Diagnosis of primary and metastatic carcinoma. Medical search. Frequent questions

Certain attributes distinguish metastases from primary tumors. (medscape.com)
Metastatic tumors are usually round, discrete tumor lobules in the dermis, with a Grenz zone, and are usually unassociated with the epidermis. (medscape.com)
Surgical treatment may be considered for cases with even rapid-growing tumors such as gastric carcinoma with no evidence of multi-organ dissemination, especially when presenting with progressive neurological deterioration. (unboundmedicine.com)
Tumors from Merkel cell carcinoma typically appear on sun-exposed areas of skin. (clevelandclinic.org)
The tumors are under 6cm but they've been growing over the last month or so as I've been going through the process of diagnosis and preparing for treatment. (cancer.org)
The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary lesions of the pineal region, including parenchymal pineal tumors, papillary ependymoma, papillary meningioma, choroid plexus papilloma, and metastatic papillary carcinoma. (wikipedia.org)
however, morphologically the tumors appeared to be less differentiated than a choroid plexus papilloma and more differentiated than a choroid plexus carcinoma. (wikipedia.org)
Of primary adrenal tumors, ACC is less common than cortical adenoma and pheochromocytoma. (cap.org)
Lacrimal gland tumors account for 9% of all orbital lesions with inflammatory, lymphocytic, metastatic, or primary epithelial origin. (logicalimages.com)
Special consideration is made toward the primary epithelial tumors pleomorphic adenoma and adenoid cystic carcinoma, which carry malignant transformation potential. (logicalimages.com)
Determination of blood vessel density in the peritumoral stroma may be an additional parameter for differential diagnosis of trichogenic tumors of uncertain dignity. (uni-wuerzburg.de)
In clinical practice, the detection of biomarkers is mostly based on primary tumors for its convenience in acquisition. (biomedcentral.com)
PD-1, PD-L1 and PD-L2 were differentially expressed between primary and metastatic tumors. (biomedcentral.com)
Among them, the heterogeneity of the tumor may play an important role, especially the heterogeneity between the primary and metastatic tumors. (biomedcentral.com)
Magnetic resonance imaging (MRI) of the liver can be useful in detecting and characterizing primary tumors, and MRI may be slightly more sensitive than CT scanning in detecting multiple intrahepatic recurrent lesions. (medscape.com)
This phase II trial studies how well olaparib works in treating patients with bladder cancer and other genitourinary tumors with deoxyribonucleic acid (DNA)-repair defects that has spread to other places in the body (advanced or metastatic) and usually cannot be cured or controlled with treatment. (bcan.org)
Because the most common causative primary tumors are those of the testes, lungs, colon and rectum, and pancreas, examination of these areas must be thorough. (msdmanuals.com)
Increasing numbers of immunocytochemical stains can be used to test available cancerous tissue to help determine the primary site and can potentially identify tumors arising from the lung, colon, or breast. (msdmanuals.com)
In addition, immune peroxidase staining for immunoglobulin, chromosome studies, and immunophenotyping may help diagnose the various subtypes of malignant lymphomas, which may be difficult to recognize and differentiate from other tumors (even carcinomas) outside lymph nodes. (msdmanuals.com)
Prostate cancer should always be considered in the differential diagnosis of elderly men presenting with metastatic epithelial tumors even in unusual sites. (hindawi.com)
Although immune checkpoint inhibitors have opened a new mode of treatment for solid tumors, their efficacy in nasopharyngeal carcinoma (NPC) needs to be further investigated. (jcancer.org)
Results: In 18 of 20 patients, the primary tumors disappeared or were markedly reduced after radiation therapy. (iiarjournals.org)
For patients who are expected to survive for more than 1 year, almost curative-dose irradiation to primary tumors is recommended. (iiarjournals.org)
Advanced BCC encompasses a heterogeneous assortment of cases, including metastatic BCC as well as locally advanced BCC (for which no formal definition exists but which generally includes large, deep, aggressive, or recurrent tumors). (saveyourskin.ca)
Malignant Liver Tumors (Metastatic Liver Disease). (booksca.ca)
These tumors include all primary cancers (including hepatocellular cancer and cholangiocarcinoma), all metastatic cancers (including colorectal, neuroendocrine and others), and any nonmalignant tumors. (uky.edu)
In 149 cases from the subgroup of 171 primary lung cancer cases the tumors originated mainly in the upper lobes (45%) and main stem bronchi (29%), whereas in 26% of the cases the exact location of origin was not well defined. (cdc.gov)
Radionuclide sulfur-colloid scans or scans obtained with labeled red blood cells are occasionally useful in the differentiation of fibrolamellar carcinomas from other types of hepatic tumors. (medscape.com)
They include primary cardiac tumors and metastatic tumors to the heart. (bvsalud.org)
Differential VHL Mutation Patterns in Bilateral Clear Cell RCC Distinguishes Between Independent Primary Tumors and Contralateral Metastatic Disease. (cdc.gov)
Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. (cancercentrum.se)

