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  • GPCR
  • Background- Diacylglycerol is a lipid second messenger that accumulates in cardiomyocytes when stimulated by Gqα protein-coupled receptor (GPCR) agonists such as angiotensin II, phenylephrine, and others. (ahajournals.org)
  • We hypothesized that DGK might prevent GPCR agonist-induced activation of diacylglycerol downstream signaling cascades and subsequent cardiac hypertrophy. (ahajournals.org)
  • 2-6 Gqα protein-coupled receptor (GPCR) agonists such as angiotensin II, 7 endothelin-1, 8 and phenylephrine 9 activate phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate, which produces inositol 1,4,5-trisphosphate and diacylglycerol (DAG). (ahajournals.org)
  • membrane
  • Concordantly, DGKzeta-/- bone marrow-derived mast cells (BMMCs) demonstrate impaired degranulation after Fc epsilonRI cross-linking, associated with diminished phospholipase Cgamma activity, calcium flux, and protein kinase C-betaII membrane recruitment. (duke.edu)
  • antibody
  • Western blot analysis of whole cell lysates probed with diacylglycerol kinase alpha antibody ( VMA00496 ) followed by detection with Goat anti Mouse HRP conjugated ( STAR207P ) and visualized on the ChemiDoc™ MP with 68 second exposure. (bio-rad-antibodies.com)
  • fatty acid
  • The possibility that lipid-induced insulin resistance in human muscle is related to alterations in diacylglycerol (DAG)/protein kinase C (PKC) signaling was investigated in normal volunteers during euglycemic-hyperinsulinemic clamping in which plasma free fatty acid (FFA) levels were increased by a lipid/heparin infusion. (diabetesjournals.org)
  • The objective of the present study was to compare the effects of dietary diacylglycerol (DAG) oil with triacylglycerol (TAG) oil with a similar fatty acid composition (fatty acid chain range: C14-C22, C18 fatty acid chain: >90%) on protein kinase C (PKC) activation and on 1,2-DAG levels. (sigmaaldrich.com)
  • calcium
  • Calcium and diacylglycerol are critical second messengers that together effect mast cell degranulation after allergen cross-linking of immunoglobulin (Ig)E-bound FcepsilonRI. (duke.edu)
  • alpha
  • ATP-NAD kinase contains two domains, where domain 1 has an alpha/beta topology that is related in structure to the N-terminal of phosphofructokinase, and domain 2 has an atypical beta-sandwich topology made of four structural repeats of beta(3) units [ PMID: 16242716 , PMID: 15269221 ]. (ebi.ac.uk)