Post-kala-azar derMucocutaneous leishmaniasisKala-azarForms of leishmaniasisTuberculosisLeprosyTravelersCases of cutaneous leishmaniasisMillion cases of cutaneousParasitic diseaseHuman visceral leishmaniasisInfectionsParasitesCenters for DiseasEndemic areasAfricaType of leishmaniasisForm of leishmaniasisTypes of leishmaniasisAreas where leishmaniasisDiseasesSandflyRecidivansDiseaseSkin soresTreatmentSymptomsDiffusePrevent leishmaniasisMucosal leishmaniasisCentral and SouLaboratoryDifferentialSoresLesionsSystemicEpidemiologyPentavalentLiverParasiteSandfliesWorld Health OrganBrazilSerologicalClinical PresentationIndia
Post-kala-azar der3
- Post-kala-azar dermal leishmaniasis follows the treatment of visceral leishmaniasis and has predominantly been described in Africa (about 2% of cases) and India (about 10% of cases). (medscape.com)
- VANESSA YARDLEY: This video will describe the procedures used when looking for Leishmania amastigotes in tissue samples with a patient with suspected visceral leishmaniasis or post kala-azar dermal leishmaniasis. (futurelearn.com)
- A varying proportion of visceral cases may evolve into a cutaneous form known as post-kala-azar dermal leishmaniasis, which requires lengthy and costly treatment. (who.int)
Mucocutaneous leishmaniasis7
- This is mucocutaneous leishmaniasis and only occurs in limited areas of Bolivia, Brazil, and Peru. (medicinenet.com)
- Mucocutaneous leishmaniasis consists of the relentless destruction of the oropharynx and nose, resulting in extensive midfacial destruction. (medscape.com)
- Mucocutaneous leishmaniasis. (webmd.com)
- The aim of this study is to report a rare case of mucocutaneous leishmaniasis, discussing ways of diagnosis and treatment. (bvsalud.org)
- New World disease may progress to mucocutaneous leishmaniasis. (medscape.com)
- The disease can present in three main ways as: cutaneous leishmaniasis, mucocutaneous leishmaniasis and visceral leishmaniasis. (disabled-world.com)
- The cutaneous form tends to heal spontaneously leaving scars which, depending on the species of Leishmania responsible, may evolve into diffuse cutaneous leishmaniasis, recidivans leishmaniasis, or mucocutaneous leishmaniasis, with disastrous aesthetic consequences for the patient. (who.int)
Kala-azar4
- Another type is visceral leishmaniasis (also called kala-azar or dum-dum fever ). (medicinenet.com)
- Visceral leishmaniasis (kala-azar) affects the internal organs, particularly the bone marrow, lymph nodes, liver, and spleen. (msdmanuals.com)
- Visceral leishmaniasis (VL), commonly known as kala-azar, from the Hindu vernacular, is a human systemic disease caused by parasitic protozoan species of the genus Leishmania . (plos.org)
- Kala-azar epidemiology, diagnosis and control in Nepal / editors: Shekhar Koirala and S. C. Parija. (who.int)
Forms of leishmaniasis2
- There are several different forms of leishmaniasis. (medlineplus.gov)
- Many different forms of leishmaniasis exist that affect people. (disabled-world.com)
Tuberculosis2
- Collecting a detailed travel history, particularly when signs and/or symptoms of gastrointestinal infections as mentioned above, mumps, varicella, tuberculosis, malaria, leishmaniasis, hepatitis A, and COVID-19 are present, may help in identifying and taking appropriate action to prevent further spread of these diseases within the United States. (cdc.gov)
- Acute phase proteins as predictors of disease activity in tropical infections : visceral leishmaniasis and tuberculosis / Kevin Monique Ajilong Wasunna. (who.int)
Leprosy1
- The broad spectrum of clinical manifestations of cutaneous leishmaniasis often is compared with that of leprosy. (medscape.com)
Travelers4
- In other regions, such as the United States and Europe, travelers from affected areas may have leishmaniasis. (medicinenet.com)
- Physicians in the United States must be alert to the diagnosis of leishmaniasis in travelers returning from endemic areas. (aafp.org)
- Detecting infectious diseases and other diagnoses among travelers can serve as sentinel surveillance for new or emerging pathogens and provide information to improve case identification, clinical management, and public health prevention and response. (cdc.gov)
