• For the emergency physician, however, the cell origin of the tumor is less of a concern than the consequent syndromes of spinal cord dysfunction. (medscape.com)
  • The severity of spinal cord compromise secondary to a tumor spans a wide range. (medscape.com)
  • Radiation therapy may be used to relieve bone pain or to shrink a tumor that is pushing on the spinal cord. (medlineplus.gov)
  • The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
  • Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
  • Primary spinal intradural extraskeletal Ewing sarcoma mimicking a giant nerve sheath tumor: case report and review of the literature. (nih.gov)
  • We present three patients with intrathoracic malignant neurogenic tumor. (springeropen.com)
  • Because there is no effective chemotherapeutic regimen for intrathoracic malignant neurogenic tumor, all three patients received high-dose chemotherapy followed by hematopoietic stem cell transplantation. (springeropen.com)
  • Neurogenic tumor is a common intrathoracic neoplasm, representing approximately 20% of all adult and 35% of all pediatric mediastinal neoplasms [ 1 ]. (springeropen.com)
  • Among these cases, malignant neurogenic tumor (MNT) of the thorax is rare. (springeropen.com)
  • 2. Subject has histologically confirmed diagnosis of any one of the indicated tumor types 3. (mycancergenome.org)
  • Tumor markers are tumor-derived or tumor-associated proteins, antigens, genes or hormones that can also aid in diagnosis, in the measurement of therapeutic response, in locating tumor origin or in determining recurrence. (oncolink.org)
  • We report a complication of single dose intent to treat SBRT for a sacral chordoma that should serve to remind oncologists that radiation therapy, like surgery, is not without serious potential complications and that surgical resection may still be the best option for patients whose tumor can be treated with en bloc resection. (fortuneonline.org)
  • Current literature clearly demonstrates that wide en bloc resection with negative surgical margins is the single most important predictor of tumor recurrence and long term survival [1, 2]. (fortuneonline.org)
  • Medulloblastoma is the most common malignant central nervous system (CNS) tumor of childhood, with an annual incidence of about 0.5-0.8/100,000 in children younger than 19 years. (medscape.com)
  • Recent advances in the molecular diagnosis and treatment of pineoblastoma, a rare embryonal tumor of the pineal gland with particular penetrance in infants and young children, are also highlighted in this review. (medlink.com)
  • however, that term is no longer used to refer to a single tumor type but rather to a mixed neoplasm. (msdmanuals.com)
  • Some factors such as individual treatment strategy, according to the histology of the primary tumor, plan of treatment strategies carried out in a multidisciplinary manner, risk-benefit of radiotherapy, assessment of the degree of spinal instability, improvement in communication and referral between specialists in oncology showed an increase in the survival of these patients. (bvsalud.org)
  • Metastatic lesions are responsible for about 85% of neoplastic spinal cord compression cases, with the other 15% due to primary neoplastic lesions of the spine. (medscape.com)
  • Metastatic spinal cord compression is due to invading lesion(s) in the epidural space, between the vertebral bones and the dura of the thecal sac, compressing the thecal sac, spinal cord, or cauda equina. (medscape.com)
  • Metastatic spinal cord compression usually follows arterial hematogenous dissemination of malignant cells to the vertebral bodies, with subsequent expansion into the epidural space. (medscape.com)
  • Metastatic lesions that involve the spinal cord affect about 5-10% of patients with cancer. (medscape.com)
  • Magnetic resonance imaging scans can detect malignant vertebral lesions early, but acute healing compression fractures may mimic the findings of metastatic lesions. (nih.gov)
  • Metastatic lesions are featured in this discussion since they cause 85% of the cases of neoplastic spinal cord compression. (medscape.com)
  • Metastatic tumors that cause epidural cord compression and dysfunction are the most common causes of oncologic CNS injury. (medscape.com)
  • While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
  • Metastatic disease impinging on the spinal cord or threatening spinal cord compression. (mycancergenome.org)
  • 3 ] [ 4 ] The malignant counterpart, liposarcoma, is rare and is characterized by infiltrative growth, low metastatic rate and high recurrence rate. (thieme-connect.com)
  • Among such inhibitors Vemurafenib, a competitive small molecule that selectively recognizes the ATP binding domain of the BRAFV600E mutant, has proved effective in the treatment of metastatic melanoma, a neoplasm frequently mutated for BRAF. (biomedcentral.com)
  • in contrast, spinal tumors secondary to metastatic disease tend to be extradural. (mhmedical.com)
  • The study was carried out to exhaust the scientific literature regarding surgery associated with radiotherapy in patients suffering from metastatic spinal cord compression and to assist in the decision of oncology physicians and professionals in choosing the best treatment for the patient. (bvsalud.org)