Immunohistochemical analysis of a biopsy specimen was used to make the diagnosis of metastatic clear cell renal cell carcinoma in this patient, whose primary malignancy was previously unknown. (agd.org)
Therefore, we aimed to compare the differential expressions of PD-1, PD-L1 and PD-L2 between the primary and metastatic sites of renal cell carcinoma (RCC). (biomedcentral.com)
Renal cell carcinoma (RCC) is originated from the epithelium of renal tubules. (biomedcentral.com)
We report a patient with renal cell carcinoma during pregnancy who was treated with robot-assisted partial nephrectomy. (bvsalud.org)
This is report of a metastatic renal cell carcinoma initially presented with intramedullary spinal cord lesion, to our knowledge there are few similar reports in literature. (biomedcentral.com)
After thorough imaging investigation she underwent radical nephrectomy which confirmed renal cell carcinoma. (biomedcentral.com)
The therapeutic approach to renal cell carcinoma (RCC) is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)
Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it also is used for palliation in metastatic disease. (medscape.com)
Renal cell carcinoma is an immunogenic tumor, and spontaneous regressions have been documented. (medscape.com)
The study also revealed increased risk of death due to renal cell carcinoma in patients who did not undergo surgical resection of metastasis. (medscape.com)
[ 18 ] A study by Alt et al found that complete resection of multiple renal cell carcinoma metastases may be associated with long-term survival. (medscape.com)
The treatment of metastatic renal cell carcinoma is problematic, and, whenever possible, patients should be directed to approved and controlled clinical trials. (medscape.com)
This applies as well in the adjuvant treatment of surgically resected renal cell carcinoma, for which no therapy has yet been found to offer survival benefit. (medscape.com)
Go to Renal Cell Carcinoma Treatment Protocols , Clear Cell Renal Cell Carcinoma , and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
Genetic Analysis Reveals the Important Role of the APC Gene in Clear Cell Renal Cell Carcinoma. (cdc.gov)

The term carcinoma of unknown primary site (CUPS) is used when dealing with a metastasis that occurs before primary tumor diagnosis. (medscape.com)
In dealing with cutaneous CUPS, the age, sex, and affected skin region of the patient, as well as the histology of the lesion, are useful in determining the location of the likely primary tumor. (medscape.com)
[ 2 ] On the other hand, some metastases may be epidermotropic and simulate a primary epidermal tumor. (medscape.com)
The primary tumor had been treated 2 years previously. (unboundmedicine.com)
The primary purpose of this study is to assess novel tumor genomic biomarkers (TRAF3 and CYLD gene defects and HPV integration) of recurrence risk in patients with Human papillomavirus+oropharyngeal squamous cell carcinoma (HPV+OPSCC) undergoing curative-intent therapy. (mayo.edu)
Its therapeutic use is limited to the treatment of hypercalcemia and Paget's osteopathy, and as a tumor marker in medullary carcinoma. (teknon.es)
Half of the patients with ACC exhibit symptoms and signs of excess steroid hormone production, while the remaining are asymptomatic at the time of diagnosis or experience mechanical effects related to tumor growth. (cap.org)
However, immune checkpoints may express differently between primary and metastatic tumor. (biomedcentral.com)
[ 8 ] Fibrolamellar carcinoma occurs in a younger population than does HCC , and it is typically not associated with underlying liver disease or elevated serum levels of alpha-fetoprotein tumor markers. (medscape.com)
the carcinoma appears as an area of hypervascularity and tumor blush in the inferior aspect of the liver. (medscape.com)
Resection of large tumor masses, of metastatic disease, and even of recurrent disease can extend patient survival. (medscape.com)
To explore tumor-mutational profiles in metastatic tumor biopsies, saliva "normal" DNA, changes in tumor or peripheral immune characteristics, or tumor associated somatic mutation load in blood DNA in response to treatment. (bcan.org)
At this point, a pathological diagnosis should be performed immediately to determine the nature and source of the tumor. (spandidos-publications.com)
A patient is considered to have a cancer of unknown primary origin when cancer is detected at one or more sites and routine evaluation fails to identify the primary tumor. (msdmanuals.com)
However, they have a limited effect on patients with locally advanced or distantly metastatic disease, and approximately 30% of high-risk patients still experience tumor recurrence, with distant metastasis as the primary failure pattern [ 4 ]. (jcancer.org)
Prognostic significance of tumor cell proliferation rate as determined by the MIB-1 antibody in breast carcinoma: Its relationship with vimentin and p53 protein. (mpg.de)
Carcinoma tumor initially develops in the tissue that lines to vital body organs such as kidneys and liver, or the skin's epithelial tissue. (medicalopedia.org)
It is the second stage of Carcinoma cancer when the tumor has moved out of the primary tissue layer to the surrounding tissues. (medicalopedia.org)
Chemotherapy treats Carcinoma cancer with drugs to destroy the tumor cells, either in the specific area or throughout the body. (medicalopedia.org)
However, three patients had primary tumor progression at 7, 9, and 15 months after irradiation with total doses of 56.8, 58.4, and 68.3 Gy in EQD2, respectively. (iiarjournals.org)
In fact, around 3% of patients at diagnosis have uterine cervical cancer at stage IVB with spread of the tumor beyond the pelvis, such as lung, liver, and bone metastases, based on the International Federation of Gynecology and Obstetrics staging system ( 3 , 4 ). (iiarjournals.org)
Even in such patients, radiation therapy has been positively used with palliative intent to relieve severe symptoms, including bleeding and pain, via primary tumor control. (iiarjournals.org)
Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
This article describes the use of common tumor markers in primary care practice. (aafp.org)
The possibility of disease-free survival increases after resection of primary tumor and isolated metastasis excision. (medscape.com)
Multidisciplinary Liver Tumor Program at UK HealthCare provides timely diagnosis and individualized treatment and surveillance for patients - based on expert consensus across multiple medical and surgical disciplines involved with liver disease. (uky.edu)
One aim is that our imaging and biomarker research on primary melanoma in the future can help to reflect biological aggression, metastatic potential and predict treatment response in a specific melanoma tumor. (lu.se)
In this respect, in contrast to predictors based for each serum protein was determined by comparing the samples upon tumor characteristics at the time of surgery, serum is a par- collected at the primary operation and then 3-6 mo later. (lu.se)
The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
before resection of the primary tumor and then postoperatively every 6-12 mo, resulting in three to five samples per patient. (lu.se)