- a number of the instances of cutaneous leishmaniasis in American civilian travelers have been acquired in common tourist destinations such as Costa Rica or other Latin American destinations. (disabled-world.com)
Cases of cutaneous leishmaniasis3
- The lack of an integrated national system prevents the Islamic Republic of Iran from registering and reporting all cases of cutaneous leishmaniasis. (who.int)
- Only 19 cases of cutaneous leishmaniasis and 12 cases of visceral disease were diagnosed in this group. (aafp.org)
- 5 Preliminary data on 22 cases of cutaneous leishmaniasis contracted by American troops in Afghanistan, Kuwait, and Iraq and treated at Walter Reed Army Medical Center between August 2002 and September 2003 were recently released. (aafp.org)
Million cases of cutaneous1
- It is difficult to pinpoint how many cases occur globally, since most may occur in rural, poor areas without established systems of reporting, but the World Health Organization (WHO) reports over 1 million cases of cutaneous (skin) leishmaniasis in the last five years. (medicinenet.com)
Parasitic disease4
- Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. (medlineplus.gov)
- Leishmaniasis is a parasitic disease found in parts of southern Europe, the tropics, and the subtropics. (webmd.com)
- Cutaneous leishmaniasis is a parasitic disease occurring throughout the Americas from Texas to Argentina, and in the Old World, particularly the Middle East and North Africa. (aafp.org)
- Leishmaniasis Parasitic Disease - (Alternative - leishmaniosis) - A disease caused by protozoan parasites of the genus Leishmania and spread by the bite of certain types of sandflies. (disabled-world.com)
Human visceral leishmaniasis1
- Is urine a reliable clinical sample for the diagnosis of human visceral leishmaniasis? (jpgmonline.com)
Infections1
Parasites10
- Leishmaniasis encompasses a group of neglected tropical diseases caused by Leishmania parasites. (who.int)
- Visceral leishmaniasis (VL) is caused by obligate intracellular protozoan parasites, primarily Leishmania infantum (considered synonymous with L. chagasi ) and L. donovani . (cdc.gov)
- Laboratory confirmation of the diagnosis is achieved by detecting Leishmania parasites or DNA in infected blood, bone marrow, liver, or lymph nodes through light-microscopic examination of stained specimens, molecular methods, or tissue culture techniques. (cdc.gov)
- Leishmaniasis is caused by Leishmania parasites that are transmitted by the bite of phlebotomine sand flies. (webmd.com)
- When testing for leishmaniasis, specimens may be taken from your skin sores or bone marrow to be examined for Leishmania parasites. (webmd.com)
- Leishmaniasis is a vector-borne disease caused by protozoan parasites of the genus Leishmania. (degruyter.com)
- Previously, diagnosis of leishmaniasis relied mainly on invasive techniques of detecting parasites in splenic and bone marrow aspirates. (degruyter.com)
- Leishmaniasis, a neglected tropical disease that is caused by protozoan parasites from the genus Leishmania, is not well understood. (healthinternetwork.org)
- Different species of Leishmania parasites can cause leishmaniasis. (healthinternetwork.org)
- Parasites that cause leishmaniasis are living and thriving in the U.S. Those findings were recently confirmed and bolstered by new research from the CDC. (kcbx.org)
Centers for Diseas3
- If you are in the United States, you should contact the Centers for Disease Control and Prevention (CDC), which can help test you for leishmaniasis. (webmd.com)
- Title : Accurately Identifying Neglected Tropical Diseases : using AMD methods to improve diagnosis and clinical management of leishmaniasis Corporate Authors(s) : Centers for Disease Control and Prevention (U.S.). CDC's AMD Initiative. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) recommends that clinicians be on alert for cases of measles that meet the case definition , as well as other infectious diseases, including mumps , leishmaniasis , and malaria , among evacuees (including both Afghan nationals and U.S. citizens) from Afghanistan. (cdc.gov)
Endemic areas6
