolization. (ajnr.org)
Neoplasms2
- Nonmesotheliomatous cancers of the pleura include an assortment of malignant neoplasms that primarily or secondarily involve pleura. (medscape.com)
- The categories were heart disease (4.4 million), delivery (4.0 million), psychoses (1.6 million), pneumonia (1.4 million), malignant neoplasms (1.3 million), and fractures (1.1 million). (cdc.gov)
Lesions13
- Magnetic resonance imaging (MRI) has a high sensitivity for differentiating between malignant and non-malignant breast lesions but is sometimes limited due to its low specificity. (hindawi.com)
- Here, we performed a meta-analysis to evaluate the diagnostic performance of mean kurtosis (MK) and mean diffusivity (MD) values in magnetic resonance diffusion kurtosis imaging (DKI) for benign and malignant breast lesions. (hindawi.com)
- Fourteen studies involving 1,099 (451 benign and 648 malignant) lesions were analyzed. (hindawi.com)
- Analysis of the data from 14 studies showed that MK had a higher pooled sensitivity, pooled specificity, and diagnostic performance for differentiating between breast lesions, compared with MD. (hindawi.com)
- Since the past decades, a lot of efforts have been directed toward developing techniques for improving the specificity of breast MRI to differentiate between malignant and nonmalignant breast lesions [ 2 - 4 ]. (hindawi.com)
- The use of apparent diffusion coefficient (ADC) values, calculated by fitting diffusion-weighted imaging signals in a single exponential model, has improved the diagnostic accuracy for differentiating between breast lesions [ 5 - 8 ]. (hindawi.com)
- DKI technology has been shown to improve the sensitivity and accuracy for diagnosing benign and malignant breast lesions and is therefore regarded as a promising technique for the differential diagnosis of breast lesions [ 14 , 15 ]. (hindawi.com)
- The objective of our study was to determine the diagnostic accuracy of contrast-enhanced magnetic resonance imaging pelvis in differentiating indeterminate adnexal lesions into benign and malignant, while considering histopathological examinations as the gold standard. (ijbcp.com)
- The diagnostic accuracy of contrast-enhanced MRI was found to be significantly high (79.65%) in differentiating indeterminate adnexal lesions into benign and malignant lesions. (ijbcp.com)
- Pierce N, Narayanan P, Sahdev A. Ovarian lesions pose diagnostic dilemmas. (ijbcp.com)
- Using a case series, we propose an algorithmic approach that is simple and will help identify the malignant lesions and institute appropriate management. (scirp.org)
- The lesions may transform into malignant carcinomas, usually after age 30 years. (lu.se)
- For localized multiple malignant lesions, autotransplantation of skin from uninvolved skin has been reported with success in preventing further development of cancers. (lu.se)
Neoplasm5
- By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
- The term fibroma is inappropriate because the neoplasm exhibits defined histologic features that differ from those of fibromas and may express malignant behavior. (medscape.com)
- Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
- PURPOSE Malignant optic glioma of adulthood is a rare, invasive neoplasm of the anterior visual pathway with 66 cases reported in the literature. (uzh.ch)
- Introduction: Malignant lymphomas are heterogeneous group of neoplasm comprising of proliferating lymphoid cells or their precursors. (aacrjournals.org)
Effusions17
- Diagnostic value of clot examination for malignant cells in serous effusions. (bvsalud.org)
- To assess the diagnostic value of clot examination for satisfactory processing and confirmation of malignancy in serous effusions in routine cytological evaluation and compare the results with those of conventional smear and cell block preparations. (bvsalud.org)
- Thoracic computed tomography scans and ultrasound are helpful in distinguishing malignant from benign effusions. (ox.ac.uk)
- Lung cancer and breast cancer account for about 50-65% of malignant pleural effusions. (wikipedia.org)
- Clinical factors predicting the diagnosis of malignant pleural effusions are symptoms lasting more than 1 month and the absence of fever. (wikipedia.org)
