• Diacylglycerol acyltransferase (DGAT) plays a critical role in the synthesis of triacylglycerol . (bvsalud.org)
  • The Acyl CoA:diacylglycerol (DGAT) is a membrane enzyme that catalyses the final step in TAG biosynthesis. (usda.gov)
  • Inhibitor of diacylglycerol acyltransferase (DGAT). (enzolifesciences.com)
  • A 922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively). (adooq.com)
  • AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively. (adooq.com)
  • ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50= 8 nM). (adooq.com)
  • Pfizer and Bayer say that they have entered into a licensing deal that grants the former exclusive worldwide rights to Bayer's DGAT-1 (diacylglycerol acyltransferase 1) inhibitors, a new class of drug for type 2 diabetes and obesity. (pharmatimes.com)
  • The Acyltransferase family includes acyl-CoA:cholesterol AT (ACAT), diacylglycerol AT (DGAT), and monoacylglycerol AT (MGAT) for the metabolism of lipids. (medchemexpress.cn)
  • DGAT (acyl-CoA:diacylglycerol acyltransferase) is an integral membrane enzyme that catalyses the last step of triacylglycerol synthesis from diacylglycerol and acyl-CoA. (medchemexpress.cn)
  • Gene expression analysis showed an over-expression of acyl carrying protein ( ACP) , stearoyl-ACP desaturase (SAD) , fatty acid acyl-ACP thioesterase (FATA) , and diacylglycerol acyltransferase ( DGAT ) genes, which were mainly induced by nitrogen limitation. (techscience.com)
  • Diacylglycerol acyltransferase (DGAT), an integral membrane protein of the endoplasmic reticulum, catalyses the final step in the sn-glycerol-3-phosphate pathway leading to triacylglycerol. (uleth.ca)
  • PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. (adooq.com)
  • A diglyceride , more correctly known as a diacylglycerol , is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages. (wikidoc.org)
  • Diacylglycerol is a precursor to triacylglycerol (triglyceride), which is formed in the addition of a third fatty acid to the diacylglycerol under the catalysis of diglyceride acyltransferase . (wikidoc.org)
  • Phosphatidic acid is then de-phosphorylated to form diacylglycerol.Diacylglycerols are precursors to triacylglycerols (triglyceride), which are formed by the addition of a third fatty acid to the diacylglycerol under the catalysis of diglyceride acyltransferase. (hmdb.ca)
  • Transfection of HepG2 cells with sense or antisense miR-370 or miR-122 upregulated and downregulated, respectively, the transcription factor sterol-regulatory element binding protein 1c (SREBP-1c) and the enzymes diacylglycerol acyltransferase-2 (DGAT2), fatty acid synthase (FAS), and acyl-CoA carboxylase 1 (ACC1) that regulate fatty acid and triglyceride biosynthesis. (nih.gov)
  • PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM. (adooq.com)
  • T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. (adooq.com)
  • Pradigastat (LCQ-908) is a diacylglycerol acyltransferase 1 (DGAT1) inhibitor. (adooq.com)
  • GSK2973980A is a potent and selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 3 nM. (adooq.com)
  • Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. (ymdb.ca)
  • MGAT (acyl-CoA:monoacylglycerol acyltransferase) catalyzes the synthesis of diacylglycerol, the precursor of physiologically important lipids such as triacylglycerol and phospholipids. (medchemexpress.cn)
  • Synthesis of diacylglycerol begins with glycerol-3-phosphate, which is derived primarily from dihydroxyacetone phosphate , a product of glycolysis (usually in the cytoplasm of liver or adipose tissue cells). (wikidoc.org)
  • The observation that mice lacking the enzyme sn-glycerol-3-phosphate acyltransferase are protected from insulin resistance suggests the possibility that the regulation of TG synthesis be a target for therapy. (oregonstate.edu)
  • Since diacylglycerol is synthesized via phosphatidic acid, it will usually contain a saturated fatty acid at the C-1 position on the glycerol moiety and an unsaturated fatty acid at the C-2 position. (wikidoc.org)
  • Since diacylglycerols are synthesized via phosphatidic acid, they will usually contain a saturated fatty acid at the C-1 position on the glycerol moiety and an unsaturated fatty acid at the C-2 position. (hmdb.ca)
  • Phosphatidic acid is then de-phosphorylated to form diacylglycerol. (wikidoc.org)