- To establish a laboratory network for the improvement of diagnosis and surveillance of cutaneous leishmaniasis in endemic areas of the Islamic Republic of Iran using parasitological and molecular methods. (who.int)
- This descriptive, cross-sectional, pilot study examined 49 laboratories in the 2 endemic areas for cutaneous leishmaniasis in the Islamic Republic of Iran. (who.int)
- Physicians working for short periods in endemic areas often must make the diagnosis and should be aware of local disease patterns. (aafp.org)
- This chapter reviews the global perspective of Leishmaniasis with increasing recognition of emerging "Atypical forms" and new surge of disease across the world mainly due to increasing conflicts in endemic areas leading to forced migration among other causes. (intechopen.com)
- The diagnosis is a real challenge to the entire professional team, especially if the patient does not reside in endemic areas and also by the vast possibility of differential diagnoses, including the results of laboratory and anatomopathological tests. (bvsalud.org)
- In endemic areas, cutaneous leishmaniasis may occasionally be part of the differential diagnosis. (medscape.com)
Africa7
- Leishmaniasis occurs in several temperate and tropical countries of Central and South America (New World), the Middle East, East Africa, and East Asia (Old World). (medicinenet.com)
- Cutaneous leishmaniasis is most common in Central and South America, the Middle East, and North and East Africa. (medicinenet.com)
- Old World' (Eastern hemisphere) leishmaniasis occurs in tropical parts of Asia, the Middle East, East and North Africa, and southern Europe. (medicinenet.com)
- Leishmaniasis is endemic in 88 countries throughout Africa, Asia, Europe, and North and South America. (aafp.org)
- In the Eastern Hemisphere, leishmaniasis is found in some parts of the Middle East, Asia, Africa - especially in the tropical regain and North Africa, and southern Europe. (disabled-world.com)
- Objectives To understand stakeholders' perceptions of the access barriers to quality-assured diagnostics and medicines for leishmaniasis in the high-burden region of eastern Africa, and to identify key bottlenecks to improve the supply of commodities for neglected tropical diseases. (bmj.com)
- The authors are all members of the Leishmaniasis East Africa Platform and are currently engaged in the clinical development of paromomycin for treatment of visceral leishmaniasis. (plos.org)
Type of leishmaniasis3
- The most common type of leishmaniasis is cutaneous leishmaniasis. (medicinenet.com)
- Treatment consists of medications that are specific to the type of leishmaniasis, the species of the parasite, and the country in which the patient acquired the disease. (medicinenet.com)
- This type of leishmaniasis typically develops years after your cutaneous leishmaniasis sores have healed. (webmd.com)
Form of leishmaniasis2
- Medications used to treat the infection depend on the clinical form of leishmaniasis, the status of the person's immune system, which species of Leishmania is causing the infection, and where the infection was acquired. (msdmanuals.com)
- Mucosal leishmaniasis is a less common form of leishmaniasis. (disabled-world.com)
Types of leishmaniasis1
- There are 3 types of leishmaniasis: visceral, cutaneous, and mucocutaneous, and cutaneous leishmaniasis (CL) is the most prevalent. (who.int)
Areas where leishmaniasis3
- People of all genders and ages are at risk if they go to areas where leishmaniasis occurs. (webmd.com)
- This infection is typically more common in rural areas, so be sure to take precautions as needed if you spend a lot of time outdoors in areas where leishmaniasis occurs. (webmd.com)
- In several geographic areas where leishmaniasis is found in people, infected people are not needed in order to maintain the transmission cycle of the parasite. (disabled-world.com)
Diseases5
- Leishmaniasis is on the World Health Organization's list of 'neglected tropical diseases. (medicinenet.com)
- WHO considers Leishmaniasis as one of the "Neglected Tropical Diseases" that continues to be prevalent despite international, national, and local efforts towards its control and elimination over the last decade. (intechopen.com)
