• Vancomycin, a commonly used antibiotic for hospitalacquired infections, can cause severe, refractory thrombocytopenia due to antibody-mediated platelet destruction. (imedpub.com)
  • We describe a unique case of severe vancomycin induced thrombocytopenia with a lower nadir and longer effect duration than previously described. (imedpub.com)
  • Results of laboratory tests revealed severe thrombocytopenia and a careful history disclosed dengue fever as the cause. (bvsalud.org)
  • minocycline and abacavir are the main culprit drugs causing severe lung involvement. (wikipedia.org)
  • CONCLUSIONS: This pilot study demonstrates that single use of Romiplostim is efficacious, cost-effective, and safe without side effects for liver biopsy with severe thrombocytopenia. (sages.org)
  • Single use of Romiplostim should be considered before Trans jugular intra-hepatic porto-systemic shunts or portal hemodynamic procedures and prior to surgical interventions with severe thrombocytopenia. (sages.org)
  • Severe thrombocytopenia is a rare adverse event of panitumumab. (sagepub.com)
  • Here, we report the first patient with metastatic colorectal cancer who developed severe thrombocytopenia, diagnosed as panitumumab-associated drug-induced immune thrombocytopenia (DITP). (sagepub.com)
  • Other systemic disorders that can present with MAHA and thrombocytopenia include pregnancy-associated syndromes (eg, preeclampsia with severe features and HELLP syndrome), severe hypertension, systemic infections and malignancies, autoimmune disorders such as systemic lupus erythematosus, and complications of hematopoietic stem cell or solid organ transplantation. (medilib.ir)
  • In this case report, we describe a patient who received one dose of immunotherapy, developed severe thrombocytopenia, and clinically responded to a course of dexamethasone and Immune Globulin (Ivig) Therapy. (rroij.com)
  • Our case described a patient who developed severe thrombocytopenia following one dose of atezolizumab for metastatic hepatocarcinoma, and had improvement in platelet counts following treatment with dexamethasone and IVIG. (rroij.com)
  • Laboratory workup was significant for severe thrombocytopenia, with a platelet count of less than 3,000/µL, (baseline count of 351,000/µL), hemoglobin of 6.5 g/dL, white blood cell count.72 with a neutrophilic shift, and an International Normalized Ratio (INR) of 1.5. (rroij.com)
  • PURPOSE: Cutaneous reactions to BRAF inhibitors are common, but severe reactions resembling or consistent with drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) are relatively rare. (stanford.edu)
  • Mild to severe thrombocytopenia can be seen, and excessive bleeding is a potential complication. (msdvetmanual.com)
  • This diagnosis should be considered for foals with severe thrombocytopenia when other causes can be excluded. (msdvetmanual.com)
  • A group of lambs artificially reared and fed bovine colostrum developed severe thrombocytopenia with prolonged bleeding from puncture wounds from ear tag placement, subcutaneous bruising, weakness, and pale mucous membranes. (msdvetmanual.com)
  • SCD patients with fever, severe anaemia or pancytopenia should be investigated for early diagnosis and prompt treatment of IAH, which is a life- threatening haematological emergency for which transfusion therapy alone may not suffice. (bvsalud.org)
  • The differential diagnosis for isolated thrombocytopenia in critically ill patients is broad and includes sepsis, disseminated intravascular coagulation and thrombotic thrombocytopenic purpura and medication effects. (imedpub.com)
  • To make an accurate diagnosis, the clinician must recognize the similarity between thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS). (medscape.com)
  • Differential diagnosis of immune thrombocytopenia (ITP), thrombotic thrombocytopenic purpura (TTP), and disseminated intravascular coagulation (DIC). (medscape.com)
  • Drug-induced thrombotic thrombocytopenic purpura: A systematic review and review of European and North American pharmacovigilance data. (medscape.com)
  • It's important to note that HIT symptoms can look very similar to another blood clot condition called vaccine -induced immune thrombotic thrombocytopenia (VITT). (webmd.com)
  • Philadelphia, PA, February 3, 2006 Results from a new study of Arixtra (fondaparinux sodium) called FLEXTRA (Flexibility in Administration of Fondaparinux for Prevention of Symptomatic Venous Thromboembolism in Orthopaedic Surgery) showed the anti-thrombotic drug was generally well tolerated and effective in the prevention of symptomatic venous thromboembolism (VTE) when administered to patients the morning after orthopedic surgery. (webwire.com)
