HistiocytosisHistiocyticEosinophilicLesionsCellsAbnormal proliferationEtiologyTumorDendritic cellPulmonaryHistiocytesDifferential DiagnosesMacrophagesCell HistiocytosesFibroblast proliferationClinicalPatientsMultisystemAberrantConsidered in the differential diagnosisLungLesionImmunohistochemicalBenignIsletsTissuesMelanocytesBiopsyPathologyKeratinocytesDisorderIndex of suspicionPathologicalBRAFRenalLungsCase
Histiocytosis50
- The most common considerations include: chronic hypersensitivity pneumonitis non-specific interstitial pneumonia sarcoidosis pulmonary Langerhans cell histiocytosis asbestosis Oxygen therapy may assist with daily living. (wikipedia.org)
- Clinical and microbiological evaluation of the oral cavity of patients with Langerhans Cell Histiocytosis. (authorea.com)
- The Langerhans Cell Histiocytosis (LCH) is a disease characterized by the clonal proliferation of Langerhans cells. (authorea.com)
- Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (msdmanuals.com)
- Langerhans Cell Histiocytosis Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. (msdmanuals.com)
- Pulmonary Langerhans cell histiocytosis is a disease in which monoclonal CD1a-positive Langerhans cells (a type of histiocyte) infiltrate the bronchioles and alveolar interstitium, accompanied by lymphocytes, plasma cells, neutrophils, and eosinophils. (msdmanuals.com)
- We present a case of multiorgan, multisite Langerhans cell histiocytosis (LCH), positive for the oncogenic BRAF V600E mutation, in a preterm neonate. (thieme-connect.de)
- Here, we outline the most likely diagnoses with this presentation and discuss a case of Langerhans cell histiocytosis (LCH) in a preterm neonate with severe multiorgan involvement. (thieme-connect.de)
- Pathology of the tissue biopsy demonstrated proliferation of macrophages or dendritic cells, and positive staining with CD1a confirmed a diagnosis of Langerhans' cell histiocytosis (See Figure 2) . (reviewofophthalmology.com)
- Langerhans' cell histiocytosis (LCH), previously known as histiocytosis X, describes a rare spectrum of conditions with abnormal proliferation of histiocytes, occuring in various locations throughout the body. (reviewofophthalmology.com)
- Langerhans cell histiocytosis (LCH) is a group of unexplainable abnormal proliferation and aggregation of Langerhans cell. (bvsalud.org)
- Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. (engineering.org.cn)
- Langerhans cell histiocytosis is a rare disease involving clonal proliferation of langerhans cells seen in children and young adults. (scirp.org)
- We report a rare case of adult Langerhans cell histiocytosis in the dorsal spine causing a spinal cord compression associated with a pulmonary process treated by surgery, radiotherapy and systemic therapy with good evolution. (scirp.org)
- Final diagnosis was therefore Langerhans cell histiocytosis of the dorsal spine complicated by spinal cord compression. (scirp.org)
- A chest CT scan revealed a tumoral process measuring 25 mm at the lower lobe of the left lung evoking a Langerhans cell histiocytosis ( Figure 3 ). (scirp.org)
- Juvenile xanthogranuloma is a rare non-Langerhans cell histiocytosis that usually occurs during infancy and early childhood. (biomedcentral.com)
- Currently, the preferred term is Langerhans cell histiocytosis. (thedoctorsdoctor.com)
- Langerhans cell histiocytosis presenting in the neonatal period: a retrospective case series. (thedoctorsdoctor.com)
- OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
- Epidemiologic study of Langerhans cell histiocytosis in children. (thedoctorsdoctor.com)
- OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)
- Symptoms of Langerhans' Cell Histiocytosis vary depending on the part of the body affected and the severity of the disease. (homeremedylifestyle.com)
- Langerhans' cell histiocytosis can cause symptoms in the skin, bones, lungs, and other parts of the body. (homeremedylifestyle.com)
- The symptoms of Langerhans' cell histiocytosis include pain, swelling, and brown or red skin sores. (homeremedylifestyle.com)
- Langerhans' cell histiocytosis is a rare disease . (homeremedylifestyle.com)
- Children with Langerhans' cell histiocytosis have a high risk of developing cancer. (homeremedylifestyle.com)
- Single-system Langerhans' cell histiocytosis responds well to chemotherapy. (homeremedylifestyle.com)