- This ecological study focused on the spatial pattern of visceral leishmaniasis cases in Brazil from 2007 to 2020 using data from the Information System for Notifiable Diseases (SINAN). (paho.org)
- In resolution WHA43.18 on tropical disease research, the Health Assembly recognized that leishmaniasis, one of the targeted diseases of the then UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, continued to be a major public health problem. (who.int)
- A study in PLOS Neglected Tropical Diseases published in the journal PLOS said that improving access and diagnosis is key to decreasing the disease's burden. (healthinternetwork.org)
Sandfly5
- Leishmaniasis is a disease caused by an intracellular protozoan parasite (genus Leishmania ) transmitted by the bite of a female phlebotomine sandfly. (medscape.com)
- In World War II, there was a high incidence of leishmaniasis and sandfly fever in troops deployed to the Persian Gulf region. (aafp.org)
- Leishmaniasis is transmitted by an infected female sandfly. (escholarship.org)
- Leishmaniasis is caused by a parasite transmitted between infected individuals by the sandfly. (escholarship.org)
- The geographic distribution of cutaneous leishmaniasis is mainly determined by the sandfly vectors ( Phlebotomus sp. (escholarship.org)
Recidivans1
- Leishmaniasis recidivans may occur years after a localized cutaneous lesion has healed, commonly presenting on the face (see the following image). (medscape.com)
Disease33
- Consultation with the CDC and an infectious disease consultant can assist with the diagnosis and treatment of cases imported into the United States. (medicinenet.com)
- Leishmaniasis is a 'vector-borne' infection, meaning that an insect from another host or 'reservoir' (disease carrier) transmits it. (medicinenet.com)
- The clinical spectrum of leishmaniasis ranges from a self-resolving cutaneous ulcer to a mutilating mucocutaneous disease and even to a lethal systemic illness. (medscape.com)
- Classified as a neglected tropical disease (NTD), leishmaniasis is an infection spread by phlebotomine sand flies. (webmd.com)
- This disease must be considered in at-risk patients, and family physicians should know the basics of diagnosis and where to go for more help. (aafp.org)
- Although the incidence of leishmaniasis is greater in the Old World than in the New World, the U.S. traveler is most likely to contract this disease in Latin America. (aafp.org)
- Leishmaniasis is a disease associated with rural areas and poverty, but it has adapted to the urban environment as well. (aafp.org)
- Some species cause visceral leishmaniasis, some cause cutaneous disease, and some cause both. (aafp.org)
- This article focuses on cutaneous leishmaniasis, the more common form of the disease. (aafp.org)
- Leishmaniasis is a vector-borne tropical/subtropical disease caused by an intracellular parasite transmitted to humans by sand fly bite. (intechopen.com)
- All these challenges related to environment, disease, and vector pose major implications on WHO's leishmaniasis control and elimination plan. (intechopen.com)
- Leishmaniasis is a vector-borne disease caused by an obligate intracellular protozoa of genus Leishmania and is transmitted by the bite of a female phlebotomine sand fly ( Figure 1 ). (intechopen.com)
- Leishmaniasis represents a serious public health problem in Brazil and abroad, being endemic in 88 countries and the second most important disease caused by protozoan with medical relevance, exceeded only by malaria. (bvsalud.org)
- Leishmaniasis produces a spectrum of disease. (msdmanuals.com)
- This article provides a brief and updated systematic review on the epidemiology, diagnosis and treatment of this neglected disease. (degruyter.com)
- After recovery or successful treatment, cutaneous leishmaniasis induces immunity to reinfection by the species of Leishmania that caused the disease. (medscape.com)
- The disease has a very long history and lesions like leishmaniasis have been described dating back to the ninth century (Balkan sore). (escholarship.org)
- The disease is transmitted from human to human, but rural or zoonotic leishmaniasis comes from the interaction of man with animals. (escholarship.org)