  • Drug-induced thrombotic microangiopathies (DTMAs) are increasingly being recognized as an important category of thrombotic microangiopathies (TMAs). (hindawi.com)
  • Common anticancer chemotherapeutic agents causing drug-induced thrombotic microangiopathy via immune-mediated mechanism or dose-dependent toxicity or both [ 4 , 7 ]. (hindawi.com)
  • INTRODUCTION - The initial evaluation of a patient with suspected thrombotic thrombocytopenic purpura (TTP) or another primary thrombotic microangiopathy (TMA) syndrome must focus on distinguishing these primary syndromes from other systemic disorders that can present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. (medilib.ir)
  • Thrombotic microangiopathy (TMA) - Not all episodes of MAHA are caused by a TMA, and not all TMA will present with MAHA and thrombocytopenia. (medilib.ir)
  • Case Report: A Case of COVID Vaccine-Induced Thrombotic Thrombocytopenia Manifested as Pulmonary Embolism and Hemorrhagia. (frontiersin.org)
  • The hematologic changes of preeclampsia, ie, thrombocytopenia and microangiopathic hemolytic anemia, are similar to those found in thrombotic thrombocytopenic purpura or hemolytic uremic syndrome - disorders in which endothelial dysfunction is thought to be important. (health.am)
  • Adult chronic immune thrombocytopenic purpura (chronic ITP) is an autoimmune disorder in which patients produce anti-platelet antibodies that destroy their platelets leading to a low blood platelet count (thrombocytopenia) that may produce bruising or excessive bleeding. (ndtv.com)
  • Thrombocytopenia is a hematologic disorder that is characterized by a markedly decreased number of circulating blood platelets. (bvsalud.org)
  • Bleeding Time is a screening test for disorder of platelets function, both congenital and acquired: useful in the diagnosis of Von Willebrand's disease. (medical-labs.net)
  • Primary immune thrombocytopenia (ITP) is an autoimmune disease characterized by increased destruction and impaired production of platelets caused by autoantibodies directed against the platelets and megakaryocytes and an increased risk of bleeding. (frontiersin.org)
  • In patients with heparin-induced thrombocytopenia (HIT), this antibody-antigen complex leads to platelet activation, removal of platelets from the circulation, and ultimately, thrombocytopenia. (clinicaladvisor.com)
  • If the patient suffers from idiopathic autoimmune thrombocytopenia, corticosteroids are administered because they decrease the body's inflammatory response and block the antibodies generated against platelets. (lotofhubs.com)
  • Disorders of platelets can be divided into acquired or congenital thrombocytopenias and acquired or congenital functional disorders (thrombocytopathias), with acquired thrombocytopenia being the most common. (msdvetmanual.com)
  • Thrombocytopenia is any disorder in which there is an abnormally low amount of platelets. (medlineplus.gov)
  • Use of certain drugs may also lead to a low production of platelets in the bone marrow. (medlineplus.gov)
  • Heparin-induced thrombocytopenia antibody was negative. (imedpub.com)
  • Background: Heparin-induced thrombocytopenia (HIT) is a rare cause of thrombocytopenia and a potentially life-threatening adverse drug reaction. (uni-regensburg.de)
  • HIT was confirmed by heparin-induced platelet activation (HIPA) test. (uni-regensburg.de)
  • Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse drug reaction characterized by thrombocytopenia and thromboembolism. (biomedcentral.com)
  • Heparin-induced thrombocytopenia (HIT) is a rare but important cause of morbidity and mortality in patients exposed to heparin [ 1 ]. (biomedcentral.com)
  • Heparin -induced thrombocytopenia (HIT) is a life-threatening condition that can happen to some people after they take a medicine called heparin, a blood -thinning drug that helps prevent clots. (webmd.com)
  • When you have heparin-induced thrombocytopenia, your immune system sees heparin-PF4 as an intruder and attacks it, setting off a chain reaction that leads to blood clots. (webmd.com)
  • His primary areas of study are Heparin, Heparin-induced thrombocytopenia, Platelet, Internal medicine and Immunology. (research.com)
  • His Heparin-induced thrombocytopenia study combines topics from a wide range of disciplines, such as Anesthesia and Argatroban, Lepirudin, Danaparoid. (research.com)