- Multisystem Langerhans' cell histiocytosis, however, is fatal in severe cases. (homeremedylifestyle.com)
- The treatment for Langerhans' cell histiocytosis will depend on the organs affected. (homeremedylifestyle.com)
- Having a diagnosis of Langerhans' Cell Histiocytosis can be a scary time for a family. (homeremedylifestyle.com)
- A diagnosis of Langerhans' Cell Histiocytosis is dependent on a number of factors. (homeremedylifestyle.com)
- A diagnosis of Langerhans' cell histiocytosis should be made only after the patient has undergone a biopsy . (homeremedylifestyle.com)
- Another way to diagnose Langerhans cell histiocytosis is by examining the lymph nodes. (homeremedylifestyle.com)
- The best way to treat Langerhans' cell histiocytosis is to have the disease treated by experts who understand the disease. (homeremedylifestyle.com)
- Approximately one out of every 200,000 children develops Langerhans cell histiocytosis every year. (homeremedylifestyle.com)
- Cystic fibrosis and Langerhans cell histiocytosis (eosinophilic granuloma) share this feature. (medscape.com)
- Large lung volumes and interstitial disease on plain film also can be seen with Langerhans cell histiocytosis, sarcoidosis, and extrinsic allergic alveolitis. (medscape.com)
- Langerhans cell histiocytosis affecting the lungs. (nih.gov)
- Some researchers believe that langerhans cell histiocytosis in children is a malignant disease, while others consider this form of histiocytosis as a non-tumor process. (antibiotic-store.com)
- Localized histiocytosis is known as eosinophilic granuloma, as well as Langerhans cell granuloma. (antibiotic-store.com)
- To date, it has been proven that the proliferation process (neoplasm of cells and intracellular structures - mitochondria, endoplasmic reticulum, ribosomes, etc.) of Langerhans cells with histiocytosis X is characterized by a monoclonal (belonging to the same cell clone) character. (antibiotic-store.com)
- Langerhans cell histiocytosis in the hypothalamic-pituitary region: a case report. (pacs.de)
- Langerhans cell histiocytosis in a 6-year-old girl with headaches and diabetes insipidus. (pacs.de)
- Axial T1 with contrast (below right) again shows the thick enhancing pituitary stalk and enhancing lesions in both sphenoid wings and in the left orbit.The diagnosis was Langerhans cell histiocytosis of the pituitary and Langerhans cell histiocytosis of the orbit. (pacs.de)
- The central nervous system (CNS) is an uncommonly involved organ system in Langerhans cell histiocytosis (LCH) . (pacs.de)
- For a general discussion of this disease please refer to the article on Langerhans cell histiocytosis (LCH) . (pacs.de)
- JXG does not carry BRAF V600E mutation, except in patients with both Langerhans' cells histiocytosis (LCH) and JXG (non-Langerhan cells histiocytosis) diseases and in the aggressive forms of JXG. (eyewiki.org)
- Langerhans cell histiocytosis: skeletal sites commonly involved, age and incidence ratio F:M. The femoral region has been circled, showing the object of our case [1]. (pacs.de)
- 2009), and investigated the pathophysiology of diseases of this cellular system, incliding Langerhans cell histiocytosis (Senechal et al. (cerclefser.org)
Histiocytic8
- In histiocytic proliferations the distribution of BRAF mutations and their relevance has not been clarified. (oncotarget.com)
- Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF -V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. (oncotarget.com)
- In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. (oncotarget.com)
- Histiocytic/dendritic proliferations involving the synovial tissues are not uncommon. (medscape.com)
- These lesions as well as the rare multicentric reticulohistiocytosis (MRH), a systemic monocytoid/histiocytic disorder with multinucleated giant cells, polyarthritis, and papulonodular skin lesions, should be considered in the differential diagnosis. (medscape.com)
- Histiocytic infiltration and proliferation within the synovium is a common finding associated with inflammatory processes. (medscape.com)
- It emphasizes the importance of immunocytochemistry to separate this histiocyte-like cell proliferation from true histiocytic and other dendritic cell types. (medscape.com)
- Juvenile xanthogranuloma (JXG) is a rare benign histiocytic proliferation that develops in infants and young children. (eyewiki.org)