- The other main form of the disease is visceral leishmaniasis, which affects several of a person's internal organs such as their liver, spleen and bone marrow. (disabled-world.com)
- In 1903, Leishman and Donovan separately described the protozoan now called Leishmania donovani in splenic tissue from patients in India with the life-threatening disease now called visceral leishmaniasis. (unboundmedicine.com)
- A pressing need is for the technological advances in the understanding of the immune response to leishmania and the pathogenesis of leishmaniasis to be translated into field-applicable and affordable methods for diagnosis, treatment, and prevention of this disease. (unboundmedicine.com)
- Leishmaniasis is caused by a protozoal parasite of the genus Leishmania which multiplies in certain vertebrates that act as reservoirs of the disease. (who.int)
- Expression of the two basic forms of the disease, namely cutaneous and visceral leishmaniasis, depends on the species of Leishmania responsible and the immune response to infection. (who.int)
- The global mortality from visceral leishmaniasis can only be estimated, because in many countries the disease is not notifiable or is frequently undiagnosed, especially where there is no access to medication. (who.int)
- There is a shortage of information on the actual cost of leishmaniasis, although it is known that in some parts of Asia a family in which there is a case of leishmaniasis is three times more likely than an unaffected family to have sold its cow or rice field, plunging it into a vicious circle of disease-poverty-malnutrition-disease. (who.int)
- Visceral Leishmaniasis, which can affect the liver and spleen, is the most severe type of this disease. (healthinternetwork.org)
- According to the authors, governments need to invest more in research into leishmaniasis and create new tools for diagnosing and treating the disease. (healthinternetwork.org)
- Leishmaniasis, a neglected and serious tropical disease, affects many millions around the globe. (healthinternetwork.org)
- ABSTRACT Visceral leishmaniasis (VL) has shown endemic pattern and epidemic episodes in urban and rural areas, however, there are still gaps in knowledge with regards to disease transmission. (scielo.br)
- Bern C, Maguire JH, Alvar J. Complexities of assessing the disease burden attributable to leishmaniasis. (aaem.pl)
- How universal is coverage and access to diagnosis and treatment for Chagas disease in Colombia? (dndi.org)
- Specific recommendations aimed at improving access to diagnosis and treatment of Chagas disease are made, along with opportunities that will help inform additional planned health reforms. (dndi.org)
- Aronoff-Spencer's team adapted an existing informatics structure to serve as an end-to-end solution for diagnosis and management of the neglected tropical disease, and then ran a pilot study comparing mHealth-assisted care to standard care. (nih.gov)
Skin sores2
- People may have mild or no symptoms or have skin sores (cutaneous leishmaniasis), or sores in the nose, mouth, or throat that can lead to severe disfigurement (mucosal leishmaniasis), or have fever, weight loss, fatigue, and enlargement of the spleen and liver (visceral leishmaniasis). (msdmanuals.com)
- The most common form is cutaneous leishmaniasis which causes skin sores. (disabled-world.com)
Treatment22
- MedicineNet does not provide medical advice, diagnosis or treatment. (medicinenet.com)
- Visceral leishmaniasis is a systemic infection characterized by fever, weight loss, and hepatosplenomegaly, and it is usually fatal without treatment. (aafp.org)
- Therapy of leishmaniasis ranges from local treatment of cutaneous lesions to systemic often toxic, therapy for disseminated CL, ML and VL. (degruyter.com)
- The long-term treatment outcome of visceral leishmaniasis (VL) patients with HIV co-infection is complicated by a high relapse rate, especially when the CD4 count is low. (dndi.org)
- Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment * * Work performed at West ParanĂ¡ State University (UNIOESTE) - Cascavel (PR), Brazil. (scielo.br)
- Guidelines for the diagnosis and treatment of dermatitis herpetiformis. (scielo.br)
- Diagnosis and treatment of leishmaniasis. (utmb.edu)