  • In enzymology, a phospholipid:diacylglycerol acyltransferase (EC 2.3.1.158) is an enzyme that catalyzes the chemical reaction phospholipid + 1,2-diacylglycerol ⇌ {\displaystyle \rightleftharpoons } lysophospholipid + triacylglycerol Thus, the two substrates of this enzyme are phospholipid and 1,2-diacylglycerol, whereas its two products are lysophospholipid and triacylglycerol. (wikipedia.org)
  • The systematic name of this enzyme class is phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase. (wikipedia.org)
  • Diacylglycerol acyltransferases (DGATs) catalyze the final acylation of sn-1, 2-diacylglycerol (DAG) to form TAG, which is the last and limiting step in the acyl-CoA dependent TAG formation pathway [11]. (researchsquare.com)
  • Here we report a soluble acyl-CoA-dependent DAG acyltransferase from Arabidopsis thaliana. (iisc.ac.in)
  • ACAT (acyl-coenzyme A:cholesterol acyltransferase) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and fatty acyl-coenzyme A. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. (medchemexpress.cn)
  • Proposed mechanisms of action of OM3FAs include inhibition of diacylglycerol acyltransferase, increased plasma lipoprotein lipase activity, decreased hepatic lipogenesis, and increased hepatic β-oxidation. (ku.edu)
  • Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. (enzolifesciences.com)
  • An uncharacterized membrane-bound O-acyltransferase (MBOAT) family member was the most abundant acyltransferase in the endosperm but was absent from the aril. (nih.gov)
  • In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid , a resultant of a reaction conducted by enzyme phospholipase C (PLC) (a membrane -bound enzyme ) that, through the same reaction, produces inositol triphosphate (IP3). (wikidoc.org)
  • Although inositol triphosphate (IP 3 ) diffuses into the cytosol , diacylglycerol (DAG) stays close to the plasma membrane , due to its hydrophobic properties. (wikidoc.org)
  • LA offset the rise in blood and liver TG by inhibiting liver lipogenic gene expression (e.g. sn-glycerol-3-phosphate acyltransferase-1 and diacylglycerol O-acyltransferase-2), lowering hepatic TG secretion, and stimulating clearance of TG-rich lipoproteins. (oregonstate.edu)
  • Taken together, these data suggest that a broad specific DAG acyltransferase may be involved in the cutin as well as in the TAG biosynthesis by supplying hydroxy fatty acid. (iisc.ac.in)
  • An important human protein from this family is lecithin-cholesterol acyltransferase. (wikipedia.org)
  • In silico analysis has revealed that the DCR (defective in cuticular ridges) (At5g23940) gene has a typical HX4D acyltransferase motif at the N-terminal end and a lipid binding motif VX(2)GF at the middle of the sequence. (iisc.ac.in)
  • Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1. (rhea-db.org)
  • Yeast microsomes expressing EaDAcT possessed acetyl-CoA diacylglycerol acetyltransferase activity but lacked long-chain acyl-CoA diacylglycerol acyltransferase activity. (nih.gov)
  • Shown on the right is 1- palmitoyl -2- oleoyl - glycerol but diacylglycerol can have many different combinations of fatty acids attached at the C-1 and C-2 positions. (wikidoc.org)
  • Diacylglycerols can have many different combinations of fatty acids attached at both the C-1 and C-2 positions. (hmdb.ca)
  • Polymorphisms of diacylglycerol acyltransferase 2 gene and their relationship with growth traits in goats. (bvsalud.org)
  • Here, we show that formation of mitochondrial diacylglycerol (DAG) and its binding to PKD1 is the means by which PKD1 is localized to the mitochondria in response to ROS. (biologists.com)
  • Mono- and Diacylglycerols are common food additives used to blend together certain ingredients, such as oil and water, which would not otherwise blend well. (wikidoc.org)
  • Decanoyl coenzyme A (Decanoyl CoA) is coupled with S-adenosylmethionine (SAM) by Vibrio cholera CqsA enzyme to produce a potent quorum-sensing molecule, 3-aminotridec-2-en-4-one (Ea-CAI-1. (sigmaaldrich.com)
  • Acyltransferase (AT) catalyzes the transfer of an acyl moiety from acyl-coenzyme A (acyl-CoA) to an acceptor. (medchemexpress.cn)
  • This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. (wikipedia.org)
  • A key step in the triacylglycerol (TAG) biosynthetic pathway is the final acylation of diacylglycerol (DAG) by DAG acyltransferase. (iisc.ac.in)
  • Acyltransferases play important roles in the maintenance of homeostasis in the human body and have been linked to various diseases. (medchemexpress.cn)