Eosinophilic2
- It consists of Langerhans cells with oval, grooved and convoluted nucleus and slightly eosinophilic cytoplasm, associated with eosinophils, lymphocytes and plasma cells (H & E × 400). (scirp.org)
- Immunohistochemical diagnosis of pulmonary eosinophilic granuloma on lung biopsy. (nih.gov)
Lesions6
- Patients with this diagnosis can present several manifestations in the oral cavity frequently found are bone lesions and periodontitis. (authorea.com)
- Langerhans cell granulomatosis (LCG) is a clonal disorder characterized by lesions containing histiocyte-like cells, giant cells, and eosinophils. (medscape.com)
- Biopsy of the lesion is necessary to confirm the diagnosis as other orbital lesions in children, such as neuroblastoma, Ewing sarcoma and Wilms tumor, and other bony tumors may also present similarly on clinical exam and radiographic imaging. (reviewofophthalmology.com)
- MA should be included in the differential diagnosis of pigmented lesions of the oral cavity. (biomedcentral.com)
- RDD shows some variability in the involvement of the entire neuraxis, and because its ability to mimic meningeal and primary brain tumors, it is essential to be aware of this entity and consider RDD in the differential diagnosis of various lesions of the CNS. (surgicalneurologyint.com)
- Pathophysiology: The specific pathogenesis is unknown, but is benign proliferation of the cutaneous basal cells that results in smooth or warty elevated lesions (McCance and Huether, 2014). (qualitywriters.org)
Cells23
- Pathophysiology may involve recruitment and proliferation of Langerhans cells in response to cytokines and growth factors secreted by alveolar macrophages in response to cigarette smoke. (msdmanuals.com)
- [ 3 , 4 ] Langerhans cells are stellate dendritic cells that arise from CD34-positive bone marrow stem cells [ 5 ] and are not a member of the mononuclear phagocytic system. (medscape.com)
- Langerhans cell granulomatosis cells are abnormal and coexpress S100 and CD1a, and these markers are used to separate this subpopulation of dendritic cells from other histiocyte-like cells. (medscape.com)
- Microscopic review of the tissue specimen revealed proliferation of histiocytes (left) with positive CD1a staining, a marker for Langerhans' cells (right). (reviewofophthalmology.com)
- Positive immunohistological staining with neuronal markers S100 and CD1a are specific for Langerhans' cells and help to confirm the diagnosis. (reviewofophthalmology.com)
- They all share histologically a significant infiltration of affected tissues by langerhans cells. (scirp.org)
- The histopathologic diagnosis of the lingual neoformation was histiocitary proliferation with the presence of giant cells, Touton type, compatible with juvenile xanthogranuloma. (biomedcentral.com)
- Characteristics of the cells may not be sufficient in many instances to yield a definitive diagnosis or indicate the probable behavior of the lesion. (merckvetmanual.com)
- The antibody is a new monoclonal antibody against a C-type lectin found on the surface of Langerhans cells. (homeremedylifestyle.com)
- The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans . (wikipedia.org)
- Other intrinsic risk factors include the susceptibility of some subpopulations of fibroblasts and keratinocytes to phenytoin, cyclosporine, and/or nifedipine, and the number of Langerhans cells present in oral epithelium. (medscape.com)
- Specifically, the RAS/MAPK pathway regulates the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis). (medlineplus.gov)
- It is characterized by an interstitial proliferation of Langerhans cells in the lung parenchyma. (nih.gov)
- As a result of such normal processes, the lymph nodes can enlarge through either proliferation of normal cells or infiltration by abnormal cells. (medscape.com)
- In LPS-stimulated human monocyte-derived dendritic cells and Langerhans-like cells, the peptides blocked IL-6 secretion, downregulated expression of maturation markers and inhibited dendritic cell migration. (nature.com)
- [16] One theory proposed the coexistence of LCH and JXG could be the result of chemotherapy-induced maturation of Langerhans' cells into macrophages, in particular foamy cells. (eyewiki.org)
- Both antibodies recognized human Langerhans cells, previously shown to express RANK, while dermal dendritic cells were poorly labeled. (cnrs.fr)
