• [ 5 ] Other, rarer cystic lesions, such as solid pseudopapillary epithelial neoplasm and cystic pancreatic neuroendocrine tumor (cPNET), tend to harbor features that suggest a specific diagnosis, usually leading to surgical removal. (medscape.com)
  • In their analysis of acinar cell carcinomas, the DKFZ researchers found no recurrent cancer-promoting point mutations in tumor-relevant genes, which are characteristic for pancreatic ductal carcinomas. (dkfz.de)
  • The results confirm that acinar cell carcinoma of the pancreas has a completely different tumor biology and, hence, a different development history than tumors of the pancreatic duct," Schmezer said. (dkfz.de)
  • Patients with SCA, specially with this pseudo solid-appearance, such as the present case, may have imaging findings that closely resemble those of patients with pancreatic neuroendocrine neoplasms (pNENs), metastatic renal cell carcinoma, solid pseudopapillary tumor or acinar cell carcinomas (1,4). (spg.pt)
  • While the tumor is often considered to arise from neuroendocrine proliferation or possibly dedifferentiation of an acinar carcinoma, the precise etiology remains uncertain. (karger.com)
  • It is the most common malignant pancreatic tumor in young children and has a mean age of diagnosis of 5 years. (orpha.net)
  • It is a malignant embryonal tumor that seems to recapitulate the embryogenesis of the pancreas, presumably because it originates from the pluripotent pancreatic stem cells during foregut development. (orpha.net)
  • Pancreatoblastoma is usually a large (2 to 20 cm), encapsulated mass with a histological picture of multiple squamoid nests composed of whorls of spindle-shaped cells that are diagnostic of this tumor. (orpha.net)
  • Atypical Carcinoid Tumor Versus Large-Cell Neuroendocrine Carcinoma Yoon E, Cai G . Atypical Carcinoid Tumor Versus Large-Cell Neuroendocrine Carcinoma. (yale.edu)
  • Small-Cell Carcinoma Versus Atypical Carcinoid Tumor Yoon E, Zhang X, Cai G . Small-Cell Carcinoma Versus Atypical Carcinoid Tumor. (yale.edu)
  • Sixty-three cases were reclassified, mostly as well-differentiated neuroendocrine tumor (NET) or acinar cell carcinoma, and eliminated. (johnshopkins.edu)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • On microscopic examination, the smears were cellular and showed many loose cohesive clusters and dispersed tumor cells in a background of abundant reactive lymphoid cells and hemorrhage [Figure 1a and b ]. (cytojournal.com)
  • The tumor cells were arranged in focal acinar or follicular pattern with a round-to-oval nucleus, moderate anisonucleosis, fine nuclear chromatin, and moderate-to-abundant fragile cytoplasm with the focal presence of fine granules. (cytojournal.com)
  • Few bizarre and binucleated tumor cells were also noted [Figure 1c and d ]. (cytojournal.com)
  • On the basis of characteristic cytological features, a diagnosis of metastatic neuroendocrine tumor/paraganglioma was suggested. (cytojournal.com)
  • A core needle biopsy was taken from the mediastinal mass and showed epithelial tumor cells arranged in nesting pattern with focal acinar formation. (hindawi.com)
  • Other less common pancreatic cancers include acinar cell carcinoma, anaplastic carcinoma, osteoclast-like giant cell tumor, mucinous non-cystic carcinoma, adenosquamous carcinoma, signet-ring cell carcinoma and small cell carcinoma [1]. (elsevierpure.com)
  • Acinar cell carcinoma is a rare pancreatic tumor comprising 1% of all exocrine neoplasms, despite the fact that acinar cells make up most of the pancreatic parenchyma [2]. (elsevierpure.com)
  • On CT, the tumor typically is large, partly necrotic, locally invasive, and invariably metastatic at the time of diagnosis [4]. (elsevierpure.com)
  • Giant Cell tumor. (nationalhospital.org)
  • Pancreatic cancer is a life-threatening type of cancer that occurs when the DNA of cells within the pancreas becomes damaged, and tumor forms. (actchealth.com)
  • It's a mixed tumor, meaning it contains a combination of mucous and epidermoid (skin-like) cells. (healthtrip.com)
  • The predominant histologic pattern was nested, with islands of tumor cells compartmentalized by thin-walled capillary vasculature. (elsevierpure.com)
  • Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)
  • Immunohistochemical stains reveal that the tumor cells, exhibit membranous carbonic anhydrase 9 (Figure 3) staining and in contrast to the majority of other clear cell renal cell carcinomas are diffusely positive for CK7 (Figure 4). (mayocliniclabs.com)