  • His Heparin-induced thrombocytopenia study integrates concerns from other disciplines, such as Argatroban and Danaparoid. (research.com)
  • John G. Kelton mainly focuses on Platelet, Immunology, Heparin-induced thrombocytopenia, Heparin and Platelet factor 4. (research.com)
  • Nonheparin anticoagulants for heparin-induced thrombocytopenia. (research.com)
  • Given the patient's history and skin findings, a diagnosis of heparin-induced skin necrosis was rendered. (clinicaladvisor.com)
  • Heparin-induced skin necrosis was. (clinicaladvisor.com)
  • Heparin-induced skin necrosis was first reported in 1973 by physician Richard O'Toole after observing what he described as a localized allergic reaction to subcutaneous heparin in four different patients whose skin lesions became progressively necrotic over time. (clinicaladvisor.com)
  • 4 As this case illustrates, heparin-induced skin necrosis typically begins as a tender, small, erythematous macule that evolves into a larger, dusky, and variably necrotic patch that often features a central bulla.6 Necrosis typically develops at the site of heparin administration and preferentially occurs at sites rich in subcutaneous adipose tissue (e.g., abdomen, thighs, buttocks, and breasts). (clinicaladvisor.com)
  • There are many hypotheses regarding the pathogenesis of heparin-induced skin necrosis, whose histopathology is characterized by microvascular thrombi of dermal vessels, epidermal necrosis, and a variable inflammatory infiltrate. (clinicaladvisor.com)
  • 2,8 Although circulating heparin-PF4 antibodies are often detected in individuals with heparin-induced skin necrosis, these patients rarely demonstrate profound thrombocytopenia or significant activation of the coagulation cascade, which is seen in classic HIT.2,7 It remains important to evaluate patients for these associations, however. (clinicaladvisor.com)
  • Other clinical entities that can present similarly to heparin-induced skin necrosis include calciphylaxis, pyoderma gangrenosum, disseminated intravascular coagulation (DIC), leukocytoclastic vasculitis, and other bullous disorders. (clinicaladvisor.com)
  • Drugs:Heparin induced Thrombocytopenia. (247healthblog.com)
  • A detailed overview, Antithrombotic Drug Therapy in Cardiovascular Disease presents the evidence demonstrating the efficacy of available antithrombotic therapies in specific disease states such as atrial fibrillation, cardiomyopathy, valvular heart disease, and heparin-induced thrombocytopenia (HIT). (clevelandclinic.org)
  • The study looked at 29 patients and demonstrated that the thrombocytopenia was immune mediated. (imedpub.com)
  • Here, we report the first case of ixazomib-induced DTMA due to cumulative toxicity rather than immune-mediated mechanism. (hindawi.com)
  • A response to first line therapy with steroids supports the diagnosis of ITP, whereas absence of response does not exclude ITP but raises the likelihood of alternative causes of thrombocytopenia. (mja.com.au)
  • Important to exclude more dangerous causes of thrombocytopenia. (emdocs.net)
  • Presence of lymphadenopathy or hepatosplenomegaly should NOT be found in ITP and requires consideration of more serious causes of thrombocytopenia. (emdocs.net)
  • The diagnosis is one of exclusion and other causes like drug-induced thrombocytopenia, Immune thrombocytopenia associated with other diseases like collagen vascular disease, lymphoproliferative disorders and infections need to be excluded. (ndtv.com)
  • b)The following conditions will have been excluded either by history or appropriate laboratory investigation: HIV infection (see below), lymphoproliferative disorders, myelodysplasia, SLE, drug-induced or alloimmune thrombocytopenia, or dysglobulinemias. (astrazenecaclinicaltrials.com)
  • All forms of immune thrombocytopenia except for primary ITP.The secondary form of the disease may occur in association with Systemic Lupus Erythematosus, antiphospholipid antibody syndrome, immunodeficient states, lymphoproliferative disorders, viral infections, and therapies using drugs such as quinidine, sulfa and heparin. (247healthblog.com)
  • Our aim with this project is to call for old and new ITP drug reports and for new insights regarding the pathophysiology of ITP. (frontiersin.org)
  • Concomitant use of other drugs that affect hemostasis, such as non-steroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, other anticoagulants. (rxlist.com)