- Langerhans antigen presenting cells in the skin, travel from the skin to the regional lymph nodes interacting with T-cells. (qualitywriters.org)
- Lymphangiomyomatosis is a disorder resulting from proliferation of abnormal smooth muscle like cells, mostly in the lungs but can also occur in other body parts such as kidney , mediastinum or axial lymphatics . (wikidoc.org)
- This proliferation of immature muscle cells starts covering alveolar walls, bronchioles , pleura and vessels, including lymphatic routes. (wikidoc.org)
- Excessive proteolytic activity from the proliferation of the smooth muscle cells result in lung destruction and formation of cysts. (wikidoc.org)
- 1.2/ Investigate the development and functions of 'resident' networks of macrophages and Dcs such as langerhans cells and microglia, and their potential roles in inflammation. (cerclefser.org)
- Where are Langerhans cells found? (elitenursinghomeworks.com)
Abnormal proliferation1
- The abnormal proliferation and formation of cysts, causes obstructive pattern of lung disease [9] . (wikidoc.org)
Etiology1
- This article provides a rational approach to determining the etiology of the lymph node disorder, highlights various disorders to consider in treating a child with lymphadenopathy, and discusses various means of obtaining a tissue diagnosis when the cause of lymphadenopathy is uncertain. (medscape.com)
Tumor2
- The clinical, morphological, immunohistochemical, molecular cytogenetic characteristics and histological subtypes of the tumor as well as differential diagnosis have been presented in detail. (bvsalud.org)
- The serine/threonine protein kinase BRAF is an important player in the mitogen-activated protein kinase (MAPK) signaling pathway that transduces mitogenic signals from activated cell-surface growth factor receptors to the cell nucleus and as a result modulates many important cellular processes, such as tumor growth, differentiation, proliferation, and angiogenesis. (hindawi.com)
Dendritic cell1
- The Langerhans cell is a dendritic cell, found in many organs. (springeropen.com)
Pulmonary2
- When pulmonary features of LAM are identified in males, consider a diagnosis of TSC. (medscape.com)
- The purpose of this consensus statement is to provide assistance to clinicians in the diagnosis and management of idiopathic pulmonary fibrosis (IPF). (atsjournals.org)
Histiocytes3
- This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation and may allow histiocytes to grow and divide uncontrollably, leading to the abnormal accumulation of histiocytes that occurs in Erdheim-Chester disease. (medlineplus.gov)
- This disease is characterized by enhanced proliferation (reproduction of cellular elements) of histiocytes, as well as their accumulation in different tissues and the formation of granulomas. (antibiotic-store.com)
- Juvenile xanthogranuloma (JXG) is a benign, self-limiting reactive prolif- erative disorder of non-Langerhans cell histiocytes seen predominantly in infants and young children and occa- sional y in adults. (who.int)
Differential Diagnoses1
- The objectives of the present study were to report a case of multifocal MA in the hard palate and to highlight the main differential diagnoses and immunohistochemical findings. (biomedcentral.com)
Macrophages1
- Hemophagocytic lymphohistiocytosis (HLH) is characterized by aberrant activation and proliferation of polyclonal CD8 + T lymphocytes and macrophages that infiltrate multiple organs and overproduce inflammatory cytokines [ 1 ]. (biomedcentral.com)
Cell Histiocytoses3
- Broadly speaking, they can be divided into Langerhans and non-Langerhans cell histiocytoses. (thedoctorsdoctor.com)
- Langerhans cell histiocytoses are all defined by the presence of a unique ultrastructural organelle, the Birbeck granule. (thedoctorsdoctor.com)
- JXG is the most common form of non-Langerhans' cell histiocytoses. (eyewiki.org)
Fibroblast proliferation2
- It is an area of active fibroblast proliferation within the interstitium of the lung. (wikipedia.org)
- Overview of Interstitial Lung Disease Interstitial lung diseases are a heterogeneous group of disorders characterized by alveolar septal thickening, fibroblast proliferation, collagen deposition, and, if the process remains unchecked. (msdmanuals.com)
Clinical7
- Diagnosis is based on clinical. (msdmanuals.com)
