• In histiocytic proliferations the distribution of BRAF mutations and their relevance has not been clarified. (oncotarget.com)
  • Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF -V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. (oncotarget.com)
  • In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. (oncotarget.com)
  • Histiocytic/dendritic proliferations involving the synovial tissues are not uncommon. (medscape.com)
  • These lesions as well as the rare multicentric reticulohistiocytosis (MRH), a systemic monocytoid/histiocytic disorder with multinucleated giant cells, polyarthritis, and papulonodular skin lesions, should be considered in the differential diagnosis. (medscape.com)
  • Histiocytic infiltration and proliferation within the synovium is a common finding associated with inflammatory processes. (medscape.com)
  • It emphasizes the importance of immunocytochemistry to separate this histiocyte-like cell proliferation from true histiocytic and other dendritic cell types. (medscape.com)
  • Juvenile xanthogranuloma (JXG) is a rare benign histiocytic proliferation that develops in infants and young children. (eyewiki.org)
  • Patients with this diagnosis can present several manifestations in the oral cavity frequently found are bone lesions and periodontitis. (authorea.com)
  • Langerhans cell granulomatosis (LCG) is a clonal disorder characterized by lesions containing histiocyte-like cells, giant cells, and eosinophils. (medscape.com)
  • Biopsy of the lesion is necessary to confirm the diagnosis as other orbital lesions in children, such as neuroblastoma, Ewing sarcoma and Wilms tumor, and other bony tumors may also present similarly on clinical exam and radiographic imaging. (reviewofophthalmology.com)
  • MA should be included in the differential diagnosis of pigmented lesions of the oral cavity. (biomedcentral.com)
  • RDD shows some variability in the involvement of the entire neuraxis, and because its ability to mimic meningeal and primary brain tumors, it is essential to be aware of this entity and consider RDD in the differential diagnosis of various lesions of the CNS. (surgicalneurologyint.com)
  • Pathophysiology: The specific pathogenesis is unknown, but is benign proliferation of the cutaneous basal cells that results in smooth or warty elevated lesions (McCance and Huether, 2014). (qualitywriters.org)
  • Pathophysiology may involve recruitment and proliferation of Langerhans cells in response to cytokines and growth factors secreted by alveolar macrophages in response to cigarette smoke. (msdmanuals.com)
  • [ 3 , 4 ] Langerhans cells are stellate dendritic cells that arise from CD34-positive bone marrow stem cells [ 5 ] and are not a member of the mononuclear phagocytic system. (medscape.com)
  • Langerhans cell granulomatosis cells are abnormal and coexpress S100 and CD1a, and these markers are used to separate this subpopulation of dendritic cells from other histiocyte-like cells. (medscape.com)
  • Microscopic review of the tissue specimen revealed proliferation of histiocytes (left) with positive CD1a staining, a marker for Langerhans' cells (right). (reviewofophthalmology.com)
  • Positive immunohistological staining with neuronal markers S100 and CD1a are specific for Langerhans' cells and help to confirm the diagnosis. (reviewofophthalmology.com)
  • They all share histologically a significant infiltration of affected tissues by langerhans cells. (scirp.org)
  • The histopathologic diagnosis of the lingual neoformation was histiocitary proliferation with the presence of giant cells, Touton type, compatible with juvenile xanthogranuloma. (biomedcentral.com)
  • Characteristics of the cells may not be sufficient in many instances to yield a definitive diagnosis or indicate the probable behavior of the lesion. (merckvetmanual.com)
  • The antibody is a new monoclonal antibody against a C-type lectin found on the surface of Langerhans cells. (homeremedylifestyle.com)
  • The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans . (wikipedia.org)
  • Other intrinsic risk factors include the susceptibility of some subpopulations of fibroblasts and keratinocytes to phenytoin, cyclosporine, and/or nifedipine, and the number of Langerhans cells present in oral epithelium. (medscape.com)
  • Specifically, the RAS/MAPK pathway regulates the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis). (medlineplus.gov)
  • It is characterized by an interstitial proliferation of Langerhans cells in the lung parenchyma. (nih.gov)
  • As a result of such normal processes, the lymph nodes can enlarge through either proliferation of normal cells or infiltration by abnormal cells. (medscape.com)
  • In LPS-stimulated human monocyte-derived dendritic cells and Langerhans-like cells, the peptides blocked IL-6 secretion, downregulated expression of maturation markers and inhibited dendritic cell migration. (nature.com)
  • [16] One theory proposed the coexistence of LCH and JXG could be the result of chemotherapy-induced maturation of Langerhans' cells into macrophages, in particular foamy cells. (eyewiki.org)
  • Both antibodies recognized human Langerhans cells, previously shown to express RANK, while dermal dendritic cells were poorly labeled. (cnrs.fr)
  • Langerhans antigen presenting cells in the skin, travel from the skin to the regional lymph nodes interacting with T-cells. (qualitywriters.org)
  • Lymphangiomyomatosis is a disorder resulting from proliferation of abnormal smooth muscle like cells, mostly in the lungs but can also occur in other body parts such as kidney , mediastinum or axial lymphatics . (wikidoc.org)