  • Drug rash with eosinophilia and systemic symptoms or drug reaction with eosinophilia and systemic symptoms (DRESS), also termed drug-induced hypersensitivity syndrome (DIHS), is a rare reaction to certain medications. (wikipedia.org)
  • Clinical features of drug-induced hypersensitivity syndrome to BRAF inhibitors with and without previous immune checkpoint inhibition: a review. (stanford.edu)
  • Drug-induced hypersensitivity syndrome like reaction with angioedema and hypotension associated with BRAF inhibitor use and antecedent immune checkpoint therapy. (stanford.edu)
  • Continued assessment for development of thrombocytopenia/VITT is required. (hematology.org)
  • A reduction in platelet number or function can occur through a variety of mechanisms, including autoimmune destruction, spleen sequestration, bone marrow infiltration by tumor cells, infection (e.g. dengue fever), and adverse drug reaction. (bvsalud.org)
  • Swiss children found significant differences bocytopenia with clinically no apparent in history of infection preceding the onset associated conditions or no other cause of of ITP between the Asian and European thrombocytopenia, such as HIV infection, cohorts [ 16 ]. (who.int)
  • [ 3 ] Major causes of acquired neutropenia are infection, drugs (through direct toxicity or immune effects), and autoimmunity. (medscape.com)
  • INITIAL EVALUATION (ALL PATIENTS) - Individuals with a TMA may come to medical attention with any of a variety of presentations including unexplained anemia or thrombocytopenia, unexplained neurologic findings (suspected stroke or transient ischemic attack), or other acute illness. (medilib.ir)
  • Concurrent anemia, thrombocytopenia, and/or an abnormal result on a peripheral blood smear from a patient with neutropenia suggest an underlying hematologic disorder. (medscape.com)
  • Based on the clinical examination, hematological disorder due to dengue fever was chiefly considered, while differential diagnoses included oral squamous cell carcinoma of tongue and buccal mucosa and other infections like influenza, measles, rubella and bacterial sepsis. (bvsalud.org)
  • ITP is diagnosed by exclusions, with a hallmark laboratory finding of isolated thrombocytopenia. (mja.com.au)
  • Recent reports from several Western countries, including the United States, have described an ill-known hantavirus disease, commonly called hemorrhagic fever with renal syndrome (HFRS), induced by Seoul orthohantavirus (SEOV) and spread by infected wild, laboratory, and pet rats. (cdc.gov)
  • Conclusion: Our study shows that in a university hospital setting HIT is well-known, but diagnosis requires a precise laboratory confirmation. (uni-regensburg.de)
  • It is usually straightforward to confirm the diagnosis using simple laboratory studies, such as a serum biochemistry panel and T4 determinations. (vin.com)
  • Accurate diagnosis depends on an ability to recognize the signs and symptoms that indicate an underlying bleeding disorder, followed by appropriate laboratory testing and interpretation of abnormal coagulation studies. (medscape.com)
  • New World human hantavirus illnesses already described in 1993 were HFRS cases, not HCPS cases, in leptospirosis-suspected patients with acute kidney injury (AKI) and thrombocytopenia, whereas the earliest characterized hantavirus pathogen in the United States was not Sin Nombre orthohantavirus (SNV) but SEOV, isolated from a wharf rat in Philadelphia in 1984 ( 1 ). (cdc.gov)
  • In addition to DRESS, SCARs includes four other drug-induced skin reactions: the Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), Stevens-Johnson/toxic epidermal necrolysis overlap syndrome (SJS/TEN) and acute generalized exanthematous pustulosis (AGEP). (wikipedia.org)
  • Acute: 0-12 months from diagnosis. (emdocs.net)
  • She spends time on urticaria, fixed drug eruption, serum-sickness reaction, hypersensitivity vasculitis, morbilliform rash, drug reaction with eosinophilia and systemic symptoms, erythema multiforme, toxic epidermal necrolysis and less familiar drug reactions (acute generalized exanthematous pustulosis, symmetric drug related intertriginous and flexural exanthem). (freemedicalvideos.com)
  • INTRODUCTION:Thrombocytopenia is a common entity in Chronic Liver Disease (CLD) with or without cirrhosis. (sages.org)
  • Although many excellent summaries have recently been published for audiences elsewhere, we present our accumulated consensus perspectives on the diagnosis and management of ITP, specifically addressing clinically relevant areas where there are limitations to the available evidence 1 , 2 , 3 (the guideline development process is described in the online Supporting Information , box). (mja.com.au)