- Ultrasound has a sensitivity of 73% and specificity of 100% at distinguishing malignant pleural effusions from other causes of pleural effusion, based on the presence of visible pleural metastases, pleural thickening greater than 1 cm, pleural nodularity, diaphragmatic thickening measuring greater than 7mm and an echogenic swirling pattern visible in the pleural fluid. (wikipedia.org)
- Malignant pleural effusions are exudates. (wikipedia.org)
- Identification of pleural fluid biomarkers to distinguish malignant pleural effusions from other causes of exudative effusions would help diagnosis. (wikipedia.org)
- Biomarkers that have been shown to be raised in malignant pleural effusions compared to benign disease include vascular endothelial growth factor (VEGF), endostatin, matrix metalloproteinases and tumour markers such as carcinoembryonic antigen. (wikipedia.org)
- The goal of treatment of malignant pleural effusions is relief of shortness of breath. (wikipedia.org)
- Pleural fluid pH in malignant effusions. (wikipedia.org)
- Low glucose and pH levels in malignant pleural effusions. (wikipedia.org)
- Methods Fibulin-3 and soluble mesothelin were determined by ELISA in the plasma and pleural fluid of 153 patients presenting with a pleural effusion including 82 with MM, 36 with non-MM malignant effusions and 35 with benign effusions. (bmj.com)
- While fibulin-3 levels are elevated in the plasma of mesothelioma patients compared with controls, soluble mesothelin has a much greater diagnostic accuracy and fibulin-3 levels in pleural effusions are not specific for mesothelioma. (bmj.com)
- Many studies have investigated the usefulness of cytokeratin 19 fragments (CYFRA 21-1) in pleural fluid for the differential diagnosis of benign (BPE) and malignant pleural (MPE) effusions. (archivesofmedicalscience.com)
- Small malignant pleural effusions may not be observed on standard radiographs. (medscape.com)
- Histological examination and culture of pleural biopsy were the most useful diagnostic workup for tuberculosis effusions, whereas repeated cytological examination of pleural fluid and pleural biopsy were most useful for malignant effusions. (who.int)
Lymphoma1
- Chemokine receptor 4 (CXCR4) has been explored with radiolabelled CXCR4 antagonist (AMD3100) for imaging and future targeted radiation therapy for malignant lymphoma. (aacrjournals.org)
Melanoma9
- 5 ). Data from case reports, case series, cohort studies, in Cutavirus in Malignant vitro work, and animal studies indicate that the infectious Melanoma period for sexual transmission of Zika virus is consider- ably shorter than the period during which viral RNA can be detected in semen. (cdc.gov)
- Primary malignant melanoma of the lung (PML) is extremely rare. (biomedcentral.com)
- Cytology of the pleural effusion in the right lung was performed, and malignant melanoma or clear cell sarcoma was suspected. (biomedcentral.com)
- The patient was diagnosed with malignant melanoma. (biomedcentral.com)
- Typically, 15-20% of malignant melanomas have mutations in the neuroblastoma RAS viral oncogene homolog ( NRAS ) gene [ 4 ], but no cases of NRAS -mutated primary malignant melanoma of the lung have been reported in the English literature. (biomedcentral.com)
- We present the case of a 74-year-old female, who died of primary malignant melanoma of the lung involving an NRAS mutation. (biomedcentral.com)
- We suspected malignant melanoma or clear cell sarcoma (Fig. 2 ). (biomedcentral.com)
- Understanding delay : a grounded theory examination of the pre-diagnostic journey of individuals with malignant melanoma. (brad.ac.uk)
- An analysis of the experiences of individuals subsequently diagnosed with high risk malignant melanoma from problem identification through to initial specialist treatment. (brad.ac.uk)
Computed tomography1
- Although ultrasound, routine contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) allow the detection of enlarged cervical LNs, none of these methods can distinguish between benign and malignant causes of enlargement with any accuracy [ 7 ], as they use standard parameters (shape, size, internal architecture, extranodal invasion, and vascular features) that are nonspecific for malignancy [ 8 , 9 ]. (hindawi.com)