  • This proliferation of immature muscle cells starts covering alveolar walls, bronchioles , pleura and vessels, including lymphatic routes. (wikidoc.org)
  • Excessive proteolytic activity from the proliferation of the smooth muscle cells result in lung destruction and formation of cysts. (wikidoc.org)
  • 1.2/ Investigate the development and functions of 'resident' networks of macrophages and Dcs such as langerhans cells and microglia, and their potential roles in inflammation. (cerclefser.org)
  • Where are Langerhans cells found? (elitenursinghomeworks.com)
  • The abnormal proliferation and formation of cysts, causes obstructive pattern of lung disease [9] . (wikidoc.org)
  • This article provides a rational approach to determining the etiology of the lymph node disorder, highlights various disorders to consider in treating a child with lymphadenopathy, and discusses various means of obtaining a tissue diagnosis when the cause of lymphadenopathy is uncertain. (medscape.com)
  • The clinical, morphological, immunohistochemical, molecular cytogenetic characteristics and histological subtypes of the tumor as well as differential diagnosis have been presented in detail. (bvsalud.org)
  • The serine/threonine protein kinase BRAF is an important player in the mitogen-activated protein kinase (MAPK) signaling pathway that transduces mitogenic signals from activated cell-surface growth factor receptors to the cell nucleus and as a result modulates many important cellular processes, such as tumor growth, differentiation, proliferation, and angiogenesis. (hindawi.com)
  • The Langerhans cell is a dendritic cell, found in many organs. (springeropen.com)
  • When pulmonary features of LAM are identified in males, consider a diagnosis of TSC. (medscape.com)
  • The purpose of this consensus statement is to provide assistance to clinicians in the diagnosis and management of idiopathic pulmonary fibrosis (IPF). (atsjournals.org)
  • This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation and may allow histiocytes to grow and divide uncontrollably, leading to the abnormal accumulation of histiocytes that occurs in Erdheim-Chester disease. (medlineplus.gov)
  • This disease is characterized by enhanced proliferation (reproduction of cellular elements) of histiocytes, as well as their accumulation in different tissues and the formation of granulomas. (antibiotic-store.com)
  • Juvenile xanthogranuloma (JXG) is a benign, self-limiting reactive prolif- erative disorder of non-Langerhans cell histiocytes seen predominantly in infants and young children and occa- sional y in adults. (who.int)
  • The objectives of the present study were to report a case of multifocal MA in the hard palate and to highlight the main differential diagnoses and immunohistochemical findings. (biomedcentral.com)
  • Hemophagocytic lymphohistiocytosis (HLH) is characterized by aberrant activation and proliferation of polyclonal CD8 + T lymphocytes and macrophages that infiltrate multiple organs and overproduce inflammatory cytokines [ 1 ]. (biomedcentral.com)
  • Broadly speaking, they can be divided into Langerhans and non-Langerhans cell histiocytoses. (thedoctorsdoctor.com)
  • Langerhans cell histiocytoses are all defined by the presence of a unique ultrastructural organelle, the Birbeck granule. (thedoctorsdoctor.com)
  • JXG is the most common form of non-Langerhans' cell histiocytoses. (eyewiki.org)
  • It is an area of active fibroblast proliferation within the interstitium of the lung. (wikipedia.org)
  • Overview of Interstitial Lung Disease Interstitial lung diseases are a heterogeneous group of disorders characterized by alveolar septal thickening, fibroblast proliferation, collagen deposition, and, if the process remains unchecked. (msdmanuals.com)
  • Diagnosis is based on clinical. (msdmanuals.com)
  • This case can further provide references for the clinical diagnosis and treatment of LCH. (bvsalud.org)
  • Information from radiology, surgical, oncology and other clinical colleagues involved in the diagnosis and treatment of primary bone tumours should be properly assessed before undertaking a structured approach to specimen handling and histological reporting. (biomedcentral.com)
  • Frequently, a confident diagnosis cannot be made based on CT alone and integration with clinical information is critical. (springeropen.com)
  • Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. (nih.gov)
  • Evaluation: Diagnosis is made generally on the clinical manifestations alone. (qualitywriters.org)
  • Clinical Manifestations: Obtaining an extensive patient history is very important in the diagnosis of lichen planus. (qualitywriters.org)
  • There are limited studies examining the outcomes specific to patients with RMS metastatic to bone marrow despite an incidence of 6% at diagnosis. (stanfordchildrens.org)
  • The four patients, three adults and one child, were followed for at least 6 months following the initial diagnosis (range 6-18 months). (ima.org.il)
  • Multiple immunological abnormalities have been reported in T1D patients including autoantibody production against the insulin molecule, the 65 kD isoform of glutamic acid decarboxylase (GAD65), various islet antigens, and the zinc transporter 8 (ZnT8) as well as decreased regulatory T cell (Treg) capacity to suppress T-cell mediated destruction of the islets of Langerhans 3 . (nature.com)
  • The results of a multiorgan workup performed at the time of diagnosis were predictive of which patients in this cohort manifested multisystem disease. (thedoctorsdoctor.com)
  • In orthodontic patients, gingival overgrowth has been suggested to be due to nickel accumulation and epithelial cell proliferation. (medscape.com)