  • There were 11 malignant and 11 benign lesions. (nih.gov)
  • Magnetic resonance imaging reliably distinguished benign versus malignant lesions based on the anatomic distribution and intensity of signal changes of bone and adjacent tissues, contrast enhancement characteristics, and changes over time. (nih.gov)
  • Only one malignant lesion was misinterpreted by both neuroradiologists as benign, whereas there was one additional missed malignant lesion and three misinterpreted benign lesions by one radiologist. (nih.gov)
  • [ 3 ] Approximately 15% of all primary CNS lesions arise from the spinal cord, with an estimated incidence rate of 0.5-2.5 cases per 100,000 population. (medscape.com)
  • 2 1 Skeletal abnormalities are found in the majority of MM patients at the time of diagnosis, and manifestations of bone disease in MM include osteolytic lesions, osteopenia/osteoporosis, and fractures. (haematologica.org)
  • Pancoast syndrome (Pancoast's syndrome) typically results when a malignant neoplasm of the superior sulcus of the lung leads to destructive lesions of the thoracic inlet and involvement of the brachial plexus and cervical sympathetic nerves (stellate ganglion). (medscape.com)
  • Brain tumors may be congenital in children younger than 3 years of age and range from benign complex lesions to highly malignant neoplasms. (medlink.com)
  • A group of congenital malformations involving the brainstem, cerebellum, upper spinal cord , and surrounding bony structures. (lookformedical.com)
  • The Department of Neurology deals with various diseases that affect the central nervous system (e.g., the cerebrum, cerebellum, brainstem, and spinal cord), peripheral nerves, and muscles. (keio.ac.jp)
  • The neoplasm can also invade adjacent brainstem structures, including the cardiorespiratory centers of the fourth ventricular floor. (medscape.com)
  • They can present as large tumors occupying contiguous cerebral lobes or as primary pineal, brainstem, or spinal cord tumors. (medlink.com)
  • The patient was referred to the Department of Pulmonology and Lung Cancers of Wroclaw Medical University for a nodule differential diagnosis. (cdc.gov)
  • Dynamic Posturography Aetna considers dynamic posturography (also known as balance board testing, computerized dynamic posturography [CDP], equilibrium platform testing [EPT], and moving platform posturography) experimental and investigational for the diagnosis and staging of patients with Meniere's disease and other balance disorders, for the differential diagnosis of multiple sclerosis and disequilibrium, and all other indications because its clinical value has not been established. (kipdf.com)
  • PTPR should be included in the differential diagnosis of pineal region masses. (surgicalneurologyint.com)
  • While the causes of myelopathy may be multiple, the acuity of presentation and symptom onset frame a practical approach to the differential diagnosis. (bvsalud.org)
  • A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
  • MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • Clinical Policy Bulletin: Chronic Vertigo Revised Feburary 2015 Number: 0238 (Replaces CPB 230) Policy I. Maneuvers for Benign Paroxysmal Positioning Vertigo Aetna considers the Hallpike maneuver medically necessary for the diagnosis of benign paroxysmal positioning vertigo (BPPV). (kipdf.com)
  • Depending on the underlying malignancy, 2% to 5% of patients will develop clinical signs and symptoms of epidural spinal cord compression (ESCC) during the course of their disease. (mhmedical.com)
  • Critical organ involvement of the heart (causing ventricular tachycardia), superior vena cava, brain, and spinal cord may pose a significant clinical challenge. (medscape.com)
  • Diagnosis requires specific clinical criteria and imaging. (msdmanuals.com)
  • Myelopathy is a clinical diagnosis with localization of the neurological findings to the spinal cord, rather than the brain or the peripheral nervous system, and then to a particular segment of the spinal cord. (bvsalud.org)
  • It is more probable that lipomas are at the benign end of the spectrum of tumors, which, at the malignant end, include liposarcomas (see Pathophysiology ). (medscape.com)
  • The authors investigate the usefulness of magnetic resonance imaging in differentiating benign versus malignant compression fractures by reviewing patients and a fracture model in a canine model. (nih.gov)
  • The use of contrast-enhanced magnetic resonance imaging scans and serial magnetic resonance imagings are helpful for additional differentiation between benign and malignant compression fractures. (nih.gov)
  • Information on date of birth, MM diagnosis, fractures, and death was collected from central registries. (haematologica.org)
  • 9 8 This imbalance, along with decreased bone mineral density and treatment-related factors such as treatment with glucocorticoids, can lead to fractures in MM. 11 10 5 In a population-based retrospective study, MM patients were found to have a 9-fold increase in risk of fractures after MM diagnosis, as compared to expected fracture rates in the population. (haematologica.org)
