In 2008, it was found that the mRNA expression of PPARGC1A was markedly reduced in pancreatic islets from type 2 diabetic donors compared with that of non-diabetic donors. (wikipedia.org)
In human type 2 diabetic islets, reduced PPARGC1A mRNA levels were associated with impaired glucose-mediated insulin secretion. (wikipedia.org)
Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. (e-dmj.org)
Nephropathy7
Since miR-192 was shown to regulate extracellular matrix proteins Collagen, type I, α1 and α2 (Col1α1 and 2) that accumulate during diabetic nephropathy, miR-192 may play a role in kidney diseases as well. (wikipedia.org)
A correlation between elevated Notch signaling pathway gene expression, which is important for cell to cell communication, and diabetic nephropathy has also been shown. (wikipedia.org)
Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)
Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan. (e-dmj.org)
We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. (e-dmj.org)
CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (e-dmj.org)
Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy. (e-dmj.org)
Microvascular complications3
In vivo Corneal Confocal Microscopy and Nerve Growth Factor in Diabetic Microvascular Complications. (e-dmj.org)
Moreover, NGFs and receptors are also expressed in retina and renal mesangial cells, suggesting their possible role in the common pathogenesis of diabetic microvascular complications. (e-dmj.org)
CONCLUSION: Our results provide a possibility of using novel tools, IVCCM and NGF, as common diagnostic tools for diabetic microvascular complications, but it should be followed by a large population study. (e-dmj.org)
Pathogenesis1
Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
Neuropathy2
In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus in detail. (e-dmj.org)
Nerve growth factors (NGF) are believed to regulate peripheral and central nervous system, neuronal differentiation, and regeneration of damaged nerves, and their role in diabetic neuropathy is being emphasized these days. (e-dmj.org)
Patients5
This means that expression from the PPARGC1A genes were turned down in the diabetic patients. (wikipedia.org)
Further testing revealed that the more PPARGC1A was expressed, the more insulin was released from the islets, and as expected, in diabetic patients there was less PPARGC1A expressed and also less insulin secreted. (wikipedia.org)
Although in all diabetic patients, GFR is initially normal or mildly elevated with no histological alterations, it progresses to produce thick glomerular basement membrane and expand to mesangial, followed by high glomerular capillary pressure and microalbuminuria. (scialert.net)
We plan to examine corneal structures of diabetic patients and compare IVCCM with conventional tools and analyze their serum and tear NGF levels. (e-dmj.org)
METHODS: IVCCM, nerve conduction velocity (NCV), and serum, urine, and tear samplings were done to 42 diabetic patients. (e-dmj.org)
Cells2
Using bisulfite testing, it was also found that there was an approximately twofold increase in DNA methylation of the PPARGC1A promoter of human islet cells from diabetics as compared to non-diabetic human islet cells. (wikipedia.org)
Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
Diabetes2
In a different study where transcriptional changes due to a risk factors for diabetes, were examined, changes in the methylation patterns of the PPARGC1A gene were also found. (wikipedia.org)
Long term diabetes and poor glycemic control are the most important risk factors for DN development ( DCCT Research Group, 1993 ). (scialert.net)
Levels1
Also miR-192 levels have been shown to be increased in glomeruli isolated from diabetic mice when compared to non-diabetic mice, suggesting that it is involved as well. (wikipedia.org)
Important1
Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. (scialert.net)
Type3
In 2008, it was found that the mRNA expression of PPARGC1A was markedly reduced in pancreatic islets from type 2 diabetic donors compared with that of non-diabetic donors. (wikipedia.org)
In human type 2 diabetic islets, reduced PPARGC1A mRNA levels were associated with impaired glucose-mediated insulin secretion. (wikipedia.org)
Since miR-192 was shown to regulate extracellular matrix proteins Collagen, type I, α1 and α2 (Col1α1 and 2) that accumulate during diabetic nephropathy, miR-192 may play a role in kidney diseases as well. (wikipedia.org)
Shown2
Also miR-192 levels have been shown to be increased in glomeruli isolated from diabetic mice when compared to non-diabetic mice, suggesting that it is involved as well. (wikipedia.org)
A correlation between elevated Notch signaling pathway gene expression, which is important for cell to cell communication, and diabetic nephropathy has also been shown. (wikipedia.org)
Found1
Using bisulfite testing, it was also found that there was an approximately twofold increase in DNA methylation of the PPARGC1A promoter of human islet cells from diabetics as compared to non-diabetic human islet cells. (wikipedia.org)