  • Despite major accomplishments in our understanding of the pathogenesis of lung fibrosis ( 1 ), the diagnosis and management of patients with IPF continues to pose significant challenges ( 2-4 ). (atsjournals.org)
  • This is an international consensus statement defining the diagnosis, evaluation, and management of patients with IPF that has been produced as a collaborative effort from the American Thoracic Society (ATS), European Respiratory Society (ERS), and the American College of Chest Physicians (ACCP). (atsjournals.org)
  • Even in these instances the diagnosis of IPF was frequently not well established and the series often included patients with other diseases or potential causes of lung fibrosis. (atsjournals.org)
  • The prognosis of lymphangiomyomatosis is poor, with 70% of patients not surviving more than 10 years after diagnosis. (wikidoc.org)
  • Clinicians, radiologists, and pathologists should exchange information to determine the diagnosis in individual patients. (merckmanuals.com)
  • A multiorgan evaluation at the time of diagnosis may be predictive of the probability of multisystem involvement with LCH. (thedoctorsdoctor.com)
  • The differential diagnosis for diseases characterised by lung cysts is broad ranging from isolated chest disorders to rare multisystem diseases. (springeropen.com)
  • The differential diagnosis for lung cysts is broad and encompasses multisystem diseases in addition to cystic diseases isolated to the chest (Table 1 ). (springeropen.com)
  • Actinic keratosis is a premalignant lesion made of aberrant proliferations of epidermal caused by prolonged exposure to UV radiation (McCance and Huether, 2014). (qualitywriters.org)
  • It is less rare than once thought and is not usually considered in the differential diagnosis of chronic daily headaches for months. (jcimcr.org)
  • The differential diagnosis includes other types of lung disease that cause similar symptoms and show similar abnormalities on chest radiographs. (wikipedia.org)
  • Disorders characterised by clustered cyst formation, such as cystic bronchiectasis or fibrotic lung disease associated with honeycombing, are unlikely to ever be in the differential diagnosis of diffuse cystic lung disease and therefore these are not discussed in this review. (springeropen.com)
  • LAM is characterized by nonneoplastic peribronchial, perivascular, and perilymphatic proliferation of atypical smooth muscle resulting in vascular and airway obstruction, cyst formation, and a progressive decline in lung function. (medscape.com)
  • Pneumofibrosis is a disease characterized by proliferation of the connective tissue of the lung due to the inflammatory process, which causes a violation of the structure of the lungs and a decrease in their ventilation function. (antibiotic-store.com)
  • Approximately five years ago, a 49-year-old Caucasian woman came to our hospital for diagnosis, evaluation and treatment of a lingual lesion. (biomedcentral.com)
  • The child is 7 years old now, with 5 years follow-up after the diagnosis of JXG: the JXG lesion resolved completely without residual. (who.int)
  • The diagnosis is made with histological and immunohistochemical tests and the main form of treatment is chemotherapy. (authorea.com)
  • To establish an accurate diagnosis, microscopic evaluation and immunohistochemical staining are necessary. (biomedcentral.com)
  • benign, self-healing, non-Langerhans was referred to the dermatology clinic No dysmorphic features were noted. (who.int)
  • However, it is not only a powerful mechanism to control proliferation of microorganisms, it also -unfortunately- damages host tissues and contributes in the long term to many features of ageing and to cardiovascular and neurological diseases. (cerclefser.org)
  • They are a critical mediator of the inflammatory response, which is a powerful mechanism to control proliferation of microorganisms, but that also -unfortunately- damages host tissues and contribute in the long term to many features of ageing and to cardiovascular and neurological diseases that decrease quality of life and shorten our lifespan. (cerclefser.org)
  • The unregulated cell proliferation of early melanocytes leads to a large patch of darkly pigmented skin characteristic of giant congenital melanocytic nevus. (medlineplus.gov)
  • According to these authors, MA corresponds to Bloch's melanoepithelioma type 1, a rare variant of pigmented seborrheic keratosis characterized by the proliferation of melanocytes and keratinocytes in the lower layers of the epithelium [ 2 ]. (biomedcentral.com)
  • Histologically, MA is characterized by the proliferation of sparse melanocytes throughout the epithelium and epithelial spongiosis. (biomedcentral.com)
  • Doctors of various specialties are engaged in the diagnosis and treatment of this category of diseases: allergic pathology and immune insufficiency are in the field of view of allergologists-immunologists, autoimmune diseases (depending on the leading syndrome) are in the competence of specialists-rheumatologists, endocrinologists, neurologists, gastroenterologists, cardiologists, etc. (medic-journal.com)
  • Rosai-Dorfman disease is a rare disorder characterized by overproduction (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body (lymphadenopathy), most often those of the neck (cervical lymphadenopathy). (rarediseases.org)
  • A high index of suspicion and knowledge about possible causes are required for accurate diagnosis and effective treatment. (medscape.com)
  • Radiologically, the main feature required for a confident diagnosis of UIP is honeycomb change in the periphery and the lower portions (bases) of the lungs. (wikipedia.org)
  • We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. (medscape.com)