See Cutaneous Clues to Diagnosing Metastatic Cancer , a Critical Images slideshow, to help identify various skin lesions that are cause for concern. (medscape.com)
Sabattini S , Renzi A , Buracco P , Comparative assessment of the accuracy of cytological and histologic biopsies in the diagnosis of canine bone lesions . (avma.org)
Many carcinomas are solid, while several cystic or mixed lesions are benign. (teknon.es)
Radiologic and FNA cytologic studies are also useful in staging patients with possible metastatic lesions. (cap.org)
In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
Histopathological examination of these immune check points in metastatic lesions of mRCC should be noticed, and its accurate diagnosis may be one of the effective ways to realize the individualized treatment. (biomedcentral.com)
Metastatic Disease of the Extremity is a malignant pathologic process that is the most common cause of destructive bone lesions in the extremities of adult patients. (orthobullets.com)
1] Hematogenous dissemination is rare at diagnosis but is more common in patients with advanced, neglected lesions. (cancernetwork.com)

Cutaneous metastases from carcinoma (see the image below) are relatively uncommon in clinical practice, but they are very important to recognize. (medscape.com)
Primary cutaneous adnexal carcinomas may be difficult to distinguish from metastases in certain situations. (medscape.com)
Extrahepatic metastases of hepatocellular carcinoma. (bmj.com)
In addition, estrogen receptor staining may be a useful technique in evaluating metastases in patients with unknown primaries in whom the possibility of metastatic breast carcinoma is in the differential diagnosis. (bccancer.bc.ca)
Small bowel metastases from primary carcinoma of the lung are very uncommon and occur usually in patients with terminal stage disease. (ispub.com)
Metastases affecting the small bowel and originating from carcinoma of the lung are a rare occurrence, but recent reports suggest that they may be more frequent than previously thought as they rarely produce symptoms. (ispub.com)
We present a case of a 61 year old patient with upper gastrointestinal bleeding due to duodenal metastases from a primary adenocarcinoma of the lung with secondary deposits in the abdominal lymph nodes. (ispub.com)
The occurrence of small intestinal metastases from primary lung cancer is rare. (spandidos-publications.com)
Lung cancer is the leading cause of cancer-related death worldwide, with most patients presenting with metastases during diagnosis ( 1 ). (spandidos-publications.com)
Unusual prostate carcinoma metastases are usually encountered in the presence of known advanced disease but rarely as the first presentation. (hindawi.com)

The American Cancer Society (ACS) estimated 41,260 new diagnoses and 30,520 deaths from liver cancer in 2022. (healthline.com)
In March 2022 Health Canada approved Libtayo® (cemiplimab) for patients with locally advanced basal cell carcinoma (LaBCC), previously treated with a hedgehog pathway inhibitor (HPI). (saveyourskin.ca)

patients with multifocal, multicentric, and synchronous bilateral, and primary inflammatory breast cancers are allowed. (valleyhealth.com)
Cancer of unknown primary constitutes up to 7% of all cancers and poses a therapeutic dilemma because cancer treatment is typically determined by the specific primary tissue of origin. (msdmanuals.com)
For most other unknown primary cancers, the responses to this regimen and to other multidrug chemotherapy regimens are modest and of brief duration (eg, median survival 1 year). (msdmanuals.com)
Conversely adenocarcinoma was the most frequent cancer (84%) in the cases excluded as probably metastatic cancers. (cdc.gov)