  • Taken together, the immunohistochemical and morphologic features of this tumor are consistent with what has been described as a renal carcinoma with fibromuscular stroma. (mayocliniclabs.com)
  • Ovarian High-grade Serous Carcinoma with Transitional-like (SET) Morphology: A Homologous Recombination-deficient Tumor. (cdc.gov)
  • Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland. (nih.gov)
  • and 5) Mixed NE carcinoma - acinar adenocarcinoma. (nih.gov)
  • It can sometimes mimic acinar adenocarcinoma with a high Gleason score (GS). (johnshopkins.edu)
  • In this study, we used 2 tissue microarrays including 63 cases of prostate cancer (18 pure SmCC, 37 pure acinar adenocarcinoma, and 8 mixed acinar adenocarcinoma and SmCC) to validate the value of CD44. (johnshopkins.edu)
  • When analyzed as a continuous variable, CD44 positivity was significantly higher in acinar adenocarcinoma with GS 8 than GS 9 to 10 (P =.027). (johnshopkins.edu)
  • However, the difference of CD44 expression between SmCC and acinar adenocarcinoma was insignificant. (johnshopkins.edu)
  • The current study fails to confirm the value of CD44 in differential diagnosis between prostatic SmCC and acinar adenocarcinoma. (johnshopkins.edu)
  • A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)
  • It is less usually described in association with pancreatic carcinoma: usually of the acinar cell carcinoma (in 80% of cases), which represents 10% of pancreatic malignant tumours [5,7], although it has been reported in the course of some other carcinomas, such as ductal adenocarcinoma and neuroendocrine carcinoma [3]. (scitcentral.com)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • On core biopsy, the diagnosis of pleomorphic carcinoma in a background of adenocarcinoma was made. (turkjpath.org)
  • 20/2 mm 2 and a Gleason score 9 acinar adenocarcinoma (4+5) ISUP 5 (2019) in 5% of the neoplasia. (auanews.net)
  • Neuroendocrine carcinoma of the prostate may develop in patients with previous acinar adenocarcinoma in later stages of castration-resistant prostate cancer owing to lineage plasticity as an adaptative mechanism to targeted therapy. (auanews.net)
  • 2,3 Adenocarcinoma of the prostate cells may acquire neuroendocrine differentiation and in extreme cases a complete transformation of small cell carcinoma. (auanews.net)
  • The most commonly diagnosed exocrine cell cancer is pancreatic ductal adenocarcinoma (PDAC), representing approximately 85% of cases. (actchealth.com)
  • Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • Adenocarcinoma is a type of cancer that originates in the glandular cells of the salivary glands. (healthtrip.com)
  • Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
  • Malignant cystadenocarcinoma and intramedullary mucinous carcinomas may be further subdivided into noninvasive and invasive types. (medscape.com)
  • Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignant exocrine tumour of the pancreas. (wikipedia.org)
  • A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. (nih.gov)
  • [ 1 ] At an international conference in 1989, the term PIN was accepted as a replacement for various other terms (eg, intraductal hyperplasia, hyperplasia with malignant change, large acinar atypical hyperplasia, marked atypia, ductal-acinar dysplasia). (medscape.com)
  • Acinic cell carcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of primary salivary gland malignancies. (nih.gov)
  • The diagnosis is usually confirmed with a fine needle aspiration biopsy, and surgical excision is the main treatment of this malignant neoplasm. (nih.gov)
  • Histologically, this malignant epithelial pancreatic neoplasm of the exocrine cells is characterized by multiple lines of differentiation (acinar, ductal, mesenchymal, neuroendocrine) and the presence of squamoid nests. (orpha.net)
  • Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma Baine M, Cai G , Zhang X. Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma. (yale.edu)
  • Ab-3 shows no reaction with a variety of normal tissues .CEA is not found in benign glands, stroma, or malignant prostatic cells. (samatashkhis.com)
  • An overlapping cytological and growth pattern may also be seen in other malignant renal cell tumours such as conventional RCC (cRCC) and papillary RCC (pRCC). (biomedcentral.com)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • 3,7] Histologically, the just malignant lesion which can be baffled for tubular adenoma is tubular carcinoma. (biopaqc.com)
  • Prostate carcinoma is the second most common malignant disease in men. (hindawi.com)
  • Current diagnosis and management of unusual pancreatic tumors. (nih.gov)