- This case can further provide references for the clinical diagnosis and treatment of LCH. (bvsalud.org)
- Information from radiology, surgical, oncology and other clinical colleagues involved in the diagnosis and treatment of primary bone tumours should be properly assessed before undertaking a structured approach to specimen handling and histological reporting. (biomedcentral.com)
- Frequently, a confident diagnosis cannot be made based on CT alone and integration with clinical information is critical. (springeropen.com)
- Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. (nih.gov)
- Evaluation: Diagnosis is made generally on the clinical manifestations alone. (qualitywriters.org)
- Clinical Manifestations: Obtaining an extensive patient history is very important in the diagnosis of lichen planus. (qualitywriters.org)
Patients10
- There are limited studies examining the outcomes specific to patients with RMS metastatic to bone marrow despite an incidence of 6% at diagnosis. (stanfordchildrens.org)
- The four patients, three adults and one child, were followed for at least 6 months following the initial diagnosis (range 6-18 months). (ima.org.il)
- Multiple immunological abnormalities have been reported in T1D patients including autoantibody production against the insulin molecule, the 65 kD isoform of glutamic acid decarboxylase (GAD65), various islet antigens, and the zinc transporter 8 (ZnT8) as well as decreased regulatory T cell (Treg) capacity to suppress T-cell mediated destruction of the islets of Langerhans 3 . (nature.com)
- The results of a multiorgan workup performed at the time of diagnosis were predictive of which patients in this cohort manifested multisystem disease. (thedoctorsdoctor.com)
- In orthodontic patients, gingival overgrowth has been suggested to be due to nickel accumulation and epithelial cell proliferation. (medscape.com)
- Despite major accomplishments in our understanding of the pathogenesis of lung fibrosis ( 1 ), the diagnosis and management of patients with IPF continues to pose significant challenges ( 2-4 ). (atsjournals.org)
- This is an international consensus statement defining the diagnosis, evaluation, and management of patients with IPF that has been produced as a collaborative effort from the American Thoracic Society (ATS), European Respiratory Society (ERS), and the American College of Chest Physicians (ACCP). (atsjournals.org)
- Even in these instances the diagnosis of IPF was frequently not well established and the series often included patients with other diseases or potential causes of lung fibrosis. (atsjournals.org)
- The prognosis of lymphangiomyomatosis is poor, with 70% of patients not surviving more than 10 years after diagnosis. (wikidoc.org)
- Clinicians, radiologists, and pathologists should exchange information to determine the diagnosis in individual patients. (merckmanuals.com)
Multisystem3
- A multiorgan evaluation at the time of diagnosis may be predictive of the probability of multisystem involvement with LCH. (thedoctorsdoctor.com)
- The differential diagnosis for diseases characterised by lung cysts is broad ranging from isolated chest disorders to rare multisystem diseases. (springeropen.com)
- The differential diagnosis for lung cysts is broad and encompasses multisystem diseases in addition to cystic diseases isolated to the chest (Table 1 ). (springeropen.com)
Aberrant1
- Actinic keratosis is a premalignant lesion made of aberrant proliferations of epidermal caused by prolonged exposure to UV radiation (McCance and Huether, 2014). (qualitywriters.org)
Considered in the differential diagnosis1
- It is less rare than once thought and is not usually considered in the differential diagnosis of chronic daily headaches for months. (jcimcr.org)
Lung4
- The differential diagnosis includes other types of lung disease that cause similar symptoms and show similar abnormalities on chest radiographs. (wikipedia.org)
- Disorders characterised by clustered cyst formation, such as cystic bronchiectasis or fibrotic lung disease associated with honeycombing, are unlikely to ever be in the differential diagnosis of diffuse cystic lung disease and therefore these are not discussed in this review. (springeropen.com)