Alopecia neoplastica due to metastatic breast cancer. (medscape.com)
For example, prostate cancer is very common, but cutaneous metastasis from prostate carcinoma is relatively uncommon. (medscape.com)
Paget disease may be a sign of underlying breast, genitourinary, or colon cancer, or it may be a primary neoplasm of indeterminate glands in the skin. (medscape.com)
This cancer continues to cause challenges for diagnosis and treatment because of its rarity, overlapping features with benign parathyroid disease, and lack of distinct characteristics. (nih.gov)
Results Nine-hundred patients with primary ovarian cancer were reviewed, out of which 94 patients (10.4%) had MOC. (thieme-connect.de)
Merkel cell carcinoma is a rare but aggressive type of skin cancer that can be life-threatening. (clevelandclinic.org)
Merkel cell carcinoma is a very rare type of skin cancer , affecting approximately 3,000 Americans every year. (clevelandclinic.org)
UV rays from sun exposure or artificial light sources like tanning beds cause most types of skin cancer, including Merkel cell carcinoma. (clevelandclinic.org)
Having other types of skin cancer like basal cell carcinoma, squamous cell carcinoma or melanoma. (clevelandclinic.org)
Merkel cell carcinoma is an aggressive cancer that spreads quickly to other parts of your body. (clevelandclinic.org)
When cancer spreads from its primary site, you have metastatic cancer . (clevelandclinic.org)
Metastatic cancer is more difficult to treat. (clevelandclinic.org)
The most common category of nonmesotheliomatous cancer to involve the pleura is represented by extrapleural primary malignancies that secondarily involve the pleura via metastatic spread. (medscape.com)
[ 5 ] An earlier report, in 1956, by Babolini and Blasi, described the same clinicopathological entity using the nomenclature, "The pleural form of primary cancer of the lung. (medscape.com)
Inframammillae: Consider inverse psoriasis, candidal infection, inflammatory metastatic breast cancer, Paget disease, or benign familial pemphigus (Hailey-Hailey disease). (medscape.com)
Hepatocellular carcinoma is a type of liver cancer. (healthline.com)
Hepatocellular carcinoma (HCC) is the most common type of liver cancer . (healthline.com)
Although the patient had no medical history of breast cancer, due to this result, she was referred to a mastologist, who investigated her breast nodules for the possible primary focus of the carcinoma. (bvsalud.org)
I. To evaluate the efficacy of olaparib in two cohorts of patients with metastatic/advanced non prostate genitourinary (GU) cancer pre-selected by DNA-repair defects as measured by overall response rate (ORR). (bcan.org)
I. To determine the proportion of patients with DNA-repair pathway-mutated genes in metastatic non-prostate GU cancer (patient cohort referred for screening). (bcan.org)
Postoperative pathological analysis confirmed the final diagnosis to be small intestinal metastasis from primary lung cancer. (spandidos-publications.com)
Patients with early-stage lung cancer are asymptomatic, whereas those with advanced metastasis are frequently symptomatic due to metastatic sites. (spandidos-publications.com)
Furthermore, the gastrointestinal (GI) tract is not a common site of primary lung cancer metastasis ( 4 ). (spandidos-publications.com)
Furthermore, the literature relevant to the occurrence, diagnosis and treatment of GI metastasis of lung cancer was reviewed. (spandidos-publications.com)
Mediastinum and retroperitoneum are exceedingly rare sites for metastatic prostate cancer to occur. (hindawi.com)
Less frequently, patients present initially with metastatic prostate cancer. (hindawi.com)
The surgeon often has a central role in the diagnosis, treatment, and aftercare of the cancer patient in an emergency situation. (vin.com)
People with recurrent or metastatic ovarian, fallopian, primary peritoneal or carcinoma are asked to participate in a research study being conducted by Monter Cancer Center. (brany.com)
With 4.3 million cases reported annually in the US alone, Carcinoma is the most common type of skin cancer. (medicalopedia.org)
Of all Carcinoma cancer types, Basal Cell Carcinoma is quite prevalent. (medicalopedia.org)
Regardless of the type of cancer, early diagnosis is indispensable for effective treatment. (medicalopedia.org)
Clinical outcomes and patterns of population-based management of urachal carcinoma of the bladder: An analysis of the National Cancer Database. (nih.gov)
Basal cell carcinoma, in general, is the most common form of skin cancer in the world," says Dr. Vanessa Bernstein, BC Cancer Agency. (saveyourskin.ca)
But the majority of the cases of basal cell cancer won't be locally advanced or metastatic. (saveyourskin.ca)
Dr. Max Sauder, Onco-dermatologist at Princess Margaret Cancer Centre, reviews the latest news, clinical data and other updates as they relate to the treatment of cutaneous basal cell carcinoma (BCC), a common and sometimes metastatic skin cancer. (saveyourskin.ca)
Dr. Sauder provides an update on skin cancer statistics in Canada, the science behind primary and metastatic BCC diagnosis and treatment, and shares his key insights into what the landscape of metastatic BCC immuno-oncology treatment looks like for the near future in Canada. (saveyourskin.ca)
Metastatic Breast Cancer. (booksca.ca)
Diagnosis and Management of Gallbladder Cancer. (booksca.ca)
Considering the prevalence of cancer, it is imperative that clinicians be mindful of occult carcinoma as the cause of suspicious intramedullary spinal cord lesion. (biomedcentral.com)
Background: Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. (edu.au)
Methods: Information collected prospectively was analysed for all patients seen from 1999 to 2009 with primary breast cancer and who had biopsy of a local or distant recurrence. (edu.au)
12.7%) breast cancer had biopsy of the metastatic site. (edu.au)
Only one patient demonstrated HER2 discordance - primary lesion was positive whilst a metastatic site was negative.Conclusions: This single institution study demonstrated a low rate of HER2 discordance between primary and recurrent breast cancer as assessed by in-situ hybridisation. (edu.au)
Background: Cancer diagnosis impacts not only on the patients but their family. (edu.au)
Background: The addition of bevacizumab to chemotherapy improves progression-free survival in metastatic breast cancer and pathological complete response rates in the neoadjuvant setting. (edu.au)
Cancer antigen (CA) 27.29 most frequently is used to follow response to therapy in patients with metastatic breast cancer. (aafp.org)
AFP and β-hCG also may be useful in evaluating potential origins of poorly differentiated metastatic cancer. (aafp.org)
PSA is used to screen for prostate cancer, detect recurrence of the malignancy, and evaluate specific syndromes of adenocarcinoma of unknown primary. (aafp.org)
However, cancer that occurs only in the liver is known as hepatocellular carcinoma. (uky.edu)
Among these, 331 cases (9.9%) were submitted with a diagnosis of lung cancer. (cdc.gov)
Subsequently a subgroup of 171 primary lung cancer cases was selected from the total of 306 cases in which the diagnosis of a primary lung cancer was beyond any reasonable doubt. (cdc.gov)
The age and mining histories were similar in the 331 group of lung cancer cases and the subgroup of 171 cases with primary lung cancer. (cdc.gov)
On the other hand, in the 171 primary lung cancer cases the squamous cell cancer was the predominant type followed by equal proportions of adenocarcinomas and small cell carcinomas. (cdc.gov)
The specific aims of our research are to identify risk factors and prognostic factors associated with certain skin cancer diagnoses, as malignant melanoma, basal cell carcinoma and cutaneous squamous cell carcinoma. (lu.se)
We also strive to identify factors that can optimize the care of patients with a skin cancer diagnosis, both before the diagnosis and after the diagnosis. (lu.se)
Within the BioMEL project, we collaborate with LUCC (Lund University Cancer Center) and many of the clinical units that perform metastatic surgery and treatment for disseminated malignant melanoma. (lu.se)
A skin cancer diagnosis has impact not only on health economics but also on the quality of life of the individual. (lu.se)
However, a simple way to screened 240 sera from 64 patients with primary breast cancer. (lu.se)
This predict the likelihood of a later recurrence, i.e., an indicator that unique longitudinal sample material was collected from each pa- allows risk assessment for breast cancer metastasis, would be tient between 0 and 36 mo after the primary operation. (lu.se)
In Sweden, there has been a steady prostate-specific antigen (PSA) velocity for the diagnosis of pros- decrease in age-standardized breast cancer mortality in women up tate cancer (15). (lu.se)
The role of staging laparoscopy in primary gall bladder cancer--an analysis of 409 patients: a prospective study to evaluate the role of staging laparoscopy in the management of gallbladder cancer. (cancercentrum.se)
Schiza A, Fredriksson I, Sund M, Valachis A. De novo metastatic breast cancer in men vs women: a Swedish population-based cohort study. (cancercentrum.se)