  • In general, pancreatic tumors are divided into two broad categories based on the type of cell that the cancer originated in. (moffitt.org)
  • Differential diagnoses include poorly differentiated adenocarcinomas, solid pseudopapillary tumors, pancreatic carcinoma, pancreatic neuroendocrine tumors and autoimmune pancreatitis. (orpha.net)
  • Most pancreatic cancers are exocrine tumors that develop from ductal and acinar cells. (msdmanuals.com)
  • By the time of diagnosis, 90% of patients have locally advanced tumors that have involved retroperitoneal structures, spread to regional lymph nodes, or metastasized to the liver or lung. (msdmanuals.com)
  • These tumors can pop up in neuroendocrine cells anywhere in the body. (webmd.com)
  • Rarely, tumors grow inside neuroendocrine cells of the prostate. (webmd.com)
  • Cancer Research UK: "Types of Prostate Cancer," "Small cell prostate cancer," "What are neuroendocrine tumors? (webmd.com)
  • Prostate cancer should always be considered in the differential diagnosis of elderly men presenting with metastatic epithelial tumors even in unusual sites. (hindawi.com)
  • This type of pancreatic cancer presents as pancreatic neuroendocrine tumors (PNETs) or islet cell tumors, denoting the specific type of cells they grow from. (actchealth.com)
  • Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
  • Renal cell carcinoma with leiomyomatous stroma" harbor somatic mutations of TSC1, TSC2, MTOR, and/or ELOC (TCEB1): clinicopathologic and molecular characterization of 18 sporadic tumors supports a distinct entity. (mayocliniclabs.com)
  • Poorly differentiated neuroendocrine carcinoma of the pancreas is a highly aggressive neoplasm, with frequent metastases and poor survival. (johnshopkins.edu)
  • 3,6,7,9] Open in another window Figure 2 Histopathology of tubular adenoma showing densely packed tubules lined by dual layer of cells with scanty intervening stroma (H & E stain, 10 watch) Conclusion Predicated on the research of 1 of the biggest group of tubular adenoma of breasts, as reported in English literature, we conclude that uncommon benign neoplasm could be determined with certainty just after HP evaluation. (biopaqc.com)
  • As per the recent 2021 world health organization (WHO) classification of thoracic tumours, this rare neoplasm along with pleomorphic carcinoma and carcinosarcoma comes under the broad category of sarcomatoid carcinomas 5 . (turkjpath.org)
  • Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry Meiklejohn K, Hrones M, Wang M, Prasad M, Cai G , Adeniran A, Gilani S. Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry. (yale.edu)
  • Acinic cell carcinoma is a type of salivary gland cancer that typically grows slowly. (healthtrip.com)
  • Renal oncocytoma, a benign tumour of the kidney, may pose a differential diagnostic problem due to overlapping phenotype with chromophobe renal cell carcinoma or other types of renal cell tumours. (biomedcentral.com)
  • Renal oncocytoma (RO) is a benign tumour of the kidney accounting for approximately 5% of renal cell tumours. (biomedcentral.com)
  • We used the Affymetrix Human Genome U133 A and B GeneChip sets [ 16 ] to establish the gene expression in normal kidney tissues and distinct types of renal cell tumours. (biomedcentral.com)
  • These arise most commonly after skin cancers, but secondary tumours have also been reported following carcinomas of the renal cells, lung, breast and gastrointestinal tract. (medicolegal-partners.com)
  • We report the morphologic, immunophenotypic, ultrastructural, and molecular features of 11 renal carcinomas bearing a t(X;1)(p11.2;q21) and/or the resulting PRCC-TFE3 gene fusion. (elsevierpure.com)
  • Ultrastructurally, all of the six neoplasms examined showed features consistent with conventional-type (clear cell) renal carcinoma, although two demonstrated distinctive intracisternal microtubules. (elsevierpure.com)
  • The differential diagnosis includes conventional-type papillary renal cell carcinoma, conventional-type (clear cell) renal carcinoma, and the ASPL-TFE3 renal carcinomas associated with the t(X;17)(p11,2;q25), with the latter two being morphologically the most similar to the t(X;1) renal carcinomas. (elsevierpure.com)
  • A diagnosis of renal cell carcinoma with fibromyomatous stroma in the appropriate clinical context can therefore have important implications for establishing a diagnosis of tuberous sclerosis complex. (mayocliniclabs.com)
  • Tuberous sclerosis-associated renal cell carcinoma: a clinicopathologic study of 57 separate carcinomas in 18 patients. (mayocliniclabs.com)