Suspected malignant mesothelioma1
- Twenty-eight consecutive patients referred for the evaluation of suspected malignant mesothelioma were evaluated by FDG-PET imaging. (nih.gov)
Pathology1
- Pathology is also a vital part of the mesothelioma diagnostic process . (mesothelioma.com)
Specificity3
- Conclusions Serum mesothelin showed moderate sensitivity and high specificity to differentiate malignant pleural mesothelioma from metastatic malignancy to pleura and from benign pleural diseases. (lamblawoffice.com)
- With a SUV cutoff of 2.0 to differentiate between malignant and benign disease, a sensitivity of 91% and a specificity of 100% could be achieved, although the activity in some epithelial mesotheliomas tended to be close to this threshold. (nih.gov)
- Pleural fluid mesothelin has a sensitivity of 71%, greater than that of cytology, and a specificity of 89% for the diagnosis of malignant mesothelioma. (wikipedia.org)
Evaluation of malignant1
- We have assessed the value of positron emission tomography (PET) with 2-fluoro-2-deoxy-D-glucose (FDG) in the evaluation of malignant mesothelioma. (nih.gov)
Majority of malignant1
- A solid component was observed in the majority of malignant nodules (61.6%, P = 0.0376) and mixed component was observed in the majority of benign nodules (51.7%, P = 0.0376). (jofem.org)
Ultrasound1
- however, its diagnostic performance has never been validated with ultrasound biomicroscopy (UBM) criteria. (bmj.com)
Positron emission t2
- The combination of positron emission tomography (PET) and CT is a new diagnostic and staging modality in the evaluation of the patient with head and neck cancer. (medscape.com)
- German scientists developed a computer program that enhances the diagnostic accuracy of positron emission tomography (PET) scans with Alzheimer's patients, opening the door for earlier treatment of this progressive brain disorder. (news-medical.net)
Diagnosis6
- Although the presence of a t(X;18) rearrangement or expression of TLE1 can help confirm the diagnosis of synovial sarcoma, negative results for these tests are not diagnostic of malignant peripheral nerve sheath tumor. (eurekamag.com)
- Therefore, SOX10 is a specific (93%), albeit not very sensitive (67%), diagnostic marker to support a diagnosis of malignant peripheral nerve sheath tumor over synovial sarcoma. (eurekamag.com)
- Most patients report a globus or foreign-body sensation in the throat for months to years before diagnosis of a postcricoid malignant tumor. (medscape.com)
- The diagnosis of malignant mesothelioma is a challenging medical problem. (nih.gov)
- In the present meta-analysis, the reported studies on the diagnosis between CYFRA 21-1 and pleural effusion were assessed to summarize the diagnostic characteristics of CYFRA 21-1 in Chinese patients. (archivesofmedicalscience.com)
- The cancer diagnostics market is on the verge of explosion, as the researchers approach major technological breakthroughs in tumor diagnosis and therapy, discover new specific antigens, and unlock the mystery of the genetic basis of the disease. (aarkstore.com)
Differentiate between benign2
- CT often cannot differentiate between benign diffuse pleural thickening and malignant mesothelioma, while thoracentesis and CT-guided biopsies are insensitive. (nih.gov)
- Promising results with DWI to help detect cervical LN metastases (especially in normal-sized nodes) and to differentiate between benign and malignant enlarged nodes have been reported. (hindawi.com)
Metastatic2
- However, malignant SFTs, which comprise 10%-15% of SFTs, not only aggressively infiltrate adjacent structures but are also capable of metastatic spread. (medscape.com)
- Oral MPNST can occur either de novo or by malignant transformation of neurofibromas or very rarely can represent a metastatic lesion. (amrita.edu)
Specimens1
Prognostic3
- Background We evaluated possible diagnostic and prognostic values of serum midkine in malignant pleural mesothelioma in comparison with those of serum mesothelin, a well-established diagnostic biomarker. (lamblawoffice.com)
- A reliable diagnostic and prognostic marker for MM will significantly enhance clinical care and is an area of intense research. (bmj.com)