Histology of the tissue confirmed a metastatic hepatocellular carcinoma. (bmj.com)
However, hepatocellular carcinoma is the most common. (healthline.com)
In this article, we delve deeper into hepatocellular carcinoma. (healthline.com)
What is hepatocellular carcinoma? (healthline.com)
What are the symptoms of hepatocellular carcinoma? (healthline.com)
Who's at risk for hepatocellular carcinoma? (healthline.com)
How is hepatocellular carcinoma diagnosed and staged? (healthline.com)
How is hepatocellular carcinoma treated? (healthline.com)
Fibrolamellar hepatocellular carcinoma, or fibrolamellar carcinoma , is a rare primary malignant neoplasm of the liver that constitutes 0.8-16% of all hepatocellular malignancies. (medscape.com)
[ 6 , 7 ] and radiographic features that distinguish it from the relatively more common hepatocellular carcinoma ( HCC ). (medscape.com)
See the images of fibrolamellar hepatocellular carcinoma below. (medscape.com)
Transarterial Chemoembolization in Children to Treat Unresectable Hepatocellular Carcinoma. (stanford.edu)
pubMedId':'29707868','pubMedUrl':'https://www.ncbi.nlm.nih.gov/pubmed/29707868','publicationId':'464438','title':'Transarterial chemoembolization in children to treat unresectable hepatocellular carcinoma. (stanford.edu)
Alpha-fetoprotein (AFP), a marker for hepatocellular carcinoma, sometimes is used to screen highly selected populations and to assess hepatic masses in patients at particular risk for developing hepatic malignancy. (aafp.org)
While hepatocellular carcinoma is common in many parts of the world, it is not as common in the United States and most developed countries. (uky.edu)
There are other factors making the development of hepatocellular carcinoma more likely, such as being sex, obesity, type 2 diabetes, and anabolic steroid use. (uky.edu)
Fibrolamellar hepatocellular carcinoma, or fibrolamellar carcinoma, is an uncommon malignant neoplasm of the liver. (medscape.com)