  • Metastasis of cancerous cells can affect organs surrounding the pancreas, including the stomach and the colon. (medscape.com)
  • Metastatic Acinar Cell Carcinoma of the Pancreas: A Retrospective Cohort Study on Systemic Chemotherapy and Review of the Literature. (nih.gov)
  • In addition, there are a number of much less common cancer types, including acinar cell carcinoma, that develop from specific exocrine cells of the pancreas. (dkfz.de)
  • For very rare cancers such as acinar cell carcinoma of the pancreas, it is difficult to test the effectiveness of novel drugs in classic clinical trials. (dkfz.de)
  • Pancreatic neuroendocrine tumour (pNET) originates from the endocrine cells within the pancreas. (medicalchannelasia.com)
  • Pancreatic acinar cell carcinoma originates from the acinar cells within the pancreas. (medicalchannelasia.com)
  • Dr Lee: Diagnosis of pancreas cancer requires scans and tissue diagnosis. (medicalchannelasia.com)
  • Those are cells that make hormones to help the function of the organ they occupy, such as the lungs, stomach , and pancreas . (webmd.com)
  • Acinar cell carcinomas are less aggressive and have a better prognosis than the typical ductal carcinoma of the pancreas. (elsevierpure.com)
  • ACC begins in the cells that produce digestive enzymes of the pancreas and represents approximately 2% of cases of pancreatic in adults and roughly 15% in children. (actchealth.com)
  • Approximately 75% of all pancreatic carcinomas occur within the head or neck of the pancreas, 15-20% occur in the body of the pancreas, and 5-10% occur in the tail. (medscape.com)
  • Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features. (nih.gov)
  • Abrahamsson PA: Neuroendocrine differentiation in prostatic carcinoma. (karger.com)
  • It shows significant acinar cell differentiation but also ductal, mesenchymal and neuroendocrine differentiation. (orpha.net)
  • Immunohistochemical labeling for neuroendocrine and acinar differentiation markers was performed. (johnshopkins.edu)
  • However, other variants such as neuroendocrine differentiation of prostate cell lines have increasingly become a clinical challenge. (auanews.net)
  • Finally, a new class was defined called carcinoma with pleomorphic, sarcomatoid, or sarcomatous elements, which brings together a number of proliferations characterized by a spectrum of epithelial to mesenchymal differentiation. (ersjournals.com)
  • One patient with metastatic disease died shortly after diagnosis, the other was lost to follow-up. (karger.com)
  • Metastatic follicular carcinoma. (cytojournal.com)
  • Being aware of this unusual and rare presentation of metastatic prostate carcinoma might decrease diagnostic delay and allow earlier treatment. (hindawi.com)
  • The diagnosis was stage IV metastatic prostate carcinoma (pM1a). (hindawi.com)
  • The majority of pancreatic cancers arise in the exocrine cells. (moffitt.org)
  • These cancers start in the gland cells of the prostate. (webmd.com)
  • Small-cell carcinomas make up about 1% of prostate cancers. (webmd.com)
  • EUS-FNA alone may not accurately differentiate SCA from other pancreatic neoplasms, making the preoperative diagnosis a challenge (1,2), thus leading to unnecessary surgical resections in many cases. (spg.pt)
  • SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
  • Artificial intelligence using deep learning analysis of endoscopic ultrasonography images for the differential diagnosis of pancreatic masses. (nih.gov)
  • A previous study showed that immunohistochemical staining for CD44 could help in the differential diagnosis of these 2 entities. (johnshopkins.edu)
  • Therefore, the differential diagnosis between the benign RO and some chRCC based exclusively on the cellular characteristics can be difficult. (biomedcentral.com)
  • Pneumoconioses: pathological findings and differential diagnosis, in particular silicosis and asbestosis. (unibo.it)
  • Granulomatous lung diseases: sarcoidosis and tuberculosis (and their differential diagnosis). (unibo.it)
  • In spite of their aggressive biologic behavior, some ductal adenocarcinomas show bland nuclear features, making the distinction of benign lesion from an invasive carcinoma difficult, particularly on small biopsy specimens (Fig. 1). (coek.info)
  • Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). (samatashkhis.com)
  • Light microscopy of an acinar cell carcinoma biopsy typically shows granular appearance. (wikipedia.org)
  • Biopsy of the pancreatic and hepatic masses were positive for an acinar cell carcinoma. (hss.edu)
  • Pseudo solid-appearing pancreatic serous microcystic adenomas: Histologic diagnosis with the EUS core biopsy fork-tip needle. (spg.pt)