- Conclusions Soluble mesothelin is a superior diagnostic biomarker for MM compared with fibulin-3, whereas fibulin-3 provides superior prognostic information compared with mesothelin. (bmj.com)
Tumours1
- It accounts for 5% of all malignant tumours worldwide [ 1 ]. (hindawi.com)
Atypical6
- The aim of this study was to find out the characteristic morphology of malignant atypical cells which were missed on routine cytology of urine. (cytojournal.com)
- Necrosis in the background and necrosed papillae were mostly seen in malignant atypical cells. (cytojournal.com)
- The comet cells and cells with India ink nuclei (single cells with deep black structure-less nuclei) were only observed in malignant atypical cells. (cytojournal.com)
- The present study emphasizes that nuclear features such as high N/C ratio, hyperchromasia and chromatin abnormalities are particularly useful for assessing the malignant atypical cells. (cytojournal.com)
- In this present paper we analyzed the characteristic morphology of malignant atypical cells which were missed on routine cytology of urine. (cytojournal.com)
- However, with the addition of the clot preparation, the number of cases in which atypical/malignant cells were seen increased from 42 to 85 (19.4%), with a P (bvsalud.org)
Nodules3
- The purpose of this study was to retrospectively analyze the diagnostic performance of different international guidelines to detect benign from malignant nodules using fine-needle aspiration biopsy as a reference test. (jofem.org)
- The cohort showed 26 (13%) malignant nodules and 174 (87%) benign nodules. (jofem.org)
- Even in the high risk group studied in NLST, "false positive" non-malignant lung nodules were far more frequently detected than malignant lung nodules. (cdc.gov)
Imaging9
- In this highly selected population, FDG-PET imaging was a sensitive method to identify malignant mesothelioma and determine the extent of the disease process. (nih.gov)
- The remaining imaging findings are not helpful in predicting the histological subtype of malignant mesothelioma. (nih.gov)
- Diagnostic imaging approach to posteromedial knee (medial popliteal fossa) masses. (scirp.org)
- Since leaps in AI-based image recognition technology opened the market gates, over 60 entities including 40 new firms globally have set out to commercialize AI-based medical diagnostics based on various imaging modalities. (idtechex.com)
- Our attendance at major medical conferences and forums around the world is a key component in our strategic mission to make that uncompromising Bracco mark on the future of diagnostic imaging. (bracco.com)
- In Diagnostic Imaging knowledge of the patient's history and clinical information is fundamental to answer the clinical question. (bracco.com)
- Bracco is present worldwide at all major international and regional diagnostic imaging events. (bracco.com)
- We are an active part of the healthcare sector, and a global leader in diagnostic imaging. (bracco.com)
- Laboratory tests, imaging tests, or other diagnostic procedures are sometimes. (msdmanuals.com)
Peripheral4
- Synovial sarcoma and malignant peripheral nerve sheath tumor pose a significant diagnostic challenge given similar histomorphology. (eurekamag.com)
- The goal of the present study was to determine the diagnostic utility of SOX10 to discriminate between synovial sarcoma and malignant peripheral nerve sheath tumor. (eurekamag.com)
- Forty-eight cases of malignant peripheral nerve sheath tumor, all from patients with documented neurofibromatosis, and 97 cases of genetically confirmed synovial sarcoma, including 4 intraneural synovial sarcomas, were immunohistochemically stained for SOX10. (eurekamag.com)
- Intraoral neurofibromas associated with NF-1 are quite common, but the occurrence of malignant peripheral nerve sheath tumor (MPNST) in the oral cavity is very rare. (amrita.edu)
Asbestos2
- Background Pleural malignant mesothelioma (MM) is a deadly tumour predominantly associated with asbestos exposure. (bmj.com)
- Asbestos exposure causes malignant mesothelioma . (mesothelioma.com)
Differential1
- The SOX10 transcription factor, a putative marker of neural crest differentiation, may have diagnostic utility in this differential, but immunohistochemical data are limited. (eurekamag.com)