  • Dans une étude cas-témoins rétrospective menée en milieu hospitalier en 2011-2012, des adultes atteints de maladies lymphoprolifératives (n = 130) ont été recrutés dans des services de consultations externes à Menoufia (Égypte), tandis que les témoins appariés pour l'âge et le sexe (n = 130) recrutés souffraient de fractures. (who.int)
  • Intradural, extramedullary spinal Ewing's sarcoma in childhood. (nih.gov)
  • Neoplastic disease can cause neurologic symptoms by compression of the thecal sac, spinal cord, or cauda equina, as well as compression of the attendant vascular supply, which results in cord edema and ischemia. (medscape.com)
  • The histological examination of the residual lesion showed the presence, in addition to the glial component, of mature ganglion cells, leading to a diagnosis of ganglioglioma (GG) (Figure 2 ) with classical morphology, i.e. neoplastic astrocytes and ganglion cells with dysplastic, binucleated neuron, embedded in tissue with eosinhophilic granular body and lymphocytic intratumoral infiltrate. (biomedcentral.com)
  • Neoplastic diseases in the spinal column and spinal cord can have a dramatic impact on an individual as well as on their family members and friends. (mhmedical.com)
  • In addition to confirming the spinal injury, a solitary pulmonary nodule (SPN), 1.3-1.8 cm, in the third segment of the right lung upper lobe was detected by chest radiography and computed tomography ( Figure , panels A, B). The lesion was of high density and had well-defined borders. (cdc.gov)
  • Our department provides individually tailored medical care that not only diagnoses and treats respiratory disease, but also supports patients' rehabilitation to diagnose and treat lung cancer, we hold joint conferences with the Department of General Thoracic Surgery, Department of Radiology, and Department of Diagnostic Pathology. (keio.ac.jp)
  • Multiple myeloma (MM) is a malignant neoplasm of plasma cells in the bone marrow. (haematologica.org)
  • Plasma cell neoplasms (including multiple myeloma) treatment (PDQ) - health professional version. (medlineplus.gov)
  • Lipoblastoma is an exceptional, benign, lobulated, mesenchymal neoplasm arising from embryonal adipose tissue cells or lipoblasts or immature adipocytes. (lupinepublishers.com)
  • As a lobulated, mesenchymal neoplasm comprised of embryonal or foetal adipose tissue, lipoblastoma, characteristically demonstrates a benign biological behaviour, preliminary discernment, male predominance and brisk tumour evolution. (lupinepublishers.com)
  • Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. (embl.de)
  • Type II is the most common, and features compression of the medulla and cerebellar tonsils into the upper cervical spinal canal and an associated MENINGOMYELOCELE . (lookformedical.com)
  • MRI performed during diagnostic work up revealed a bulky mass with cystic component extending from medulla into cervical spinal cord to C5 and dislocating the pons, the floor of the IV ventricle, the cerebellar vermis and tonsils (Figure 1 A). As gross total resection (GTR) was not considered feasible, surgical decompression and a biopsy of the exophitic portion of the lesion were performed revealing a LGG with features compatible with PA. (biomedcentral.com)
  • Figure 1 T2 weighted sagittal magnetic resonance image showing increased signal within the whole spinal cord and medulla oblongata mg/dL is the normal range for cerebrospinal fluid protein in our laboratory) and glu- cose content was 58 mg/dL (simultane- ous blood sugar 90 mg/dL). (who.int)
  • Disseminated via the cerebrospinal fluid or by direct parenchymal spread, metastases to the CNS typically invade the brain, spinal cord, and leptomeninges. (biomedcentral.com)
  • No malignant cells were seen in the cerebrospinal fluid. (who.int)
  • Metastases to the substance of the cord (intramedullary) are relatively rare. (medscape.com)
  • Spinal metastases may result in focal findings at a spinal cord level or nerve root pain. (medscape.com)
  • FNA said "cellular specimen with prominent hurthle cell features, consistent with Hurthle cell neoplasm" the second said "suspicious for follicular neoplasm with hurthle cell features", and "our diagnosis is in exact agreement with that rendered at. (cancer.org)
  • Leptomeningeal metastasis presents as multifocal neurological deficits referable to the spinal cord. (medscape.com)
  • 7 6 In MM bone disease, the interaction between malignant plasma cells and the bone microenvironment leads to osteoclastic bone destruction, reduced osteoblast function, and blocking of bone repair. (haematologica.org)
  • Previous studies have shown that skeletal-related events (radiation to the bone, a pathologic or osteoporotic fracture, hypercalcemia, spinal cord compression, or surgery to the bone) are associated with reduced survival in both breast cancer and prostate cancer. (haematologica.org)
  • Many affected individuals have widespread disease at diagnosis, with involved regions often including multiple lymph nodes, the spleen, and, potentially, the bone marrow, the liver, and/or regions of the digestive (gastrointestinal) tract. (rarediseases.org)