  • The availability of tools to interrogate the transcriptome and proteome, such as expression profiling, have identified a substantial library of products that could aid in distinguishing a well-differentiated pancreatic carcinoma from a benign pancreatic lesion.2 Many of these proteins can be detected immunohistochemically and are thus available to the practicing pathologist (Table 2).3 Some of these markers have been validated on biopsy specimens as well. (coek.info)
  • Diagnosis is by CT or MRI/MRCP, and then endoscopic ultrasonography with biopsy. (msdmanuals.com)
  • these are followed by endoscopic ultrasonography with fine-needle aspiration (EUS/FNA) biopsy for tissue diagnosis and to assess surgical resectability. (msdmanuals.com)
  • A transrectal ultrasound biopsy was performed reporting small cell neuroendocrine carcinoma. (auanews.net)
  • Richardson RL, Weiland LH: Undifferentiated small cell carcinomas in extrapulmonary sites. (karger.com)
  • Furtado P, Lima MVA, Nogueira C, Franco M, Tavora F: Review of small cell carcinomas of the prostate. (karger.com)
  • Summary Small cell carcinoma (SmCC) of the prostate is a rare and aggressive histologic subtype of the prostate cancer. (johnshopkins.edu)
  • HGPIN is characterized by architecturally benign prostatic acini and ducts lined with atypical cells whose morphologic, histochemical, immunohistochemical, and genetic changes are similar to those of prostate cancer. (medscape.com)
  • The different types of prostate cancer start in different cells. (webmd.com)
  • Rubenstein JH, Katin MJ, Mangano MM, Dauphin J, Salenius SA, Dosoretz DE, Blitzer PH: Small cell anaplastic carcinoma of the prostate: seven new cases, review of the literature and discussion of a therapeutic strategy. (karger.com)
  • Anaplastic carcinoma comprises 2-7% of all pancreatic carcinomas. (elsevierpure.com)
  • A definite diagnosis of pulmonary blastoma was established on the left lung lobectomy specimen based on morphological and immunohistochemical findings. (turkjpath.org)
  • The category ASAP includes a group of lesions (eg, lesions of adenosis, atypical adenomatous hyperplasia, intraductal hyperplasia, and acinar atypical hyperplasia) that have varying clinical significance. (medscape.com)
  • It is envisioned that specific criteria associated with the refined diagnostic terminology will lead to clinically relevant pathologic diagnoses that will stimulate further clinical and molecular investigation and identification of appropriate targeted therapies. (nih.gov)
  • Correctly interpret the diagnoses of the pathologic conditions mentioned above, with a clear understanding of their value for the definition of patient prognosis and treatment. (unibo.it)
  • A total of 107 pancreatic resections originally diagnosed as poorly differentiated neuroendocrine carcinomas were reassessed using the classification and grading (mitotic rate/Ki67 index) criteria put forth by the World Health Organization in 2010 for the gastroenteropancreatic system. (johnshopkins.edu)
  • The clinicopathologic features and survival of the remaining 44 poorly differentiated neuroendocrine carcinomas were further assessed. (johnshopkins.edu)
  • Well-differentiated NET and acinar cell carcinoma are often misdiagnosed as poorly differentiated neuroendocrine carcinoma, emphasizing that diagnostic criteria need to be clearly followed to ensure accurate diagnosis. (johnshopkins.edu)
  • Using an approach that includes consideration of the morphologic features, appropriate immunohistochemistry, and correct clinical context aids in making the proper diagnosis. (medscape.com)
  • Recent immunohistochemistry (IHC) studies have shown ERG overexpression linkage with carcinomatous changes whereas CK5 expression in normal basal cell layers in prostate is an established fact. (journalcra.com)
  • Immunohistochemistry and electron microscopy are invaluable techniques for diagnosis and subclassification, but our intention was to render the classification simple and practical to every surgical laboratory, so that most lung tumours could be classified by light microscopic criteria. (ersjournals.com)
  • The histological examination from the FNA sample revealed a scarce specimen for evaluation, with columnar epithelial cells with mild atypia, positive for CK7 and 19, negative for p53, chromogranin A and synaptophysin. (spg.pt)
  • Diagnosis is based on histological characteristics. (orpha.net)
  • A combination of clinical, radiographic and histological examinations is fundamental for diagnosis, due to the possibility of overlapping clinical characteristics common to other lesions. (bvsalud.org)
  • atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (ersjournals.com)
  • In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
  • MRI revealed a cystic lesion with multiple millimetric cysts separated by filiform septations with mild wall enhancement and no restricted diffusion, establishing a diagnosis of serous cystadenoma. (spg.pt)
  • On computed tomography, acinar cell carcinoma typically is a well-circumscribed, exophytic, low-attenuation mass that may be partially cystic or contain calcifications (Figure 11.1) [3]. (elsevierpure.com)
  • Diseases of the salivary glands are uncommon but they can be particularly challenging to diagnose as the clinical signs and symptoms associated with them can be very diverse, and there is a wide range of possible diagnoses. (medicolegal-partners.com)
  • Tumour classification systems provide the foundation for tumour diagnosis and patient therapy and a critical basis for epidemiological and clinical studies. (ersjournals.com)
  • This study presents three cases of sialolithiasis of minor salivary glands of the upper and lower lip, addresses their clinical characteristics and correlation with microscopic findings, diagnosis and treatment plans. (bvsalud.org)
  • Pancreatic panniculitis is a very rare complication associated with pancreatic disease, appearing in approximately 2 to 3% of all patients, most commonly those with acute or chronic pancreatitis, but also in patients with pancreatic carcinoma. (scitcentral.com)
  • Local invasion and metastasis to the liver (most commonly), lungs and/or regional lymph nodes can often be discovered at diagnosis. (orpha.net)
  • The survival outcome in these patients is very poor due to the high rate of tumour recurrence and distant metastasis, and about two-third of the patients succumb to the disease within 2 years of the diagnosis 7 . (turkjpath.org)
  • GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression Wang M, Chen P, Cai G . GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression. (yale.edu)
  • Histologically, it is indistinguishable from small cell carcinoma of the lung. (elsevierpure.com)
  • Non-neoplastic smoke-related lung disease: chronic obstructive pulmonary disease, small airways disease/respiratory bronchiolitis, Langerhans cell histiocytosis of the lung. (unibo.it)
  • While rare, skin signs associated with pancreatic disease may lead to an early diagnosis or predict the severity of the underlying illness and clinicians should be aware of these cutaneous signs in pancreatic pathology in order to recognize them and appropriately direct management [2]. (scitcentral.com)
  • In addition to performing a literature review and discuss the etiopathogenesis, diagnosis and treatment of this pathology. (bvsalud.org)
  • Prognostic Assessment and Risk Stratification in Patients With Postoperative Major Salivary Acinar Cell Carcinoma. (nih.gov)
  • Radiation damages the acinar cells, and this significantly affects the functionality of the salivary glands. (medicolegal-partners.com)
  • This sample is then examined to identify the nature of the cells, helping in the diagnosis of the type of salivary gland cancer. (healthtrip.com)
  • Prognosis is poor because disease is often advanced at the time of diagnosis. (msdmanuals.com)
  • The large cell carcinoma class has been enriched with several variants, including the LCNEC and the basaloid carcinoma, both with a dismal prognosis. (ersjournals.com)
  • Etiology and factors that should be considered during diagnosis, appropriate treatment and improved prognosis are discussed in this study. (bvsalud.org)
  • The cells show enlarged nuclei and abundant eosinophilic cytoplasm with focal necrosis and scattered mitoses (Figure 3 ). (hindawi.com)
  • Histologically, they consist of a single layer of cuboidal glycogen-rich cells with round nuclei and clarified cytoplasm (1-3). (spg.pt)
  • Examination of the smears reveals that 65.4% of them can be interpreted as fibroadenoma, based on the presence of tight clusters of benign breast duct cells often with focal papillary configurations, plenty of bare nuclei and variable amounts of stromal fragments. (biopaqc.com)
  • Clinico-radio-cytological evaluation might help recognize the benign character of a breasts lesion, but early preoperative definitive medical diagnosis continues to be beyond our reach. (biopaqc.com)
  • As seen on H/E, the above mass forming lesion is comprised of cells with clear cytoplasm arranged in alveolar/ acinar patterns with intersecting bands of fibromyomatous stroma (Figure 1). (mayocliniclabs.com)