- LAM is characterized by nonneoplastic peribronchial, perivascular, and perilymphatic proliferation of atypical smooth muscle resulting in vascular and airway obstruction, cyst formation, and a progressive decline in lung function. (medscape.com)
- Pneumofibrosis is a disease characterized by proliferation of the connective tissue of the lung due to the inflammatory process, which causes a violation of the structure of the lungs and a decrease in their ventilation function. (antibiotic-store.com)
Lesion2
- Approximately five years ago, a 49-year-old Caucasian woman came to our hospital for diagnosis, evaluation and treatment of a lingual lesion. (biomedcentral.com)
- The child is 7 years old now, with 5 years follow-up after the diagnosis of JXG: the JXG lesion resolved completely without residual. (who.int)
Immunohistochemical2
- The diagnosis is made with histological and immunohistochemical tests and the main form of treatment is chemotherapy. (authorea.com)
- To establish an accurate diagnosis, microscopic evaluation and immunohistochemical staining are necessary. (biomedcentral.com)
Benign1
- benign, self-healing, non-Langerhans was referred to the dermatology clinic No dysmorphic features were noted. (who.int)
Islets1
- Islets of Langerhans" redirects here. (wikipedia.org)
Tissues2
- However, it is not only a powerful mechanism to control proliferation of microorganisms, it also -unfortunately- damages host tissues and contributes in the long term to many features of ageing and to cardiovascular and neurological diseases. (cerclefser.org)
- They are a critical mediator of the inflammatory response, which is a powerful mechanism to control proliferation of microorganisms, but that also -unfortunately- damages host tissues and contribute in the long term to many features of ageing and to cardiovascular and neurological diseases that decrease quality of life and shorten our lifespan. (cerclefser.org)
Melanocytes3
- The unregulated cell proliferation of early melanocytes leads to a large patch of darkly pigmented skin characteristic of giant congenital melanocytic nevus. (medlineplus.gov)
- According to these authors, MA corresponds to Bloch's melanoepithelioma type 1, a rare variant of pigmented seborrheic keratosis characterized by the proliferation of melanocytes and keratinocytes in the lower layers of the epithelium [ 2 ]. (biomedcentral.com)
- Histologically, MA is characterized by the proliferation of sparse melanocytes throughout the epithelium and epithelial spongiosis. (biomedcentral.com)
Biopsy4
- Diagnosis is based on history and imaging tests and sometimes on bronchoalveolar lavage and biopsy findings. (msdmanuals.com)
- Once the diagnosis is established by tissue biopsy, systemic evaluation is necessary for proper staging of the disease. (reviewofophthalmology.com)
- Based on the differential diagnosis of melanoma, a punch biopsy (4 mm in diameter) was performed. (biomedcentral.com)
- Pre-treatment biopsy demonstrates bland spindle cell proliferation and irregular bony trabeculae resembling fibrous dysplasia. (medscape.com)
Pathology1
- Doctors of various specialties are engaged in the diagnosis and treatment of this category of diseases: allergic pathology and immune insufficiency are in the field of view of allergologists-immunologists, autoimmune diseases (depending on the leading syndrome) are in the competence of specialists-rheumatologists, endocrinologists, neurologists, gastroenterologists, cardiologists, etc. (medic-journal.com)
Keratinocytes1
- In contrast, SALPs did not affect proliferation of keratinocytes. (nature.com)
Disorder1
- Rosai-Dorfman disease is a rare disorder characterized by overproduction (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body (lymphadenopathy), most often those of the neck (cervical lymphadenopathy). (rarediseases.org)
Index of suspicion1
- A high index of suspicion and knowledge about possible causes are required for accurate diagnosis and effective treatment. (medscape.com)
BRAF1
- This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation. (medlineplus.gov)
Renal1
- CT detection of a renal angiomyolipoma or chylous ascites further supports the diagnosis. (medscape.com)
Lungs1
- Radiologically, the main feature required for a confident diagnosis of UIP is honeycomb change in the periphery and the lower portions (bases) of the lungs. (wikipedia.org)
Case1
- We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. (medscape.com)