Composite resection of the metastatic lesion was performed, and the mandible was reconstructed with an osteomyocutaneous free tissue transfer and a custom plate. (agd.org)
As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
Diagnosis is made with plain radiographs of the affected limb including the joint above and below the lesion. (orthobullets.com)
In patients where a primary carcinoma is not identified, obtaining a biopsy is necessary to rule out a primary bone lesion. (orthobullets.com)

Ultrasound-guided fine-needle aspiration biopsy cytology (FNAB-C) is able to detect approximately 63% of medullary thyroid carcinoma (MTC). (unicatt.it)
Biopsy proven squamous cell carcinoma of the oropharynx or unknown primary. (mayo.edu)
Histological examination and immunohistochemical staining of the biopsy specimen strongly supported the diagnosis of metastatic lung adenocarcinoma. (ispub.com)
Percutaneous biopsy with CT scanning or ultrasonographic guidance may be necessary for a definitive preoperative diagnosis of fibrolamellar carcinoma. (medscape.com)

Cutaneous metastasis may herald the diagnosis of internal malignancy, and early recognition can lead to accurate and prompt diagnosis and timely treatment. (medscape.com)
Some primary melanomas may arise in the dermis and simulate a metastasis. (medscape.com)
A 42-year-old male presented with a rare intramedullary spinal cord metastasis from gastric carcinoma manifesting as rapidly worsening motor and sphincter disturbances. (unboundmedicine.com)
Anatomopathological and immunohistochemical study revealed a preliminary diagnosis of breast carcinoma metastasis. (bvsalud.org)
New anatomopathological and immunohistochemical exams confirmed the diagnosis of breast carcinoma metastasis. (bvsalud.org)
In terms of survival analysis, patients with PD-1 expression either in the primary or metastasis had a shorter overall survival (OS) (HR: 1.59, 95% CI 1.08-2.36, p = 0.02). (biomedcentral.com)
We describe the case of 61 year-old patient with primary adenocarcinoma of the lung , presenting with melaena as the first manifestation of small bowel metastasis. (ispub.com)
The study population comprised of 116 patients with adequate tissue in both primary and metastasis. (edu.au)
About 25-30% of patients have metastatic disease at diagnosis, and fewer than 5% have a solitary metastasis. (medscape.com)

The efficacy of classical adjuvant therapies, such as radiotherapy and chemotherapy, in management of persistent, recurrent, or metastatic disease has been disappointing. (nih.gov)
Bavencio has received first-line maintenance therapy and best supportive care for the patients with previously untreated locally advanced or metastatic urothelial carcinoma (UC) whose disease did not progress on induction chemotherapy. (delveinsight.com)
During admission for the second round of chemotherapy and one month after diagnosis, the patient complained of diffuse abdominal pain and abdominal tenderness. (ispub.com)
Survival benefit of chemotherapy in a contemporary cohort of metastatic urachal carcinoma. (nih.gov)

Merkel cell carcinoma most commonly spreads to your lymphatic system (lymph nodes) first. (clevelandclinic.org)
Metastatic BCC is defined as primary cutaneous basal cell carcinoma that has spread to local or distant lymph nodes or to distant organs or tissues. (saveyourskin.ca)

Sometimes adnexal carcinomas arise in the setting of a precursor benign adnexal neoplasm, making diagnosis straightforward. (medscape.com)
Parathyroid carcinoma is a malignant neoplasm affecting 0.5 to 5.0% of all patients suffering from primary hyperparathyroidism. (nih.gov)
By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (bvsalud.org)

Merck and Pfizer have announced the results of Phase III clinical studies of BAVENCIO for the treatment of untreated locally advanced or metastatic urothelial carcinoma (UC). (delveinsight.com)
Immunomedics, BMS, Rexahn Pharmaceuticals are some other pharma companies developing therapies to advance Urothelial carcinoma market. (delveinsight.com)
Bladder urachal urothelial carcinoma that has spread to another anatomic site. (nih.gov)

Early en bloc surgical resection of the primary tumour with clear margins remains the best curative treatment. (nih.gov)
Surgical resection is recommended in selected patients with metastatic renal carcinoma. (medscape.com)
More than a quarter of the ovary which made the diagnosis and thus the was removed by wedge resection and was management straightforward with wedge sent for frozen sectioning. (who.int)
Hepatic resection in 485 R0 pT2 and pT3 cases of advanced carcinoma of the gallbladder: results of a Japanese Society of Biliary Surgery survey--a multicenter study. (cancercentrum.se)