- It describes activities in the areas of screening, diagnosis and treatment, and the search for more effective medicines. (who.int)
- First-line treatment, especially for visceral leishmaniasis, is expensive and needs to be administered, by injection, in hospital. (who.int)
- Antimonial drugs are the most commonly used treatment for leishmaniasis. (healthinternetwork.org)
- There is no treatment for leishmaniasis. (healthinternetwork.org)
- Experts are unanimous in agreeing that better diagnosis and easier access to treatment are essential for reducing this disease's burden. (healthinternetwork.org)
- It is possible to lessen the disease's burden by improving diagnosis and treatment. (healthinternetwork.org)
- Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis. (wikipedia.org)
- Developments in diagnosis and treatment of visceral leishmaniasis during the last decade and future prospects. (wikipedia.org)
- The patient wasn't responding to treatment because he, in fact, had leishmaniasis. (kcbx.org)
- Do the diminishing efficacy and increasing toxicity of sodium stibogluconate in the treatment of visceral leishmaniasis in Bihar, India, justify its continued use as a first-line drug? (ajtmh.org)
- Treatment of visceral leishmaniasis in Kenya by aminosidine alone or combined with sodium stibogluconate. (ajtmh.org)
- Based on decisions made by health workers, the app then refers some patients for laboratory testing and, if a positive diagnosis is the result, the app monitors a patient throughout treatment. (nih.gov)
- Treatment Failure in Severe Mpox Patient With Untreated HIV In this case, mpox treatments were rendered ineffective in a patient with untreated HIV, highlighting the importance of initiating ART at the time of diagnosis. (medscape.com)
- Developing a single-dose cure for African sleeping sickness or an effective treatment for leishmaniasis, for example, could generate enormous social returns. (cgdev.org)
- Drug resistance and treatment failure in leishmaniasis: A 21st century challenge. (cdc.gov)
Symptoms5
- Symptoms depend on whether you have cutaneous, mucocutaneous, or visceral leishmaniasis. (webmd.com)
- As with cutaneous leishmaniasis, some people with visceral leishmaniasis won't have symptoms. (webmd.com)
- To find out if you have leishmaniasis, you should ask yourself if you've been in a part of the world where leishmaniasis occurs and check if you have any of the symptoms covered above. (webmd.com)
- Symptoms of mucosal leishmaniasis can develop while the skin sore is present or months to years after the sore heals. (msdmanuals.com)
- Aloe vera gel, turmeric and other natural remedies can be used to reduce symptoms of leishmaniasis. (healthinternetwork.org)
Diffuse3
- Cutaneous leishmaniasis can be simple or diffuse (disseminated). (medscape.com)
- Diffuse (disseminated) cutaneous leishmaniasis. (medscape.com)
- This clinical syndrome should be distinguished from DCL or diffuse cutaneous leishmaniasis, which has been well described throughout central/south America and the Caribbean, but is usually due to L. amazonensis or L. mexicana . (uab.edu)
Prevent leishmaniasis2
- Read on to learn more about how to recognize, treat, and prevent leishmaniasis. (webmd.com)
- There are no drugs or vaccines available to prevent leishmaniasis infection. (disabled-world.com)
Mucosal leishmaniasis3
- Mucosal leishmaniasis affects the mucous membranes of the nose and mouth, causing sores and destroying tissue. (msdmanuals.com)
- Mucosal leishmaniasis may be a consequence of infection with some of the species of the parasite that cause cutaneous leishmaniasis in parts of Latin America. (disabled-world.com)
- The sensitivity of the IIF for mucosal leishmaniasis only was 81.3% (n=16). (bvsalud.org)
Central and Sou1
- New World' (Western hemisphere) leishmaniasis occurs in tropical parts of Mexico and Central and South America. (medicinenet.com)
Laboratory2
- Implementation of a cutaneous leishmaniasis laboratory network can enhance diagnosis, unify diagnostic methods and improve patient care. (who.int)
- Laboratory diagnosis of an imported case of visceral leishmaniasis in Henan Province]. (nih.gov)
Differential2