Cancer Diagnostics2
- This new report from provides a strategic analysis of the major business opportunities emerging in the cancer diagnostics market during the next five years. (aarkstore.com)
- During the next five years, the cancer diagnostics market is promising to be an exciting, dynamic and rapidly expanding field. (aarkstore.com)
Oncology1
- The South Florida community now has access to expanded malignant hematology/oncology services closer to home. (moffitt.org)
Mesothelioma3
- How does the diagnostic accuracy of the newly proposed malignant mesothelioma biomarker fibulin-3 compare with the 'gold standard' biomarker, soluble mesothelin? (bmj.com)
- It concentrates on understanding how malignant mesothelioma forms and progresses. (mesothelioma.com)
- The "missing cases" of pleural malignant mesothelioma in Minnesota, 1979-81: preliminary report. (cdc.gov)
Cytology1
- Pleural fluid cytology is diagnostic in about 60% of cases. (ox.ac.uk)
Lung2
- Previously, first-line treatment for recurrent symptomatic malignant pleural effusion was chest drain insertion and talc pleurodesis, with indwelling pleural catheter insertion reserved for patients with trapped lung or failed talc pleurodesis. (ox.ac.uk)
- Malignant pleural effusion is a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue (pleura) lining the outside of the lung and the wall of the chest cavity. (wikipedia.org)
Vitro1
- Veracyte's exclusive diagnostics rights to the nCounter Analysis System allows us to perform our tests globally as in vitro diagnostics (IVDs). (clpmag.com)
Biomarker1
- Soluble mesothelin is the most studied and an FDA-approved biomarker for MM. A recent report showed promising results using fibulin-3 as a new diagnostic marker. (bmj.com)
Soft-tissue1
- Malignant mesenchymoma, which was described by Stout in 1948, is defined as a malignant soft tissue tumor that consists of two or more distinctly different mesenchymal components in addition to fibrosarcomatous elements. (biomedcentral.com)
Disease6
- Histologic examination in six patients confirmed malignant nodal disease in five cases and indicated granulomatous lymphadenitis in one. (nih.gov)
- CONCLUSIONS Malignant optic glioma is a diagnostic challenge and remains a devastating and lethal disease. (uzh.ch)
- Since 2010, over 60 entities including 40 new firms globally have set out to capitalise on these technological advances, seeking to commercialise AI-based diagnostics services in fields such as cancer and cardiovascular disease (CVD). (idtechex.com)
- AS-OCT was classified into two mechanisms, PIC versus non-PIC, of primary angle closure disease (PACD) and AS-OCT-PIC diagnostic performance was tested with DxPIC. (bmj.com)
- The primary objectives in a diagnostic evaluation for suspected cancer are determinations of the tissue type, the primary site of malignancy, the extent of disease within the body and the tumor's future recurrence potential. (oncolink.org)
- It is most applicable for malignant disease in the central nervous system, spine, head and neck and musculoskeletal system, aiding in detection, localization and staging. (oncolink.org)
Pleural fluid1
- Results Mesothelin provides better diagnostic accuracy than fibulin-3 for MM whether measured in plasma or pleural effusion: area under the curve (AUC) for plasma was 0.822 (95% CI 0.76 to 0.87) compared with 0.671 (0.61 to 0.73), respectively, and for pleural fluid AUC was 0.815 (0.74 to 0.87) compared with 0.588 (0.51 to 0.67), respectively. (bmj.com)
Cytopathology1
- In thyroid cancer, for example, many patients have historically undergone unnecessary diagnostic surgery because cytopathology results on their fine needle aspirations were indeterminate. (clpmag.com)
Chondrosarcoma1
- A case of malignant mesenchymoma of the bladder containing leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, osteosarcoma, and myxomatous components is described. (biomedcentral.com)
Significantly1
- The general consensus is that ADCs of malignant nodes are significantly lower than those of benign nodes [ 15 ]. (hindawi.com)
Melanomas1
- Typically, 15-20% of malignant melanomas possess NRAS gene mutations, but no cases of NRAS -mutated PML have been reported in the English literature. (biomedcentral.com)