The histological diagnosis was gastric adenocarcinoma. (unboundmedicine.com)
[ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
This report documents the case of a 57‑year‑old male patient initially diagnosed with non‑metastatic lung adenocarcinoma, who presented with abdominal pain 6 months later. (spandidos-publications.com)
Here, we present the case of a 67-year-old male patient with incidental findings of mediastinal and retroperitoneal masses which were found to be due to metastatic prostate adenocarcinoma based on histopathology and immunohistochemical studies and later on supported by the significantly elevated Prostate Specific Antigen (PSA) levels. (hindawi.com)
Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance. (nih.gov)

Seventy percent of NPC patients have locally advanced disease at the first diagnosis. (jcancer.org)

myeloma involves the mandible more commonly than metastatic disease (breast, lung, prostate), whereas primary malignancy (osteosarcoma) is rare. (bmj.com)
The third/second generation PTH assay ratio provides valuable information to distinguish between benign parathyroid disease and parathyroid carcinoma. (nih.gov)
1) could indicate a high suspicion regarding carcinoma and metastatic disease. (nih.gov)
Although prolonged survival is possible with recurrent or metastatic disease, cure is rarely achievable. (nih.gov)
In metastatic disease the goal of therapeutic support is to control the PTH-driven hypercalcemia that represents the primary cause of mortality. (nih.gov)
No evidence of distant metastatic disease. (mayo.edu)
Malignancies include metastatic carcinoma, Paget disease, or Bowen disease. (medscape.com)
Among all RCC patients, nearly 20-30% of them were initially diagnosed as metastatic RCC (mRCC), and 20-40% of patients with localized disease will eventually develop metastatic disease after surgery [ 3 ]. (biomedcentral.com)
Patients with this type of carcinoma should be treated with a cisplatin -based regimen because nearly 50% have long disease-free intervals. (msdmanuals.com)
Prostate carcinoma is the second most common malignant disease in men. (hindawi.com)
However, some patients are still found to have advanced-stage disease at diagnosis. (iiarjournals.org)
Scrotal Paget's disease associated with metastatic carcinoma with apocrine features and ERBB2-amplification/HER2 overexpression responding well to weekly paclitaxel combined with trastuzumab and pertuzumab. (aau.dk)
These include disease-free interval, which may raise the possibility of a new malignancy and the accuracy of initial HER2 assessment of the primary tumour. (edu.au)
Testing for the beta subunit of human chorionic gonadotropin (β-hCG) is an integral part of the diagnosis and management of gestational trophoblastic disease. (aafp.org)
Targeted therapy and immunomodulatory agents are considered standard of care in patients with metastatic disease. (medscape.com)
An increase in serum phosphatase activity is associated with primary hyperparathyroidism, secondary hyperparathyroidism owing to chronic renal disease, rickets, and osteitis deformans juvenilia due to vitamin D deficiency and malabsorption or renal tubular dystrophies. (cdc.gov)
AST measurements are used in the diagnosis and treatment of certain types of liver and heart disease. (cdc.gov)

Using an approach that includes consideration of the morphologic features, appropriate immunohistochemistry, and correct clinical context aids in making the proper diagnosis. (medscape.com)
Tumour classification systems provide the foundation for tumour diagnosis and patient therapy and a critical basis for epidemiological and clinical studies. (ersjournals.com)

The histologic diagnosis will determine the prognosis and treatment. (logicalimages.com)
The large cell carcinoma class has been enriched with several variants, including the LCNEC and the basaloid carcinoma, both with a dismal prognosis. (ersjournals.com)
Diagnosis of nosis of the cause of PE is essential, as the exudative PE was confirmed according to treatment and prognosis may vary. (who.int)
[ 9 ] Also, fibrolamellar carcinoma may have a slightly better prognosis than HCC . (medscape.com)

Primary cutaneous apocrine carcinomas can be particularly difficult to differentiate from adenocarcinomas of mammary origin because of the identical morphological and immunohistochemical features they may exhibit. (medscape.com)

I've been diagnosed with Metastatic Squamous Cell Carcinoma of the Head and Neck with an unknown primary. (cancer.org)
Management of Squamous Cell Carcinoma of the Oropharynx (OPSCC). (booksca.ca)

Testing is done on the primary tumour and/or the recurrent tumour. (bccancer.bc.ca)
Upper gastrointestinal endoscopy performed with a colonoscope revealed active bleeding from a metastatic tumour involving the duodenum and the proximal jejunum. (ispub.com)
Several studies have demonstrated discordant HER2 status in the primary and metastatic tumour. (edu.au)

Even if a precise histologic diagnosis cannot be made, a constellation of findings may suggest an origin. (msdmanuals.com)

In cases with studies [10-12], their diagnostic perform- transudate PE, the diagnosis is usually made ance for identification of TB or malignancy without any difficulties but exudative PE in patients with the exudative type of PE has requires careful differential diagnosis that not been studied or compared yet. (who.int)