- Consider VL in the differential diagnosis of people with a relevant travel history even in the distant past, and a persistent, unexplained febrile illness, especially if accompanied by other suggestive manifestations (e.g., pancytopenia or splenomegaly). (cdc.gov)
- Differential diagnosis also includes poststeroid panniculitis and frostbite. (medscape.com)
Sores1
- Less commonly, people who have had cutaneous leishmaniasis may get new sores in the mucous membranes of the mouth, nose, and larynx even years after the cutaneous leishmaniasis has resolved. (medicinenet.com)
Lesions7
- The hallmark of cutaneous leishmaniasis is skin lesions, which can spontaneously heal in 2-10 months. (medscape.com)
- Lesions of cutaneous leishmaniasis may occur anywhere on the body but the most likely sites are the exposed parts. (escholarship.org)
- Skin lesions are the most prevalent form of cutaneous Leishmaniasis. (healthinternetwork.org)
- An mHealth app developed and tested with Fogarty support helps a health worker evaluate patients with suspected leishmaniasis lesions in a remote area. (nih.gov)
- Cutaneous leishmaniasis - caused by bites from infected sandflies - produces skin lesions that leave behind both scars and stigma that last a lifetime. (nih.gov)
- It's our intention to use machine learning and artificial intelligence to combine the pictures of lesions with history and prevalence in the area to come up with predictive models to automatically diagnose leishmaniasis ," he says. (nih.gov)
- In order to determine the sensitivity of the IIF, a total of 95 patients with proven lesions of leishmaniasis were subjected to skin test, histopathology, culture and IIF. (bvsalud.org)
Systemic1
- Systemic leishmaniasis is rarer in Pakistan and invariably fatal if not treated promptly. (escholarship.org)
Epidemiology1
- Studies on the epidemiology of visceral leishmaniasis in Baringo district, Kenya / Kay-Uwe Eberhard Schaefer. (who.int)
Pentavalent2
- Agents with efficacy against leishmaniasis include amphotericin B, pentavalent antimonial drugs, paromomycin and miltefosine. (degruyter.com)
- Pentavalent antimony compounds have been the mainstay of antileishmanial therapy for half a century, but lipid formulations of amphotericin B (though expensive and administered parenterally) represent a major advance for treating visceral leishmaniasis. (unboundmedicine.com)
Liver1
- Leishmaniasis includes several disorders that affect the skin, the mucous membranes of the nose, mouth, or throat or internal organs including the liver, spleen, and bone marrow. (msdmanuals.com)
Parasite1
- A parasite that spreads to humans through the bite of infected Phlebotomus sand flies causes leishmaniasis. (medicinenet.com)
Sandflies2
- Leishmaniasis is transmitted by the bite of female phlebotomine sandflies. (plos.org)
- Leishmaniasis can be caused by the biting of infected sandflies. (healthinternetwork.org)
World Health Organ2
- According to the World Health Organization (WHO), leishmaniasis is endemic in 88 countries, with a total of 350 million people at risk. (escholarship.org)
- According to the World Health Organization (WHO), 12 million people have leishmaniasis at present. (healthinternetwork.org)
Brazil1
- The global Moran index was calculated to assess the existence of spatial autocorrelation, and the local Moran index was used to identify areas with higher and lower risk of visceral leishmaniasis in Brazil. (paho.org)
Serological2
- Nevertheless, serological tests using the recombinant kinesin antigen (rK39) and molecular methods (polymerase chain reaction) are considered the best options for diagnosis today, despite problems related to varying sensitivities and specificities and field adaptability. (degruyter.com)
- Immunofluorescence of perilesional area is considered the gold standard for diagnosis, but serological tests help in cases where it is negative. (scielo.br)
Clinical Presentation1
- In endemics areas a presumptive diagnosis is carried out based on the clinical presentation and reactivity to the skin test. (bvsalud.org)
India1
- Cutaneous leishmaniasis has been given various names in different civilizations such as "Delhi boil" in India, "Baghdad boil" in Iraq, and "saldana" in Afghanistan. (escholarship.org)