  • This review introduces and discusses different types of liposomes and scaffolds, and also the application of liposome-scaffold composite systems in different diseases, such as cancer, diabetes, skin-related diseases, infection and human immunodeficiency virus, and in tissue regeneration like bone, teeth, spinal cord and wound healing. (abo.fi)
  • In this article, the authors provide an overview of current concepts of clinicopathologic characteristics, specific molecular diagnosis, and general treatment strategies for these rare embryonal tumors of childhood. (medlink.com)
  • From 1961 to 1980, he joined the staff of the National Institute of Health and became Chief of Neurosurgery, studying treatment of malignant neoplasms, the biomechanics and mechanisms of brain injury, and memory. (wikipedia.org)
  • Spinal tumors are classically grouped into three categories: extradural tumors, intradural extramedullary tumors, and intradural intramedullary tumors ( Fig. 17-1 ). (mhmedical.com)
  • Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)
  • A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)
  • A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
  • These patients require rapid diagnosis and treatment to prevent permanent complications (see Presentation , Workup , and Treatment ). (medscape.com)
  • He returned to Pakistan in 2005 after diagnosis of Alzheimer's disease in 2004. (wikipedia.org)
  • People who have mild disease or in whom the diagnosis is not certain are usually closely monitored without giving treatment. (medlineplus.gov)
  • If you or any of your family members have a confirmed or suspected diagnosis of Alpha-1 Liver Disease, you may be eligible. (policylab.us)
  • Imaging procedures play a vital role in diagnosis, allowing physicians to ascertain the presence of a mass, localize it for biopsy, characterize tissue, and determine anatomical extent of disease in preparation for subsequent therapy (surgery and radiation therapy, for example). (oncolink.org)
  • Brain tumors can be cancerous (malignant) or noncancerous (benign). (iraniansurgery.com)
  • Some affected individuals may also be susceptible to developing certain benign (noncancerous) or malignant tumors. (seniorhealthcarematters.com)
  • In order to rule out spinal cord pathol- lar immune derangements that potentially ogy, craniospinal magnetic resonance imag- result in neuronal injury and demyelina- ing (MRI) was obtained immediately. (who.int)
  • Do Hurthle cell adenomas turn malignant in time? (cancer.org)
  • The same team reported the treatment of spinal cord AVMs by percutaneous embolization of an intercostal artery using stainless steel pellets. (wikipedia.org)
  • The use of the Epley maneuver (also known as canalith repositioning procedure) or the Semont maneuver for the treatment of BPPV is considered medically necessary when both of the following selection criteria are satisfied: A. Diagnosis of BPPV has been confirmed by a positive Hallpike test, and B. Member had symptoms of BPPV for at least 4 months. (kipdf.com)
  • It is not intended as a substitute for professional medical advice, diagnosis or treatment. (embl.de)
  • According to Schrijvers, "30-40% of patients [with cancer] present this symptom [pain] at diagnosis, 40-70% during treatment and 70-90% during the palliative care phase. (ndnr.com)
  • Based on our medical experts' knowledge and experience, our department provides accurate diagnoses, and proposes the optimal treatment according to the patient's symptoms. (keio.ac.jp)
  • When possible, en bloc surgical resection has been the recommended treatment for these tumors. (fortuneonline.org)
  • And since doctors see so few young women with breast cancer, there is a gap in research about fertility, early-onset menopause and other effects of diagnosis, treatment and outcomes in young women. (breastcancertalk.net)
  • Disclaimer: The ACR Committee on Appropriateness Criteria and its expert panels have developed criteria for determining appropriate imaging examinations for diagnosis and treatment of specified medical condition(s). (bvsalud.org)
  • We did not detect any changes in the bronchial trees, vocal cords, or trachea. (cdc.gov)
  • A nodule extending from the dorsal lamina of T8 (black arrow) causes ventral and leftward displacement and compression of the spinal cord (white arrow) and the subarachnoid space. (avma.org)
  • The previously mentioned tendency of medulloblastoma to spread via CSF pathways can lead to diffuse "sugar coating" of the subarachnoid space and to nodular growths along the spinal cord or even ventricular surfaces. (medscape.com)
  • Occasionally, an enlarging cancerous lymph node may also compress the cord. (medscape.com)
  • central nervous system disorders will have an effect on either brain or spinal cord that conclusion in psychiatric disorders or neurologic disorders. (crgconferences.com)
  • However, certain malignancies do have characteristic or highly suggestive findings to aid in diagnosis. (oncolink.org)
  • Lipomas are common benign neoplasms originating from subcutaneous tissue adipocytes, with no tendency to metastasize. (thieme-connect.com)
  • in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (embl.de)
  • Anatomically, neoplasms of the spinal cord may be classified according to the compartment of origin, either intramedullary (inside the cord) or extramedullary (outside the cord). (medscape.com)