Being aware of this unusual and rare presentation of metastatic prostate carcinoma might decrease diagnostic delay and allow earlier treatment. (hindawi.com)
The diagnosis was stage IV metastatic prostate carcinoma (pM1a). (hindawi.com)

Neuroendocrine carcinoma of the skin. (clevelandclinic.org)
Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)

The results of cytological examination of bronchial excretions however, proved positive for non-small cell carcinoma of the lung. (ispub.com)

Differential diagnoses for intertrigo are described below. (medscape.com)

Incidentally found adrenal masses can be further classified as benign or malignant and primary adrenal versus metastatic using radiologic-cytologic or pathologic correlation. (cap.org)

Primary carcinoma of the vagina accounts for 1% to 3% of all gynecologic malignancies, with 70% of cases occurring in women over age 60. (cancernetwork.com)

The study has met its primary end point of overall survival (OS). (delveinsight.com)
p21/WAF 1/Cip 1 expression in invasive ductal breast carcinoma: relationship to p53, proliferation rate, vimentin, cathepsin D and survival at 5 years. (mpg.de)

Liver biopsies aren't always a part of HCC diagnosis. (healthline.com)
Despite an active investigation through imaging tests, biopsies, and mammotomy, without finding any possible primary focus on the breasts. (bvsalud.org)

Evaluation of the patient with carcinoma of unknown origin metastatic to bone. (wheelessonline.com)

Abdominal computed tomography (CT) scanning is the preferred examination for the detection, diagnosis, staging, and postoperative follow-up evaluation of fibrolamellar carcinoma. (medscape.com)
Despite the current findings, the decision to obtain metastatic tissue for evaluation is influenced by other factors. (edu.au)

Early and accurate diagnosis is important to choosing the most appropriate care strategies, even if the patient is not exhibiting symptoms. (cdc.gov)

The estrogen receptor status of breast carcinoma can be determined by immunocytochemical staining of tissue specimens or of aspirates. (bccancer.bc.ca)

Currently, derma market has high unmet medical needs such as the absence of standard approved therapies, and proper diagnosis of different diseases. (delveinsight.com)
The anamnesis should include previous oncologic diagnoses, procedures, and therapies. (vin.com)

Patients must have a histologically confirmed diagnosis of invasive breast carcinoma with positive estrogen (ER)- and/or progesterone-receptor (PR) status, and negative human epidermal growth factor receptor (HER)2, for whom standard adjuvant endocrine therapy is planned. (valleyhealth.com)

Poorly differentiated carcinomas near or at midline regions of the mediastinum or retroperitoneum in young or middle-aged males should be considered germ cell neoplasms-even in the absence of a testicular mass. (msdmanuals.com)

The role of radiotherapy and chemoradiation in the management of primary liver tumours. (cancercentrum.se)

How common is Merkel cell carcinoma? (clevelandclinic.org)
All patients were given a clini- common ways of establishing a diagnosis cal examination, chest radiograph, blood of tuberculous PE or malignant PE [10-12]. (who.int)

Contrast-enhanced computed tomography (CT) scan of fibrolamellar carcinoma demonstrates a large, heterogeneously enhancing mass in the right lobe of the liver, with a hypoattenuating central scar and punctate, central calcification. (medscape.com)
of cryptogenic or primary liver abscess, i.e., abscesses without underlying hepatobiliary diseases, in pyogenic Methods liver abscess ( 4,5 ). (cdc.gov)
This battery of measurements are used in the diagnosis and treatment of certain liver, heart, and kidney diseases, acid-base imbalance in the respiratory and metabolic systems, other diseases involving lipid metabolism and various endocrine disorders as well as other metabolic or nutritional disorders. (cdc.gov)
Alanine aminotransferase measurements are used in the diagnosis and treatment of certain liver diseases (e.g., viral hepatitis and cirrhosis) and heart diseases. (cdc.gov)
Albumin measurements are used in the diagnosis and treatment of numerous diseases primarily involving the liver or kidneys. (cdc.gov)

Definitive diagnosis of cT1aN0M0 RCC was made by enhanced computed tomography. (bvsalud.org)

Anatomy9

Organisms4

Diseases111

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment71

Phenomena and Processes24

Disciplines and Occupations2

Information Science8

Named Groups1

Health Care26

Geographicals1

Tumors31

Renal cell carc15

Tumor30

Lesions8

Metastases10

20222

Cancers4

Cancer62

Hepatocellular17

Lesion4

Biopsy4

Metastasis9

Chemotherapy4

Lymph nodes2

Neoplasm5

Urothelial carcinoma3

Resection4

Adenocarcinoma6

Locally advanced1

Disease17

Clinical2

Prognosis4

Cutaneous1

Squamous-cell2

Tumour3

Histologic1

Malignancy1

Prostate2

Neuroendocrine2

Small-cell carc1

Differential diagnoses1

Benign1

Malignancies1

Survival2

Biopsies2

Bone1

Evaluation2

Symptoms1

Tissue1

Therapies2

Breast1

Neoplasms1

Radiotherapy1

Common2

Liver5

Computed tomography1