  • Three of the patients recovered promptly after drug discontinuation alone whereas the other patients received additional corticosteroid therapy. (henryford.com)
  • Design, Setting, and Participants: Unblinded, comparative effectiveness, noninferiority randomized clinical trial conducted at 67 oncology practices in the US that enrolled 671 patients with cancer (any invasive solid tumor, lymphoma, multiple myeloma, or chronic lymphocytic leukemia) who had a new clinical or radiological diagnosis of VTE. (bvsalud.org)
  • Physicians and patients selected any DOAC or any LMWH (or fondaparinux) and physicians selected drug doses. (bvsalud.org)
  • This case emphasizes the significance of suspecting HIT in patients with unexplained rapid thrombocytopenia after frequent heparin exposure. (biomedcentral.com)
  • Pertuzumab, a humanized antibody drug, has improved outcomes of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, when administered in combination with trastuzumab and other chemotherapies. (sagepub.com)
  • Patients must have a diagnosis of chronic refractory ITP for at least 3 months. (astrazenecaclinicaltrials.com)
  • Patients who have a history of relevant drug hypersensitivity are excluded. (astrazenecaclinicaltrials.com)
  • Patients who have a history of substance abuse, drug addiction or alcoholism are excluded. (astrazenecaclinicaltrials.com)
  • One-third of CIT episodes were managed in hospital, and for the subset of patients hospitalized with a first-listed diagnosis of CIT, mean length of stay was 4.6 (4.4-5.0) days and mean cost of inpatient care was $36,448 (32,332-41,331). (pai2.com)
  • Further studies are needed to further assess the role of dexamethasone and IVIG in patients with immunotherapy induced thrombocytopenia. (rroij.com)
  • Multiple myeloma in patients whose disease has relapsed or is refractory despite receiving ≥1 previous drug therapies (as monotherapy). (unboundmedicine.com)
  • Multiple myeloma in patients whose disease has relapsed or is refractory despite receiving 1-3 previous drug therapies (in combination with dexamethasone, or lenalidomide + dexamethasone, or daratumumab + dexamethasone, or daratumumab/hyaluronidase + dexamethasone, or isatuximab + dexamethasone). (unboundmedicine.com)
  • aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are common causes of abnormal platelet function, and platelet function testing may need to be deferred if patients have been taking these medications. (arupconsult.com)
  • All cases of BRAF-induced DIHS generally improved on systemic steroids/supportive care, and no cases of death were identified.CONCLUSION: Dermatologists should consider a diagnosis of DIHS following BRAF inhibitor initiation, particularly in the setting of past checkpoint inhibition, with atypical features including relatively rapid onset and steroid responsiveness, lack of peripheral eosinophilia, lymphocytosis, or lymphadenopathy, and increased risk of thrombocytopenia and hypotension. (stanford.edu)
  • Prior to 1996, there were numerous reports on individuals presenting with a medication-induced disorder now recognized as the DRESS syndrome. (wikipedia.org)
  • The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8-16 weeks after exposure to an offending drug. (wikipedia.org)
  • The workup of a patient with a platelet-type bleeding pattern typically includes correlation with platelet count ( thrombocytopenia ), evaluation of platelet morphology on peripheral smear, exclusion of acquired causes of platelet dysfunction, and testing for von Willebrand disease (VWD) . (arupconsult.com)
  • Diagnosis is usually based on complete blood count and peripheral smear and, in selected cases, bone marrow aspiration. (who.int)
  • Thrombocytopenia is also another commonly reported adverse effect as PIs interfere directly with the budding of megakaryocytes rather than causing direct damage to the bone marrow [ 19 ]. (hindawi.com)
  • The degree of thrombocytopenia did not correlate with severity of clinical symptoms, nor did it predict the amount of IgG on the platelet surface. (henryford.com)
  • You can also get HIT symptoms long after you stop taking the drug. (webmd.com)
  • This presents a diagnostic challenge and requires maintaining a high index of suspicion as treatment interventions include avoiding drug exposure. (imedpub.com)
  • In both cohorts, DIHS occurred relatively early, with median time to onset from drug exposure of 8-10days. (stanford.edu)